1.
Chem Commun (Camb)
; 53(65): 9109-9112, 2017 Aug 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28759056
RESUMO
A FRET donor-acceptor xanthene-coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The "locked" FRET pair was selectively "unlocked" by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.