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1.
BMC Gastroenterol ; 22(1): 101, 2022 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-35255813

RESUMO

BACKGROUND: Protein-losing gastroenteropathy (PLGE) is a syndrome with a chief complaint of hypoalbuminemia, which occurs due to plasma protein leakage in the gastrointestinal tract, leading to general edema, ascites, and pleural effusions. CASE PRESENTATION: A 71-year-old woman visited another hospital for evaluation of hypoalbuminemia and systemic edema. She was hospitalized for a close inspection of hypoalbuminemia and was diagnosed with PLGE. Steroid and azathioprine therapy was prescribed; however, hypoalbuminemia did not improve, and the patient's condition worsened due to anasarca. As hospitalization was prolonged, the patient was transferred to our hospital. She was infected with Helicobacter pylori, and we performed H. pylori eradication. Following H. pylori eradication, her edema improved remarkably. CONCLUSION: We present the first case wherein H. pylori eradication successfully improved protein leakage in the lower gastrointestinal tract in a patient diagnosed with PLGE complicated with refractory to immunosuppressant treatment. H. pylori eradication should be considered in patients with PLGE complicated with H. pylori infection, without specific endoscopic finding or refractory to immunosuppressants.


Assuntos
Antibacterianos , Infecções por Helicobacter , Helicobacter pylori , Cirrose Hepática Biliar , Enteropatias Perdedoras de Proteínas , Idoso , Antibacterianos/uso terapêutico , Proteínas Sanguíneas/metabolismo , Feminino , Infecções por Helicobacter/sangue , Infecções por Helicobacter/complicações , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori/isolamento & purificação , Humanos , Imunossupressores/uso terapêutico , Cirrose Hepática Biliar/sangue , Cirrose Hepática Biliar/complicações , Cirrose Hepática Biliar/microbiologia , Enteropatias Perdedoras de Proteínas/sangue , Enteropatias Perdedoras de Proteínas/complicações , Enteropatias Perdedoras de Proteínas/tratamento farmacológico , Enteropatias Perdedoras de Proteínas/microbiologia
2.
Eur J Gastroenterol Hepatol ; 31(5): 642-645, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30694911

RESUMO

Whipple's disease is a rare, multisystem infection caused by the Gram-positive Tropheryma whippelii organism. In addition to neurological and rheumatological manifestations, this disease can result in significant gastrointestinal symptoms such as malabsorption, diarrhea, and weight loss. Given the diagnostic challenge and rare occurrence, a high index of suspicion is critical to prevent morbidity and mortality from this otherwise highly infectious disease transmitted via the fecal-oral route. We present a very rare but near-fatal case of hypovolemic shock secondary to protein-losing enteropathy and gastrointestinal bleeding from small bowel T. whippelii infection. Furthermore, the epidemiology, clinical presentation, diagnosis, and management of Whipple's disease is reviewed.


Assuntos
Hemorragia Gastrointestinal/microbiologia , Enteropatias Perdedoras de Proteínas/microbiologia , Choque/microbiologia , Tropheryma/patogenicidade , Doença de Whipple/microbiologia , Antibacterianos/uso terapêutico , Biópsia , Diagnóstico Tardio , Progressão da Doença , Duodenoscopia , Hemorragia Gastrointestinal/diagnóstico , Hemorragia Gastrointestinal/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Enteropatias Perdedoras de Proteínas/diagnóstico , Enteropatias Perdedoras de Proteínas/tratamento farmacológico , Choque/diagnóstico , Choque/tratamento farmacológico , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Tropheryma/efeitos dos fármacos , Vasoconstritores/uso terapêutico , Doença de Whipple/complicações , Doença de Whipple/diagnóstico , Doença de Whipple/tratamento farmacológico
3.
J Vet Med Sci ; 80(5): 749-754, 2018 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-29643280

