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1.
Int Immunopharmacol ; 15(4): 752-5, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23499641

RESUMO

Intravenous immunoglobulin (IVIG) replacement has been shown to decrease the risk of post-transplant infections secondary to hypogammaglobulinemia, however the use of subcutaneous immunoglobulin (SCIG) in this population has not been reported. A retrospective analysis of the efficacy and tolerability of subcutaneous immunoglobulin replacement on 10 lung-transplant recipients was performed. All 10 patients demonstrated an increase in IgG levels at three months that was sustained at 6-12 months with SCIG replacement therapy, with the majority (70%) tolerating infusion without complications. The results of this study suggest that subcutaneous IgG replacement therapy is a well tolerated alternative to IVIG.


Assuntos
Deficiência de IgG/prevenção & controle , Imunoglobulina G , Fatores Imunológicos , Transplante de Pulmão , Idoso , Registros Eletrônicos de Saúde , Feminino , Humanos , Deficiência de IgG/sangue , Imunoglobulina G/administração & dosagem , Imunoglobulina G/efeitos adversos , Imunoglobulina G/uso terapêutico , Imunoglobulinas/administração & dosagem , Imunoglobulinas/efeitos adversos , Imunoglobulinas/uso terapêutico , Fatores Imunológicos/administração & dosagem , Fatores Imunológicos/efeitos adversos , Fatores Imunológicos/uso terapêutico , Infusões Subcutâneas , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
2.
Rev Med Interne ; 21(3): 236-41, 2000 Mar.
Artigo em Francês | MEDLINE | ID: mdl-10763184

RESUMO

PURPOSE: To study the association of polyclonal B-cell lymphocytosis with binucleated lymphocytes with clinical manifestations suggesting the existence of an immunodeficiency, to evaluate the effect of cigarette smoking on this 'benign lymphoid proliferation', to analyze the clonality of lymphocytes, to determine the levels of immunoglobulins (Ig) G, A, M. METHODS: Description and analysis of the results obtained in four patients and literature review. RESULTS: Polyclonal B-cell lymphocytosis is associated with both a decrease in IgA and IgG and an increase in IgM. Recurrent infectious episodes (bronchitis) were observed in two patients. Transient smoking cessation allowed a decrease in lymphocytosis and IgM levels in two patients. No hematological malignancy occurred during the follow-up, while biological abnormalities persisted. CONCLUSION: Persistent polyclonal B-cell lymphocytosis may be associated with minor clinical features of immunodeficiency. Smoking cessation may sometimes lead to a decrease in lymphocytosis and IgM.


Assuntos
Linfócitos B , Deficiência de IgA/sangue , Deficiência de IgA/etiologia , Deficiência de IgG/sangue , Deficiência de IgG/etiologia , Imunoglobulina M/sangue , Linfocitose/sangue , Linfocitose/etiologia , Fumar/efeitos adversos , Adulto , Idoso , Linfócitos B/ultraestrutura , Bronquite/etiologia , Feminino , Antígeno HLA-DR7/genética , Humanos , Deficiência de IgA/diagnóstico , Deficiência de IgA/prevenção & controle , Deficiência de IgG/diagnóstico , Deficiência de IgG/prevenção & controle , Contagem de Linfócitos , Linfocitose/diagnóstico , Linfocitose/prevenção & controle , Masculino , Pessoa de Meia-Idade , Prognóstico , Recidiva , Abandono do Hábito de Fumar , Prevenção do Hábito de Fumar
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