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1.
Learn Mem ; 31(5)2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38862163

RESUMO

In his treatise on arthropod brains, Hans von Alten (1910) focuses on a specific functional group of insects-the flying Hymenoptera-which exhibit a spectrum of lifestyles ranging from solitary to social. His work presents a distinctive comparative neuro-anatomical approach rooted in an eco-evolutionary and eco-behavioral background. We regard his publication as an exceptionally valuable source of information and seek to inspire the research community dedicated to the study of the insect brain to explore its insights further, even after more than 110 years. We have translated and annotated his work, expecting it to engage researchers not just with its remarkable drawings but also with its substantive content and exemplary research strategy. The present text is designed to complement von Alten's publication, situating it within the temporal context of nineteenth-century and early twentieth-century studies, and to draw connections to contemporary perspectives, especially concerning a central brain structure: the mushroom body.


Assuntos
Evolução Biológica , Encéfalo , Cognição , Himenópteros , Animais , Encéfalo/fisiologia , Encéfalo/anatomia & histologia , Cognição/fisiologia , História do Século XX , Himenópteros/fisiologia , Himenópteros/anatomia & histologia , História do Século XIX , Adaptação Fisiológica/fisiologia , Corpos Pedunculados/fisiologia , Corpos Pedunculados/anatomia & histologia
2.
Nat Commun ; 15(1): 4872, 2024 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-38849331

RESUMO

Brain evolution has primarily been studied at the macroscopic level by comparing the relative size of homologous brain centers between species. How neuronal circuits change at the cellular level over evolutionary time remains largely unanswered. Here, using a phylogenetically informed framework, we compare the olfactory circuits of three closely related Drosophila species that differ in their chemical ecology: the generalists Drosophila melanogaster and Drosophila simulans and Drosophila sechellia that specializes on ripe noni fruit. We examine a central part of the olfactory circuit that, to our knowledge, has not been investigated in these species-the connections between projection neurons and the Kenyon cells of the mushroom body-and identify species-specific connectivity patterns. We found that neurons encoding food odors connect more frequently with Kenyon cells, giving rise to species-specific biases in connectivity. These species-specific connectivity differences reflect two distinct neuronal phenotypes: in the number of projection neurons or in the number of presynaptic boutons formed by individual projection neurons. Finally, behavioral analyses suggest that such increased connectivity enhances learning performance in an associative task. Our study shows how fine-grained aspects of connectivity architecture in an associative brain center can change during evolution to reflect the chemical ecology of a species.


Assuntos
Evolução Biológica , Drosophila , Corpos Pedunculados , Especificidade da Espécie , Animais , Corpos Pedunculados/fisiologia , Corpos Pedunculados/citologia , Corpos Pedunculados/anatomia & histologia , Drosophila/fisiologia , Drosophila/anatomia & histologia , Neurônios/fisiologia , Drosophila melanogaster/fisiologia , Drosophila melanogaster/anatomia & histologia , Filogenia , Olfato/fisiologia , Odorantes , Condutos Olfatórios/fisiologia , Condutos Olfatórios/anatomia & histologia , Masculino , Feminino , Terminações Pré-Sinápticas/fisiologia
3.
Elife ; 102021 02 09.
Artigo em Inglês | MEDLINE | ID: mdl-33559601

RESUMO

Neural organization of mushroom bodies is largely consistent across insects, whereas the ancestral ground pattern diverges broadly across crustacean lineages resulting in successive loss of columns and the acquisition of domed centers retaining ancestral Hebbian-like networks and aminergic connections. We demonstrate here a major departure from this evolutionary trend in Brachyura, the most recent malacostracan lineage. In the shore crab Hemigrapsus nudus, instead of occupying the rostral surface of the lateral protocerebrum, mushroom body calyces are buried deep within it with their columns extending outwards to an expansive system of gyri on the brain's surface. The organization amongst mushroom body neurons reaches extreme elaboration throughout its constituent neuropils. The calyces, columns, and especially the gyri show DC0 immunoreactivity, an indicator of extensive circuits involved in learning and memory.


