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1.
Ultrasound Med Biol ; 47(7): 1957-1963, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33926755

RESUMO

The aim of this work was to determine the feasibility of combined ultrasonography and elastography measurement to characterize the mechanical properties of the intercostal space during breathing. Eighteen asymptomatic participants (ages 13 ± 2 y) and six participants with adolescent idiopathic scoliosis (AIS) were included (Cobb angle 60° ± 12°). Ultrasonographic and elastographic clips were acquired of T8-T9 ribs and the intercostal space. The two adjacent ribs were tracked to infer the breathing cycle. Shear-wave speed (SWS) was measured in the intercostal space at different stages of the breathing cycle. SWS was symmetric in the control group, during both expiration and inspiration. In AIS, the SWS during inspiration was higher in the convex side than in the concave one (p = 0.02). Furthermore, SWS was higher during inspiration than expiration in the control group and in the AIS convex side, but not in the AIS concave side (p > 0.05). This new method combining echography and shear-wave elastography allowed measurement of the mechanical characteristics of the intercostal space at different phases of the breathing cycle and highlighted differences between the AIS and control groups. This approach opens the way to further analyses of the biomechanical characteristics of breathing in severe AIS.


Assuntos
Costelas/diagnóstico por imagem , Costelas/fisiopatologia , Escoliose/diagnóstico por imagem , Adolescente , Fenômenos Biomecânicos , Criança , Técnicas de Imagem por Elasticidade , Estudos de Viabilidade , Feminino , Humanos , Imagem Multimodal , Ultrassonografia
2.
Curr Sports Med Rep ; 20(3): 164-168, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33655998

RESUMO

ABSTRACT: Slipping rib syndrome is pain created at the lower, anterior border of the rib cage when performing upper-extremity activities, coughing, laughing, or leaning over. Defects in the costal cartilage of ribs 8 to 10 result in increased movement of the ribs, impinging soft tissue and intercostal nerves. Advancements have been made in the diagnosis of slipping rib syndrome by dynamic ultrasound. Ultrasound can identify abnormalities in the rib and cartilage anatomy, as well as soft tissue swelling. Although the mainstays of treatment continue to be reassurance, nonsteroidal anti-inflammatory drugs, physical therapy, intercostal nerve injections, osteopathic manipulative treatment, surgery for refractory pain, and botulinum toxin injections have been attempted, and there may be a role for prolotherapy in treatment. Surgical techniques are being examined secondary to recurrence of pain following resection. The hooking maneuver and surgery remain important for identification and treatment, respectively.


Assuntos
Costelas/diagnóstico por imagem , Costelas/fisiopatologia , Doenças Torácicas/diagnóstico por imagem , Dor no Peito/diagnóstico por imagem , Dor no Peito/etiologia , Dor no Peito/cirurgia , Dor no Peito/terapia , Tratamento Conservador , Humanos , Dor Intratável/diagnóstico por imagem , Dor Intratável/etiologia , Dor Intratável/cirurgia , Dor Intratável/terapia , Recidiva , Síndrome , Doenças Torácicas/etiologia , Doenças Torácicas/terapia , Ultrassonografia
3.
Orthopedics ; 44(2): e287-e293, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33373463

RESUMO

Spinal muscular atrophy (SMA) is a neuromuscular disease with manifestations of scoliosis, pulmonary function decline, and, uniquely, collapse of the ribs. Methods to quantify rib deformity and its impact on pulmonary function are sparse. The authors propose new radiographic measurements to quantify the aspect of SMA known as collapsing parasol deformity and correlate these measurements with pulmonary function. Twenty-eight full-spine radiographs of pediatric SMA patients were measured twice by 3 independent investigators, with 2 weeks separating each measurement. Radiographic measurements, demographics, spirometry results, and assisted ventilation rating were obtained. Twenty-one patients with spirometry metrics were assessed to correlate pulmonary function and spinal measurements. The intrarater intraclass correlation coefficient (ICC) for the measurements ranged from 0.706 to 0.99, and the interrater ICC ranged from 0.64 to 0.97. Eighteen of 19 variables had ICC values greater than 0.75 for inter- and intrarater reliability. Twenty-one patients with forced expiratory volume in 1 second and forced vital capacity were assessed in terms of these measurements. Ratio of the concave hemithoracic width at T6/convex hemithoracic width at T6 (P=.004) and ratio of convex vertical rib displacement at the apical rib/concave vertical rib displacement (P=.021) were both significantly correlated with decreased pulmonary function. No significant correlation was found examining the average vertical rib displacement at the apical rib. High inter-and intrarater reliability can be obtained in a variety of spinal measurements of SMA patients. Various measurements are correlated to diminished pulmonary function, specifically variables showing asymmetric changes in the chest cavity. [Orthopedics. 2021;44(2):e287-e293.].


