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2.
Vet Parasitol ; 273: 1-4, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31442886

RESUMO

Pulmonary endarteritis caused by Dirofilaria immitis and pulmonary hypertension (PH) are closely linked and the determination of PH could be validated to assess the severity and chronicity of the vascular damage, i.e. by the use of the Right Pulmonary Artery Distensibility (RPAD) Index. The aim was to evaluate the RPAD Index in dogs 10 months after the last dose of adulticide. The study included 23 client-owned dogs with heartworm brought for adulticide treatment. Echocardiographic exam was carried out to estimate worm burden, RPAD Index as well as other routine echocardiographic values on day 0 (diagnosis), day 120 (discharge), and 10 months after the last dose of adulticide. No significant differences were observed in the RPAD Index over time, neither when microfilaremic status and parasite burden were evaluated. An RPAD Index <29% was found in 52.2% of the dogs on day 0, day 120, and 10 months after the last dose of adulticide. Regarding other echocardiographic parameters, only significant differences were observed on tricuspid annular plane systolic excursion (TAPSE) values between day 0:day 120 (p = 0.008), and day 0:end of the study (p = 0.037). There was not significant improvement in pulmonary damage 10 months after the elimination of the parasites (p = 0.296), suggesting that, once the endarteritis has developed, the vascular changes are chronic and may not be reversible. The modifications of the TAPSE value suggest an improvement in the systolic function of the right ventricle after the disappearance of the worms, independently of the presence of PH. The endarteritis causes a decrease in the elasticity in the pulmonary vasculature and an increase in the resistance that, chronically, and depending on the severity, will cause the development of PH and later right heart failure. This complication of the disease is one of the most damaging and frequent, so it is necessary to adequately monitor PH in dogs undergoing adulticide treatment. Furthermore, knowing the pulmonary status could provide valuable information to help provide an objective prognosis and help assess the need to add additional treatments, once the worms have been eliminated.


Assuntos
Dirofilaria immitis , Dirofilariose/patologia , Doenças do Cão/patologia , Endarterite/veterinária , Pneumopatias/veterinária , Animais , Antiparasitários/uso terapêutico , Dirofilariose/complicações , Dirofilariose/tratamento farmacológico , Doenças do Cão/diagnóstico , Doenças do Cão/tratamento farmacológico , Cães , Endarterite/complicações , Endarterite/diagnóstico , Endarterite/patologia , Concentração de Íons de Hidrogênio , Pneumopatias/complicações , Pneumopatias/diagnóstico , Pneumopatias/patologia , Fatores de Tempo
3.
Dermatology ; 234(5-6): 194-197, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30199871

RESUMO

BACKGROUND: The histological characteristic of hypertensive leg ulcers (HLU) is the presence of "arteriolosclerosis." The pertinence of performing a skin biopsy to diagnose HLU is questionable, as cutaneous arteriolosclerosis may be related to patient comorbidities. The objective here was to evaluate the frequency of arteriolosclerosis in skin leg biopsies performed in patients without ulcer and in control patients with HLU. METHODS: We performed a retrospective study between January 2013 and July 2014. Patients were included if they had undergone a deep skin biopsy on the lower limbs, in the absence of any leg ulcer. Controls were patients with typical HLU. RESULTS: Fifty-eight patients and 6 controls were included. Hypertension was present in 25 patients (43%). Arteriolosclerosis, defined as fibrous endarteritis, was present in 35 out of 58 patients (60%) and in all of the controls. No hyalinosis or hyperplastic proliferative arteriolosclerosis was observed in the patients or controls. Only age was an independent factor associated with the presence of cutaneous arteriolosclerosis (p &x#3c; 0.0001). CONCLUSION: Cutaneous arteriolosclerosis is significantly and independently associated with age. Thus, skin biopsy seems not to be necessary for the diagnosis of HLU but only for a differential diagnosis.


