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1.
Prostate ; 79(14): 1622-1628, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31376187

RESUMO

BACKGROUND: The protist Trichomonas vaginalis causes a common, sexually transmitted infection and has been proposed to contribute to the development of chronic prostate conditions, including benign prostatic hyperplasia and prostate cancer. However, few studies have investigated the extent to which it involves the prostate in the current antimicrobial era. We addressed this question by investigating the relation between T. vaginalis antibody serostatus and serum prostate-specific antigen (PSA) concentration, a marker of prostate infection, inflammation, and/or cell damage, in young, male, US military members. METHODS: We measured T. vaginalis serum IgG antibodies and serum total PSA concentration in a random sample of 732 young, male US active duty military members. Associations between T. vaginalis serostatus and PSA were investigated by linear regression. RESULTS: Of the 732 participants, 341 (46.6%) had a low T. vaginalis seropositive score and 198 (27.0%) had a high score, with the remainder seronegative. No significant differences were observed in the distribution of PSA by T. vaginalis serostatus. However, slightly greater, nonsignificant differences were observed when men with high T. vaginalis seropositive scores were compared with seronegative men, and when higher PSA concentrations were examined (≥0.70 ng/mL). Specifically, 42.5% of men with high seropositive scores had a PSA concentration greater than or equal to 0.70 ng/mL compared with 33.2% of seronegative men (adjusted P = .125). CONCLUSIONS: Overall, our findings do not provide strong support for prostate involvement during T. vaginalis infection, although our suggestive positive findings for higher PSA concentrations do not rule out this possibility entirely. These suggestive findings may be relevant for prostate condition development because higher early- to mid-life PSA concentrations have been found to predict greater prostate cancer risk later in life.


Assuntos
Anticorpos Antiprotozoários/sangue , Antígeno Prostático Específico/sangue , Doenças Prostáticas/parasitologia , Tricomoníase/complicações , Trichomonas vaginalis/imunologia , Adulto , Humanos , Imunoglobulina G/sangue , Masculino , Militares , Estados Unidos
2.
Korean J Parasitol ; 57(1): 27-31, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30840796

RESUMO

PCR is known to be the most sensitive method for diagnosing Trichomonas vaginalis infections. This study aimed to compare the sensitivity of a PCR assay for trichomoniasis (HY-PCR) developed in Hanyang University with the use of a Seeplex Ace Detection Kit®, using urine collected from four Korean men with prostatic disease. Overall, HY-PCR was more sensitive than the Seeplex Kit. The use of Chelex 100 is recommended for DNA isolation in order to increase the sensitivity of the PCR test.


Assuntos
Técnicas de Diagnóstico Molecular/métodos , Reação em Cadeia da Polimerase/métodos , Doenças Prostáticas/diagnóstico , Tricomoníase/diagnóstico , Trichomonas vaginalis/isolamento & purificação , Humanos , Masculino , Doenças Prostáticas/parasitologia , Sensibilidade e Especificidade , Tricomoníase/parasitologia , Trichomonas vaginalis/genética , Urina/parasitologia
3.
Vet Pathol ; 55(3): 466-472, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29402205

RESUMO

The prostate is the only accessory male genital gland described in cetaceans. Although few studies describe the gross and histologic anatomy of the prostate in cetaceans, there is no information on pathological findings involving this organ. The prostate glands of 45 cetaceans, including 8 different odontocete species ( n = 44) and 1 mysticete, were evaluated. The main pathologic diagnoses were verminous prostatitis, septic prostatitis, viral prostatitis, benign prostatic hyperplasia, and prostatitis of unknown etiology. Verminous prostatitis ( n = 12) was caused by nematodes of the genus Crassicauda, and different presentations were observed. Septic prostatitis, identified in 2 cases, both involved nematode infestation and Clostridium spp coinfection. One case of viral prostatitis was identified and was associated with morbillivirus infection. In prostatitis of unknown cause ( n = 7), varying degrees of prostatic lesions, mostly chronic inflammation, were identified. Impacts at individual levels (eg, localized disease, loss of reproductive capacity) and population levels (eg, decreased reproductive success) are plausible. Our results indicate a high occurrence of prostatic lesions in free-ranging odontocetes. For this reason, the prostate should be routinely inspected and sampled during necropsy of odontocete cetaceans.