Assuntos
Evolução Biológica , Braquiúros/anatomia & histologia , Corpos Pedunculados/anatomia & histologia , Neurópilo/citologia , Animais
4.
J Comp Neurol ; 529(2): 259-280, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-32400022

RESUMO

Spiders possess a wide array of sensory-driven behaviors and therefore provide rich models for studying evolutionary hypotheses about the relationship between brain morphology, sensory systems, and behavior. Despite this, only a handful of studies have examined brain variation across the order of Araneae. In this study, I present descriptions of the gross brain morphology for 19 families of spiders that vary in eye morphology. Spiders showed the most variation in the secondary eye visual pathway. Based on this variation, spiders could be categorized into four groups. Group 1 spiders had small, underdeveloped laminae, no medullae, and no mushroom bodies. Group 2 spiders had large laminae, no medullae and large mushroom bodies. Group 3 spiders had laminae and some evidence of reduced medullae and mushroom bodies. Group 4 spiders had the most complex systems, with large laminae, medullae formed from optical glomeruli, and robust mushroom bodies. Within groups, there was large variation in the shape and size of individual regions, indicating possible variation in neuronal organization. The possible evolutionary implications of the loss of a dedicated olfactory organ in spiders and its effects on the mushroom body are also discussed.


Assuntos
Encéfalo/anormalidades , Olho/anatomia & histologia , Corpos Pedunculados/anatomia & histologia , Aranhas/anatomia & histologia , Vias Visuais/anatomia & histologia , Animais , Evolução Biológica , Encéfalo/ultraestrutura , Olho/ultraestrutura , Corpos Pedunculados/ultraestrutura , Aranhas/ultraestrutura , Vias Visuais/ultraestrutura
5.
J Comp Neurol ; 529(3): 501-523, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-32484921

RESUMO

The hypothesis of a common origin for high-order memory centers in bilateral animals presents the question of how different brain structures, such as the vertebrate hippocampus and the arthropod mushroom bodies, are both structurally and functionally comparable. Obtaining evidence to support the hypothesis that crustaceans possess structures equivalent to the mushroom bodies that play a role in associative memories has proved challenging. Structural evidence supports that the hemiellipsoid bodies of hermit crabs, crayfish and lobsters, spiny lobsters, and shrimps are homologous to insect mushroom bodies. Although a preliminary description and functional evidence supporting such homology in true crabs (Brachyura) has recently been shown, other authors consider the identification of a possible mushroom body homolog in Brachyura as problematic. Here we present morphological and immunohistochemical data in Neohelice granulata supporting that crabs possess well-developed hemiellipsoid bodies that are resolved as mushroom bodies-like structures. Neohelice exhibits a peduncle-like tract, from which processes project into proximal and distal domains with different neuronal specializations. The proximal domains exhibit spines and en passant-like processes and are proposed here as regions mainly receiving inputs. The distal domains exhibit a "trauben"-like compartmentalized structure with bulky terminal specializations and are proposed here as output regions. In addition, we found microglomeruli-like complexes, adult neurogenesis, aminergic innervation, and elevated expression of proteins necessary for memory processes. Finally, in vivo calcium imaging suggests that, as in insect mushroom bodies, the output regions exhibit stimulus-specific activity. Our results support the shared organization of memory centers across crustaceans and insects.


Assuntos
Química Encefálica , Encéfalo/anatomia & histologia , Corpos Pedunculados/anatomia & histologia , Corpos Pedunculados/química , Animais , Braquiúros , Encéfalo/fisiologia , Química Encefálica/fisiologia , Drosophila , Masculino , Corpos Pedunculados/fisiologia
6.
Elife ; 92020 06 26.
Artigo em Inglês | MEDLINE | ID: mdl-32589143

RESUMO

Insect navigation arises from the coordinated action of concurrent guidance systems but the neural mechanisms through which each functions, and are then coordinated, remains unknown. We propose that insects require distinct strategies to retrace familiar routes (route-following) and directly return from novel to familiar terrain (homing) using different aspects of frequency encoded views that are processed in different neural pathways. We also demonstrate how the Central Complex and Mushroom Bodies regions of the insect brain may work in tandem to coordinate the directional output of different guidance cues through a contextually switched ring-attractor inspired by neural recordings. The resultant unified model of insect navigation reproduces behavioural data from a series of cue conflict experiments in realistic animal environments and offers testable hypotheses of where and how insects process visual cues, utilise the different information that they provide and coordinate their outputs to achieve the adaptive behaviours observed in the wild.