Assuntos
Arteriolosclerose/patologia , Hipertensão/complicações , Isquemia/patologia , Úlcera da Perna/patologia , Dermatopatias Vasculares/patologia , Pele/irrigação sanguínea , Pele/patologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Arteriolosclerose/complicações , Biópsia , Estudos de Casos e Controles , Endarterite/complicações , Endarterite/patologia , Feminino , Humanos , Isquemia/diagnóstico , Isquemia/etiologia , Úlcera da Perna/diagnóstico , Úlcera da Perna/etiologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Dermatopatias Vasculares/complicações
4.
Turk Kardiyol Dern Ars ; 46(1): 66-68, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29339678

RESUMO

Infective endocarditis (IE) is an infectious disease that affects the endothelium of the large intrathoracic vessels, heart valves, and intra-cardiac foreign body material. A 20-year-old woman was admitted to the cardiology department with complaints of fever and palpitations. Transthoracic echocardiography revealed a bicuspid aortic valve, aortic root enlargement, and aortic coarctation. Transesophageal echocardiography revealed a bicuspid aortic valve, but there was no vegetation. Methicillin-sensitive Staphylococcus aureus was identified on a blood culture. 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) revealed increased intensive glucose uptake on the dilated aortic segment adjacent to the distal coarctation zone. Several reports have shown promising results for radio-labelled white blood cell single-photon emission computed tomography and 18F-FDG PET-CT imaging in IE. To our knowledge, this is the first described case in which PET-CT revealed endarteritis of the descending aorta in a patient without prosthetic material.


Assuntos
Aorta , Coartação Aórtica , Endarterite , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Adulto , Anti-Infecciosos/uso terapêutico , Aorta/diagnóstico por imagem , Aorta/patologia , Coartação Aórtica/diagnóstico por imagem , Coartação Aórtica/patologia , Ecocardiografia , Endarterite/diagnóstico por imagem , Endarterite/tratamento farmacológico , Endarterite/patologia , Feminino , Humanos , Staphylococcus aureus Resistente à Meticilina , Infecções Estafilocócicas/diagnóstico por imagem , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/patologia , Adulto Jovem
5.
Klin Khir ; (2): 62-5, 2017.
Artigo em Ucraniano | MEDLINE | ID: mdl-30273457

RESUMO

The efficacy and prognostic significance of the forced intraarterial injection of medicinal preparations in complex of treatment in patients, suffering chronic ischemia of the lower extremities tissues, was studied. In experimental conditions of the main blood flow blockade the forced intraarterial injection of medicinal preparations have promoted the release of vessels from cellular aggregates and the blood clots; and in the ischemia of degree ІІ - ІІІа ­ has determined more pronounced clinical improvement. Appearance of reactive hyperemia of the foot in terms more than 2 min have witnessed the hopelessness of the extremity saving.


Assuntos
Anestésicos Locais/uso terapêutico , Anticoagulantes/uso terapêutico , Arteriosclerose Obliterante/terapia , Endarterite/terapia , Isquemia/terapia , Doença Arterial Periférica/terapia , Vasodilatadores/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Arteriosclerose Obliterante/patologia , Arteriosclerose Obliterante/cirurgia , Gatos , Endarterite/patologia , Endarterite/cirurgia , Feminino , Heparina/uso terapêutico , Humanos , Pressão Hidrostática , Injeções Intra-Arteriais/métodos , Isquemia/patologia , Isquemia/cirurgia , Extremidade Inferior/irrigação sanguínea , Extremidade Inferior/patologia , Masculino , Pessoa de Meia-Idade , Pentoxifilina/uso terapêutico , Doença Arterial Periférica/patologia , Doença Arterial Periférica/cirurgia , Procaína/uso terapêutico
6.
J Oral Maxillofac Surg ; 74(1): 190-9, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26253013

