Effect of denosumab switched from bisphosphonates in preventing joint destruction in postmenopausal rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies.

INTRODUCTION: This study aimed to determine the effects of denosumab treatment on the joint destruction of Japanese females with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibodies. MATERIALS AND METHODS: This retrospective longitudinal study included 56 patients treated with denosumab and 50 patients treated with bisphosphonate. All participants were positive for anti-CCP antibodies. All patients also had a history of osteoporosis treatment with bisphosphonate, which was either continued or switched to 60 mg of subcutaneous denosumab injection every 6 months. To assess the progression of joint destruction, hand and foot radiographs were taken, and changes in modified total Sharp score (mTSS), erosion score (ERO), and joint space narrowing score (JSN) were evaluated at 12 months and 24 months. The changes in BMD of the lumbar spine and hip were also assessed at 12 months. RESULTS: At 12 months, there were significant differences in the change of ERO (p = 0.015) and mTSS (p = 0.01). Similarly, there were significant differences in the change of ERO (p = 0.013) and mTSS (p = 0.003) at 24 months. In contrast, no significant difference was observed in the changes of JSN and clinical parameters. There were significant differences in the changes in BMD in the femoral neck (p = 0.011) and total hip (p = 0.012). CONCLUSION: Denosumab treatment might be effective for the inhibition of bone erosion progression in the patients with RA, and it potentially contributes to the treatment of osteoporosis and prevention of destructive arthritis in patients with switching treatment from bisphosphonate.

Anterolateral approach for lateral humeral condylar fractures in children: Clinical results.

To evaluate the clinical outcomes of an anterolateral approach for lateral humeral condylar fractures in children. The patients aged < 15 years undergoing surgery with an anterolateral approach for humeral lateral condylar fractures between April 2005 and March 2014 were investigated. Medical records and radiographs from 15 patients were reviewed. Average patient age at surgery was 6.0 years (range, 3-10 years). Based on Jakob's classification, 12 patients had type II fractures, and 3 patients had type III fractures. Based on Milch classification, 1 elbow was type I, and 14 elbows were type II. The average postoperative follow-up duration was 16.4 months (range, 6-58 months). Postoperative complications, and radiographic and clinical findings, including range of motion and Flynn criteria were evaluated. To evaluate humeral deformity, Baumann angle (BA) and the carrying angle (CA) were calculated on anteroposterior radiographs. There were no postoperative complications, including secondary displacement, deep infection, nonunion, avascular necrosis, or cubitus varus or valgus deformity. In the injured elbow, follow-up radiographs revealed an average BA of 69.1° (range, 57-84°), versus 70.9° (range, 61-83°) on the contralateral side. The average CA on the injured side was 10.3° (range, 4-20°) versus 12.3° (range, 6-24°) on the contralateral side. BA gain and CA loss (affected- compared with contralateral sides) averaged -1.4° (range, -17° to 9°) and 2.3° (range, -2° to 6°), respectively. The mean range of motion in the affected elbow averaged 4.7° (range, 0-15°) in extension and 139.7° (range, 135-140°) in flexion. Over 5° loss of range of motion in the affected elbow compared with the contralateral side was not observed. However, 2 patients experienced over 5° loss of CA in the affected elbow versus the contralateral side. Based on Flynn criteria, clinical results for both cosmetics and function were excellent in 13 patients, and good in 2. The advantages of the anterolateral approach are combining an optimal view of the anterior articular surface of the trochlea and capitellum and a limited risk of devascularization injury. We strongly recommend an anterolateral approach for these fractures in children to prevent postoperative deformity and to achieve anatomical reduction and reliable fixation.

Using the Medial and Lateral Humeral Lines as an Adjunct to Intraoperative Elbow Arthrography to Guide Intraoperative Reduction and Fixation of Distal Humerus Physeal Separations Reduces the Incidence of Postoperative Cubitus Varus.