Assuntos
Cetáceos , Doenças Prostáticas/veterinária , Animais , Infecções Bacterianas/microbiologia , Infecções Bacterianas/patologia , Infecções Bacterianas/veterinária , Masculino , Morbillivirus/isolamento & purificação , Infecções por Morbillivirus/patologia , Infecções por Morbillivirus/veterinária , Próstata/microbiologia , Próstata/parasitologia , Próstata/patologia , Doenças Prostáticas/microbiologia , Doenças Prostáticas/parasitologia , Doenças Prostáticas/patologia , Viroses/veterinária , Viroses/virologia
4.
J Parasitol ; 104(1): 31-38, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29119858

RESUMO

A novel coccidian species was discovered in the prostate of an Antechinus flavipes (yellow-footed antechinus) in South Australia during the period of postmating male antechinus immunosuppression and mortality. This novel coccidian is unusual because it develops extraintestinally and sporulates endogenously within the prostate gland of its mammalian host. Histological examination of prostatic tissue revealed dense aggregations of spherical and thin-walled tetrasporocystic, dizoic, sporulated coccidian oocysts within tubular lumina, with unsporulated oocysts and gamogonic stages within the cytoplasm of glandular epithelial cells. This coccidian was observed occurring concurrently with dasyurid gammaherpesvirus 1 infection of the antechinus' prostate. Eimeria-specific 18S small-subunit ribosomal (r)DNA polymerase chain reaction amplification was used to obtain a partial 18S rDNA nucleotide sequence from the antechinus coccidian. Bayesian phylogenetic analysis based on 18S rDNA gene sequences revealed that the novel coccidian clusters with reptile-host coccidians, forming an ancestral basal lineage of the eimeriid clade. The species has been named Eimeria taggarti n. sp. on the basis of both sporulated oocyst morphology and molecular characterization. It is suspected that E. taggarti is sexually transmitted via excretion of sporulated oocysts or free sporocysts with prostatic secretions in semen.


Assuntos
Coccidiose/veterinária , Eimeria/isolamento & purificação , Marsupiais/parasitologia , Próstata/parasitologia , Doenças Prostáticas/veterinária , Animais , Sequência de Bases , Coccidiose/parasitologia , DNA de Protozoário/química , DNA de Protozoário/isolamento & purificação , DNA Ribossômico/química , DNA Ribossômico/isolamento & purificação , Eimeria/classificação , Eimeria/genética , Eimeria/ultraestrutura , Tolerância Imunológica , Masculino , Marsupiais/imunologia , Microscopia Eletrônica de Transmissão/veterinária , Oocistos/crescimento & desenvolvimento , Oocistos/ultraestrutura , Filogenia , Doenças Prostáticas/parasitologia , RNA de Protozoário/genética , RNA Ribossômico 18S/genética , Alinhamento de Sequência/veterinária , Austrália do Sul
7.
Braz J Infect Dis ; 11(5): 520-2, 2007 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17962880

RESUMO

This case report refers to a 47-year old patient with prostate cancer associated with schistosomiasis mansoni, who was submitted to radical prostatectomy. This is the third report published in the literature with respect to this association, and up to the present time it is still not known whether a cause and effect relationship exists between the two pathologies. The association between schistosomiasis and cancer has been well-documented in bladder cancer; however, there are no data yet proving the association of this disease with prostatic neoplasia. In this report, a third documented case of prostatic adenocarcinoma and schistosomiasis mansoni is described and a literature review is performed.


Assuntos
Adenocarcinoma/complicações , Neoplasias da Próstata/complicações , Esquistossomose mansoni/complicações , Adenocarcinoma/patologia , Adenocarcinoma/cirurgia , Animais , Humanos , Masculino , Pessoa de Meia-Idade , Próstata/parasitologia , Próstata/patologia , Prostatectomia , Doenças Prostáticas/parasitologia , Doenças Prostáticas/patologia , Doenças Prostáticas/cirurgia , Neoplasias da Próstata/patologia , Neoplasias da Próstata/cirurgia , Esquistossomose mansoni/patologia , Esquistossomose mansoni/cirurgia
8.
Braz. j. infect. dis ; 11(5): 520-522, Oct. 2007. ilus
Artigo em Inglês | LILACS | ID: lil-465778

RESUMO

This case report refers to a 47-year old patient with prostate cancer associated with schistosomiasis mansoni, who was submitted to radical prostatectomy. This is the third report published in the literature with respect to this association, and up to the present time it is still not known whether a cause and effect relationship exists between the two pathologies. The association between schistosomiasis and cancer has been well-documented in bladder cancer; however, there are no data yet proving the association of this disease with prostatic neoplasia. In this report, a third documented case of prostatic adenocarcinoma and schistosomiasis mansoni is described and a literature review is performed.