Assuntos
Pulmão/fisiopatologia , Atrofia Muscular Espinal/diagnóstico por imagem , Atrofia Muscular Espinal/fisiopatologia , Adolescente , Criança , Humanos , Pulmão/diagnóstico por imagem , Masculino , Atrofia Muscular Espinal/cirurgia , Procedimentos Ortopédicos , Radiografia , Reprodutibilidade dos Testes , Costelas/fisiopatologia , Costelas/cirurgia
4.
Biomed Mater ; 16(2): 021001, 2021 02 17.
Artigo em Inglês | MEDLINE | ID: mdl-32629431

RESUMO

Intermetallic porous SHS-TiNi alloys exhibit tangled and specific stress-strain characteristics. This article aims to evaluate the findings emanating from experiments using standard and proprietary instruments. Fatigue testing under repeated complex loading was used to measure the total number of load cycles before failure of the SHS-TiNi samples occurred. Of the tested samples, seventy percent passed through 106 cycles without failure due to the reversible martensite transformation in the TiNi phase, one of the prevailing constituents of a multiphase matrix. The fractured surfaces were analyzed using scanning electron microscopy and confocal laser scanning instruments. Microscopy studies showed that the entire surface of the sample is concealed by miscellaneous strata that result from the SHS processand effectively protect the porous alloy in a corrosive environment. Numerous non-metallic inclusions, which are also attributed to the SHS reaction, do not have a significant impact on the deformation behavior and fatigue performance. In this context, the successful in vivo functioning of porous grafts assessed in a canine rib-plasty model allows the bone substitute to be congruentially deformed in the body without rejection or degradation; it thus has a long operational life, often greater than 17 ×106 (22 × 60 × 24 × 540) cycles. It acknowledges the potential benefits of SHS-TiNi as a superior osteoplastic material and its high resistance to corrosion fatigue.


Assuntos
Ligas , Substitutos Ósseos/química , Ligas Dentárias/química , Teste de Materiais , Níquel/química , Costelas/fisiopatologia , Resistência à Tração , Titânio/química , Animais , Corrosão , Cães , Elasticidade , Temperatura Alta , Masculino , Microscopia Confocal , Microscopia Eletrônica de Varredura , Porosidade , Pós , Costelas/metabolismo , Resistência ao Cisalhamento , Estresse Mecânico , Viscosidade , Difração de Raios X
5.
Asian Cardiovasc Thorac Ann ; 29(2): 128-131, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33143433

RESUMO

Askin tumor (a Ewing sarcoma variant) is the most common tumor of the chest wall in the pediatric age group. Multimodal treatment is required, with complete resection being the cornerstone of effective management. We describe the case of a 13-year boy with a left paraspinal Ewing sarcoma with intraspinal extension and spinal cord compression with neurological weakness. He underwent complex surgical resection using thoracoscopic resection of multiple ribs along with vertebral resection and reconstruction, after neoadjuvant therapy.


Assuntos
Neoplasias Ósseas/cirurgia , Osteotomia , Procedimentos de Cirurgia Plástica , Costelas/cirurgia , Sarcoma de Ewing/cirurgia , Neoplasias Torácicas/cirurgia , Cirurgia Torácica Vídeoassistida , Adolescente , Neoplasias Ósseas/complicações , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/patologia , Quimiorradioterapia Adjuvante , Humanos , Masculino , Terapia Neoadjuvante , Costelas/diagnóstico por imagem , Costelas/fisiopatologia , Sarcoma de Ewing/complicações , Sarcoma de Ewing/diagnóstico por imagem , Sarcoma de Ewing/patologia , Compressão da Medula Espinal/etiologia , Neoplasias Torácicas/complicações , Neoplasias Torácicas/diagnóstico por imagem , Neoplasias Torácicas/patologia , Resultado do Tratamento
6.
Acta Bioeng Biomech ; 22(2): 3-10, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32868948