RESUMO

The intestinal microbiota was revealed with the recent advances in molecular techniques, such as high-throughput sequencing analysis. As a result, the microbial changes are thought to influence the health of humans and animals and such changes are affected by several factors including diet, genetics, age, sex, and diseases. Similar studies are being conducted in dogs, and the knowledge of intestinal microbiota in dogs is expanding. Nonetheless, basic information on intestinal microbiota in dogs is less than that of humans. Our aim was to study toy poodles (n=21), a popular companion dog, in terms of basic characteristics of the faecal microbiota by 16S rRNA gene barcoding analysis. In the faecal microbiota, Firmicutes, Bacteroidetes, Proteobacteria, and Fusobacteria were the dominant phyla (over 93.4% of faecal microbiota) regardless of the attributes of the dogs. In family level, Enterobacteriaceae, Bacteroidaceae, and Lachnospiraceae were most prevalent. In case of a dog with protein-losing enteropathy, the diversity of faecal microbiota was different between before and after treatment. This study provides basic information for studying on faecal microbiota in toy poodles.


Assuntos
Cães , Fezes/microbiologia , Microbioma Gastrointestinal/genética , Animais , Doenças do Cão/microbiologia , Feminino , Variação Genética , Japão , Masculino , Tipagem Molecular/veterinária , Enteropatias Perdedoras de Proteínas/microbiologia , Enteropatias Perdedoras de Proteínas/veterinária , RNA Ribossômico 16S , Análise de Sequência de RNA , Especificidade da Espécie
5.
J Vet Diagn Invest ; 23(5): 1014-6, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21908366

RESUMO

The present case report describes the isolation of the fungus Cokeromyces recurvatus from the intestinal tract of a canine patient. Infection by this fungus is rare, having only been reported in 8 human beings and 1 cat. The fungus is not reported to exhibit tissue invasion. Cokeromyces recurvatus is most likely an opportunistic agent, and most cases described involve some degree of immunosuppression.


Assuntos
Doenças do Cão/microbiologia , Mucorales/isolamento & purificação , Mucormicose/veterinária , Enteropatias Perdedoras de Proteínas/veterinária , Animais , Antifúngicos/uso terapêutico , Doenças do Cão/patologia , Cães , Feminino , Mucormicose/complicações , Mucormicose/tratamento farmacológico , Mucormicose/microbiologia , Enteropatias Perdedoras de Proteínas/microbiologia
6.
Braz. j. infect. dis ; 14(5): 540-543, Sept.-Oct. 2010. ilus
Artigo em Inglês | LILACS | ID: lil-570573

RESUMO

Paracoccidioidomycosis (PCM) or South American Blastomycosis is a systemic fungal infection caused by a dimorphic fungus, Paracoccidioides brasiliensis. It represents the most important systemic mycosis in South America and with higher prevalence among male inhabitants of the rural area. PCM usually affects the lungs, and rarely the intestines. The authors report three cases of PCM, treated at the University Hospital of Universidade Federal de Mato Grosso do Sul whose scintigraphy with technetium-99 labeled human albumin revead intestinal protein loss.


Assuntos
Adulto , Humanos , Masculino , Paracoccidioides/isolamento & purificação , Paracoccidioidomicose , Enteropatias Perdedoras de Proteínas , Anti-Infecciosos/uso terapêutico , Itraconazol/uso terapêutico , Paracoccidioidomicose/complicações , Paracoccidioidomicose/tratamento farmacológico , Enteropatias Perdedoras de Proteínas/tratamento farmacológico , Enteropatias Perdedoras de Proteínas/microbiologia , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
7.
Braz J Infect Dis ; 14(5): 540-3, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21221488

RESUMO

Paracoccidioidomycosis (PCM) or South American Blastomycosis is a systemic fungal infection caused by a dimorphic fungus, Paracoccidioides brasiliensis. It represents the most important systemic mycosis in South America and with higher prevalence among male inhabitants of the rural area. PCM usually affects the lungs, and rarely the intestines. The authors report three cases of PCM, treated at the University Hospital of Universidade Federal de Mato Grosso do Sul whose scintigraphy with technetium-99 labeled human albumin revead intestinal protein loss.