Assuntos
Insetos/fisiologia , Modelos Neurológicos , Fenômenos Fisiológicos do Sistema Nervoso , Navegação Espacial/fisiologia , Animais , Formigas/anatomia & histologia , Formigas/fisiologia , Encéfalo/anatomia & histologia , Encéfalo/fisiologia , Drosophila/anatomia & histologia , Drosophila/fisiologia , Insetos/anatomia & histologia , Corpos Pedunculados/anatomia & histologia , Corpos Pedunculados/fisiologia , Sistema Nervoso/anatomia & histologia , Vias Neurais/anatomia & histologia , Vias Neurais/fisiologia
7.
Sci Rep ; 10(1): 6147, 2020 04 09.
Artigo em Inglês | MEDLINE | ID: mdl-32273557

RESUMO

Value coding of external stimuli in general, and odor valence in particular, is crucial for survival. In flies, odor valence is thought to be coded by two types of neurons: mushroom body output neurons (MBONs) and lateral horn (LH) neurons. MBONs are classified as neurons that promote either attraction or aversion, but not both, and they are dynamically activated by upstream neurons. This dynamic activation updates the valence values. In contrast, LH neurons receive scaled, but non-dynamic, input from their upstream neurons. It remains unclear how such a non-dynamic system generates differential valence values. Recently, PD2a1/b1 LH neurons were demonstrated to promote approach behavior at low odor concentration in starved flies. Here, we demonstrate that at high odor concentrations, these same neurons contribute to avoidance in satiated flies. The contribution of PD2a1/b1 LH neurons to aversion is context dependent. It is diminished in starved flies, although PD2a1/b1 neural activity remains unchanged, and at lower odor concentration. In addition, PD2a1/b1 aversive effect develops over time. Thus, our results indicate that, even though PD2a1/b1 LH neurons transmit hard-wired output, their effect on valence can change. Taken together, we suggest that the valence model described for MBONs does not hold for LH neurons.


Assuntos
Drosophila melanogaster/fisiologia , Olfato , Animais , Comportamento de Escolha/fisiologia , Drosophila melanogaster/anatomia & histologia , Feminino , Masculino , Corpos Pedunculados/anatomia & histologia , Corpos Pedunculados/fisiologia , Sistema Nervoso/anatomia & histologia , Fenômenos Fisiológicos do Sistema Nervoso , Vias Neurais/anatomia & histologia , Vias Neurais/fisiologia , Neurônios/fisiologia , Odorantes , Olfato/fisiologia
8.
J Comp Neurol ; 528(15): 2595-2601, 2020 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-32266711

RESUMO

In 1882, the Italian embryologist Giuseppe Bellonci introduced a nomenclature for structures in the stomatopod crustacean Squilla mantis that he claimed correspond to insect mushroom bodies, today recognized as cardinal centers that in insects mediate associative memory. The use of Bellonci's terminology has, through a series of misunderstandings and entrenched opinions, led to contesting views regarding whether centers in crustacean and insect brains that occupy corresponding locations and receive comparable multisensory inputs are homologous or homoplasic. The following describes the fate of terms used to denote sensory association neuropils in crustacean species and relates how those terms were deployed in the 1920s and 1930s by the Swedish neuroanatomist Bertil Hanström to claim homology in insects and crustaceans. Yet the same terminology has been repurposed by subsequent researchers to promote the very opposite view: that mushroom bodies are a derived trait of hexapods and that equivalent centers in crustaceans evolved independently.


Assuntos
Evolução Biológica , Dissonância Cognitiva , Memória/fisiologia , Corpos Pedunculados/anatomia & histologia , Corpos Pedunculados/fisiologia , Terminologia como Assunto , Animais , Crustáceos , Insetos , Neurópilo/fisiologia
9.
Elife ; 92020 03 03.
Artigo em Inglês | MEDLINE | ID: mdl-32124731

RESUMO

Descriptions of crustacean brains have focused mainly on three highly derived lineages of malacostracans: the reptantian infraorders represented by spiny lobsters, lobsters, and crayfish. Those descriptions advocate the view that dome- or cap-like neuropils, referred to as 'hemiellipsoid bodies,' are the ground pattern organization of centers that are comparable to insect mushroom bodies in processing olfactory information. Here we challenge the doctrine that hemiellipsoid bodies are a derived trait of crustaceans, whereas mushroom bodies are a derived trait of hexapods. We demonstrate that mushroom bodies typify lineages that arose before Reptantia and exist in Reptantia thereby indicating that the mushroom body, not the hemiellipsoid body, provides the ground pattern for both crustaceans and hexapods. We show that evolved variations of the mushroom body ground pattern are, in some lineages, defined by extreme diminution or loss and, in others, by the incorporation of mushroom body circuits into lobeless centers. Such transformations are ascribed to modifications of the columnar organization of mushroom body lobes that, as shown in Drosophila and other hexapods, contain networks essential for learning and memory.