RESUMO

PURPOSE: The aim of this paper was to assess the histomorphometrical and mechanical properties of ribs in patients with idiopathic scoliosis who underwent corrective surgery of scoliosis combined with thoracoplasty. METHODS: The analyzed material encompasses 20 females between the ages of 12 and 18, whose pre-operative Cobb angle was 56.85 degrees, on average. The participants were divided into two age groups, up to the age of 15 and above 15 years old, taking into account the anatomical location of the assessed rib fragments with a division into floating and false ribs. The analysis of mechanical parameters was carried out by means of the quasi-static 3-point bending test, and the histomorphometric evaluation of the examined rib fragments was carried out using high-resolution computed tomography. RESULTS: The existence of explicit relationships between selected radiological parameters describing scoliosis and mechanical and histomorphometric parameters of the ribs has not been confirmed. Statistically significant correlations between age and rib stiffness as well as between Young's modulus and stiffness depending on the anatomical location of the examined rib fragment were confirmed. CONCLUSIONS: Mechanical and histomorphometric properties of bone tissue in patients with scoliosis are not explicitly associated with the radiological parameters characterizing scoliosis.


Assuntos
Costelas/patologia , Costelas/fisiopatologia , Escoliose/patologia , Escoliose/fisiopatologia , Adolescente , Fenômenos Biomecânicos , Densidade Óssea/fisiologia , Calcificação Fisiológica/fisiologia , Osso Esponjoso/patologia , Osso Esponjoso/fisiopatologia , Osso Cortical/patologia , Osso Cortical/fisiopatologia , Módulo de Elasticidade , Humanos , Adulto Jovem
7.
Biomech Model Mechanobiol ; 19(6): 2227-2239, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32444978

RESUMO

Finite element human body models (HBMs) are used to assess injury risk in a variety of impact scenarios. The ribs are a key structural component within the chest, so their accuracy within HBMs is vitally important for modeling human biomechanics. We assessed the geometric correspondence between the ribs defined within five widely used HBMs and measures drawn from population-wide studies of rib geometry, focusing on (1) rib global shape, (2) rib cross-sectional size and shape, and (3) rib cortical bone thickness. A parametric global shape model fitted to all HBM ribs was compared to expected rib parameters calculated for each HBM's subject demographic using population reference data. The GHBMC M50 and THUMS M50 male HBMs showed 24% and 50% of their fitted rib shape parameters (6 parameters per each 12 ribs) falling outside 1SD from population expected values, respectively. For female models the GHBMC F05, THUMS F05, and VIVA F50 models had 21%, 26%, and 19% of their rib shape parameters falling outside 1SD, respectively. Cross-sectional areas and inertial moments obtained along the HBM ribs were compared to average ± 1SD corridors for male and female ribs drawn from reference population data. The GHBMC M50, THUMS M50, and VIVA F50 model ribs were all larger in overall cross-sectional area than their targeted average population values by 0.9SDs (average across the rib's full length), 1.7SDs, and 1.3SDs, respectfully. When considering cortical bone cross-sectional area, the THUMS and VIVA models-which each define a constant bone thickness value across the entire rib-overestimated bone content on average by 1.1SDs and 1.2SDs, respectively. HBMs have traditionally performed poorly when predicting rib fracture onset or fracture site, and in all HBMs in this study the rib regions with the most extreme cortical bone thickness and cross-sectional area discrepancies (compared to average reference data) corresponded to regions toward the sternal end of the ribs where rib fractures most frequently occur. Results from this study highlight geometrical components of current HBM ribs that differ from the rib geometry that would be expected from within those models' target demographics, and help researchers prioritize improvements to their biofidelity.


Assuntos
Análise de Elementos Finitos , Corpo Humano , Costelas/fisiologia , Costelas/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Fenômenos Biomecânicos , Simulação por Computador , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Biológicos , Valores de Referência , Adulto Jovem
8.
Clin Nucl Med ; 45(6): 461-462, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32332314

RESUMO

A 39-year-old man presented with progressive painful swelling on the left chest since 6 months. Examination revealed osseous consistency mass. CT of the thorax suggested mass arising from left fourth rib with intrathoracic and extrathoracic soft tissue components. It had extensive sunburst periosteal reaction consistent with primary malignant bone tumor. True cut biopsy revealed plasmacytoma. Routine hematological, biochemical, and bone marrow examinations were normal. Patient referred for whole-body F-FDG PET/CT to look for skeletal and bone marrow lesions. It revealed intensely metabolic left fourth rib lesion with periosteal reaction and no other lesion in the rest of the body.


