RESUMO
Congenital candidiasis infection often presents as a skin rash with variable involvement of nails and mucous membranes. Isolated nail involvement is rare, may present late, and can often be managed with topical antifungal medication. We report a case of congenital candidiasis limited to the fingernails that resolved completely within 3 months with topical treatment.
Assuntos
Candidíase Cutânea/congênito , Dermatoses da Mão/microbiologia , Unhas Malformadas/congênito , Onicomicose/microbiologia , Administração Tópica , Antifúngicos/administração & dosagem , Candidíase Cutânea/tratamento farmacológico , Candidíase Cutânea/microbiologia , Clotrimazol/administração & dosagem , Feminino , Dermatoses da Mão/congênito , Dermatoses da Mão/tratamento farmacológico , Humanos , Recém-Nascido , Doenças do Recém-Nascido/tratamento farmacológico , Unhas Malformadas/tratamento farmacológico , Onicomicose/congênito , Onicomicose/tratamento farmacológicoRESUMO
BACKGROUND: Erythema palmare hereditarium (EPH), also known as Lane's disease, is a rare, benign condition presenting as persistent erythema involving the palms. EPH can appear at birth or later in life and usually in at least two members of the same family, although a sporadic case has been reported. METHODS: We report five cases of EPH and offer a review of the current literature. The first and second cases are twin boys presenting with erythema mainly on the thenar and hypothenar eminences and on the phalanges that appeared 8 months after birth. The third case is a girl with congenital palmar erythema and two other capillary malformations. The fourth case is a 58-year-old woman with palmar erythema that appeared after pregnancy. Her 32-year-old daughter had presented with the same palm redness since birth. RESULTS: A review of the literature shows that women are affected almost three times more than men. Dermoscopic evaluation showed red structureless areas with arborizing vessels, mainly running parallel along follicular openings. CONCLUSION: EPH should be considered in all patients presenting with palmar erythema, especially in familial long-lasting forms. It can be congenital or acquired, but the pathogenetic mechanism is unclear. To the best of our knowledge, this is the first dermatoscopic study of EPH and the largest case series reported in the literature, involving two families and one sporadic case.
Assuntos
Dermatoses da Mão/congênito , Mãos/patologia , Adulto , Pré-Escolar , Dermoscopia/métodos , Feminino , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/patologia , Humanos , Lactente , Masculino , Pessoa de Meia-IdadeRESUMO
BACKGROUND: Palmar erythema may be either congenital or acquired, hereditary or non-hereditary. Its diagnosis and management differs according to whether or not it is acquired, hereditary or associated with symptoms. Herein, we report the case of a child with hereditary palmoplantar erythema (Lane's disease). OBSERVATION: A 2½-year-old girl consulted for palmar erythema, present since birth, predominantly on the thenar and hypothenar eminences and on the palmar aspect of her fingers. She also presented mild diffuse erythema on the soles of her feet. Both her mother and grandmother had similar signs. The girl had neither impairment nor pain linked to this erythema, and she had no associated symptoms. Physical examination was otherwise normal, as were the results of standard laboratory tests. DISCUSSION: We diagnosed Lane's disease based on the girl's hereditary erythema with autosomal dominant transmission, and the congenital and asymptomatic nature of her palmoplantar erythema. Nine publications have reported cases of Lane's disease, but this condition is probably highly under-reported.
Assuntos
Dermatoses da Mão/congênito , Pré-Escolar , Feminino , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/genética , Dermatoses da Mão/patologia , HumanosAssuntos
Poroceratose/congênito , Poroceratose/patologia , Administração Tópica , Adolescente , Biópsia por Agulha , Feminino , Seguimentos , Dermatoses da Mão/congênito , Dermatoses da Mão/tratamento farmacológico , Dermatoses da Mão/patologia , Humanos , Imuno-Histoquímica , Ácido Láctico/uso terapêutico , Poroceratose/tratamento farmacológico , Medição de Risco , Índice de Gravidade de Doença , Resultado do TratamentoAssuntos
Gastrosquise/patologia , Dermatoses da Mão/patologia , Anormalidades da Pele/patologia , Anormalidades Múltiplas/genética , Anormalidades Múltiplas/patologia , Diagnóstico Diferencial , Epidermólise Bolhosa/patologia , Evolução Fatal , Dermatoses da Mão/congênito , Humanos , Recém-Nascido , Masculino , Microscopia Eletrônica , Pele/patologia , Pele/ultraestruturaAssuntos
Mucosa/anormalidades , Anormalidades da Pele , Dermatopatias/congênito , Acne Vulgar/congênito , Acne Vulgar/diagnóstico , Adulto , Fatores Etários , Diagnóstico Diferencial , Cisto Epidérmico/congênito , Cisto Epidérmico/diagnóstico , Feminino , Seguimentos , Dermatoses do Pé/congênito , Dermatoses do Pé/diagnóstico , Dermatoses da Mão/congênito , Dermatoses da Mão/diagnóstico , Hemangioma/congênito , Hemangioma/diagnóstico , Humanos , Recém-Nascido , Leucoedema Bucal/congênito , Leucoedema Bucal/diagnóstico , Masculino , Cistos Odontogênicos/congênito , Cistos Odontogênicos/diagnóstico , Transtornos da Pigmentação/congênito , Transtornos da Pigmentação/diagnóstico , Anormalidades da Pele/diagnóstico , Dermatopatias/diagnóstico , Dermatopatias Vasculares/congênito , Dermatopatias Vasculares/diagnóstico , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/diagnóstico , Hidrocele Testicular/congênito , Hidrocele Testicular/diagnóstico , Fatores de TempoRESUMO
Neonatal sucking blisters appears as unilateral or bilaterally symmetrical bullae or erosions involving the distal upper extremities at birth. They represent minor self-inflicted trauma, presumably the result of a vigorous intrauterine sucking reflex. Recognizing this benign self-limited condition avoids unnecessary tests and alleviates anxiety on the part of the infant's family and physicians.
