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1.
Vet Pathol ; 60(6): 770-782, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37650259

RESUMO

Interface dermatitis or lichenoid interface dermatitis refers to a cutaneous inflammatory pattern in which keratinocyte cell death is the essential feature. These terms have evolved from the originally described lichenoid tissue reaction. These lesions are the basis for an important group of skin diseases in animals and people where cytotoxic T-cell-mediated epidermal damage is a major pathomechanism. Yet, for largely historical reasons these commonly used morphological diagnostic terms do not reflect the essential nature of the lesion. An emphasis on subsidiary lesions, such as the presence of a lichenoid band, and definitions based on anatomical features, such as location at the dermo-epidermal location, may cause confusion and even misdiagnosis. This review covers historical aspects of the terminology, including the origin of terms such as "lichenoid." The types of cell death involved and the histopathologic lesions are described. Etiopathogenesis is discussed in terms of aberrations of immune/inflammatory mechanisms focusing on cutaneous lupus erythematosus, erythema multiforme, and Stevens-Johnson syndrome/toxic epidermal necrolysis. Mechanisms have most extensively been studied in humans and laboratory animals and the discussion is centered on these species. As interface dermatitis is firmly entrenched in dermatological parlance, rather than using "cytotoxic" as its substitute, the terminologies "interface cytotoxic dermatitis" and "panepidermal cytotoxic dermatitis" are recommended, based on location and extent of epithelium affected.


Assuntos
Antineoplásicos , Dermatite , Erupções Liquenoides , Dermatopatias , Humanos , Animais , Dermatite/veterinária , Dermatite/patologia , Dermatopatias/veterinária , Erupções Liquenoides/patologia , Erupções Liquenoides/veterinária , Queratinócitos/patologia , Epiderme/patologia
2.
J Fish Dis ; 33(10): 849-58, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20854353

RESUMO

Red-mark syndrome (RMS), a disease seen mostly in rainbow trout, Oncorhynchus mykiss, is of unknown aetiology. The research presented here indicates the presence of an intracellular bacterium in RMS-affected fish. A positive reaction was observed using immunohistochemistry (IHC) with skin lesions, liver, kidney and spleen of affected fish sampled from several locations within the United Kingdom using two different polyclonal antisera raised against Piscirickettsia salmonis. The same reaction was also seen with a number of different anti-P. salmonis monoclonal antibodies (MAbs). A disease with similar clinical signs to RMS, referred to as strawberry disease (SD), has been reported in the USA. A Rickettsia-like organism (RLO) has recently been associated with SD based on analysis of 16S rDNA sequences. Using the same panel of anti-P. salmonis antibodies used to screen the RMS samples, similar staining was obtained in tissue of SD-affected fish by IHC. A polymerase chain reaction (PCR) using RLO-specific primers was also performed on RMS-affected fish from the United Kingdom, and the samples were positive for the RLO 16S rRNA sequence. These findings suggest that the same aetiological agent may be responsible for RMS in the United Kingdom and SD in the USA.


Assuntos
Doenças dos Peixes/microbiologia , Doenças dos Peixes/patologia , Erupções Liquenoides/veterinária , Oncorhynchus mykiss , Rickettsia/imunologia , Animais , Anticorpos Monoclonais , Primers do DNA/genética , Imuno-Histoquímica/veterinária , Erupções Liquenoides/microbiologia , Erupções Liquenoides/patologia , Reação em Cadeia da Polimerase/veterinária , RNA Ribossômico 16S/genética , Rickettsia/genética , Reino Unido , Estados Unidos
3.
J S Afr Vet Assoc ; 73(2): 77-8, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12240775

RESUMO

An apparently idiopathic interface diseasee in a 2-year-old Boer billy goat is described. Clinical features of the disease were the presence of a pruritic multiple focally disseminated dermatitis with flat-topped, angular, scaly plaques and papules with corrugated surfaces in the skin of virtually the entire body. The aetiology of the disorder in the described case is unknown.


Assuntos
Doenças das Cabras/patologia , Erupções Liquenoides/veterinária , Animais , Diagnóstico Diferencial , Doenças das Cabras/diagnóstico , Cabras , Erupções Liquenoides/diagnóstico , Erupções Liquenoides/patologia , Masculino
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