Assuntos
Paracoccidioides/isolamento & purificação , Paracoccidioidomicose/diagnóstico por imagem , Enteropatias Perdedoras de Proteínas/diagnóstico por imagem , Adulto , Anti-Infecciosos/uso terapêutico , Humanos , Itraconazol/uso terapêutico , Masculino , Paracoccidioidomicose/complicações , Paracoccidioidomicose/tratamento farmacológico , Enteropatias Perdedoras de Proteínas/tratamento farmacológico , Enteropatias Perdedoras de Proteínas/microbiologia , Cintilografia , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
8.
Biochem Biophys Res Commun ; 337(3): 922-7, 2005 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-16214109

RESUMO

Enteropathogenic Escherichia coli (EPEC) infects intestinal epithelial cells and perturbs the intestinal barrier that limits the paracellular movement of molecules. The disruption of the barrier is mediated by the effectors translocated into the host cells through the bacterial type III secretion system (TTSS). A previous report has described the importance of a bacterial outer membrane protein, intimin, in EPEC-mediated disruption of the barrier, and proposed that intimin, in concert with a host intimin receptor, controls the activity of the translocated barrier-disrupting effectors [P. Dean, B. Kenny, Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein, Mol. Microbiol. 54 (2004) 665-675]. In this study, we found that the importance of intimin is in its ability to bind a bacterial intimin receptor, Tir. Additionally, the impaired ability of an intimin-negative mutant was not restored by co-infection with intimin-expressing TTSS mutants. Collectively, the results in this study favor an alternative scenario explaining the importance of intimin, that the binding of intimin with Tir on the bacterial surface triggers or promotes the translocation of factors required for the efficient disruption of the barrier. Thus, the interaction of intimin with Tir may serve as a molecular switch that controls the delivery of virulence factors into the host cells.


Assuntos
Adesinas Bacterianas/metabolismo , Membrana Celular/microbiologia , Membrana Celular/patologia , Proteínas de Escherichia coli/metabolismo , Escherichia coli/metabolismo , Escherichia coli/patogenicidade , Receptores de Superfície Celular/metabolismo , Células CACO-2 , Membrana Celular/metabolismo , Humanos , Intestinos/microbiologia , Intestinos/patologia , Ligação Proteica , Enteropatias Perdedoras de Proteínas/metabolismo , Enteropatias Perdedoras de Proteínas/microbiologia , Enteropatias Perdedoras de Proteínas/patologia
9.
Can Vet J ; 44(1): 65-6, 2003 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-12619560

RESUMO

A 5-month-old Morgan filly was presented to the Atlantic Veterinary College with a history of lethargy, fever, depression, anorexia, and dependent ventral edema. Diagnostic tests revealed severe inflammation, hypoproteinemia, and thickened small intestinal loops. Protein-losing enteropathy caused by Lawsonia intracellularis was diagnosed and treated successfully with erythromycin-rifampin.


Assuntos
Infecções por Bactérias Gram-Negativas/veterinária , Doenças dos Cavalos/diagnóstico , Lawsonia (Bactéria) , Enteropatias Perdedoras de Proteínas/veterinária , Animais , Antibacterianos/uso terapêutico , Antibióticos Antituberculose/uso terapêutico , Diagnóstico Diferencial , Quimioterapia Combinada/uso terapêutico , Eritromicina/uso terapêutico , Feminino , Infecções por Bactérias Gram-Negativas/complicações , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Doenças dos Cavalos/tratamento farmacológico , Doenças dos Cavalos/microbiologia , Cavalos , Enteropatias Perdedoras de Proteínas/microbiologia , Rifampina/uso terapêutico , Desmame
11.
Vet Pathol ; 35(2): 153-6, 1998 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9539372

RESUMO

Fluorescent in situ hybridization targeting 16S ribosomal RNA was used for specific detection of the obligate intracellular bacterium Lawsonia intracellularis in enterocytes from pigs affected by proliferative enteropathy. A specific oligonucleotide probe was designed and the specificity of the probe was determined by simultaneous comparison with indirect immunofluorescence assay for detection of L. intracellularis in formalin-fixed tissue samples from 15 pigs affected by porcine proliferative enteropathy. We used 10 tissue samples from pigs without proliferative mucosal changes as negative controls. The results showed that the oligonucleotide probe is specific for L. intracellularis and that fluorescent in situ hybridization targeting ribosomal RNA is a suitable and fast method for specific detection and histological recognition of L. intracellularis in formalin-fixed tissue.


