Assuntos
Doenças dos Nervos Cranianos/diagnóstico , Infecções Oculares Virais/diagnóstico , Herpes Zoster Oftálmico/diagnóstico , Transtornos da Motilidade Ocular/diagnóstico , Doenças Orbitárias/diagnóstico , Doenças do Nervo Abducente/diagnóstico , Doenças do Nervo Abducente/tratamento farmacológico , Doenças do Nervo Abducente/virologia , Aciclovir/uso terapêutico , Idoso , Antivirais/uso terapêutico , Doenças dos Nervos Cranianos/tratamento farmacológico , Doenças dos Nervos Cranianos/virologia , Epitélio Corneano/patologia , Infecções Oculares Virais/tratamento farmacológico , Infecções Oculares Virais/virologia , Feminino , Glucocorticoides/uso terapêutico , Herpes Zoster Oftálmico/tratamento farmacológico , Herpes Zoster Oftálmico/virologia , Humanos , Masculino , Transtornos da Motilidade Ocular/tratamento farmacológico , Transtornos da Motilidade Ocular/virologia , Doenças do Nervo Oculomotor/diagnóstico , Doenças do Nervo Oculomotor/tratamento farmacológico , Doenças do Nervo Oculomotor/virologia , Doenças do Nervo Óptico/diagnóstico , Doenças do Nervo Óptico/tratamento farmacológico , Doenças do Nervo Óptico/virologia , Doenças Orbitárias/tratamento farmacológico , Doenças Orbitárias/virologia , Prednisolona/uso terapêutico , Doenças do Nervo Trigêmeo/diagnóstico , Doenças do Nervo Trigêmeo/tratamento farmacológico , Doenças do Nervo Trigêmeo/virologia , Doenças do Nervo Troclear/diagnóstico , Doenças do Nervo Troclear/tratamento farmacológico , Doenças do Nervo Troclear/virologiaRESUMO
PURPOSE: To describe and compare the clinical presentation, treatment outcomes, and histopathologic features of ocular surface squamous neoplasia (OSSN) based on human immunodeficiency virus (HIV) status. DESIGN: Case-control study. PARTICIPANTS: A total of 200 patients with OSSN, of whom 83 (41%) had positive results for HIV and were classified as cases and 117 (59%) had negative results for HIV and were classified as controls. METHODS: Enzyme-linked immunosorbent assay for HIV, conjuntival excision biopsy, extended enucleation, orbital exenteration. MAIN OUTCOME MEASURES: Clinical features, treatment outcomes, and histopathologic characteristics. RESULTS: The mean age at presentation of OSSN in both cases and controls was 40 years (median, 40 years; range, 13-65 years) and in controls was 40 years (median, 38 years; range, 15-80 years). On comparison of cases versus controls with OSSN, HIV-positive individuals had larger (12 vs. 8 mm; P < 0.001) and thicker (3.2 vs. 2.3 mm; P = 0.041) tumors, with a higher incidence of corneal (60% vs. 40%; P = 0.007), scleral (19% vs. 9%; P = 0.044), and orbital (13% vs. 3%; P = 0.019) invasion and a higher need for extended enucleation or exenteration (27% vs. 11%; P < 0.001). The bilateral presentation (11% vs. 4%; P = 0.13), need for lamellar sclerectomy (13% vs. 8%; P = 0.29), and tumor recurrence after primary treatment (30% vs. 20%; P = 0.12) was higher in HIV-positive cases compared with HIV-negative controls. However, these features were not statistically significant. Based on American Joint Committee on Cancer classification, T1 tumor was more common in controls (13% in cases vs. 35% in controls; P = 0.0009), and T4 tumor was more common in cases (13% in cases vs. 4% in controls; P = 0.019). None of the patients demonstrated systemic metastases or died of disease during a mean follow-up period of 10 months (median, 4 months; range, <1-75 months) in cases and 9 months (median, 4 months; range, <1-99 months) in controls. CONCLUSIONS: Ocular surface squamous neoplasia in HIV-positive individuals is aggressive with larger and thicker tumors and with higher incidence of corneal, scleral, and orbital invasion. These patients are associated with poor ocular prognosis with higher need for extended enucleation, exenteration, or both.
Assuntos
Carcinoma in Situ/patologia , Neoplasias da Túnica Conjuntiva/patologia , Infecções Oculares Virais/imunologia , Infecções por HIV/imunologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma in Situ/terapia , Carcinoma in Situ/virologia , Estudos de Casos e Controles , Neoplasias da Túnica Conjuntiva/terapia , Neoplasias da Túnica Conjuntiva/virologia , Doenças da Córnea/patologia , Doenças da Córnea/terapia , Doenças da Córnea/virologia , Ensaio de Imunoadsorção Enzimática , Enucleação Ocular , Infecções Oculares Virais/terapia , Feminino , Infecções por HIV/terapia , Humanos , Imunocompetência , Terapia de Imunossupressão , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Exenteração Orbitária , Doenças Orbitárias/patologia , Doenças Orbitárias/terapia , Doenças Orbitárias/virologia , Estudos Retrospectivos , Doenças da Esclera/patologia , Doenças da Esclera/terapia , Doenças da Esclera/virologia , Tomografia de Coerência Óptica , Resultado do TratamentoRESUMO
Dengue, one of the most common mosquito-borne flavivirus diseases affecting humans, is spread by the Aedes aegypti mosquito. Most people infected with dengue virus are asymptomatic or only have mild symptoms such as an uncomplicated fever; few have more severe features, while in a small proportion it is life-threatening. Severe dengue is defined as that associated with severe bleeding, severe organ dysfunction, or severe plasma leakage. Ophthalmic manifestations can involve both the anterior and posterior segment. We report an ocular emergency of proptosis and globe rupture in a patient with severe dengue.
