RESUMO
The smell of rotten fish is one of the characteristics of bacterial vaginosis (BV), and is due to trimethylamine (TMA). Trimethylamine can be found in human urine, although most of it occurs as the nonvolatile oxide (TMAO) form. The fraction TMA/TMAO can be expected to be the same in different body fluids if no local production of TMA occurs. In women with BV, TMAO in the vaginal fluid is expected to be chemically reduced by the local bacterial flora to the much more odorous TMA. We have therefore studied the local vaginal production of TMA in vaginal secretion compared to the general TMA-TMAO metabolism that was measured in urine using gas chromatography. Both vaginal fluid and random urine samples were collected from women, with and without BV, attending a Swedish clinic for sexually transmitted diseases, and these samples were analyzed for TMA and TMAO. The results show that a local production of TMA occurs in the vagina that is not part of the general metabolism of TMA-TMAO.
Assuntos
Metilaminas/metabolismo , Vaginose Bacteriana/metabolismo , Adulto , Líquidos Corporais/metabolismo , Candidíase Vulvovaginal/metabolismo , Candidíase Vulvovaginal/urina , Infecções por Chlamydia/metabolismo , Infecções por Chlamydia/urina , Feminino , Humanos , Metilaminas/urina , Odorantes , Vagina/metabolismo , Vaginose Bacteriana/diagnóstico , Vaginose Bacteriana/urinaRESUMO
The multiplicity of information which electronmicroscopy has contributed to our knowledge of Candida albicans and its relationship to the human host is reviewed and by means of examples presented.
Assuntos
Candida albicans/ultraestrutura , Candidíase/microbiologia , Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Candidíase/urina , Candidíase Vulvovaginal/microbiologia , Candidíase Vulvovaginal/urina , Feminino , Humanos , Nistatina/farmacologiaRESUMO
Because of the apparent increase in vulvovaginitis caused by Candida species, the chronic disability caused by this infection and its stubborn resistance to current therapy, a study of 100 women was undertaken to attempt to gain insight into the role of dietary sugar ingestion in the pathogenesis of this disease. Urinary sugar patterns of glucose, arabinose and ribose were elevated. These excretion patterns correlated well with the excessive oral ingestion of dairy products, artificial sweeteners and sucrose. Eliminating excessive use of these foods brought about a dramatic reduction in the incidence and severity of Candida vulvovaginitis.