Assuntos
Neoplasias Ósseas/fisiopatologia , Osteogênese , Plasmocitoma/fisiopatologia , Costelas/patologia , Costelas/fisiopatologia , Adulto , Biópsia , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/patologia , Fluordesoxiglucose F18 , Humanos , Masculino , Plasmocitoma/diagnóstico por imagem , Plasmocitoma/patologia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Costelas/diagnóstico por imagem
10.
Traffic Inj Prev ; 20(sup2): S88-S95, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31589083

RESUMO

Objective: The current state of the art human body models (HBMs) underpredict the number of fractured ribs. Also, it has not been shown that the models can predict the fracture locations. Efforts have been made to create subject specific rib models for fracture prediction, with mixed results. The aim of this study is to evaluate if subject-specific finite element (FE) rib models, based on state-of-the-art clinical CT data combined with subject-specific material data, can predict rib stiffness and fracture location in anterior-posterior rib bending.Method: High resolution clinical CT data was used to generate detailed subject-specific geometry for twelve FE models of the sixth rib. The cortical bone periosteal and endosteal surfaces were estimated based on a previously calibrated cortical bone mapping algorithm. The cortical and the trabecular bone were modeled using a hexa-block algorithm. The isotropic material model for the cortical bone in each rib model was assigned subject-specific material data based on tension coupon tests. Two different modeling strategies were used for the trabecular bone.The capability of the FE model to predict fracture location was carried out by modeling physical dynamic anterior-posterior rib bending tests. The rib model predictions were directly compared to the results from the tests. The predicted force-displacement time history, strain measurements at four locations, and rotation of the rib ends were compared to the results from the physical tests by means of CORA analysis. Rib fracture location in the FE model was estimated as the position for the element with the highest first principle strain at the time corresponding to rib fracture in the physical test.Results: Seven out of the twelve rib models predicted the fracture locations (at least for one of the trabecular modeling strategies) and had a force-displacement CORA score above 0.65. The other five rib models, had either a poor force-displacement CORA response or a poor fracture location prediction. It was observed that the stress-strain response for the coupon test for these five ribs showed significantly lower Young's modulus, yield stress, and elongation at fracture compared to the other seven ribs.Conclusion: This study indicates that rib fracture location can be predicted for subject specific rib models based on high resolution CT, when loaded in anterior-posterior bending, as long as the rib's cortical cortex is of sufficient thickness and has limited porosity. This study provides guidelines for further enhancements of rib modeling for fracture location prediction with HBMs.


Assuntos
Acidentes de Trânsito , Modelos Biológicos , Fraturas das Costelas/etiologia , Costelas/fisiopatologia , Análise de Elementos Finitos , Humanos , Fenômenos Mecânicos , Fraturas das Costelas/diagnóstico por imagem , Fraturas das Costelas/fisiopatologia , Costelas/diagnóstico por imagem , Rotação , Tomografia Computadorizada por Raios X
11.
J Emerg Med ; 57(4): 550-553, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31591072

RESUMO

BACKGROUND: Diagnosis of acute osteomyelitis in young children can be challenging due to the lack of specific clinical signs and symptoms. Prompt diagnosis and treatment is essential to prevent complications and to improve long-term prognosis and reduce the need for operative intervention. Point-of-care ultrasound (POCUS) may be a useful tool to detect early changes associated with osteomyelitis. CASE REPORT: A 26-month-old boy presented with 6 days of fever and 3 days of focal pain over the right anterior lower ribs without swelling, erythema, or bony deformity, and negative chest x-ray study. A POCUS was performed by the ultrasound fellows and revealed deep soft tissue swelling, periosteal elevation, and increased vascular flow with color Doppler. The patient was admitted to the pediatric service with infectious disease consultation and started on antibiotics. Magnetic resonance imaging confirmed the diagnosis of a right seventh anterior rib osteomyelitis, and the patient subsequently improved and was discharged home. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: In this case, the use of POCUS in the emergency department heightened the suspicion for acute osteomyelitis in a rare location and guided early diagnosis and treatment.


