RESUMO
PIP: The alkaloids ergocornine, vinblastine, and colcemide, with reported effects interfering with ovum implantation and development were investigated in the white New Zealand rabbit and the macaque monkey. 3 antimetabolites, 5-fluorouracil, 6-azauridine, and BW 57-323H, the 6 mercaptopurine derivative, were also investigated. Ergocornine was ineffective at the dosage employed (1.5-2.5 mg/kg) and vinblastine was teratogenic. Colcemide was administered in single doses ranging from .1-5 mg/kg. From Day 9 until term it was an extremely toxic agent to the developing fetus, death occurring within 2-4 hours after administration. At 5.0 mg/kg, 50% of the animals died from toxicity. Administration in the macaque monkey on Days 24, 45, 66, and 84 of pregnancy was without effect. 2-antimetabolites tested in the rabbit (5-fluorouracil and 6-azauridine) had little effect. BW 57-323H administered interperitoneally to pregnant rabbits resulted in complete litter destruction early in pregnancy, was teratogenic midpregnancy and ineffective in late pregnancy. This compound was without effect in macaques when administered on Days 28-30.^ieng