Assuntos
Bactérias Gram-Negativas/isolamento & purificação , Infecções por Bactérias Gram-Negativas/veterinária , Enteropatias Perdedoras de Proteínas/veterinária , RNA Ribossômico 16S/análise , Doenças dos Suínos/microbiologia , Animais , Técnica Indireta de Fluorescência para Anticorpo/veterinária , Formaldeído/química , Bactérias Gram-Negativas/genética , Infecções por Bactérias Gram-Negativas/microbiologia , Infecções por Bactérias Gram-Negativas/patologia , Íleo/química , Íleo/microbiologia , Hibridização in Situ Fluorescente/veterinária , Microscopia de Fluorescência/veterinária , Enteropatias Perdedoras de Proteínas/microbiologia , Enteropatias Perdedoras de Proteínas/patologia , Sondas RNA/química , RNA Bacteriano/análise , Suínos , Doenças dos Suínos/patologia , Fixação de Tecidos/veterinária
12.
Klin Khir ; (11-12): 64, 1997.
Artigo em Ucraniano | MEDLINE | ID: mdl-9615011

RESUMO

Bacteriological investigation of peritoneal exudate was conducted in 131 children with peritonitis. The greatest quantity of pathogenic and conventionally pathogenic Escherichias and bacteroids was revealed in March, April and September. In summer peritonitis was caused by pathogenic and conventionally pathogenic Escherichias in association with enterobacterias, staphylococci and other microorganisms.


Assuntos
Apendicite/complicações , Enterobacteriaceae/isolamento & purificação , Escherichia coli/isolamento & purificação , Peritonite/complicações , Peritonite/etiologia , Enteropatias Perdedoras de Proteínas/complicações , Enteropatias Perdedoras de Proteínas/microbiologia , Staphylococcus/isolamento & purificação , Doença Aguda , Criança , Pré-Escolar , Humanos , Estudos Retrospectivos
13.
Am J Gastroenterol ; 89(9): 1548-51, 1994 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-8079936

RESUMO

Lymphocytic gastritis (LG) is a recently described histological entity characterized by increased lymphocytes in the superficial gastric epithelium and foveolae. It includes a subgroup of patients with giant gastric folds and, often, a protein-losing state, a condition termed hypertrophic lymphocytic gastritis (HLG). Despite close endoscopic and clinical similarities to classical Menetrier's disease, the histopathological features of these two diseases are sufficiently distinct that they are regarded as separate entities. The etiology and pathogenesis of HLG are unknown, and the possible etiological role of Helicobacter pylori in particular is controversial. For this reason we report the case of a 48-yr-old female with HLG, hypoproteinemia, and H. pylori infection whose disease resolved clinically, endoscopically, and pathologically with therapeutic eradication of the H. pylori. H. pylori infection may be a treatable cause of at least some cases of HLG and should therefore be carefully sought in any patient with this condition.