Assuntos
Evolução Biológica , Crustáceos/anatomia & histologia , Corpos Pedunculados/anatomia & histologia , Animais , Crustáceos/genética , Especificidade da Espécie
10.
J Comp Neurol ; 528(2): 261-282, 2020 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-31376285

RESUMO

Brain centers possessing a suite of neuroanatomical characters that define mushroom bodies of dicondylic insects have been identified in mantis shrimps, which are basal malacostracan crustaceans. Recent studies of the caridean shrimp Lebbeus groenlandicus further demonstrate the existence of mushroom bodies in Malacostraca. Nevertheless, received opinion promulgates the hypothesis that domed centers called hemiellipsoid bodies typifying reptantian crustaceans, such as lobsters and crayfish, represent the malacostracan cerebral ground pattern. Here, we provide evidence from the marine hermit crab Pagurus hirsutiusculus that refutes this view. P. hirsutiusculus, which is a member of the infraorder Anomura, reveals a chimeric morphology that incorporates features of a domed hemiellipsoid body and a columnar mushroom body. These attributes indicate that a mushroom body morphology is the ancestral ground pattern, from which the domed hemiellipsoid body derives and that the "standard" reptantian hemiellipsoid bodies that typify Astacidea and Achelata are extreme examples of divergence from this ground pattern. This interpretation is underpinned by comparing the lateral protocerebrum of Pagurus with that of the crayfish Procambarus clarkii and Orconectes immunis, members of the reptantian infraorder Astacidea.


Assuntos
Anomuros/anatomia & histologia , Evolução Biológica , Encéfalo , Corpos Pedunculados/anatomia & histologia , Animais
11.
Artigo em Inglês | MEDLINE | ID: mdl-31705196

RESUMO

Evolutionary transitions in social behavior are often associated with changes in species' brain architecture. A recent comparative analysis showed that the structure of brains of wasps in the family Vespidae differed between solitary and social species: the mushroom bodies, a major integrative brain region, were larger relative to brain size in the solitary species. However, the earlier study did not account for body size effects, and species' relative mushroom body size increases with body size in social Vespidae. Here we extend the previous analysis by measuring the effects of body size variation on brain structure differences between social and solitary vespid wasps. We asked whether total brain volume was greater relative to body size in the solitary species, and whether relative mushroom body size was greater in solitary species, after accounting for body size effects. Both total brain volume and relative mushroom body volume were significantly greater in the solitary species after accounting for body size differences. Therefore, body size allometry did not explain the solitary versus social species differences in brain structure. The evolutionary transition from solitary to social behavior in Vespidae was accompanied by decreases in total brain size and in relative mushroom body size.


Assuntos
Comportamento Animal , Encéfalo/anatomia & histologia , Corpos Pedunculados/anatomia & histologia , Comportamento Social , Vespas/anatomia & histologia , Animais , Tamanho Corporal , Tamanho do Órgão , Especificidade da Espécie
12.
Naturwissenschaften ; 106(9-10): 49, 2019 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-31456004

RESUMO

Social interactions may shape brain development. In primitively eusocial insects, the mushroom body (MB), an area of the brain associated with sensory integration and learning, is larger in queens than in workers. This may reflect a strategy of neural investment in queens or it may be a plastic response to social interactions in the nest. Here, we show that nest foundresses-the reproductive females who will become queens but are solitary until their first workers are born-have larger MBs than workers in the primitively eusocial sweat bee Augochlorella aurata. Whole brain size and optic lobe size do not differ between the two groups, but foundresses also have larger antennal lobes than workers. This shows that increased neural investment in MBs precedes social group formation. Larger MBs among foundresses may reflect the increased larval nutrition provisioned to future queens and the lack of social aggression from a dominant queen upon adult emergence.


