RESUMO
This study is a part of the Biological Risk Assessment of Human Metal Sensitisation (BRAHMS) project with the aim of elucidating clinical and physiological effects of repeated exposures to low concentrations of metal allergens. Nickel allergic individuals (n = 35) with hand eczema and healthy controls (n = 30) were included in the study. Both groups had similar levels of nickel in urine, while the level of nickel in serum was significantly lower in nickel allergic individuals compared to controls. Nickel allergic individuals had a significantly lower intake of nickel-rich food items (chocolate, nuts, beans, porridge oats). Serum nickel levels correlated with intake of these foods, suggesting that the difference in serum nickel levels was caused by differences in dietary nickel intake.
Assuntos
Alérgenos/análise , Dermatite Alérgica de Contato/etiologia , Níquel/análise , Adulto , Idoso , Dermatite Alérgica de Contato/sangue , Dermatite Alérgica de Contato/urina , Dieta , Feminino , Análise de Alimentos , Humanos , Masculino , Pessoa de Meia-Idade , Níquel/sangue , Níquel/urina , Testes do EmplastroRESUMO
We describe here a disease related to mite-associated ulcerative dermatitis in BALB/c mice, a strain previously classified as resistant to this condition. The disease was recognized by pruritic cutaneous pathology and wasting. Pathologic studies showed a marked allergic-type inflammation in the skin. The dominant histologic feature was extensive mast cell infiltration in cutaneous lesions and in lymphoid tissues, associated with a greatly elevated serum IgE concentration. The disease was secondary to infestation with an acarian ectoparasite Myocoptes musculinus, and seemed to represent an allergic reaction to the parasite-derived substances, with an associated wasting syndrome. This condition may be a useful experimental model for allergic diseases.