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1.
Vet Med Sci ; 9(4): 1483-1487, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37224266

RESUMO

A 3-year-old, 3.5 kg, female spayed Pomeranian was referred due to persistent vomiting, anorexia, polyuria and polydipsia, 7 days after receiving general anaesthetic for a medial patellar luxation correction. Physical examination revealed lethargy, tachypnoea and 7% dehydration. Complete blood count and serum chemistry results were unremarkable, and venous blood gas analysis revealed hypokalaemia and hyperchloraemic metabolic acidosis with a normal anion gap. Urinalysis revealed a urine specific gravity (USG) of 1.005, pH of 7.0 and proteinuria, and the bacterial culture was negative. Based on these results, the dog was diagnosed with distal renal tubular acidosis, and potassium citrate was prescribed to correct metabolic acidosis. In addition, concurrent diabetes insipidus (DI) was suspected because the dog showed persistent polyuria, polydipsia and a USG below 1.006 despite dehydration. After 3 days of initial treatment, acidosis was corrected, and vomiting resolved. Desmopressin acetate and hydrochlorothiazide were also prescribed for DI, but the USG was not normalized. Based on the insignificant therapeutic response, nephrogenic DI was highly suspected. DI was resolved after 24 days. This case report describes the concomitant presence of RTA and DI in a dog after general anaesthesia.


Assuntos
Acidose Tubular Renal , Acidose , Diabetes Insípido Nefrogênico , Diabetes Mellitus , Doenças do Cão , Cães , Feminino , Animais , Acidose Tubular Renal/diagnóstico , Acidose Tubular Renal/etiologia , Acidose Tubular Renal/veterinária , Diabetes Insípido Nefrogênico/diagnóstico , Diabetes Insípido Nefrogênico/veterinária , Diabetes Insípido Nefrogênico/complicações , Poliúria/complicações , Poliúria/veterinária , Desidratação/complicações , Desidratação/veterinária , Acidose/complicações , Acidose/veterinária , Polidipsia/complicações , Polidipsia/veterinária , Anestesia Geral/efeitos adversos , Anestesia Geral/veterinária , Vômito/veterinária , Diabetes Mellitus/veterinária , Doenças do Cão/diagnóstico , Doenças do Cão/tratamento farmacológico , Doenças do Cão/etiologia
2.
N Z Vet J ; 60(4): 254-7, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22712777

RESUMO

CASE HISTORY: A 14-year-old Cleveland Bay cross gelding was presented with severe urinary incontinence that had been present for 1 year, and chronic polydipsia and polyuria over 4 years. Water intake had been recorded as 240 L over a 24-hour period. CLINICAL FINDINGS: The horse had marked urinary incontinence and polyuria and polydipsia. The urine was markedly hyposthenuric, but no abnormalities on urinalysis were detected. There were no other abnormal clinical or neurological signs. Haematological and serum biochemical examinations showed no abnormalities and ultrasonographic and endoscopic examination of the urinary tract did not reveal any abnormalities. The horse underwent a modified water deprivation test and failed to concentrate its urine after 5 days. 1-desamino-8-d-arginine vasopressin (DDAVP) was administered I/V but the urine remained isosthenuric with a specific gravity of 1.010. DIAGNOSIS: Nephrogenic diabetes insipidus. A definitive cause of the urinary incontinence was not found but overflow incontinence was considered a possibility. CLINICAL RELEVANCE: Despite being a rare condition in the horse diabetes insipidus should be considered in cases of severe polydipsia and polyuria in mature horses.


Assuntos
Diabetes Insípido Nefrogênico/veterinária , Doenças dos Cavalos/patologia , Animais , Diabetes Insípido Nefrogênico/patologia , Doenças dos Cavalos/diagnóstico , Cavalos , Masculino
3.
Vet Clin North Am Equine Pract ; 27(1): 175-95, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21392661

RESUMO

Diabetes insipidus (DI) is a rare disorder of horses characterized by profound polyuria and polydipsia (PU/PD), which can be caused by loss of production of arginine vasopressin (AVP). This condition is termed neurogenic or central DI. DI may also develop with absence or loss of AVP receptors or activity on the basolateral membrane of collecting-duct epithelial cells. This condition is termed nephrogenic DI. Equine clinicians may differentiate true DI from more common causes of PU/PD by a systematic diagnostic approach. DI may not be a correctable disorder, and supportive care of affected horses requires an adequate water source.


Assuntos
Diabetes Insípido Nefrogênico/veterinária , Diabetes Insípido/veterinária , Doenças dos Cavalos/metabolismo , Desequilíbrio Hidroeletrolítico/veterinária , Animais , Diabetes Insípido/diagnóstico , Diabetes Insípido/metabolismo , Diabetes Insípido Nefrogênico/diagnóstico , Diabetes Insípido Nefrogênico/metabolismo , Feminino , Homeostase , Doenças dos Cavalos/diagnóstico , Cavalos , Masculino , Vasopressinas/metabolismo , Água/metabolismo , Desequilíbrio Hidroeletrolítico/diagnóstico , Desequilíbrio Hidroeletrolítico/metabolismo
6.
J Vet Intern Med ; 16(5): 510-7, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12322698

RESUMO

Nephrogenic diabetes insipidus is caused by an inability of the kidney to concentrate urine despite adequate concentration of vasopressin in blood and is characterized by polyuria, polydipsia, and hyposthenuria in the presence of plasma hyperosmolality. Nephrogenic diabetes insipidus is the result of defects in water homeostasis in the kidney. Nephrogenic diabetes insipidus occurs when the kidneys cannot or do not respond to vasopressin. There are 2 categories of nephrogenic diabetes insipidus. Congenital nephrogenic diabetes insipidus is a rare, inherited, irreversible cause of polyuria and polydipsia in humans that is even rarer in animals. Acquired nephrogenic diabetes insipidus is more common and is often secondary to illness or medication that interferes with the action of vasopressin in the renal tubules. Unlike congenital nephrogenic diabetes insipidus, acquired or secondary nephrogenic diabetes insipidus is often reversible with correction of the associated or causative problem.