Assuntos
Abelhas/anatomia & histologia , Abelhas/fisiologia , Predomínio Social , Fenômenos Fisiológicos da Nutrição Animal , Animais , Comportamento Animal , Corpos Pedunculados/anatomia & histologia
13.
Elife ; 82019 05 21.
Artigo em Inglês | MEDLINE | ID: mdl-31112130

RESUMO

Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic tools for this region. We generate a collection of split-GAL4 driver lines providing genetic access to 82 LH cell types. We use these to create an anatomical and neurotransmitter map of the LH and link this to EM connectomics data. We find ~30% of LH projections converge with outputs from the mushroom body, site of olfactory learning and memory. Using optogenetic activation, we identify LH cell types that drive changes in valence behavior or specific locomotor programs. In summary, we have generated a resource for manipulating and mapping LH neurons, providing new insights into the circuit basis of innate and learned olfactory behavior.


Assuntos
Comportamento Animal , Drosophila/anatomia & histologia , Drosophila/fisiologia , Corpos Pedunculados/anatomia & histologia , Corpos Pedunculados/fisiologia , Córtex Olfatório/anatomia & histologia , Córtex Olfatório/fisiologia , Animais , Conectoma , Vias Neurais/anatomia & histologia , Vias Neurais/fisiologia , Optogenética
14.
PLoS One ; 14(3): e0213618, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30917163

RESUMO

Strongly polyphenic social insects provide excellent models to examine the neurobiological basis of division of labor. Turtle ants, Cephalotes varians, have distinct minor worker, soldier, and reproductive (gyne/queen) morphologies associated with their behavioral profiles: small-bodied task-generalist minors lack the phragmotic shield-shaped heads of soldiers, which are specialized to block and guard the nest entrance. Gynes found new colonies and during early stages of colony growth overlap behaviorally with soldiers. Here we describe patterns of brain structure and synaptic organization associated with division of labor in C. varians minor workers, soldiers, and gynes. We quantified brain volumes, determined scaling relationships among brain regions, and quantified the density and size of microglomeruli, synaptic complexes in the mushroom body calyxes important to higher-order processing abilities that may underpin behavioral performance. We found that brain volume was significantly larger in gynes; minor workers and soldiers had similar brain sizes. Consistent with their larger behavioral repertoire, minors had disproportionately larger mushroom bodies than soldiers and gynes. Soldiers and gynes had larger optic lobes, which may be important for flight and navigation in gynes, but serve different functions in soldiers. Microglomeruli were larger and less dense in minor workers; soldiers and gynes did not differ. Correspondence in brain structure despite differences in soldiers and gyne behavior may reflect developmental integration, suggesting that neurobiological metrics not only advance our understanding of brain evolution in social insects, but may also help resolve questions of the origin of novel castes.


Assuntos
Comunicação Animal , Formigas/fisiologia , Encéfalo/fisiologia , Corpos Pedunculados/fisiologia , Animais , Comportamento Animal , Tamanho Corporal , Encéfalo/anatomia & histologia , Mapeamento Encefálico , Feminino , Hierarquia Social , Masculino , Análise Multivariada , Corpos Pedunculados/anatomia & histologia , Lobo Óptico de Animais não Mamíferos/anatomia & histologia , Tamanho do Órgão , Fenótipo , Filogenia , Reprodução , Comportamento Social
15.
Cell Tissue Res ; 374(1): 39-62, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29744590

RESUMO

The desert locust Schistocerca gregaria is a major agricultural pest in North Africa and the Middle East. As such, it has been intensely studied, in particular with respect to population dynamics, sensory processing, feeding behavior flight and locomotor control, migratory behavior, and its neuroendocrine system. Being a long-range migratory species, neural mechanisms underlying sky compass orientation have been studied in detail. To further understand neuronal interactions in the brain of the locust, a deeper understanding of brain organization in this insect has become essential. As a follow-up of a previous study illustrating the layout of the locust brain (Kurylas et al. in J Comp Neurol 484:206-223, 2008), we analyze the cerebrum, the central brain minus gnathal ganglia, of the desert locust in more detail and provide a digital three-dimensional atlas of 48 distinguishable brain compartments and 7 major fiber tracts and commissures as a basis for future functional studies. Neuropils were three-dimensionally reconstructed from synapsin-immunostained whole mount brains. Neuropil composition and their internal organization were analyzed and compared to the neuropils of the fruit fly Drosophila melanogaster. Most brain areas have counterparts in Drosophila. Some neuropils recognized in the locust, however, have not been identified in the fly while certain areas in the fly could not be distinguished in the locust. This study paves the way for more detailed anatomical descriptions of neuronal connections and neuronal cell types in the locust brain, facilitates interspecies comparisons among insect brains and points out possible evolutionary differences in brain organization between hemi- and holometabolous insects.