Assuntos
Osteomielite/complicações , Costelas/anormalidades , Ultrassonografia/métodos , Pré-Escolar , Febre/etiologia , Humanos , Masculino , Osteomielite/diagnóstico por imagem , Dor/etiologia , Sistemas Automatizados de Assistência Junto ao Leito , Costelas/diagnóstico por imagem , Costelas/fisiopatologia , Parede Torácica/fisiopatologia
12.
PLoS One ; 14(8): e0221207, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31449525

RESUMO

BACKGROUND: Children and young people with neuromuscular disorders (NMD), such as Duchenne Muscular Dystrophy (DMD), develop progressive respiratory muscles weakness and pulmonary restriction. Pulmonary function monitoring of the decline in lung function allows for timely intervention with cough assist techniques and nocturnal non-invasive ventilation (NIV). NMD may find the measurement of lung function difficult using current techniques. Structured Light Plethysmography (SLP) has been proposed as a novel, non-contact, self-calibrating, non-invasive method of assessing lung function. The overarching aim of this study was to investigate the use of SLP as a novel method for monitoring respiratory function in children with neuromuscular disease. METHODS: SLP thoraco-abdominal (TA) displacement was correlated with forced vital capacity measurements recorded by spirometry and the repeatability of the measurements with both methods examined. SLP tidal breathing parameters were investigated to assess the range and repeatability of regional right and left side TA displacement and rib cage and abdominal wall displacement. RESULTS: The comparison of the FVC measured with SLP and with spirometry, while having good correlation (R = 0.78) had poor measurement agreement (95% limits of agreement: -1.2 to 1.2L) The mean relative contribution of right and left TA displacement in healthy controls was 50:50 with a narrow range. Repeatability of this measure with SLP was found to be good in healthy controls and moderate in NMD children with/without scoliosis but with a wider range. The majority of the control group displayed a predominant rib cage displacement during tidal breathing and those who displayed predominant abdominal wall displacement showed displacement of both regions close to 50:50 with similar results for the rib cage and abdomen. In comparison, children with NMD have a more variable contribution for all of these parameters. In addition, SLP was able to detect a reduction in abdominal contribution to TA displacement with age in the DMD group and detect paradoxical breathing in children with NMD. Using SLP tracings during tidal breathing we were able to identify three specific patterns of breathing amongst healthy individuals and in children with NMD. CONCLUSIONS: SLP is a novel method for measuring lung function that requires limited patient cooperation and may be especially useful in children with neuromuscular disorders. Measuring the relative contributions of the right and left chest wall and chest versus abdominal movements allows a more detailed assessment.


Assuntos
Tosse/fisiopatologia , Pulmão/fisiopatologia , Distrofia Muscular de Duchenne/diagnóstico por imagem , Pletismografia , Músculos Abdominais/diagnóstico por imagem , Músculos Abdominais/fisiopatologia , Adolescente , Adulto , Criança , Tosse/diagnóstico por imagem , Feminino , Humanos , Pulmão/diagnóstico por imagem , Masculino , Distrofia Muscular de Duchenne/fisiopatologia , Ventilação não Invasiva , Respiração , Insuficiência Respiratória/diagnóstico por imagem , Insuficiência Respiratória/fisiopatologia , Fenômenos Fisiológicos Respiratórios , Costelas/diagnóstico por imagem , Costelas/fisiopatologia , Espirometria , Adulto Jovem
13.
Sci Rep ; 9(1): 8146, 2019 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-31148581

RESUMO

This study was conducted to assess the accuracy of cone-beam computed tomography (CBCT) of different voxel sizes in the detection of alveolar bone defects, and to select the optimal voxel size for clinical use. 46 in-vitro teeth were placed in bovine ribs in which alveolar bone defects were randomly simulated. In total, 32 alveolar bone defects and 14 teeth without periodontal defects were used. CBCT images were acquired with the use of three different voxel sizes: 0.125-mm, 0.2-mm and 0.4-mm. The scan data were 3D-reconstructed in Mimics software and evaluated by two observers with more than 5 years of experience in CBCT. Receiver operating characteristic (ROC) curves and diagnostic values were obtained. Pairwise comparison of ROC curves was made for evaluation of the diagnostic values of different voxel sizes. Kappa statistics assessed the observer reliability. Results were considered significant at P < 0.05. It showed no statistically significant difference between 0.125-mm group and 0.2-mm group, but 0.4-mm group had lower Az values that differed significantly from 0.125-mm and 0.2-mm groups (P < 0.05). Based on diagnostic value and radiation protection, 0.2-mm voxel size may be a good choice for the detection of bone defects with CBCT.