Assuntos
Diabetes Insípido Nefrogênico/metabolismo , Diabetes Insípido Nefrogênico/veterinária , Rim/metabolismo , Água/metabolismo , Animais , Diabetes Insípido Nefrogênico/tratamento farmacológico , Diabetes Insípido Nefrogênico/etiologia , Humanos , Rim/fisiopatologia , Vasopressinas/metabolismo , Desequilíbrio Hidroeletrolítico
7.
J Am Vet Med Assoc ; 215(12): 1818-20, 1806, 1999 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-10613214

RESUMO

Nephrogenic diabetes insipidus was diagnosed in a dog with an intestinal leiomyosarcoma. The diagnosis of nephrogenic diabetes insipidus was made on the basis of results of serum biochemical tests, urinalyses, and a water-deprivation test, along with a lack of response to exogenous administration of vasopressin following the water-deprivation test. The temporal association between resection of the intestinal mass and resolution of clinical signs of diabetes insipidus (i.e., polyuria and polydipsia) and between recurrence of clinical signs and detection of metastatic disease suggests that there may have been a causal relationship, and nephrogenic diabetes insipidus may have developed as a paraneoplastic syndrome in this dog.


Assuntos
Diabetes Insípido Nefrogênico/veterinária , Doenças do Cão/etiologia , Neoplasias Intestinais/veterinária , Leiomiossarcoma/veterinária , Síndromes Paraneoplásicas/veterinária , Animais , Antineoplásicos/uso terapêutico , Desamino Arginina Vasopressina/uso terapêutico , Diabetes Insípido Nefrogênico/etiologia , Diabetes Insípido Nefrogênico/terapia , Doenças do Cão/cirurgia , Doenças do Cão/terapia , Cães , Doxorrubicina/uso terapêutico , Evolução Fatal , Neoplasias Intestinais/complicações , Neoplasias Intestinais/cirurgia , Leiomiossarcoma/complicações , Leiomiossarcoma/cirurgia , Masculino , Recidiva Local de Neoplasia/veterinária , Síndromes Paraneoplásicas/etiologia , Síndromes Paraneoplásicas/terapia , Radiografia Abdominal/veterinária , Fármacos Renais/uso terapêutico , Gravidade Específica/efeitos dos fármacos , Ultrassonografia/veterinária
8.
J Small Anim Pract ; 39(12): 592-4, 1998 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-9888114

RESUMO

A two-year-old intact male shiba inu dog with excessive polyuria and polydipsia (PU-PD) was diagnosed as having congenital nephrogenic diabetes insipidus based on clinical findings, the results of urinalysis, blood examinations, a modified water deprivation test and a low dose dexamethasone suppression test. The owner was advised to provide adequate access to drinking water, and treatment with a low dose of hydrochlorothiazide (2 mg/kg, twice daily) together with a low sodium diet was initiated. As a result, the daily water intake decreased significantly from 6500 to 7500 ml/day (800 to 980 ml/kg/day) to 1400 to 1900 ml/day (170 to 230 ml/kg/day) and the clinical signs associated with the PU-PD and dehydration improved over the following two years.


Assuntos
Diabetes Insípido Nefrogênico/veterinária , Doenças do Cão/tratamento farmacológico , Hidroclorotiazida/uso terapêutico , Inibidores de Simportadores de Cloreto de Sódio/uso terapêutico , Animais , Diabetes Insípido Nefrogênico/tratamento farmacológico , Diuréticos , Cães , Ingestão de Líquidos , Masculino , Sódio na Dieta
9.
J Vet Intern Med ; 9(5): 361-5, 1995.
Artigo em Inglês | MEDLINE | ID: mdl-8531185

RESUMO

Central diabetes insipidus was diagnosed by vasopressin measurements during hypertonic stimulation in a 9-year-old male giant Schnauzer with polyuria and polydipsia. The impaired release of vasopressin was believed to be caused by a large pituitary tumor, which was visualized by computed tomography. Studies of the function of the anterior lobe and the pars intermedia of the pituitary gland were conducted, and high concentrations of ACTH and alpha-melanotrophic hormone (alpha-MSH) were found without concomitant hyperadrenocorticism. Studies of the molecular size of the immunoreactive ACTH in plasma by gel filtration revealed that most of the circulating immunoreactivity was not ACTH but its precursor pro-opiomelanocortin (POMC) and low-molecular-weight POMC-derived peptides. The pituitary tumor of this dog probably originated from melanotrophic cells of the pars intermedia. The sensitivity of the pituitary-adrenocortical system for the suppressive effect of dexamethasone was unaffected.


Assuntos
Diabetes Insípido Nefrogênico/veterinária , Doenças do Cão/etiologia , Neoplasias Hipofisárias/veterinária , Pró-Opiomelanocortina/metabolismo , Hiperfunção Adrenocortical/veterinária , Animais , Diabetes Insípido Nefrogênico/etiologia , Doenças do Cão/metabolismo , Cães , Masculino , Neoplasias Hipofisárias/complicações , Neoplasias Hipofisárias/diagnóstico por imagem , Neoplasias Hipofisárias/metabolismo , Radiografia
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