Assuntos
Andrologia/normas , Suplementos Nutricionais , Doenças dos Genitais Masculinos/dietoterapia , Infertilidade Masculina/dietoterapia , Medicina Reprodutiva/normas , Disfunções Sexuais Fisiológicas/dietoterapia , Andrologia/organização & administração , Suplementos Nutricionais/normas , Prática Clínica Baseada em Evidências/normas , Humanos , Itália , Masculino , Doenças Prostáticas/dietoterapia , Medicina Reprodutiva/organização & administração , Comportamento Sexual/fisiologia , Sociedades Médicas/organização & administração , Sociedades Médicas/normas , Vitaminas/uso terapêuticoRESUMO
BACKGROUND: Lower urinary tract symptoms (LUTS) in men are associated with obesity, particularly central obesity as measured by waist circumference (WC), and may improve with weight loss. We aimed to compare effects of a meal-replacement based diet with isocaloric reduced-fat plan on LUTS and nutrient intake in obese Asian men. METHODS: Obese Asian [mean (range) body mass index of 32.9 (30.5-42.3) kg m(-2) ] men [mean (range) age 40.2 (30-61) years] were randomised to a reduced-fat (< 30% of energy) diet [conventional reduced-fat diet (CD) group; n = 23] or meal-replacement-based plan [meal replacement (MR) group; n = 23], to reduce daily intake by 2000 kJ for 12 weeks. RESULTS: CD and MR groups had statistically significant and similar reductions in weight (-2.6 ± 1.9 kg versus -4.2 ± 3.8 kg), overall LUTS severity measured with International Prostate Symptom Scale (IPSS) scores (-1.71 ± 1.93 points versus -2.42 ± 2.12 points) and insulin resistance [homeostasis model assessment (HOMA) calculated from plasma glucose and insulin]. The MR group had significantly greater decreases in WC (-4.8 ± 3.3 cm versus -2.5 ± 2.3 cm), fat mass (-2.47 ± 3.63 kg versus -1.59 ± 2.32 kg), fat intake, plasma C-reactive protein, and in storage LUTS score (-1.59 ± 1.33 points versus -1.00 ± 0.87 points), which was associated with a decreased fat intake (r = 0.48, P = 0.03). A decrease in overall IPSS score was associated with reductions in weight, WC and HOMA. CONCLUSIONS: Weight loss as a result of CD or MR had similar efficacy in relieving LUTS. MR produced greater reductions in fat intake, adiposity and storage LUTS.
Assuntos
Dieta com Restrição de Gorduras , Ingestão de Energia , Obesidade/complicações , Doenças Urológicas/dietoterapia , Doenças Urológicas/etiologia , Adiposidade , Adulto , Glicemia/análise , Dieta , Metabolismo Energético , Humanos , Insulina/sangue , Resistência à Insulina , Masculino , Refeições , Pessoa de Meia-Idade , Doenças Prostáticas/dietoterapia , Circunferência da Cintura , Redução de PesoRESUMO
Dietary supplements and nutraceuticals are commonly used by men with erectile dysfunction, decreased libido, BPH, and concerns about developing prostate cancer. Many preparations do not contain the advertised dosages of the active ingredient or are contaminated. Dietary supplements and nutraceuticals, particularly those addressing erectile dysfunction and libido, need to undergo rigorous testing before they can be wholeheartedly recommended.
