Assuntos
Botulismo/complicações , Botulismo/diagnóstico , Dependência de Heroína/complicações , Oftalmoplegia/etiologia , Distúrbios da Fala/etiologia , Abuso de Substâncias por Via Intravenosa/complicações , Adulto , Dependência de Heroína/microbiologia , Humanos , Intubação Intratraqueal , Masculino , Exame Neurológico , Oftalmoplegia/microbiologia , Distúrbios da Fala/microbiologia , Abuso de Substâncias por Via Intravenosa/microbiologia , Ferimentos e Lesões/microbiologiaAssuntos
Encéfalo/patologia , Encéfalo/fisiopatologia , Cardiolipinas/metabolismo , Colesterol/metabolismo , Demência/líquido cefalorraquidiano , Demência/microbiologia , Neurossífilis/líquido cefalorraquidiano , Fosfatidilcolinas/metabolismo , Adulto , Atrofia/líquido cefalorraquidiano , Atrofia/diagnóstico , Atrofia/microbiologia , Encéfalo/microbiologia , Cardiolipinas/análise , Colesterol/análise , Demência/diagnóstico , Progressão da Doença , Reações Falso-Negativas , Alucinações/líquido cefalorraquidiano , Alucinações/microbiologia , Humanos , Injeções Intravenosas , Imageamento por Ressonância Magnética , Masculino , Transtornos da Memória/líquido cefalorraquidiano , Transtornos da Memória/microbiologia , Transtornos das Habilidades Motoras/líquido cefalorraquidiano , Transtornos das Habilidades Motoras/microbiologia , Transtornos Neurocognitivos/líquido cefalorraquidiano , Transtornos Neurocognitivos/diagnóstico , Transtornos Neurocognitivos/microbiologia , Neurossífilis/diagnóstico , Penicilinas/administração & dosagem , Transtornos da Personalidade/líquido cefalorraquidiano , Transtornos da Personalidade/diagnóstico , Transtornos da Personalidade/microbiologia , Fosfatidilcolinas/análise , Distúrbios da Fala/líquido cefalorraquidiano , Distúrbios da Fala/microbiologia , Lobo Temporal/microbiologia , Lobo Temporal/patologia , Lobo Temporal/fisiopatologia , Resultado do Tratamento , Treponema pallidum/fisiologiaRESUMO
OBJECTIVE: The purpose of this study was to analyze the relationship between oral bacterial colonization and oral motor dysfunction. STUDY DESIGN: Oral motor dysfunction (swallowing and speech disorders) and detection of oral bacterial species from dental plaque in 55 elderly persons who had remained hospitalized for more than 3 months were investigated and statistically analyzed. RESULTS: The detection rates of methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Streptococcus agalactiae, and Stenotrophomonas maltophilia were significantly higher in subjects with than in those without a swallowing disorder. A similar result was found with regard to the presence of a speech disorder. About half of subjects who had oral motor dysfunction and hypoalbuminemia had colonization by MRSA and/or Pseudomonas aeruginosa. CONCLUSION: These results suggest that the combination of oral motor dysfunction and hypoalbminemia elevated the risk of opportunistic microorganisms colonization in the oral cavity of elderly patients hospitalized over the long term.
Assuntos
Bactérias/classificação , Transtornos de Deglutição/microbiologia , Imobilização , Doenças da Boca/microbiologia , Distúrbios da Fala/microbiologia , Idoso , Idoso de 80 Anos ou mais , Transtornos de Deglutição/sangue , Placa Dentária/microbiologia , Feminino , Infecções por Bactérias Gram-Negativas/diagnóstico , Hospitalização , Humanos , Hipoalbuminemia/microbiologia , Masculino , Resistência a Meticilina , Pessoa de Meia-Idade , Infecções Oportunistas/diagnóstico , Infecções por Pseudomonas/diagnóstico , Pseudomonas aeruginosa/isolamento & purificação , Distúrbios da Fala/sangue , Infecções Estafilocócicas/diagnóstico , Staphylococcus aureus/isolamento & purificação , Stenotrophomonas maltophilia/isolamento & purificação , Infecções Estreptocócicas/diagnóstico , Streptococcus agalactiae/isolamento & purificaçãoRESUMO
OBJECTIVE: To describe important sequelae occurring among a cohort of children aged 5 years who had had meningitis during the first year of life and who had been identified by a prospective national study of meningitis in infancy in England and Wales between 1985 and 1987. DESIGN: Follow up questionnaires asking about the children's health and development were sent to general practitioners and parents of the children and to parents of matched controls. The organism that caused the infection and age at infection were also recorded. SETTING: England and Wales. PARTICIPANTS: General practitioners and parents of children who had had meningitis before the age of 1 year and of matched controls. MAIN OUTCOME MEASURES: The prevalence of health and developmental problems and overall disability among children who had had meningitis compared with controls. RESULTS: Altogether, 1584 of 1717 (92.2%) children who had had meningitis and 1391 of 1485 (93.6%) controls were successfully followed up. Among children who survived to age 5 years 247 of 1584 (15.6%) had a disability; there was a 10-fold increase in the risk of severe or moderate disability at 5 years of age among children who had had meningitis (relative risk 10.3, 95% confidence interval 6.7 to 16.0, P<0.001). There was considerable variation in the rates of severe or moderate disability in children infected with different organisms. CONCLUSION: The long term consequences of having meningitis during the first year of life are significant: 32 of 1717 (1.8%) children died within five years. Not only did almost a fifth of children with meningitis have a permanent, severe or moderately severe disability, but subtle deficits were also more prevalent.
