RESUMO
Sodium alginate/Na(+)rectorite-graft-itaconic acid/acrylamide (SA/Na(+)REC-g-IA/AM) hydrogel film was prepared via solution polymerization. The effect of Na(+)REC, KPS, and NMBA content and the ratio of IA to AM on graft ratio, graft efficiency and absorption of liquids were investigated. The structure and morphology were analyzed by FTIR, XRD, TEM and SEM. Results revealed that the optimal Na(+)REC, KPS, and NMBA content and the ratio of IA to AM were 2wt%, 0.8wt%, 0.38wt% and 4, respectively. The hydrogel film was found to exhibit an intercalative structure and coarse surface. The mechanism of graft copolymerization was discussed. A slower and more continuous release of salicylic acid for SA/Na(+)REC-g-IA/AM composite hydrogel film was shown in vitro drug-controlled release studies, in comparison with SA film. The salicylic acid release mechanism of SA/Na(+)REC-g-IA/AM hydrogel film followed Fickian diffusion.
Assuntos
Acrilamida/química , Alginatos/química , Silicatos de Alumínio/química , Preparações de Ação Retardada/química , Hidrogel de Polietilenoglicol-Dimetacrilato/química , Minerais/química , Succinatos/química , Acrilamida/síntese química , Alginatos/síntese química , Silicatos de Alumínio/síntese química , Anti-Infecciosos/administração & dosagem , Cátions Monovalentes/síntese química , Cátions Monovalentes/química , Preparações de Ação Retardada/síntese química , Ácido Glucurônico/síntese química , Ácido Glucurônico/química , Ácidos Hexurônicos/síntese química , Ácidos Hexurônicos/química , Hidrogel de Polietilenoglicol-Dimetacrilato/síntese química , Minerais/síntese química , Polimerização , Ácido Salicílico/administração & dosagem , Succinatos/síntese químicaRESUMO
A series of pyridinium-based cationic surfactants has been synthesised and their amphiphilic properties have been studied by conductivity and surface tension measurements. The modification of the substitution pattern on the pyridinium ring by hydrophobic moieties (methyl vs. hydrogen and presence or not of condensed benzene ring) gave the opportunity to investigate structure-activity relationships. Characterization by conductivity and surface tension measurements shed light on the behaviour at the air/water interface and in the micellar environment. In particular, the tendency to form ion pairs at very low concentration was evidenced for all the surfactants substituted on the ring, but not for the simple pyridinium ones. The formation of ion pairs affects both the conductivity and the surface tension plots, showing that a series of steps is involved during the adsorption to the air/water surface. An attempt was made to qualify the single steps in the adsorption at the surface layer. Those steps were attributed to different chemical species (free surfactant ions or ion pairs) and to different arrangements of the surfactant. This work also represents a contribution of investigation at very low surfactant concentrations and high surface tension values.
