[Non-inflammatory muscle pain]. / Nichtentzündliche Muskelschmerzen.

Muscle pain as a common symptom in daily practice frequently occurs as a non-specific accompanying symptom in multiple internal and neurological diseases. Primarily inflammatory or autoimmune muscular diseases are causing muscle pain. However, a number of non-inflammatory causes of pain can also be considered for differential diagnosis. These are presented in this article. In principle, a distinction must be made between focal and diffuse muscle pain. As an invasive diagnostic procedure, a muscle biopsy should only be performed as the last step in the diagnostic alogorithm. If diffuse muscle pain is only associated with slight muscle weakness or is completely absent, there is usually a primary rheumatic cause. Statins (HMG-CoA reductase inhibitors) can lead to rhabdomyolysis, muscle fiber atrophy and muscle necrosis by damaging the muscle fiber membrane. Myotonias are autosomal dominant or autosomal recessive inherited disorders of muscle function. The genetic defect leads to pronounced muscle stiffness. The cause of metabolic myopathies can be disorders of the carbohydrate, fat or purine metabolism. Fibromyalgia syndrome (FMS) is a non-inflammatory disease and, according to the current knowledge, recognized as the result of an exposure to physical, biological and psychosocial factors (biopsychological disease model). To help diagnosing FMS, pain regions and core symptoms (fatigue, sleep disturbances) can be detected using questionnaires (Widespread Pain Index [WPI] and Symptom Severity Scale [SSS]).

Automatic identification and classification of muscle spasms in long-term EMG recordings.

Spinal cord injured (SCI) individuals may be afflicted by spasticity, a condition in which involuntary muscle spasms are common. EMG recordings can be analyzed to quantify this symptom of spasticity but manual identification and classification of spasms are time consuming. Here, an algorithm was created to find and classify spasm events automatically within 24-h recordings of EMG. The algorithm used expert rules and time-frequency techniques to classify spasm events as tonic, unit, or clonus spasms. A companion graphical user interface (GUI) program was also built to verify and correct the results of the automatic algorithm or manually defined events. Eight channel EMG recordings were made from seven different SCI subjects. The algorithm was able to correctly identify an average (±SD) of 94.5 ± 3.6% spasm events and correctly classify 91.6 ± 1.9% of spasm events, with an accuracy of 61.7 ± 16.2%. The accuracy improved to 85.5 ± 5.9% and the false positive rate decreased to 7.1 ± 7.3%, respectively, if noise events between spasms were removed. On average, the algorithm was more than 11 times faster than manual analysis. Use of both the algorithm and the GUI program provide a powerful tool for characterizing muscle spasms in 24-h EMG recordings, information which is important for clinical management of spasticity.

[Classification and clinical characteristics of masticatory myospasm].

OBJECTIVE: To determine the classification of masticatory myospasm by analyzing characteristics of clinical appearances. METHODS: Thirty-six cases of masticatory myospasm from 2000 to 2010 were included. The clinical data of these patients were analyzed, including patient information, patient history, clinical characteristics, severity and the frequency of myospasmodic movement, electromyogram (EMG), and the efficacy of botulinum toxin injection treatment. RESULTS: There were 11 males and 25 females, aged from 15 to 71. According to the clinical manifestation and EMG findings, patients could be divided into two groups: 18 cases were classified as jaw closing type which involved masseter and/or temporalis muscles presenting as trismus and acute pain, the other 18 cases were jaw opening type which involved lateral pterygoid muscles complaining difficulty in jaw closing and teeth clenching. The jaw closing type was often seen in patients of 20 to 50 years old, the jaw opening was frequently seen in patients over 50 years old. Jaw closing type was attacked intermittently and unilaterally, but jaw opening was often attacked continually and bilaterally. The rating scale of the severity of spasmodic movement was not different between the two types, but the frequency of spasmodic attack was much higher for jaw opening type (P < 0.05). The EMG of jaw closing type was classified into persistent, rhythmic and irregular type. The EMG of jaw opening type was classified into spontaneous and exercise-induced type. Twelve cases were treated by botulinum toxin injection that could significantly relieve symptoms. CONCLUSIONS: Masticatory myospasm can be classified into jaw closing and jaw opening types. Jaw closing type involves masseter and/or temporalis muscles and jaw opening type involves lateral pterygoid muscles. Botulinum toxin injection was the most effective therapy for the masticatory myospasm.