Assuntos
Processo Alveolar/diagnóstico por imagem , Tomografia Computadorizada de Feixe Cônico/métodos , Processo Alveolar/fisiopatologia , Animais , Bovinos , Simulação por Computador , Processamento de Imagem Assistida por Computador , Imageamento Tridimensional , Técnicas In Vitro , Curva ROC , Reprodutibilidade dos Testes , Costelas/diagnóstico por imagem , Costelas/fisiopatologia , Software
14.
Exp Physiol ; 104(5): 729-739, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30758090

RESUMO

NEW FINDINGS: What is the central question of this study? Clinical reports have described and suggested central and peripheral respiratory abnormalities in Parkinson's disease (PD) patients; however, these reports have never addressed the occurrence of these abnormalities in an animal model. What is the main finding and its importance? A mouse model of PD has reduced neurokinin-1 receptor immunoreactivity in the pre-BÓ§tzinger complex and Phox2b-expressing neurons in the retrotrapezoid nucleus. The PD mouse has impairments of respiratory frequency and the hypercapnic ventilatory response. Lung collagen deposition and ribcage stiffness appear in PD mice. ABSTRACT: Parkinson's disease (PD) is a neurodegenerative motor disorder characterized by dopaminergic deficits in the brain. Parkinson's disease patients may experience shortness of breath, dyspnoea, breathing difficulties and pneumonia, which can be linked as a cause of morbidity and mortality of those patients. The aim of the present study was to clarify whether a mouse model of PD could develop central brainstem and lung respiratory abnormalities. Adult male C57BL/6 mice received bilateral injections of 6-hydroxydopamine (10 µg µl-1 ; 0.5 µl) or vehicle into the striatum. Ventilatory parameters were assessed in the 40 days after induction of PD, by whole-body plethysmography. In addition, measurements of respiratory input impedance (closed and opened thorax) were performed. 6-Hydroxydopamine reduced the number of tyrosine hydroxylase neurons in the substantia nigra pars compacta, the density of neurokinin-1 receptor immunoreactivity in the pre-BÓ§tzinger complex and the number of Phox2b neurons in the retrotrapezoid nucleus. Physiological experiments revealed a reduction in resting respiratory frequency in PD animals, owing to an increase in expiratory time and a blunted hypercapnic ventilatory response. Measurements of respiratory input impedance showed that only PD animals with the thorax preserved had increased viscance, indicating that the ribcage could be stiff in this animal model of PD. Consistent with stiffened ribcage mechanics, abnormal collagen deposits in alveolar septa and airways were observed in PD animals. Our data showed that our mouse model of PD presented with neurodegeneration in respiratory brainstem centres and disruption of lung mechanical properties, suggesting that both central and peripheral deficiencies contribute to PD-related respiratory pathologies.


Assuntos
Doença de Parkinson Secundária/fisiopatologia , Transtornos Respiratórios/etiologia , Transtornos Respiratórios/fisiopatologia , Animais , Fenômenos Biomecânicos , Colágeno/metabolismo , Hipercapnia/fisiopatologia , Pulmão/fisiopatologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Microinjeções , Neostriado , Oxidopamina , Doença de Parkinson Secundária/induzido quimicamente , Pletismografia , Alvéolos Pulmonares/metabolismo , Taxa Respiratória , Costelas/fisiopatologia
15.
Skeletal Radiol ; 48(5): 741-751, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30612161

RESUMO

OBJECTIVE: Slipping rib syndrome (SRS) affects adolescents and young adults. Dynamic ultrasound plays a potential and likely significant role; however, limited data exist describing the protocol and techniques available. It is our intent to describe the development of a reproducible protocol for imaging in patients with SRS. MATERIALS AND METHODS: Retrospective review of suspected SRS patients from March 2017 to April 2018. A total of 46 patients were evaluated. Focused history and imaging was performed at the site of pain. Images of the ribs were obtained in the parasagittal plane at rest and with dynamic maneuvers. Dynamic maneuvers included Valsalva, crunch, rib push maneuver, and any provocative movement that elicited pain. Imaging was compared with records from the pediatric surgeon specializing in slipping ribs. Statistical analysis was performed. RESULTS: Thirty-six of the 46 patients had a diagnosis of SRS, and had an average age of 17 years. Thirty-one patients were female, 15 were male. Thirty-one out of 46 (67%) were athletes. Average BMI was 22.6. Dynamic ultrasound correctly detected SRS in 89% of patients (32 out of 36) and correctly detected the absence in 100% (10 out of 10). Push maneuver had the highest sensitivity (87%; 0.70, 0.96) followed by morphology (68%; 0.51, 0.81) and crunch maneuver (54%; 0.37, 0.71). Valsalva was the least sensitive (13%; 0.04, 0.29). CONCLUSION: Dynamic ultrasound of the ribs, particularly with crunch and push maneuvers, is an effective and reproducible tool for diagnosing SRS. Valsalva plays a limited role. In addition to diagnosing SRS, ultrasound can give the surgeon morphological data and information on additional ribs at risk, thereby assisting in surgical planning.