BACKGROUND: Distal humerus physeal separations are rare pediatric elbow fractures that are often misdiagnosed and difficult to treat. Adequate reduction is often technically challenging and up to 71% of children develop postoperative cubitus varus. We propose using the medial and lateral humeral lines as an adjunct to elbow arthrography in order to guide intraoperative fixation of distal humerus physeal separations to reduce the incidence of postoperative cubitus varus. METHODS: From 2009 to 2014, all pediatric patients under the age of 3 diagnosed with a distal humerus physeal separation and treated surgically at our institution were included for analysis. Two senior pediatric orthopaedic surgeons separately reviewed the preoperative, intraoperative, and postoperative images of all patients and measured the position of the ulnar axis relative to the medial and lateral humeral lines. The medial and lateral humeral shafts were defined as parallel lines drawn along the medial and lateral humeral diaphysis. Adequate reduction was defined by reduction of the ulnar axis within the boundaries of the medial and lateral humeral lines. Patients were assessed at latest follow-up for cubitus varus and any other surgical complications. RESULTS: Thirteen patients fulfilled the inclusion criteria and were on average 1.70 years old, ranging from 0.62 to 3 years old. Intraoperatively and immediately postoperatively, all 13 patients (100%) were noted to have adequate reduction of the ulnar axis within the boundaries medial and lateral humeral lines. None of the patients required intraoperative arthrography (0%). At the date of latest follow-up, 12 patients (92.3%) had no angular deformities compared with the contralateral limb and 1 patient (7.7%) had developed cubitus varus. No surgical complications were noted (0%). CONCLUSION: Intraoperative reduction of the ulnar axis within the boundaries of the medial and lateral humeral lines is associated with a lower incidence of postoperative cubitus varus in the treatment of distal humerus physeal separations in children. LEVEL OF EVIDENCE: Level IV.

Mitigating Risk of Ankle Valgus From Ankle Osteochondroma Resection Using a Transfibular Approach: A Retrospective Study With Six Years of Follow-Up.

To prevent worsening of ankle valgus and functional repercussions, a distal inter-tibiofibular osteochondroma can be removed using a transfibular approach. We evaluated the difference between the preoperative and postoperative tibiotalar tilt at the last follow-up examination and the clinical and radiologic outcomes. We included 10 consecutive ankles that had undergone removal of an osteochondroma using a transfibular approach. The mean patient age was 10.6 years. One ankle was lost to follow-up. The mean postoperative follow-up duration was 5.9 years. The mean preoperative and postoperative tibiotalar tilt was 7.2° and 7.1°, respectively, with no significant difference. The mean postoperative American Orthopaedic Foot and Ankle Society score was 92.4. Tibiofibular synostosis developed in 7 cases. Osteochondroma recurred in 1 case. The transfibular approach stabilizes ankle valgus and is associated with good functional outcomes. However, it is an extensive procedure associated with postoperative synostosis and, thus, should be considered primarily when surgical access for an anterior approach is limited.

Reliable Method for Avoiding Malrotation Deformity After Intramedullary Nailing of Comminuted Femur Fractures: Clinical Validation of a Previously Described Technique.

OBJECTIVES: To evaluate a previously described technique using the inherent anteversion of intramedullary nail (IMN) to avoid malrotation in comminuted femur fractures and describe the use of magnetic resonance imaging (MRI) as an alternative method for assessing postoperative femoral version. DESIGN: Prospective consecutive cohort study. SETTING: Level I trauma center. PATIENT/PARTICIPANTS: Twenty-five consecutive patients with comminuted femur fractures (Winquist III/IV, OTA/AO 32-B/32-C) treated by a single surgeon with IMN between September 1, 2011, and February 28, 2015. INTERVENTION: IMN on a fracture table with intraoperative femoral version set by the inherent version of the implant. All patients received a postoperative computed tomography (CT) or MRI to assess femoral version. MAIN OUTCOME MEASUREMENTS: Mean difference in postoperative femoral anteversion (DFA) between injured limb and uninjured limb as measured by CT or MRI. Mean difference in postoperative femoral version of the injured femur from the inherent version of the implant (12 degrees) was measured with CT or MRI. RESULTS: The mean postoperative DFA was 9.1 ± 5.6 degrees. Postoperative DFA greater than 15 degrees was found in 2 (8.0%) patients. Mean difference in postoperative version of the injured femur from the inherent 12 degrees of the implant was 7.1 ± 5.4 degrees. Patients tolerated MRI studies well. CONCLUSIONS: Our previously described technique using the inherent anteversion of an IMN is effective and leads to a very low rate of malrotation, even in highly comminuted fractures. The technique is particularly useful in treating bilateral femur fractures. MRI can be used safely and effectively to assess anteversion after fixation of femur fractures. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Is there a correlation between the change in the interscrew angle of the eight-plate and the delta joint orientation angles?