Assuntos
Cérebro/anatomia & histologia , Clima Desértico , Gafanhotos/anatomia & histologia , Animais , Feminino , Imageamento Tridimensional , Corpos Pedunculados/anatomia & histologia , Neurópilo/metabolismo
16.
Brain Behav Evol ; 90(3): 243-254, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29059675

RESUMO

Haller's rule states that brains scale allometrically with body size in all animals, meaning that relative brain size increases with decreasing body size. This rule applies both on inter- and intraspecific comparisons. Only 1 species, the extremely small parasitic wasp Trichogramma evanescens, is known as an exception and shows an isometric brain-body size relation in an intraspecific comparison between differently sized individuals. Here, we investigated if such an isometric brain-body size relationship also occurs in an intraspecific comparison with a slightly larger parasitic wasp, Nasonia vitripennis, a species that may vary 10-fold in body weight upon differences in levels of scramble competition during larval development. We show that Nasonia exhibits diphasic brain-body size scaling: larger wasps scale allometrically, following Haller's rule, whereas the smallest wasps show isometric scaling. Brains of smaller wasps are, therefore, smaller than expected and we hypothesized that this may lead to adaptations in brain architecture. Volumetric analysis of neuropil composition revealed that wasps of different sizes differed in relative volume of multiple neuropils. The optic lobes and mushroom bodies in particular were smaller in the smallest wasps. Furthermore, smaller brains had a relatively smaller total neuropil volume and larger cellular rind than large brains. These changes in relative brain size and brain architecture suggest that the energetic constraints on brain tissue outweigh specific cognitive requirements in small Nasonia wasps.


Assuntos
Tamanho Corporal/fisiologia , Encéfalo/anatomia & histologia , Vespas/anatomia & histologia , Adaptação Fisiológica/fisiologia , Animais , Evolução Biológica , Corpos Pedunculados/anatomia & histologia , Neurópilo/fisiologia , Lobo Óptico de Animais não Mamíferos/anatomia & histologia
17.
Elife ; 62017 09 26.
Artigo em Inglês | MEDLINE | ID: mdl-28949916

RESUMO

Mushroom bodies are the iconic learning and memory centers of insects. No previously described crustacean possesses a mushroom body as defined by strict morphological criteria although crustacean centers called hemiellipsoid bodies, which serve functions in sensory integration, have been viewed as evolutionarily convergent with mushroom bodies. Here, using key identifiers to characterize neural arrangements, we demonstrate insect-like mushroom bodies in stomatopod crustaceans (mantis shrimps). More than any other crustacean taxon, mantis shrimps display sophisticated behaviors relating to predation, spatial memory, and visual recognition comparable to those of insects. However, neuroanatomy-based cladistics suggesting close phylogenetic proximity of insects and stomatopod crustaceans conflicts with genomic evidence showing hexapods closely related to simple crustaceans called remipedes. We discuss whether corresponding anatomical phenotypes described here reflect the cerebral morphology of a common ancestor of Pancrustacea or an extraordinary example of convergent evolution.


Assuntos
Crustáceos/anatomia & histologia , Corpos Pedunculados/anatomia & histologia , Animais , Evolução Biológica , Encéfalo/anatomia & histologia
18.
Curr Opin Insect Sci ; 22: 54-61, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-28805639

