RESUMO
Hyperoxaluria, alone or associated with hypercalciuria, has been detected in 69 of 450 patients with recurrent stones (15.3 per cent). The 3 main findings associated with hyperoxaluria were 1) oxalate hyperabsorption, 2) hyperoxalemia and 3) increased or decreased oxalate clearance. Correction of oxalate hyperabsorption by administration of diethylaminoethanol cellulose showed good results through a 5-year followup. Succinimide, given to the hyperoxalemic group, and a combination of phosphate and magnesium, given to the group with altered clearances, showed poorer results.
Assuntos
Oxalato de Cálcio/metabolismo , Celulose/análogos & derivados , DEAE-Celulose/uso terapêutico , Cálculos Renais/tratamento farmacológico , Magnésio/uso terapêutico , Fosfatos/uso terapêutico , Succinimidas/uso terapêutico , Adulto , Humanos , Absorção Intestinal , Cálculos Renais/metabolismo , Cloreto de Magnésio , Oxalatos/metabolismo , Recidiva , Fatores de TempoRESUMO
There were 22 patients in whom oxalate stones formed and who had absorptive hyperoxaluria treated with diethylaminoethanol-cellulose. In more than 2 years this form of treatment did not seem to have any serious side effects. It achieved a decrease of urinary oxalate values in all patients in whom oxalate hyperabsorption had been found. Diethylaminoethanol-cellulose is an anionic exchanger capable of retaining oxalate in vitro and in vivo.