OBJECTIVES: It is known that the screws of the eight-plate hemiepiphysiodesis construct diverge as growth occurs through the physis. Our objective was to investigate whether there is a correlation between the amount of change of the joint orientation angle (JOA) and that of the interscrew angle (ISA) of the eight-plate hemiepiphysiodesis construct before and after correction. PATIENTS AND METHODS: After the institutional review board approval, medical charts and X-rays of all patients operated for either genu valgum or genu varum with eight-plate hemiepiphysiodesis were analyzed retrospectively. All consecutive patients at various ages with miscellaneous diagnoses were included. JOA and ISA were measured before and after correction. After review of the X-rays, statistical analyses were performed which included Pearson correlation coefficient and regression analyses. RESULTS: There were 53 segments of 30 patients included in the study. Eighteen were males, and 12 were females. Mean age at surgery was 9.1 (range 3-17). Mean follow-up time was 21.5 (range, 7-46) months. The diagnoses were diverse. A strong correlation was found between the delta JOA (d-JOA) and delta ISA (d-ISA) of the eight-plate hemiepiphysiodesis construct (r = 0.759 (0.615-0.854, 95%CI), p < 0.001). This correlation was independent of the age and gender of the patient. CONCLUSIONS: There is a strong correlation between the d-ISA and the d-JOA. The d-ISA follows the d-JOA at a predictable amount through formulas which regression analysis yielded. This study confirms the clinical observation of the diverging angle between the screws is in correlation with the correction of the JOA. LEVEL OF EVIDENCE: Level IV, Therapeutic study.

Three-Dimensional Printing and Surgical Simulation for Preoperative Planning of Deformity Correction in Foot and Ankle Surgery.

A paucity of published data is available describing the methods for the integration of 3-dimensional (3D) printing technology and surgical simulation into orthopedic surgery. The cost of this technology has decreased and the ease of use has increased, making routine use of 3D printed models and surgical simulation for difficult orthopedic problems a realistic option. We report the use of 3D printed models and surgical simulation for preoperative planning and patient education in the case of deformity correction in foot and ankle surgery using open source, free software.

Clinical outcomes of operative repair of complete rupture of the proximal interphalangeal joint collateral ligament: Comparison with non-operative treatment.

OBJECTIVES: The purpose of this study was to compare the outcomes of non-operative treatment and operative repair of grade III injuries with complete rupture of the collateral ligament of the proximal interphalangeal (PIP) joint. PATIENTS AND METHODS: Seventeen patients with grade III injuries with at least 6 months of follow-up were included. Seven patients underwent non-operative treatment and 10 patients underwent operative treatment. We evaluated the following clinical outcomes after treatment: 1) range of motion of the PIP and distal interphalangeal (DIP) joints, 2) joint stability, 3) pain score, and 4) amount of fusiform deformity of the PIP joint. RESULTS: There was no instability in the lateral stress test in either group. The ranges of motion of the PIP and DIP joints were not statistically different between the two groups at final follow-up. However, the ranges of motion recovered more quickly in the operative group than the non-operative group within the first 3 months after treatment. Patients in the operative group had less pain and better cosmetic appearance of the PIP joint. CONCLUSION: Our results suggest that operative repair of the PIP collateral ligament can provide good joint stability, rapid functional recovery, and minimize fusiform deformity of the PIP joint. LEVEL OF EVIDENCE: Level III, Therapeutic study.

Osteoarticular allograft reconstruction of post-traumatic defect of distal femur in a pediatric patient: A case report and literature review.

Successful results of osteoarticular allografts in reconstruction of periarticular bone defect after tumor resection encouraged its utilization in post-traumatic defects. Here we describe a case of post-traumatic skeletal defect in a 4 year-old girl treated with osteoarticular allograft reconstruction. Due to severity of the associated soft tissue injury and contamination at presentation staged treatment with antibiotic spacer followed by the reconstruction was carried out. At the end of one year the patient achieved 'Musculoskeletal tumor society' functional score of 27 points and radiographic score of 93%. Reconstruction immediately after healing of soft tissues prevented development of any varus or valgus deformity of the knee. Our case demonstrates utility of osteoarticular allograft in a pediatric post-traumatic skeletal defect.

[Bony injuries of the knee region in childhood and adolescence]. / Knöcherne Verletzungen der Knieregion im Kindes- und Jugendalter.