Assuntos
Dor no Peito/diagnóstico por imagem , Dor no Peito/fisiopatologia , Dor Musculoesquelética/diagnóstico por imagem , Dor Musculoesquelética/fisiopatologia , Costelas/diagnóstico por imagem , Costelas/fisiopatologia , Ultrassonografia/métodos , Adolescente , Atletas , Feminino , Humanos , Masculino , Estudos Retrospectivos , Sensibilidade e Especificidade , Síndrome , Adulto Jovem
16.
Clin J Sport Med ; 29(1): 18-23, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-29023277

RESUMO

OBJECTIVE: (1) To investigate the clinical presentation, diagnosis, and treatment of slipping rib syndrome in athletes; (2) to investigate the hooking maneuver for diagnosis of slipping rib syndrome. DESIGN: Retrospective chart review of 362 athletes with rib pain. SETTING: Pediatric-based sports medicine clinic between January 1, 1999, and March 1, 2014. PATIENTS: Costochondritis, Tietze, fractures, rib tip syndrome, and unclear diagnoses were excluded. Athletes were included who had a palpable rib subluxation, mechanical rib symptom, positive hooking maneuver, or resolution of pain after the resection of a slipping rib segment. MAIN OUTCOME MEASURES: Slipping rib syndrome is associated with athletic performance. RESULTS: Fifty-four athletes were diagnosed with slipping rib syndrome, of which 38 (70%) were females. Mean age at presentation was 19.1 years (range 4-40 years). Mean number of previous specialist consultations per athlete was 2.3 and mean time from symptom onset to diagnosis was 15.4 months. The hooking maneuver was attempted 21 times (38.9%). Unilateral symptoms presented in 49 athletes (90.7%). The most symptomatic rib was the 10th, affecting 24 athletes (44.4%), eighth and ninth were affected in 17 athletes (31.5%) each. Most, 39 (72.2%), reported insidious onset of symptoms. Running, rowing, lacrosse, and field hockey were frequently associated activities. Twelve athletes had psychiatric diagnoses (22.2%), 10 (19.2%) were hypermobile. Sixty-six total imaging studies were performed. The most successful treatment options included: osteopathic manipulative treatment (71.4%), surgical resection (70%), and diclofenac gel (60%). CONCLUSIONS: Most athletes with slipping rib syndrome were active females with insidious onset of unilateral pain, a high prevalence of hypermobility and prolonged pain. The hooking maneuver was underused.


Assuntos
Atletas , Dor no Peito/diagnóstico , Dor Musculoesquelética/diagnóstico , Costelas/fisiopatologia , Adolescente , Adulto , Dor no Peito/etiologia , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Dor Musculoesquelética/etiologia , Estudos Retrospectivos , Síndrome , Adulto Jovem
17.
Congenit Anom (Kyoto) ; 59(6): 190-192, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30499140

RESUMO

Thoracolumbar supernumerary ribs (TSRs) are classified as less severe skeletal anomalies in rat developmental toxicity studies, although their incidence is relatively high in rodent studies. To investigate the characteristics of the critical window for chemically-induced TSR, in this study, rats were administered 5-fluorocytocine (5-FC) or sodium salicylate (SAL) at one of three time periods on gestational day (GD) 9, early morning (7:00 am), midday (12:00 pm to 1:00 pm), or late afternoon (4:00 pm or 7:00 pm). The incidence of TSR and other anomalies were assessed in GD20 fetuses. A single treatment with both chemicals on GD9-induced TSR, with the incidence highest when administered at 7:00 Am, decreasing gradually when administered later. This trajectory was clearer in rats treated with 5-FC than with SAL. The critical period of TSR induction is shorter in rats administered 5-FC than SAL. The characteristics of the critical window may cause variability in the incidence of TSR observed in developmental toxicity studies.