Assuntos
Exoftalmia/virologia , Infecções Oculares Virais/virologia , Doenças Orbitárias/virologia , Dengue Grave/virologia , Bandagens , Vírus da Dengue/isolamento & purificação , Emergências , Tratamento de Emergência , Exoftalmia/diagnóstico , Exoftalmia/terapia , Infecções Oculares Virais/diagnóstico , Infecções Oculares Virais/terapia , Humanos , Masculino , Doenças Orbitárias/diagnóstico , Doenças Orbitárias/terapia , Ruptura Espontânea , Dengue Grave/diagnóstico , Dengue Grave/terapia , Adulto JovemRESUMO
A 34-year-old patient presented with giant, transient urticarial skin lesions and periorbital edema after a 3-month stay in DR Congo. Retrospective analysis of stored samples revealed that these signs were prodromal manifestations of acute hepatitis B infection. The hepatitis B infection was spontaneously cleared; the skin lesion did not recur.
Assuntos
Edema/virologia , Hepatite B/complicações , Doenças Orbitárias/virologia , Urticária/virologia , Adulto , República Democrática do Congo , Hepatite B/sangue , Vírus da Hepatite B/genética , Vírus da Hepatite B/isolamento & purificação , Humanos , Testes de Função Hepática , Masculino , Países Baixos , Reação em Cadeia da Polimerase , ViagemRESUMO
INTRODUCTION: Infectious mononucleosis may lead to numerous complications. Tonsillar hyperplasia with risk of airway obstruction is well known. Dacryocystitis is a rare but potentially severe complication. OBSERVATION: A 6-year-old child with primary mononucleosis infectious diagnosed 8 days before, developed acute dacryocystitis, with rapid evolution to orbital cellulitis, despite adequate antibiotherapy. Emergency surgical drainage was required. DISCUSSION: Dacryocystitis is a rare and little documented complication of EBV infection. Its acute evolution to orbital cellulitis is possible and potentially severe. Its physiopathology is specific. Patients are initially free of chronic stenosis and epiphora, which express acute obstruction of the lachrymal sac due to general lymphoid hyperplasia.
Assuntos
Dacriocistite/virologia , Mononucleose Infecciosa/complicações , Doença Aguda , Celulite (Flegmão)/virologia , Criança , Drenagem , Humanos , Obstrução dos Ductos Lacrimais/virologia , Masculino , Doenças Orbitárias/virologiaRESUMO
The orbital apex syndrome is defined by the association of visual loss, ophtalmoplegia, blepharoptosis, proptosis along with forehead and upper eyelid anesthesia. This syndrome is secondary to traumatism, malignancy or infection of orbital apex. Herpes zoster is an uncommon cause. We discuss the physiopathologic mechanism, evolution and management of this affection.
Assuntos
Herpes Zoster/diagnóstico , Doenças Orbitárias/virologia , Aciclovir/uso terapêutico , Idoso , Antivirais/uso terapêutico , Feminino , Herpes Zoster/tratamento farmacológico , Herpes Zoster/virologia , Humanos , Doenças Orbitárias/tratamento farmacológico , SíndromeRESUMO
Chronic active Epstein-Barr virus (CAEBV) infection is characterized by a status of lymphoproliferative disease of EBV-infected cells, resulting in chronic or recurrent infectious mononucleosis-like symptoms. CAEBV is always accompanied by life-threatening complications. We report the case of a 2-year-old female patient with CAEBV who subsequently developed Langerhans cell histiocytosis (LCH) presenting with bilateral exophthalmos, bone, and skin involvement. In situ hybridization for EBER revealed EBV-infected B-cells present in lesional tissue implying that interactions between EBV-infected B-cells and lesional Langerhans cells may be associated with the development of LCH.
Assuntos
Infecções por Vírus Epstein-Barr/complicações , Histiocitose de Células de Langerhans/virologia , Anti-Inflamatórios/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Linfócitos B/virologia , Pré-Escolar , Doença Crônica , Ciclosporina/uso terapêutico , Infecções por Vírus Epstein-Barr/tratamento farmacológico , Infecções por Vírus Epstein-Barr/imunologia , Feminino , Humanos , Imunossupressores/uso terapêutico , Hibridização In Situ , Lactente , Doenças Orbitárias/tratamento farmacológico , Doenças Orbitárias/patologia , Doenças Orbitárias/virologia , Reação em Cadeia da Polimerase , Prednisolona/uso terapêutico , RNA Viral/análise , Dermatopatias/tratamento farmacológico , Dermatopatias/patologia , Dermatopatias/virologia , Linfócitos T/virologiaRESUMO
OBJECTIVE: This study aimed to describe a recently recognized and rare presentation of varicella zoster virus (VZV) retrobulbar optic neuritis preceding retinitis in patients with acquired immune deficiency syndrome and to identify factors that may relate to improved visual outcome. METHODS: Diagnosis, treatment, and clinical course are described for three eyes of two patients with this viral infection. RESULTS: Patients had decreased vision, headache, and recent zoster dermatitis. Varicella zoster virus retrobulbar optic neuritis was diagnosed on the bases of clinical, laboratory, and electrophysiologic examination results. Profound vision loss and peripheral retinitis ensued despite intravenous antiviral treatment. Combination intravenous and intravitreous antiviral injections were administered with dramatic visual recovery. CONCLUSIONS: Varicella zoster virus retrobulbar optic neuritis should be considered in immunocompromised patients with visual loss. Early diagnosis and aggressive combination therapy via systemic and intravitreous routes may enable return of useful vision.