Episodios paroxísticos no epilépticos por anoxia cerebral: espasmos del sollozo y síncopes / Non-epileptic paroxismal episodes due to cerebral anoxia: weeping spasms and syncopes

Dentro de los episodios paroxísticos no epilépticos los más frecuentes son los debidos a la anoxia cerebral; son procesos benignos con recuperación espontánea a la normalidad, pero que producen problemas de diagnóstico diferencial, ya que pueden ser confundidos con otras patologías de mayor gravedad. Dentro de este grupo se incluyen los espasmos del sollozo y los síncopes. Los espasmos del sollozo son propios de niños entre 6 meses y 4 años; son llamados también espasmos del llanto ya que consisten en una detención de la respiración durante el llanto; el diagnóstico diferencial se basa fundamentalmente en la clínica y el tratamiento debe basarse en tranquilizar a la familia. Los síncopes son propios de niños más mayores, se distinguen fundamentalmente los síncopes neurocardigénicos o vasovagales y los de origen cardiaco. Es necesario valorar la posibilidad de una patología cardiaca (AU)

The most common paroxystic episodes other than epilepsy are syncope and breath-holding spells. There are unexpected benign events with spontaneous recuperation, but sometimes we can confuse it with other pathologies. The breath holding spells and common in infancy and early childhood, and patients frequently referred to paediatric cardiology or/and neurology. The diagnosis differential is possible with the anamnesis. The syncope is usually referred to either neurology or cardiology. The diagnostic rests principally upon the history, but is it possible required investigation to support the clinical diagnosis (AU)

Management of post-operative bladder spasm.

OBJECTIVE: Pain management following bladder surgery in children is often complicated by bladder spasm. The overall severity of spasm can be reduced with opioids, anticholinergic medication and sedatives, although breakthrough spasms often occur. At the Royal Children's Hospital, Melbourne, intravesical bupivacaine has been used to manage postoperative bladder spasm to good effect. The administration of intravesical bupivacaine is analysed in this prospective audit of locally applied intravesical anaesthetic and compared with other methods. METHOD: From February to August 2003, histories of 58 patients who had intravesical bupivacaine were studied and compared with six other methods of management of postoperative bladder spasm. CONCLUSION: Data showed that epidural anaesthesia was the most effective treatment of pain, with a pain score reduction of 6.6, compared with a reduction of 6.1 with intravesical bupivacaine, and 4.5 using intravenous morphine. However, intravesical bupivacaine was the most effective method for the relief of bladder spasm.

Difficulties in the differential diagnosis of vaginismus, dyspareunia and mixed sexual pain disorder.

This retrospective study was undertaken to investigate predictors of vaginismus, dyspareunia and mixed sexual pain disorder in respect of symptom profile and treatment history variables of female patients and their partners. The study sample consisted of 147 female patients attending a university hospital outpatient clinic for Psychosomatic Gynecology and Sexology. All patients met the DSM-III-R criteria of the diagnoses of vaginismus (n = 50), dyspareunia (n = 46), or of both diagnoses (n = 51). No univariate differences were found between members of the three groups or between their partners. It was not possible to make a multivariate prediction of group membership.

[Disordered gastric motor-evacuatory function in patients following organ-preserving operations with vagotomy]. / Narushenie motorno-évakuatornoi funktsii zheludka u bol'nykh posle organosokhraniaiushchikh operatsii s vagotomiei.

The authors examined 527 patients who underwent organ-preserving operations with vagotomy for bleeding duodenal ulcers. Motor-evacuation disorders were encountered in 23.3% of patients in the form of gastrostasis. A classification of gastrostasis was formulated on the basis of the obtained data. The possibility of establishing the differential diagnosis of the causes of gastrostasis is shown. The aspects of individualization of the therapeutic tactics according to the etiology and severity of gastrostasis are discussed.

Orthostatic tremor: an association with essential tremor.

Orthostatic tremor is characterized by tremor of the trunk and legs while standing. Rapid frequency has been emphasized as an important criterion for the diagnosis of this tremor. We observed five patients who had the typical findings of orthostatic tremor but had a wide range of frequencies. All five also had postural hand tremor and a family history of essential tremor, suggesting a relationship between orthostatic tremor and essential tremor. This report also emphasizes the association of orthostatic tremor with painful cramps and a relatively consistent improvement with clonazepam.

Contraction abnormalities of the esophageal body in patients referred to manometry. A new approach to manometric classification.

A method is proposed for classifying conventional esophageal manometry findings according to the features observed in the esophageal body rather than the disease name. Patients who demonstrate increases in mean distal wave amplitude, mean distal wave duration, or number of abnormal motor responses (repetitive or simultaneous contractions) or the presence of triple-peaked waves are classified as having distal contraction abnormalities. Severity is scored by the cumulative number of these abnormalities. Of the 210 patients referred for esophageal manometry over a 23-month period, 119 (57%) were found to have one or more of the contraction abnormalities, making this the most common esophageal body manometric classification. The presence of one or two abnormalities was most common. Patients with all four abnormalities represented less than 5% of the referred population and, as a group, would satisfy usual manometric criteria for diffuse esophageal spasm. The proposed system allows for recognition of patients with only one or several of the manometric features typically seen in diffuse esophageal spasm and provides a method for intra- and interstudy comparison of patients with these common findings.

The nosology of extrapyramidal disorders.

The author presents a new classification of extrapyramidal diseases based on a clinical and genetic approach to the nosology. This classification is intended as a working frame for a reevaluation of the pathogenesis of many of the illnesses listed. A discussion of some theoretic possibilities derived from such a study concludes the paper.