Fractures of the knee region in childhood and adolescence are rare but are an important group of injuries due to the high incidence of secondary complications from growth disturbances. Meticulous primary diagnostics and fracture treatment with clear indications for surgical treatment are essential for avoiding posttraumatic deformities, although these can occur even despite correct primary treatment and are therefore inherent to specific fractures and therefore often unavoidable. In cases of growth disturbance where a deformity is imminent or has already taken place, watchful waiting until closure of the growth plate is only rarely indicated due to the progress made in directing growth via surgical means. Even surgeons who are primarily working in the field of fracture treatment must be aware of current strategies for correction of posttraumatic deformities in order to prevent or treat them in time or at least be able to prophylactically inform patients and parents during primary fracture treatment.

Item Development and Face Validity of the Rheumatoid Arthritis Patient Priorities in Pharmacological Interventions Outcome Measures.

BACKGROUND: The assessment of rheumatoid arthritis (RA) is dominated by core sets and indices that have been developed by RA professionals. Previous research developed a set of eight priority treatment outcomes generated by patients to complement the professionally developed core sets for RA. OBJECTIVE: This study aimed to facilitate quantitative measurement of these outcomes. METHODS: Two consultation meetings with patient research partners diagnosed with RA (n = 18) were held to identify face validity in existing instruments (Phase 1) at the Bristol Royal Infirmary. Where validated measures did not exist, new numerical rating scales (NRS) were constructed and discussed at two focus groups with patients diagnosed with RA (n = 8) at the Bristol Royal Infirmary and the Royal National Hospital for Rheumatic Diseases (Phase 2). Feedback on the stem question, time frame, anchors and layout was recorded and transcribed verbatim. RESULTS: Of the eight priorities, existing NRS for pain, activities of daily living and fatigue were voted as acceptable (Phase 1), but new NRS were required for five priorities. The partners strongly recommended that the three separate domains of severity, effect and ability to cope in each measurement area be assessed, as in the existing validated fatigue NRS. Focus group participants (Phase 2) made significant contributions to the phrasing of questions, for example how to ensure 'mobility' could be uniformly understood and how changes in valued activities be judged appropriately. CONCLUSION: Through extensive patient feedback, 24 NRS were constructed based on priorities identified by patients and encompassing domains where existing questionnaires contain many more items and do not address three important concepts endorsed by patients: severity, effect and coping. The Rheumatoid Arthritis Patient Priorities in Pharmacological Interventions patient-reported outcome measures are now ready for the evaluation of comprehension, construct validity and sensitivity through an observational study.

Patients with gout can be cured in primary care.

Gout affects 2.5% of the total UK population and is four times more common in men than women. The peak prevalence and incidence in the UK is in those aged 80-84 years. Gout is associated with comorbidities such as nephrolithiasis, chronic renal impairment, metabolic syndrome, depression and heart disease. It is also associated with increased mortality. Untreated gout can result in disabling irreversible peripheral joint damage and chronic usage-related pain. However, gout is curable. The pathogenic agents that cause gout i.e.urate crystals can be eliminated through a combination of effective patient education and evidence-based, targeted urate-lowering therapy. Gout is caused by the precipitation of monosodium urate crystals in and around a joint. The crystals preferentially form in peripheral, cooler joints and especially in those with osteoarthritis. It is thought that some of these preformed crystals within articular cartilage spill over into the joint space and trigger an acute attack of inflammation. Uric acid is predominantly renally excreted and the common heritable component of gout results from relative inefficiency of urate excretion. Chronic kidney disease, metabolic syndrome and drugs that reduce renal function (e.g. thiazide diuretics, beta-blockers and ACE inhibitors) will all lead to reduced elimination. Patients with chronic gout can present with monoarthritis but more commonly present with asymmetrical polyarthritis or tophi. Joints affected by osteoarthritis are preferentially targeted, the most common sites of involvement are feet, knees, hands and elbows. Diagnosis can be confirmed in primary care by taking a good history and clinical examination. An acute peripheral monoarthritis which reaches its peak within 24 hours and causes 'the worst pain ever experienced' is characteristic of an acute attack. A patient may have co-existing risk factors for gout such as osteoarthritis, obesity, hypertension, renal impairment, diuretic and antihypertensive drug use or increased beer or spirit consumption. A raised serum uric acid can confirm the diagnosis, however, this can be normal in the acute phase. Radiographs are rarely helpful but joint ultrasound may demonstrate deposits in cartilage, the synovium and peri-articular sites.

A preliminary assessment of a novel pneumatic unloading knee brace on the gait mechanics of patients with knee osteoarthritis.