Assuntos
Animais , Humanos , Masculino , Pessoa de Meia-Idade , Adenocarcinoma/complicações , Neoplasias da Próstata/complicações , Esquistossomose mansoni/complicações , Adenocarcinoma/patologia , Adenocarcinoma/cirurgia , Prostatectomia , Próstata/parasitologia , Próstata/patologia , Doenças Prostáticas/parasitologia , Doenças Prostáticas/patologia , Doenças Prostáticas/cirurgia , Neoplasias da Próstata/patologia , Neoplasias da Próstata/cirurgia , Esquistossomose mansoni/patologia , Esquistossomose mansoni/cirurgia
11.
Mycopathologia ; 159(2): 199-204, 2005 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-15770443

RESUMO

Coccidioides immitis infection of the male reproductive tract is a rare entity that can evade diagnosis and pose a dilemma in management. Initially, patients are often evaluated for malignancy or other infections such as tuberculosis. In the past, surgery was the only management option for C. immitis infection of the male reproductive tract, but azole therapy now provides an adjunct or an alternative. We describe two patients who received azole therapy for C. immitis infection of the male reproductive tract. One received fluconazole for prostatic disease, while one received surgery followed by itraconazole for testicular disease. After 12 months of therapy, both remain asymptomatic and have decreased antibody titers against C. immitis.


Assuntos
Antifúngicos/uso terapêutico , Coccidioides/crescimento & desenvolvimento , Coccidioidomicose/tratamento farmacológico , Doenças Prostáticas/tratamento farmacológico , Doenças Prostáticas/parasitologia , Doenças Testiculares/tratamento farmacológico , Doenças Testiculares/parasitologia , Idoso , Coccidioidomicose/parasitologia , Testes de Fixação de Complemento , Fluconazol/uso terapêutico , Humanos , Itraconazol/uso terapêutico , Masculino , Pessoa de Meia-Idade
12.
J Urol ; 158(4): 1491-3, 1997 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-9302149

RESUMO

PURPOSE: Schistosomal infection of the prostate and seminal vesicles is seldom found in clinical practice and rarely mentioned in the radiological literature. However, the presence of schistosoma eggs has been reported in 50% of postmortem studies of the prostate and seminal vesicles performed in endemic areas. MATERIALS AND METHODS: We report the results of transrectal studies of the prostate and seminal vesicles performed in 9 white travelers (age less than 35 years) who complained of hemospermia. Diagnosis was confirmed by positive identification of parasites in the urine and semen. RESULTS: Prostatic calcification was observed in 7 cases, hyperechogenic foci in 2, increase in prostate size in 2, calcifications in the seminal vesicles in 1 and dilatation of the seminal vesicles and ejaculatory ducts in 1. After treatment, prostate size and hyperechogenic foci were reduced. In some cases, calcified lesions diminished during followup. CONCLUSIONS: Prostatic and seminal calcifications should alert physicians to the possibility of schistosoma infection when they are found in young patients who have been in endemic areas. Parasitological study of semen as well as urine confirms and increases the number of diagnoses.


Assuntos
Doenças Prostáticas/diagnóstico por imagem , Doenças Prostáticas/parasitologia , Esquistossomose Urinária/diagnóstico por imagem , Glândulas Seminais/diagnóstico por imagem , Glândulas Seminais/parasitologia , Adulto , Doenças dos Genitais Masculinos/diagnóstico por imagem , Doenças dos Genitais Masculinos/parasitologia , Humanos , Masculino , Ultrassonografia
14.
Actas Urol Esp ; 18(5): 612-4, 1994 May.
Artigo em Espanhol | MEDLINE | ID: mdl-8079691

RESUMO

Description and differential diagnosis of lateral cysts of the prostate gland which during their growth may invade its central section. Most cases, sized below 0.8 cm, are diagnosed by accident. A symptomatic prostate cyst is, in fact, a very uncommon condition. Presentation of one case of prostate cystadenoma which presented as a low urinary obstruction in a middle-age adult subject.


Assuntos
Cistos/diagnóstico por imagem , Doenças Prostáticas/diagnóstico por imagem , Adulto , Cistos/patologia , Cistos/cirurgia , Humanos , Masculino , Próstata/diagnóstico por imagem , Próstata/patologia , Prostatectomia , Doenças Prostáticas/parasitologia , Doenças Prostáticas/cirurgia , Ultrassonografia
15.
Urology ; 39(6): 547-9, 1992 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-1615606

RESUMO

A forty-nine-year-old patient was found to have Schistosoma eggs inside his prostatic cancer. At the time of diagnosis, the patient already had spread of metastatic disease in lumbar spine. Review of the literature revealed this to be the first such case published in English literature. Despite advanced stage of disease (Stage D2), the patient responded well to immediate orchiectomy and regional irradiation. Two years after diagnosis was established, the patient was without clinical evidence of disease, when he suddenly died. The cause of death was not established because the family declined an autopsy.


Assuntos
Adenocarcinoma/complicações , Doenças Prostáticas/complicações , Neoplasias da Próstata/complicações , Esquistossomose/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Prostáticas/parasitologia
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