RESUMO

PURPOSE: Surgery of irradiated tissue has an increased complication rate because of the development of hypovascular, hypocellular, and hypoxic tissue. This study was undertaken to perform histopathologic and histomorphometric analyses of irradiation tissue injury in bone and the surrounding soft tissues. MATERIAL AND METHODS: The histopathologic findings of 40 human mandibular bones and the surrounding soft tissue specimens obtained from different patients who underwent surgical procedures for treatment of osteoradionecrosis of the jaws were reviewed. RESULTS: Histopathologic examination showed 7 processes in the following order of appearance: hyperemia, endarteritis, thrombosis, cell loss, hypovascularity, increase of fat in the bone marrow cavity, and fibrosis. Histomorphometric analysis showed significant hypocellularity (P = .007), hypovascularity (P < .001), and fibrosis (P < .001) in irradiated specimens compared with control specimens. CONCLUSION: These results showed that radiation injuries affect the bone and surrounding soft tissues. However, the irradiation-induced injuries, such as cellular loss (hypocellularity) and fibrosis, were more expressive in bone tissue than in the surrounding soft tissues.


Assuntos
Doenças Mandibulares/patologia , Osteorradionecrose/patologia , Periodonto/efeitos da radiação , Tecido Adiposo/efeitos da radiação , Antígenos CD34/análise , Medula Óssea/efeitos da radiação , Morte Celular/efeitos da radiação , Endarterite/patologia , Endotélio Vascular/efeitos da radiação , Fibrose , Neoplasias de Cabeça e Pescoço/radioterapia , Humanos , Hiperemia/patologia , Microvasos/efeitos da radiação , Dosagem Radioterapêutica , Radioterapia de Alta Energia/métodos , Trombose/patologia
7.
Parasit Vectors ; 8: 194, 2015 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-25888952

RESUMO

BACKGROUND: Proliferative endarteritis is one of the key pathological mechanisms of cardiopulmonary dirofilariosis, a cosmopolitan parasitosis caused by Dirofilaria immitis affecting dogs and cats around the world. It has been shown that the excretory/secretory antigens from D. immitis adult worms (DiES) bind plasminogen (PLG) and activate fibrinolysis, which can lead to a survival mechanism for the parasite in its intravascular environment. However, overproduction of plasmin (final product of the route) has been related to pathological processes similar to those described in proliferative endarteritis. The aim of this study is to relate the appearance of this pathological condition with the activation of the PLG/plasmin system of the host by DiES. METHODS: Cell proliferation through the crystal violet technique, cell migration by wound healing assay and degradation of the extracellular matrix by measuring collagen degradation and levels of matrix metalloproteinases were studied in an "in vitro" model using canine vascular endothelial and smooth muscle cells. These cells were treated with a mixture of DiES + PLG. Untreated cells, cells only stimulated with DiES or with PLG, or with a mixture of DiES + PLG + εACA (an inhibitor of the PLG-plasmin conversion) were employed as controls. In addition, the effect of DiES on the expression of the fibrinolytic activators tPA and uPA, the inhibitor PAI-1 and the PLG receptor Annexin A2 was analyzed in both types of cultures by western blot. RESULTS: Plasmin generated by DiES + PLG binding produced a significant increase in the cell proliferation and migration of the endothelial and smooth muscle cells, as well as an increase in the destruction of the extracellular matrix based on a further degradation of Type I Collagen and an increased level of matrix metalloproteinase-2. DiES also induce an increase in the expression of tPA and uPA in endothelial cells in culture, as well as a decrease in the expression of PAI-1 in both types of cells. CONCLUSIONS: Our study reports an interrelationship between plasmin caused by fibrinolysis activation by metabolic products of D. immitis and the appearance of pathological events similar to those described in the emergence of proliferative endarteritis in the cardiopulmonary dirofilariosis.


