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2.
ScientificWorldJournal ; 2012: 485758, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22792043

RESUMO

OBJECTIVE: Kawasaki disease (KD) is an acute systematic vasculitis in children which causes coronary arterial lesions and hydrops of gallbladder. Our objective is to correlate the clinical significance and influence on disease outcome of patients with gallbladder abnormalities in Kawasaki dissease. METHODS: Children who met KD diagnosis criteria and were admitted for IVIG treatment were retrospectively enrolled for analysis. Patients with abdominal sonography were divided into 2 groups based on the absence (Group A, N = 61) or presence (Group B, N = 16) of gallbladder abnormalities (GBA), defined as hydrops or acalculous cholecystitis. Between the two groups, clinical features, demographic data (including admission days, coronary artery lesions, IVIG resistance), and laboratory data before/after IVIG treatment were collected for analysis. RESULTS: The presence of sonographic gallbladder abnormalities is correlated with higher levels of serum CRP, GPT, and neutrophils. It also points to an increased number of IVIG resistance rates in group B. There was no significant statistical difference among clinical features, age, gender, admission days, or coronary artery lesions between the two groups. CONCLUSION: Sonographic gallbladder abnormalities are associated with higher CRP, GPT, neutrophil and IVIG resistance in KD. It can be used as a predictor of IVIG resistance in patients with KD.


Assuntos
Edema/complicações , Doenças da Vesícula Biliar/complicações , Vesícula Biliar/anormalidades , Vesícula Biliar/diagnóstico por imagem , Imunoglobulinas Intravenosas/uso terapêutico , Síndrome de Linfonodos Mucocutâneos/complicações , Síndrome de Linfonodos Mucocutâneos/tratamento farmacológico , Colecistite Acalculosa/sangue , Colecistite Acalculosa/complicações , Colecistite Acalculosa/diagnóstico por imagem , Proteína C-Reativa/análise , Pré-Escolar , Resistência a Medicamentos , Edema/sangue , Edema/diagnóstico por imagem , Feminino , Doenças da Vesícula Biliar/sangue , Doenças da Vesícula Biliar/diagnóstico por imagem , Humanos , Lactente , Contagem de Leucócitos , Masculino , Síndrome de Linfonodos Mucocutâneos/sangue , Neutrófilos/citologia , Estudos Retrospectivos , Falha de Tratamento , Ultrassonografia
3.
Inflamm Res ; 61(9): 987-95, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22618202

RESUMO

OBJECTIVES: (1)H-NMR is a powerful approach of metabolomics. This study aimed to apply it to detect the serum metabolites in rabbits with acute acalculous cholecystitis (AAC), and to analyze their potential roles in AAC. METHODS: Fourteen rabbits were randomly divided into two groups, the AAC group and the CON group. In the AAC rabbit model, Escherichia coli solution was injected into the gallbladder, while same volume of saline, instead of E. coli solution, was injected into the gallbladder of the CON rabbit. General morphological, light microscopic and transmission electron microscopic observations were used to evaluate the model. Metabolic profiles of serum from rabbits with AAC were investigated through (1)H-NMR spectroscopy coupled with multivariate statistical analysis, such as principal components analysis and orthogonal partial least-squares discriminant analysis. RESULTS: The pathohistology of gallbladders showed a significant difference between the two groups, proving the successful induction of inflammation in the gallbladders of the AAC group. The serum concentration of lipids (LDL and VLDL) increased during AAC, while the concentrations of phospholipids, lactic acid, 3-hydroxybutyric acid, lysine, citric acid, asparagine, histidine, glucose and some other small molecular metabolites decreased. CONCLUSION: The profiling of serum metabolites in rabbits with acute acalculous cholecystitis changed significantly. These changes referred to the metabolic disturbance of carbohydrate, amino acids and lipids, inhibition of immunological functions and inflammation reaction.


Assuntos
Colecistite Acalculosa/sangue , Colecistite Aguda/sangue , Metabolômica , Colecistite Acalculosa/patologia , Animais , Colecistite Aguda/patologia , Feminino , Espectroscopia de Ressonância Magnética , Coelhos
5.
J Microbiol Immunol Infect ; 36(4): 285-7, 2003 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-14723261

RESUMO

Concomitant leptospirosis and scrub typhus is rare. The spectrum of clinical severity for both scrub typhus and leptospirosis ranges from mild to fatal. Acute pancreatitis and cholecystitis are infrequent complications in adult patients with either leptospirosis or scrub typhus. We report a case of leptospirosis and scrub typhus coinfection in a 41-year-old man presenting with acute acalculous cholecystitis, pancreatitis and acute renal failure. Abdominal computed tomography revealed edematous change of the gallbladder without intrahepatic or pancreatic lesions. The patient was successfully treated with doxycycline and ceftriaxone, and supportive management.


Assuntos
Colecistite Acalculosa/complicações , Colecistite Aguda/complicações , Leptospira interrogans , Leptospirose/complicações , Orientia tsutsugamushi , Pancreatite/complicações , Tifo por Ácaros/complicações , Colecistite Acalculosa/sangue , Colecistite Acalculosa/diagnóstico por imagem , Adulto , Antibacterianos/uso terapêutico , Anticorpos Antibacterianos/sangue , Ceftriaxona/uso terapêutico , Colecistite Aguda/sangue , Colecistite Aguda/diagnóstico por imagem , Doxiciclina/uso terapêutico , Quimioterapia Combinada , Humanos , Leptospira interrogans/imunologia , Leptospirose/diagnóstico , Militares , Orientia tsutsugamushi/imunologia , Insuficiência Renal/etiologia , Tifo por Ácaros/diagnóstico , Tomografia Computadorizada por Raios X
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