Assuntos
Vesícula/etiologia , Dermatoses da Mão/etiologia , Comportamento de Sucção , Vesícula/congênito , Feminino , Dermatoses da Mão/congênito , Humanos , Recém-NascidoRESUMO
Cutaneous ossifications or osteoma cutis can be found in many syndromes. Primary osteoma cutis, present since birth or the first months of life, in the absence of metabolic disorders or trauma, is found in congenital plate-like osteoma cutis and progressive osseous heteroplasia, coexisting in the latter with deep connective tissue ossifications. This report documents the case of a 7-year-old female with a plate-like cutaneous ossification of the forehead causing aesthetic deformities. Other dermal ossifications in the inguinal and preauricular region, as well as the left hand and a small focus in the extraocular muscles of the left orbit, were also present. These lesions did not show progression, and most of them were present since birth. The lesion of forehead was treated surgically. The lack of progression and the fact that the orbital lesion was solitary still fits the criteria for the diagnosis of plate-like osteoma cutis. Plate-like osteoma cutis and progressive osseous heteroplasia may represent varieties of the same disorder.
Assuntos
Dermatoses Faciais/congênito , Testa/patologia , Ossificação Heterotópica/congênito , Criança , Doenças do Tecido Conjuntivo/congênito , Otopatias/congênito , Orelha Externa/patologia , Estética , Feminino , Virilha , Dermatoses da Mão/congênito , Humanos , Doenças Musculares/congênito , Músculos Oculomotores/patologia , Dermatopatias/congênitoRESUMO
We report on a patient with multicentric juvenile xanthogranuloma, whose unusual clinical and histological pattern initially obscured the diagnosis. Spontaneous remission of the tumour, which has now been maintained for over 2 years, the change from the primary monomorphological fibrocytic appearance to a polymorphological histiocytic picture with multiple fat-storing giant cells, and the lacking dermonstration of specific cell organelles finally allowed the nature of the disease to the definitely diagnosed.
Assuntos
Dermatoses da Mão/congênito , Úlcera Cutânea/congênito , Xantogranuloma Juvenil/congênito , Xantogranuloma Juvenil/diagnóstico , Diagnóstico Diferencial , Imunofluorescência , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/patologia , Histiócitos/patologia , Humanos , Lactente , Recém-Nascido , Masculino , Microscopia Eletrônica , Pele/patologia , Úlcera Cutânea/diagnóstico , Úlcera Cutânea/patologia , Polegar/patologia , Xantogranuloma Juvenil/patologiaRESUMO
We observed a newborn infant of a previously reported kindred with absent dermal ridge pattern, syndactyly, and facial milia. The infant's features were consistent with three other kindreds, suggesting that this entity is a single disorder with variable expression. Furthermore, this entity should be considered in the differential diagnosis of excessive congenital facial milia and erosions.
Assuntos
Cisto Epidérmico/congênito , Cisto Epidérmico/genética , Dermatoses Faciais/congênito , Dermatoses Faciais/genética , Anormalidades da Pele , Sindactilia/genética , Adulto , Feminino , Dermatoses do Pé/congênito , Dermatoses do Pé/genética , Dermatoses da Mão/congênito , Dermatoses da Mão/genética , Humanos , Recém-Nascido , Masculino , Doenças da Unha/congênito , Doenças da Unha/genética , LinhagemRESUMO
Two patients with a rare form of congenital varicella involving the upper limb are described. The spectrum of disease, pathophysiology, principles of management and prevention are discussed.