Assuntos
Dirofilaria immitis/fisiologia , Dirofilariose/patologia , Endarterite/patologia , Ativadores de Plasminogênio/metabolismo , Plasminogênio/metabolismo , Animais , Células Cultivadas , Técnicas Citológicas , Dirofilaria immitis/metabolismo , Dirofilariose/parasitologia , Modelos Animais de Doenças , Cães , Endarterite/parasitologia , Células Endoteliais/parasitologia , Células Endoteliais/patologia , Fibrinolisina/metabolismo , Miócitos de Músculo Liso/parasitologia , Miócitos de Músculo Liso/patologia
8.
PLoS One ; 10(4): e0124445, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25875022

RESUMO

The interaction between blood-borne pathogens and fibrinolysis is one of the most important mechanisms that mediate invasion and the establishment of infectious agents in their hosts. However, overproduction of plasmin (final product of the route) has been related in other contexts to proliferation and migration of the arterial wall cells and degradation of the extracellular matrix. We have recently identified fibrinolysis-activating antigens from Dirofilaria immitis, a blood-borne parasite whose key pathological event (proliferative endarteritis) is produced by similar mechanisms to those indicated above. The objective of this work is to study how two of this antigens [actin (ACT) and fructose-bisphosphate aldolase (FBAL)] highly conserved in pathogens, activate fibrinolysis and to establish a relationship between this activation and the development of proliferative endarteritis during cardiopulmonary dirofilariasis. We demonstrate that both proteins bind plasminogen, enhance plasmin generation, stimulate the expression of the fibrinolytic activators tPA and uPA in endothelial cell cultures and are located on the surface of the worm in contact with the host's blood. ELISA, western blot and immunofluorescence techniques were employed for this purpose. Additionally, the implication of lysine residues in this interaction was analyzed by bioinformatics. The involvement of plasmin generated by the ACT/FBAL and plasminogen binding in cell proliferation and migration, and degradation of the extracellular matrix were shown in an "in vitro" model of endothelial and smooth muscle cells in culture. The obtained results indicate that ACT and FBAL from D. immitis activate fibrinolysis, which could be used by the parasite like a survival mechanism to avoid the clot formation. However, long-term overproduction of plasmin can trigger pathological events similar to those described in the emergence of proliferative endarteritis. Due to the high degree of evolutionary conservation of these antigens, similar processes may occur in other blood-borne pathogens.


Assuntos
Actinas/metabolismo , Patógenos Transmitidos pelo Sangue , Dirofilariose/patologia , Endarterite/patologia , Endotélio Vascular/patologia , Fibrinólise/imunologia , Frutose-Bifosfato Aldolase/metabolismo , Actinas/química , Actinas/genética , Sequência de Aminoácidos , Animais , Western Blotting , Movimento Celular , Proliferação de Células , Células Cultivadas , Doença Crônica , Dirofilaria immitis/patogenicidade , Dirofilariose/parasitologia , Modelos Animais de Doenças , Cães , Endarterite/parasitologia , Endotélio Vascular/parasitologia , Frutose-Bifosfato Aldolase/química , Frutose-Bifosfato Aldolase/genética , Técnicas Imunoenzimáticas , Modelos Moleculares , Dados de Sequência Molecular , Plasminogênio/metabolismo , Ativadores de Plasminogênio/metabolismo , Conformação Proteica , RNA Mensageiro/genética , Reação em Cadeia da Polimerase em Tempo Real , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Homologia de Sequência de Aminoácidos
9.
J Am Soc Nephrol ; 26(5): 1216-27, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25381427