Assuntos
Anormalidades Induzidas por Medicamentos/fisiopatologia , Feto/fisiopatologia , Anormalidades Musculoesqueléticas/fisiopatologia , Costelas/fisiopatologia , Animais , Feto/efeitos dos fármacos , Flucitosina/toxicidade , Humanos , Anormalidades Musculoesqueléticas/induzido quimicamente , Ratos , Costelas/crescimento & desenvolvimento , Salicilato de Sódio/toxicidade , Teratogênicos/farmacologia , Teratogênicos/toxicidade
19.
Cir Pediatr ; 31(4): 192-195, 2018 Oct 17.
Artigo em Espanhol | MEDLINE | ID: mdl-30371032

RESUMO

AIM OF THE STUDY: The slipping rib syndrome (SRS) is an unknown pathology for the pediatric surgeon due to its low incidence in children. The weakness of the costal ligaments allowing an area of rib hypermobility has been postulated recently as the main etiology. It produces an intermittent pain in the lower thorax or upper abdomen that can affect to the daily activities and can be the origin of unspecific chronic pain. METHODS: A retrospective review of patients diagnosed with SRS between october 2012 and march 2017 was performed. Data of demographics, symptoms, imaging studies, surgical findings and long-term follow-up were collected. RESULTS: During this period, 4 patients were diagnosed with SRS. Median age at diagnosis was 13 years (12-15 years) with a mean duration of symptoms of 13 months (12-36 months). In 2 patients the SRS was associated with Costal Dysmorphia (CD). The initial diagnosis was clinical with posterior ultrasound confirmation. Resection of the affected cartilages was performed in 3 patients and after a follow-up of 6 months (3-30 months), they all are painless and refer a good cosmetic result. One patient refused the intervention. CONCLUSIONS: The SRS is an infrequent cause of thoracic pain with an etiology not well understood. The awareness of this disease and its typical presentation can avoid unnecessary studies. The resection of the affected cartilages is a safe and effective treatment.


INTRODUCCION: El síndrome de costilla deslizante (SCD) es una entidad poco frecuente en niños. Se cree que su causa es una debilidad en los ligamentos costales que permite una hipermovilidad de las costillas. Genera un dolor intermitente en la región baja del tórax o alta del abdomen que puede afectar a las actividades de la vida diaria o generar un dolor crónico. MATERIAL Y METODOS: Revisión retrospectiva de SCD entre octubre de 2012 y diciembre de 2017. Se recogió información acerca de los datos demográficos, síntomas, estudios de imagen, hallazgos intraoperatorios, material fotográfico y seguimiento a largo plazo. RESULTADOS: Durante este periodo, 4 pacientes fueron diagnosticados de SCD. La mediana de edad al diagnóstico fue de 13 años (12-15 años) con una duración previa de los síntomas de 13 meses (12-36 meses). En 2 pacientes se asoció una dismorfia costal (DC). El diagnóstico fue clínico con confirmación ecográfica. Se realizó resección de los cartílagos afectos en 3 pacientes con un seguimiento posterior de 6 meses (3-30 meses). Actualmente se encuentran sin dolor y con un resultado estético satisfactorio. Un paciente rechazó la intervención. CONCLUSIONES: El SCD aparece en pacientes preadolescentes que en algunos casos asocian DC. Una exploración física y ecografía enfocada son las claves para un diagnóstico certero. La resección de cartílagos es efectiva a largo plazo.


Assuntos
Cartilagem/cirurgia , Dor no Peito/etiologia , Costelas/cirurgia , Adolescente , Cartilagem/diagnóstico por imagem , Criança , Feminino , Seguimentos , Humanos , Masculino , Estudos Retrospectivos , Costelas/diagnóstico por imagem , Costelas/fisiopatologia , Síndrome , Resultado do Tratamento , Ultrassonografia/métodos
20.
Semin Pediatr Surg ; 27(3): 183-188, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30078490

RESUMO

Slipping rib syndrome (SRS) is an under-diagnosed cause of intermittent, yet often debilitating lower rib and abdominal pain. SRS is caused by a hypermobility of the anterior false ribs that allows the 8th-10th ribs to slip or click as the cartilaginous rib tip abuts or slips under the rib above. Pain occurs from impingement of the intercostal nerve passing along the undersurface of the adjacent rib. Studies consistently find patients reporting months to years of typical pain symptoms, unnecessary tests and procedures prior to diagnosis. SRS is a clinical diagnosis, but dynamic ultrasound can be helpful for confirmation or diagnosis in difficult cases. Resection of the slipping rib cartilages is the mainstay of treatment, with good results for pain relief. Rib stabilization is an emerging option for recurrent symptoms.


Assuntos
Doenças Musculoesqueléticas , Costelas/fisiopatologia , Dor Abdominal/etiologia , Humanos , Doenças Musculoesqueléticas/complicações , Doenças Musculoesqueléticas/diagnóstico , Doenças Musculoesqueléticas/terapia , Dor Musculoesquelética/etiologia , Procedimentos Ortopédicos , Síndrome
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