RESUMO

We review research on brain development and brain evolution in the wasp family Vespidae. Basic vespid neuroanatomy and some aspects of functional neural circuitry are well-characterized, and genomic tools for exploring brain plasticity are being developed. Although relatively modest in terms of species richness, the Vespidae include species spanning much of the known range of animal social complexity, from solitary nesters to highly eusocial species with some of the largest known colonies and multiple reproductives. Eusocial species differ in behavior and ecology including variation in queen/worker caste differentiation and in diurnal/nocturnal activity. Species differences in overall brain size are strongly associated with brain allometry; relative sizes of visual processing tissues increase at faster rates than antennal processing tissues. The lower relative size of the central-processing mushroom bodies (MB) in eusocial species compared to solitary relatives suggests sociality may relax demands on individual cognitive abilities. However, queens have greater relative MB volumes than their workers, and MB development is positively associated with social dominance status in some species. Fruitful areas for future investigations of adaptive brain investment in the clade include sampling of key overlooked taxa with diverse social structures, and the analysis of neural correlations with ecological divergence in foraging resources and diel activity patterns.


Assuntos
Encéfalo/anatomia & histologia , Vespas/anatomia & histologia , Animais , Comportamento Animal , Evolução Biológica , Encéfalo/fisiologia , Meio Ambiente , Corpos Pedunculados/anatomia & histologia , Tamanho do Órgão , Comportamento Social , Vespas/fisiologia
19.
Elife ; 62017 07 18.
Artigo em Inglês | MEDLINE | ID: mdl-28718765

RESUMO

Understanding memory formation, storage and retrieval requires knowledge of the underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of associative learning. We reconstructed the morphologies and synaptic connections of all 983 neurons within the three functional units, or compartments, that compose the adult MB's α lobe, using a dataset of isotropic 8 nm voxels collected by focused ion-beam milling scanning electron microscopy. We found that Kenyon cells (KCs), whose sparse activity encodes sensory information, each make multiple en passant synapses to MB output neurons (MBONs) in each compartment. Some MBONs have inputs from all KCs, while others differentially sample sensory modalities. Only 6% of KC>MBON synapses receive a direct synapse from a dopaminergic neuron (DAN). We identified two unanticipated classes of synapses, KC>DAN and DAN>MBON. DAN activation produces a slow depolarization of the MBON in these DAN>MBON synapses and can weaken memory recall.


Assuntos
Conectoma , Drosophila/anatomia & histologia , Drosophila/fisiologia , Corpos Pedunculados/anatomia & histologia , Corpos Pedunculados/fisiologia , Animais , Aprendizagem , Memória
20.
J Comp Neurol ; 525(12): 2615-2631, 2017 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-28445613

RESUMO

Tyramine is an important neurotransmitter, neuromodulator, and neurohormone in insects. In honeybees, it is assumed to have functions in modulating sensory responsiveness and controlling motor behavior. Tyramine can bind to two characterized receptors in honeybees, both of which are coupled to intracellular cAMP pathways. How tyramine acts on neuronal, cellular and circuit levels is unclear. We investigated the spatial brain expression of the tyramine receptor AmTAR1 using a specific antibody. This antibody detects a membrane protein of the expected molecular weight in western blot analysis. In honeybee brains, it labels different structures which process sensory information. Labeling along the antennal nerve, in projections of the dorsal lobe and in the gnathal ganglion suggest that tyramine receptors are involved in modulating gustatory and tactile perception. Furthermore, the ellipsoid body of the central complex and giant synapses in the lateral complex show AmTAR1-like immunoreactivity (AmTAR1-IR), suggesting a role of this receptor in modulating sky-compass information and/or higher sensor-motor control. Additionally, intense signals derive from the mushroom bodies, higher-order integration centers for olfactory, visual, gustatory and tactile information. To investigate whether AmTAR1-expressing brain structures are in vicinity to tyramine releasing sites, a specific tyramine antibody was applied. Tyramine-like labeling was observed in AmTAR1-IR positive structures, although it was sometimes weak and we did not always find a direct match of ligand and receptor. Moreover, tyramine-like immunoreactivity was also found in brain regions without AmTAR1-IR (optic lobes, antennal lobes), indicating that other tyramine-specific receptors may be expressed there.


Assuntos
Abelhas/anatomia & histologia , Encéfalo/citologia , Neurônios/metabolismo , Receptores de Amina Biogênica/metabolismo , Tiramina/metabolismo , Actinas/metabolismo , Animais , Encéfalo/metabolismo , Corpos Pedunculados/anatomia & histologia , Corpos Pedunculados/metabolismo , Proteína Básica da Mielina/metabolismo , Sinapsinas/metabolismo
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