RESUMO

Isolated endarteritis of kidney transplants is increasingly recognized. Notably, microarray studies revealed absence of immunologic signatures of rejection in most isolated endarteritis biopsy samples. We investigated if isolated endarteritis responds to rejection treatment and affects kidney transplant survival. We retrospectively enrolled recipients of kidney transplant who underwent biopsies between 1999 and 2011 at seven American and Canadian centers. Exclusion criteria were recipients were blood group-incompatible or crossmatch-positive or had C4d-positive biopsy samples. After biopsy confirmation, patients were divided into three groups: isolated endarteritis (n=103), positive controls (type I acute T cell-mediated rejection with endarteritis; n=101), and negative controls (no diagnostic rejection; n=103). Primary end points were improved kidney function after rejection treatment and transplant failure. Mean decrease in serum creatinine from biopsy to 1 month after rejection treatment was 132.6 µmol/L (95% confidence interval [95% CI], 78.7 to 186.5) in patients with isolated endarteritis, 96.4 µmol/L (95% CI, 48.6 to 143.2) in positive controls (P=0.32), and 18.6 µmol/L (95% CI, 1.8 to 35.4) in untreated negative controls (P<0.001). Functional improvement after rejection treatment occurred in 80% of patients with isolated endarteritis and 81% of positive controls (P=0.72). Over the median 3.2-year follow-up period, kidney transplant survival rates were 79% in patients with isolated endarteritis, 79% in positive controls, and 91% in negative controls (P=0.01). In multivariate analysis, isolated endarteritis was associated with an adjusted 3.51-fold (95% CI, 1.16 to 10.67; P=0.03) risk for transplant failure. These data indicate that isolated endarteritis is an independent risk factor for kidney transplant failure.


Assuntos
Endarterite/etiologia , Transplante de Rim/efeitos adversos , Adulto , Biópsia , Endarterite/patologia , Endarterite/terapia , Feminino , Rejeição de Enxerto/terapia , Sobrevivência de Enxerto , Humanos , Rim/patologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
10.
Circ J ; 78(12): 2819-26, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25298073

RESUMO

Buerger's disease (thromboangiitis obliterans) is considered to be a nonatherosclerotic, inflammatory, and vaso-occlusive disease, although the details of the mechanisms of pathogenesis remain unknown. The occurrence of the disease is strongly related to tobacco abuse and its progression is closely linked to continued smoking. The purpose of this review article is to demonstrate the pathological characteristics of arteries affected with Buerger's disease from a possible immunoreactive point of view. In addition, we present the mechanisms for preserving the architecture of the arterial wall in affected vasculatures. Thereafter, we discuss the possibility that the pathogenesis of Buerger's disease is a type of endarteritis obliterans, deeply connected to the Notch pathway, distinct from arteriosclerosis obliterans and other vasculitides.


Assuntos
Endarterite/complicações , Tromboangiite Obliterante/etiologia , Artérias/imunologia , Artérias/patologia , Progressão da Doença , Endarterite/patologia , Endarterite/fisiopatologia , Matriz Extracelular/patologia , Humanos , Imunoglobulinas/análise , Subpopulações de Linfócitos/imunologia , Macrófagos/imunologia , Metaloproteinase 3 da Matriz/fisiologia , Infiltração de Neutrófilos , Receptores Notch/fisiologia , Estudos Retrospectivos , Fatores de Risco , Transdução de Sinais/fisiologia , Fumar/efeitos adversos , Fumar/fisiopatologia , Tromboangiite Obliterante/imunologia , Tromboangiite Obliterante/patologia , Túnica Íntima/imunologia , Túnica Íntima/patologia , Ativador de Plasminogênio Tipo Uroquinase/fisiologia
12.
Clin Nephrol ; 77(2): 151-5, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22257546

RESUMO

Acute glomerulonephritis (AGN) is one of the most common renal diseases. They are often associated with infections and can result in diffuse proliferative glomerulonephritis (GN). This case report reviews an interesting case in which renal endarteritis coexisted in AGN with diffuse endocapillary proliferation. The discussion highlights important pathological findings and clinical aspects in acute endocapillary proliferative GN with renal endarteritis. Coexisting endarteritis should be in the differential diagnosis of AGN in patients with persistent clinical courses.