Assuntos
Gastrite Hipertrófica/microbiologia , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori/isolamento & purificação , Enteropatias Perdedoras de Proteínas/microbiologia , Amoxicilina/uso terapêutico , Bismuto/uso terapêutico , Quimioterapia Combinada , Feminino , Mucosa Gástrica/patologia , Gastrite Hipertrófica/patologia , Infecções por Helicobacter/patologia , Humanos , Metronidazol/uso terapêutico , Pessoa de Meia-Idade , Omeprazol/uso terapêutico , Compostos Organometálicos/uso terapêutico , Enteropatias Perdedoras de Proteínas/patologia , Salicilatos/uso terapêutico
14.
Gut ; 35(5): 701-4, 1994 May.
Artigo em Inglês | MEDLINE | ID: mdl-8200570

RESUMO

Hypertrophic gastropathy--that is, Ménétrier's disease--was found, in a retrospective analysis, to be associated with Helicobacter pylori in more than 90% of patients. It is proposed that hypertrophic gastropathy represents a special form of H pylori gastritis in these patients. A case is described of a 28 year old woman with Ménétrier's disease associated with proved protein loss from the stomach. Treatment with cimetidine for more than three years had little benefit when colonisation by H pylori was detected. Density of H pylori colonisation and activity of gastritis, which was also present in the first biopsy specimens taken five years ago, were more pronounced in the body than in the antrum, which is in agreement with the characteristics of H pylori gastritis found in other cases with Ménétrier's disease. A 14 day antibacterial treatment course with 750 mg amoxicillin three times a day combined with 40 mg omeprazole three times a day was started in April 1991. This resulted in eradication of H pylori and the return to normal of giant folds and the mucosal histology. Serum protein concentrations returned to normal within six weeks and remained normal at two endoscopies during a two year follow up. This case report suggests that a subgroup of the patients with Ménétrier's disease may be healed by the eradication of H pylori.


Assuntos
Amoxicilina/uso terapêutico , Gastrite Hipertrófica/tratamento farmacológico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori , Omeprazol/uso terapêutico , Enteropatias Perdedoras de Proteínas/tratamento farmacológico , Adulto , Quimioterapia Combinada , Feminino , Gastrite Hipertrófica/microbiologia , Infecções por Helicobacter/complicações , Humanos , Enteropatias Perdedoras de Proteínas/microbiologia
15.
Gastroenterol Clin Biol ; 18(8-9): 775-8, 1994.
Artigo em Francês | MEDLINE | ID: mdl-7875449

RESUMO

The authors report a case of protein losing gastropathy associated with cytomegalovirus. This form which is extremely rare in adults occurred alone after allogenic bone marrow transplantation and become apparent by a hypoalbuminaemia causing oedema of the lower limbs. Gastrocopy showed large red folds of approximately a centimetre covered in a whitish hypersecretion coating. Biopsy demonstrated active gastritis which appeared on a hypertrophic and hypersecretive gastritis. Outcome was favourable within 3 months without treatment.


Assuntos
Transplante de Medula Óssea/efeitos adversos , Infecções por Citomegalovirus/etiologia , Gastrite Hipertrófica/etiologia , Enteropatias Perdedoras de Proteínas/etiologia , Adulto , Infecções por Citomegalovirus/microbiologia , Infecções por Citomegalovirus/patologia , Feminino , Gastrite Hipertrófica/microbiologia , Gastrite Hipertrófica/patologia , Humanos , Leucemia Mielogênica Crônica BCR-ABL Positiva/terapia , Enteropatias Perdedoras de Proteínas/microbiologia , Enteropatias Perdedoras de Proteínas/patologia , Transplante Homólogo
17.
Arch Dis Child ; 62(12): 1215-9, 1987 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-3435155

RESUMO

Three children presented with acute protein losing enteropathy and were found to have acute gastritis associated with Campylobacter pylori infection. Recovery from protein losing enteropathy was accompanied by resolution of the gastritis and the disappearance of C pylori from the gastric mucosa. Their clinical course suggested that the C pylori had caused the gastritis and the protein losing enteropathy. The association between gastritis caused by C pylori and protein losing enteropathy in children has not to our knowledge been previously described.


Assuntos
Infecções por Campylobacter/complicações , Gastrite/complicações , Enteropatias Perdedoras de Proteínas/complicações , Doença Aguda , Infecções por Campylobacter/microbiologia , Pré-Escolar , Feminino , Gastrite/microbiologia , Humanos , Masculino , Enteropatias Perdedoras de Proteínas/microbiologia
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