OBJECTIVES: To determine whether a knee brace incorporating inflatable air bladders can alter the net peak external knee adduction moment in persons with medial compartment knee osteoarthritis. DESIGN: Prospective cohort study. SETTING: Motion analysis laboratory. PARTICIPANTS: Subjects (n = 18) diagnosed with knee osteoarthritis as defined by the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. METHODS: Instrumented gait analysis was performed while subjects walked with and without the knee brace. When subjects wore the knee brace, the air bladders were either uninflated or inflated to 7 psi. The net external knee adduction moment was obtained by subtracting the abduction moment produced by the knee brace (estimated using a finite element analysis model) from the external knee adduction moment (estimated using a camera-based motion analysis system). MAIN OUTCOME MEASUREMENTS: The net external knee adduction moment was compared across all testing conditions. RESULTS: A 7.6% decrease in net peak external knee adduction moment was observed when subjects wore the knee brace uninflated compared with when they did not wear the brace. Inflation of the bladders to 7 psi led to a 26.0% decrease in net peak external knee adduction moment. CONCLUSIONS: The results of the study suggest that the effects of an unloading knee brace may be enhanced by incorporating inflatable air bladders into the design of the brace, thus leading to an improved correction of the excessive peak external knee adduction moment observed in patients with medial compartment knee osteoarthritis.

Antegrade nailing can prevent cubitus varus and valgus after pediatric supracondylar fractures with impacted columns.

Supracondylar fractures are commonly encountered in the pediatric population. An impacted radial or ulnar column may result in the deviation of the elbow axis in the frontal plane clinically seen as cubitus varus or valgus. Antegrade nailing has become a feasible alternative to treat supracondylar fractures. It is not known whether it can prevent the development of cubitus varus or valgus in the cases of fractures with impacted columns. Between 1994 and 2009, 264 supracondylar humeral fractures were treated. Nineteen patients presented with either an impacted ulnar (n = 12) or radial (n = 7) column and were included in the study. The average elbow angle in fractures with impacted radial column was 159° mean (range 153-167°) compared with 179° (range 173-184°) in fractures with an impacted ulnar column. After closed reduction and antegrade nailing, the elbow angle was restored to normal values. At follow-up examination after a mean of 3.8 years (range 2.4-7.6 years), no further changes of the humeral-ulnar angle were seen. We are able to show that antegrade nailing is a safe method to treat supracondylar humeral fractures with impacted columns.

Clinical and radiographic results of lateral condylar fracture of distal humerus in children.

BACKGROUND: The treatment goal in lateral condylar fracture is union without residual deformity. However, growth disturbance may occur despite initial anatomic reduction and secure fixation. The purpose of this study was to evaluate the clinical and functional results, including complications, of lateral condylar fracture treatments in children, and to identify differences between treatment methods. METHODS: One hundred seventy-five patients followed for more than a year with available initial and final follow-up radiographs were included. Carrying angle and range of motion limitations were assessed, and functional results were evaluated using the scoring system devised by Dhillon et al. All complications including varus, valgus, lateral overgrowth, fishtail deformity, nonunion, malunion, and avascular necrosis were investigated statistically. RESULTS: There were 113 male and 62 female of mean age 4 years 9 months. Thirty-nine patients were managed by cast immobilization. Closed reduction and internal fixation (CRIF) was carried out in 33 and open reduction and internal fixation (ORIF) in 103. Kirschner wires were removed at a mean 5.5 weeks. There were 11 superficial infections, 3 valgus, 3 delayed unions. In 135 (77.1%) of the 175 patients, obvious lateral condylar overgrowths were observed at 19.8 (+/-16.8) months (range, 12 to 120) without evidence of a functional abnormality. Development of lateral elbow prominence revealed difference between the 3 treatment methods and it was caused by the difference between cast and ORIF (1 vs. 32, P<0.001). It also showed difference between the 3 fracture types and it was caused by significant difference between type I and II (1 vs. 24) and between I and III (1 vs. 14) (P<0.001, respectively). Mean radiographic carrying angles showed a decrease of 5.0 (+/-4.6) degrees at final follow-ups, but no significant difference was observed between fracture types or treatment method (P=0.832 and 0.850, respectively). Clinically, 17 cases (9.7%) with varus deformities were observed, although there was no need for corrective surgery. At final follow-ups, 116 patients had achieved an excellent result and 59 a good result. CONCLUSION: This study shows that bone union and good clinical results can be achieved in children with a lateral condylar fracture, and that lateral overgrowth and cubitus varus are the most common residual deformities. Furthermore, these residual deformities were not remodeled at a mean 19.8 months after injury. LEVEL OF EVIDENCE: Case series, Level IV.