Assuntos
Endarterite/patologia , Glomerulonefrite/patologia , Rim/patologia , Doença Aguda , Adulto , Biópsia , Capilares/patologia , Feminino , Seguimentos , Humanos
15.
Intern Med ; 46(19): 1663-7, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17917330

RESUMO

A 49-year-old man without heart murmur was admitted with fever because of bacteremia following a tooth extraction. Antibiotics rapidly alleviated the fever; however, a small nodule in the pulmonary artery was identified on computed tomography (CT). When the patient experienced chest discomfort with fever, CT demonstrated the absence of the nodule and the appearance of an abnormal lung opacity, and echocardiography showed turbulent retrograde flow in the pulmonary artery. We had the rare opportunity to follow a case of pulmonary bacterial endarteritis and subsequent pulmonary embolism with clinically silent patent ductus arteriosus (PDA) that was confirmed by 3-dimensional CT.


Assuntos
Permeabilidade do Canal Arterial/complicações , Endarterite/etiologia , Embolia Pulmonar/etiologia , Permeabilidade do Canal Arterial/diagnóstico , Permeabilidade do Canal Arterial/patologia , Endarterite/diagnóstico , Endarterite/patologia , Humanos , Imageamento Tridimensional , Masculino , Pessoa de Meia-Idade , Artéria Pulmonar/patologia , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/patologia , Tomografia Computadorizada por Raios X
16.
Am J Transplant ; 6(6): 1285-96, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16686753

RESUMO

A nonhuman primate (NHP) study was designed to evaluate in nonlife-supporting kidney allografts the progression from acute rejection with transplant endarteritis (TXA) to chronic rejection (CR) with sclerosing vasculopathy. Group G1 (n = 6) received high cyclosporine A (CsA) immunosuppression and showed neither TXA nor CR during 90 days post-transplantation. Group G2 (n = 6) received suboptimal CsA immunosuppression and showed severe TXA with graft loss within 46 days (median). Arterial intimal changes included infiltration of macrophages and T lymphocytes (CD3, CD4, CD8) with few myofibroblasts, abundant fibronectin/collagen IV, scant collagens I/III, high rate of cellular proliferation and no C4d accumulation along peritubular capillaries. Group G3 (n = 12) received suboptimal CsA and anti-rejection therapy (rabbit ATG + methylprednisolone + CsA) of TXA. Animals developed CR and lost grafts within 65 days (median). As compared to G2, the arterial intimal changes showed less macrophages and T lymphocytes, an increased number of myofibroblasts, abundant fibronectin/collagen IV and scar collagens I/III, C4d deposition along capillaries in 60% of animals and transplant glomerulopathy in 80% of animals. In conclusion, CR is an immune stimulated process initiated during TXA with the accumulation and proliferation of myofibroblasts, and progressive deposition of collagens in the intima. Our experimental design appears well suited to study events leading to CR.


Assuntos
Rejeição de Enxerto/imunologia , Transplante de Rim/imunologia , Doenças Vasculares/imunologia , Doença Aguda , Animais , Biomarcadores/sangue , Doença Crônica , Modelos Animais de Doenças , Endarterite/imunologia , Endarterite/patologia , Feminino , Transplante de Rim/mortalidade , Transplante de Rim/patologia , Macaca fascicularis , Masculino , Período Pós-Operatório , Primatas , Análise de Sobrevida , Doenças Vasculares/etiologia
17.
Indian J Pediatr ; 73(12): 1130-2, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17202648

RESUMO

Pulmonary arterial endarteritis is a rare event even in patients with congenital heart disease. In this paper, the authors report two cases of pulmonary endarteritis diagnosed at autopsy. The first was a 3-month-old male infant with absence of congenital heart defect (who had had neonatal sepsis). This patient presented with pneumonia and succumbed within 36 hours of hospital stay despite appropriate antimicrobial therapy and supportive management. The second patient was a 13-month-old male child with previously undiagnosed tetralogy of Fallot who had clinical presentation of acute meningitis with convulsions and succumbed within 12 hours of hospital stay despite adequate treatment. The main autopsy findings were chronic arteritis of the pulmonary trunk and right pulmonary artery in the former and rupture of the pulmonary trunk in the latter.


