RESUMO
Transient hyperphosphatasemia was found in a 3-year-old male liver transplant recipient. The condition was associated with diarrheal disease due to the Epstein-Barr virus (EBV). Immunosuppression was tapered and valganciclovir prescribed for 3 months, after which the diarrhea resolved and the EBV polymerase chain reaction assays became negative. After 6 months, alkaline phosphatase levels normalized. Isolated elevation of alkaline phosphatase in conjunction with enteric infection is a rare condition. No further diagnostic or therapeutic interventions except treatment of the underlying infection are needed, as this has been shown to be a benign, transient condition.
Assuntos
Colestase/cirurgia , Enterite/virologia , Infecções por Vírus Epstein-Barr/complicações , Transplante de Fígado , Monoéster Fosfórico Hidrolases/metabolismo , Distúrbios do Metabolismo do Fósforo/diagnóstico , Complicações Pós-Operatórias/diagnóstico , Adulto , Pré-Escolar , Família , Humanos , Imunossupressores/uso terapêutico , Transplante de Fígado/imunologia , Doadores Vivos , Masculino , Distúrbios do Metabolismo do Fósforo/enzimologia , Distúrbios do Metabolismo do Fósforo/etiologia , Tacrolimo/uso terapêutico , Resultado do TratamentoRESUMO
Six children, aged 11 to 25 months, were found to have elevated serum alkaline phosphatase (ALP) levels (1,077 to 9,271 U/L) in the absence of disease. Benign transient hyperphosphatasemia (BTH) was diagnosed when the serum ALP levels returned to normal or decreased significantly within 3 months. Several theories have been suggested regarding the pathophysiology of BTH, but the exact cause is still unclear. We report six cases of BTH and review the literature. It is important to recognize this condition and to avoid extensive and unnecessary evaluation.
Assuntos
Fosfatase Alcalina/sangue , Distúrbios do Metabolismo do Fósforo/sangue , Adolescente , Adulto , Idade de Início , Criança , Feminino , Humanos , Masculino , Distúrbios do Metabolismo do Fósforo/diagnóstico , Distúrbios do Metabolismo do Fósforo/enzimologiaRESUMO
A seven-month-old boy with a diagnosis of vitamin-D deficiency rickets is presented. After treatment with vitamin-D, biochemical and radiological improvement was noted. At 14-months of age the plasma akaline phosphatase activity valve was found to be elevated even though rickets was not present. A diagnosis of hyperphosphatasemia was established. Although rare in infancy, transient hyperphospha tasemia may occur following vitamin-D deficient rickets. This possibility should be considered when evaluating laboratory results in such cases.