Prevenção de incapacidade na hanseníase com apoio em um manual de autocuidado para pacientes / Disability prevention in leprosy using a self-care manual for patients

A hanseníase é uma doença infectocontagiosa, de evolução lenta, que se manifesta por sinais e sintomas dermatoneurológicos, com lesões na pele e nos nervos periféricos. O objetivo deste estudo foi avaliar o status físico e funcional de olhos, mãos e pés de pacientes com hanseníase, em relação ao aparecimento e evolução de deficiências sensitivo-motoras, grau de incapacidade e qualidade de vida, tendo os pacientes recebido e utilizado durante um ano um manual especialmente elaborado, com orientações de autocuidados para prevenção de incapacidade. Foram realizadas e comparadas avaliações fisioterapêuticas inicial e após 12 meses de uso do manual, de 26 pacientes com hanseníase: palpação de nervos periféricos, teste de sensibilidade da córnea, teste de sensibilidade cutânea, teste manual de função muscular e dinamometria isométrica de preensão e pinças dos dedos, sendo aplicado ainda o questionário de qualidade de vida SF-36 e classificado o grau de incapacidade. Os nervos mais acometidos foram o ulnar e otibial posterior. Embora o grau de incapacidade e as deformidades preexistentes tenham persistido, houve melhora significativa nos domínios dor e aspectos sociais do questionário SF-36, bem como na função muscular das mãos e dos pés e no ressecamento da pele. Como estas últimas são diretamente relacionadas ao autocuidado, sugere-se que o manual de orientações pode ter importante papel coadjuvante na melhora de sintomas dos pacientes com hanseníase.

Leprosy is an infectious disease of slow evolution, manifested by dermatoneurological signs and symptoms, with skin and peripheral nerve injuries. The aim of this study was to assess physical and functional status of eyes, hands and feet of patients with leprosy, as well as to assess evolution of sensory-motor disabilities, degree of disability and quality of life, having specially produced and handed the patients an illustrated self-care manual for preventing disability. Twenty six patients with leprosy were assessed initially and after 12 months of using the manual as to: skin inspection, peripheral nerves palpation, corneal sensitivity, skin sensitivity, limb muscle function, hand muscle strength (finger grip and pinch strength); the disability degree was determined and patients answered the SF-36 questionnaire. Most affected nerves were the ulnar and posterior tibial ones. Results showed that, though the degree of disability and deformities persisted, there were significant improvements in SF-36 social aspects and pain domains, as well as improvements in skin dryness and hands and feet muscle function. Since the latter are directly related to self-care, this suggests that the self-care manual may have an important supporting role in relieving symptoms of patients with leprosy.

Role of muscle in the genesis and management of knee osteoarthritis.

The muscles of the lower limb play an important role in the genesis and management of knee osteoarthritis (OA). This article outlines the influence of muscle activity on knee joint loading, the deficits in muscle function observed in people who have knee OA, and available evidence pertaining to the role of muscle in the development and progression of knee OA. It also discusses whether muscle deficits can be modified in knee OA and whether improvements in muscle function lead to improved symptoms and joint structure. It concludes with a discussion of exercise prescription for muscle rehabilitation in knee OA.

Iatrogenic cervical deformity.

Iatrogenic cervical deformity can develop after anterior or posterior procedures. Careful attention to detail can minimize the likelihood of creating a sagittal or coronal plane deformity. Strategies for the prevention and correction of postoperative cervical deformity are presented.

[Reconstruction of the tibial diaphysis with transfer of the tibial head onto the proximal fibula. Follow-up after 63 years]. / Rekonstruktion der Tibiadiaphyse mittels Tibiakopftransfer auf die proximale Fibula. Follow up nach 63 Jahren.

Osteoarthritis of the knee is often diagnosed in the orthopedic trauma practice. One major cause is axial deformity with overload. In the case presented here osteomyelitis of the tibial diaphysis developed in childhood. Surgical treatment consisted of resection of the middle tibial third and transferring the tibial head onto the proximal fibula. In this way it was possible to eradicate the osteomyelitis of the lower leg and to achieve osseous consolidation between the tibia and fibula. Despite the significant shortening of the lower limb and the varus axial deformity, the knee joint function was satisfactory in the subsequent development. After a long interval without symptoms the patient developed a medially accentuated osteoarthritis of the knee.