Assuntos
Endarterite/complicações , Endarterite/etiologia , Meningite/complicações , Artéria Pulmonar/patologia , Sepse/complicações , Tetralogia de Fallot/complicações , Doença Aguda , Endarterite/patologia , Evolução Fatal , Humanos , Lactente , Recém-Nascido , Masculino , Convulsões/etiologia
18.
Vasa ; 33(2): 83-5, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15224460

RESUMO

This is a case report of a femoral artery infection with fatal outcome after using a percutaneous suture mediated closure device: A 77-year old patient underwent diagnostic angiography of his thoracic and abdominal aortic aneurysm, the puncture site was closed with the Perclose system. He developed a staphylococcal femoral artery infection with groin abscess, requiring surgical intervention with debridement and removal of the Perclose suture. After stent graft exclusion of the thoracic and abdominal aortic aneurysm a staphylococcal sepsis occurred and the patient died of aneurysm rupture months later despite long term antibiotic therapy. Since the use of the Perclose device carries an increased risk of femoral artery infection with septic endarteritis and bacteremia, it should not be used in routine diagnostic angiography.


Assuntos
Endarterite/etiologia , Endarterite/patologia , Artéria Femoral/patologia , Infecções Estafilocócicas/etiologia , Infecções Estafilocócicas/patologia , Suturas/efeitos adversos , Idoso , Angiografia/efeitos adversos , Angiografia/métodos , Evolução Fatal , Humanos , Masculino , Punções/efeitos adversos , Ferimentos Penetrantes/complicações , Ferimentos Penetrantes/terapia
19.
Vestn Khir Im I I Grek ; 163(4): 56-60, 2004.
Artigo em Russo | MEDLINE | ID: mdl-15626076

RESUMO

The results of 295 reconstructive operations on the major vessels of lower extremities were analyzed. The patients were divided into 4 groups depending on the scheme of anticoagulation therapy in the postoperative period. Under investigation was the state of hemostasis and hemorheology. The frequency of thrombohemorrhagic complications was assessed. It was found that the regimen based on the administration of low molecular weight heparins during the nearest 5 days after the intervention was the most rational regimen of anticoagulation therapy after reconstructive operations on the major arteries of lower extremities.


Assuntos
Anticoagulantes/uso terapêutico , Arteriosclerose/cirurgia , Endarterite/cirurgia , Extremidade Inferior/irrigação sanguínea , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/epidemiologia , Anticoagulantes/administração & dosagem , Artérias , Arteriosclerose/patologia , Endarterite/patologia , Feminino , Humanos , Incidência , Injeções Intramusculares , Extremidade Inferior/cirurgia , Masculino , Pessoa de Meia-Idade
20.
J Am Anim Hosp Assoc ; 39(6): 528-32, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-14736716

RESUMO

A 7-year-old, female spayed rottweiler was referred with a history of an acute onset of collapse attributable to cardiac tamponade. Thoracic radiographs revealed an enlarged cardiac silhouette compatible with pericardial effusion, sternal osteomyelitis, and an unusual mineralized lesion determined later to be within the aortic wall. The pericardial effusion was a septic exudate secondary to infection with Staphylococcus species and hemorrhage into the pericardium through a mineralized aortic lesion. The case demonstrates the importance of complete evaluation of thoracic radiographs in a patient with cardiac disease and the potential value of cytopathological evaluation of pericardial fluid.


Assuntos
Doenças do Cão/diagnóstico , Endarterite/veterinária , Osteomielite/veterinária , Pericardite/veterinária , Infecções Estafilocócicas/veterinária , Animais , Doenças do Cão/patologia , Cães , Endarterite/diagnóstico , Endarterite/patologia , Evolução Fatal , Feminino , Osteomielite/diagnóstico , Osteomielite/patologia , Pericardite/diagnóstico , Pericardite/patologia , Radiografia Torácica/veterinária , Infecções Estafilocócicas/diagnóstico , Infecções Estafilocócicas/patologia , Staphylococcus/isolamento & purificação
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