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1.
Forensic Sci Int ; 304: 109969, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31593907

RESUMO

The new psychoactive substances (NPS) in Colombia are detected by national authorities, in blotters strip, in different circumstances and places: airports, music concerts, discos and parks. Blotters are marketed as LSD and cause several cases of intoxication and death in some consumers: due to acute intoxication or when mixed with other drugs and may have different effects on the central nervous system (CNS). This study was conducted to research into and identify the chemical composition of the drugs impregnated in the blotters sold in two Colombian cities. This research provides the analysis of 70 doses coming from forensic cases of the Colombian Attorney General's Office in Bogota and from the Laboratory of Narcotics of the Colombian National Institute of Legal Medicine and Forensic Sciences (North Headquarter) in Barranquilla. Mixtures of drugs, such as DOB, 25I-NBOMe, MDMA and 25I-NBOMe imine were found within the blotters through gas chromatography coupled to mass spectrometry (CGMS); these drugs are classified by international authorities as NPS belonging to the phenylethylamines group. The results clearly warn about a growing public health problem in the country.


Assuntos
2,5-Dimetoxi-4-Metilanfetamina/análogos & derivados , Dimetoxifeniletilamina/análogos & derivados , Tráfico de Drogas , Drogas Ilícitas/isolamento & purificação , N-Metil-3,4-Metilenodioxianfetamina/isolamento & purificação , 2,5-Dimetoxi-4-Metilanfetamina/isolamento & purificação , Administração Sublingual , Colômbia , Drogas Desenhadas/isolamento & purificação , Dimetoxifeniletilamina/isolamento & purificação , Contaminação de Medicamentos , Humanos , Papel , Transtornos Relacionados ao Uso de Substâncias
2.
J Mass Spectrom ; 41(7): 872-86, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16810648

RESUMO

Studies are described on the metabolism and the toxicological analysis of the phenethylamine-derived designer drug 4-iodo-2,5-dimethoxy-beta-phenethylamine (2C-I) in rat urine using gas chromatographic/mass spectrometric (GC/MS) techniques, and for a particular question, using capillary electrophoretic/mass spectrometric (CE/MS) techniques. The identified metabolites indicated that 2C-I was metabolized on the one hand by O-demethylation in position 2 and 5, respectively, followed either by N-acetylation or by deamination with subsequent oxidation to the corresponding acid or reduction to the corresponding alcohol, respectively. The latter metabolite was hydroxylated in beta-position and further oxidized to the corresponding oxo metabolite. On the other hand, 2C-I was metabolized by deamination with subsequent oxidation to the corresponding acid or reduction to the corresponding alcohol, respectively. 2C-I and most of its metabolites were partially excreted in conjugated form. The authors' systematic toxicological analysis (STA) procedure using full-scan GC/MS after acid hydrolysis, liquid-liquid extraction and microwave-assisted acetylation allowed the detection of an intake of a dose of 2C-I in rat urine that corresponds to a common drug users' dose. Assuming similar metabolism, the described STA procedure should be suitable for proof of an intake of 2C-I in human urine.


Assuntos
Drogas Desenhadas/metabolismo , Dimetoxifeniletilamina/análogos & derivados , Animais , Ação Capilar , Drogas Desenhadas/isolamento & purificação , Dimetoxifeniletilamina/isolamento & purificação , Dimetoxifeniletilamina/urina , Eletroforese/métodos , Cromatografia Gasosa-Espectrometria de Massas/métodos , Masculino , Espectrometria de Massas/métodos , Ratos , Ratos Wistar
3.
J Pharm Sci ; 69(1): 94-5, 1980 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-7354455

RESUMO

Backebergia militaris (Andot) Bravo ex Sánchez Mejorada yielded alkaloid crystals from a fractionated ethanol extract of only 20 g of plant material. The alkaloid was identified as heliamine (6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline) hydrochloride. A second alkaloid, 3,4-dimethoxy-beta-phenethylamine hydrochloride, was crystallized after preparative TLC of the mother liquors. Both compounds were isolated previously from other cactus species.


Assuntos
Alcaloides/isolamento & purificação , Dimetoxifeniletilamina/isolamento & purificação , Isoquinolinas/isolamento & purificação , Fenetilaminas/isolamento & purificação , Extratos Vegetais/análise , Tetra-Hidroisoquinolinas
4.
J Pharm Sci ; 68(1): 85-7, 1979 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-758472

RESUMO

The biosynthetic conversion of epinephrine to normacromerine in Coryphantha macromeris (Engelm.) Br. and R. var. runyonii (Br. and R.) L. Benson (Cactacae) has been studied. Metanephrine, which has been isolated from this cactus and is a normal metabolite of epinephrine in mammalian systems, appeared to be the likely intermediate between epinephrine and normacromerine. Normacromerine turnover studies suggested a 16-day interval between metanephrine administration and harvest of the cacti. During this incubation period, the cacti specifically converted 4.77% of the administered DL-7-3H-metanephrine to normacromerine. Based on biochemical precedents, the postulated metabolic fate of normacromerine in the cactus was an enzymatic N-methylation to give macromerine. However, radiolabeled normacromerine was a very ineffecient precursor to macromerine.


Assuntos
Alcaloides/biossíntese , Dimetoxifeniletilamina/biossíntese , Alucinógenos/metabolismo , Fenetilaminas/biossíntese , Plantas/metabolismo , Alcaloides/isolamento & purificação , Dimetoxifeniletilamina/análogos & derivados , Dimetoxifeniletilamina/isolamento & purificação , Alucinógenos/isolamento & purificação , Metanefrina/metabolismo , Metilação , Fatores de Tempo
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