Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 208
Filtrar
1.
Ann Allergy Asthma Immunol ; 121(1): 98-104, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29777744

RESUMO

BACKGROUND: Aspirin desensitization has been associated with benefit in management of aspirin-exacerbated respiratory disease (AERD). An intervention that would encourage aspirin desensitization to be performed more frequently has substantial potential for improving outcomes and quality of life in patients with AERD. OBJECTIVE: We investigated whether omalizumab administration would be associated with attenuation of aspirin-provoked bronchospasm in patients with AERD undergoing aspirin desensitization. METHODS: We carried out a randomized, double-blind, placebo-controlled study in which subjects with AERD who fulfilled label criteria for omalizumab received omalizumab or placebo for 16 weeks, and then underwent aspirin desensitization. RESULTS: Eleven subjects completed aspirin desensitization. Of the 7 who were randomized to omalizumab, 5 had no respiratory reaction during aspirin desensitization. Compared with placebo, omalizumab was associated with a significantly greater likelihood for subjects with AERD to have no respiratory reaction during desensitization (P = .04, Fisher exact test). There was an overall difference in urinary leukotriene E4 (LTE4) levels in subjects who received omalizumab and did not have a respiratory reaction during desensitization compared with subjects randomized to placebo (P = .035, mixed model with interaction). Urinary LTE4 levels were significantly higher with respiratory reaction in placebo subjects compared with levels obtained after the 100-mg dose in AERD subjects who had no respiratory reaction (P < .001, mixed model with interaction). CONCLUSION: In atopic AERD subjects, omalizumab administration for 16 weeks was associated with "clinically silent" desensitization. Further studies to investigate the therapeutic utility of omalizumab in patients with AERD who are candidates for aspirin desensitization are warranted based on these findings. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT00555971.


Assuntos
Antiasmáticos/uso terapêutico , Aspirina/efeitos adversos , Asma Induzida por Aspirina/tratamento farmacológico , Espasmo Brônquico/prevenção & controle , Dessensibilização Imunológica/métodos , Omalizumab/uso terapêutico , Adulto , Asma Induzida por Aspirina/etiologia , Asma Induzida por Aspirina/imunologia , Asma Induzida por Aspirina/urina , Biomarcadores/urina , Espasmo Brônquico/etiologia , Espasmo Brônquico/imunologia , Espasmo Brônquico/urina , Método Duplo-Cego , Esquema de Medicação , Feminino , Humanos , Leucotrieno E4/urina , Masculino , Pessoa de Meia-Idade
5.
Probl Radiac Med Radiobiol ; 22: 463-475, 2017 Dec.
Artigo em Inglês, Ucraniano | MEDLINE | ID: mdl-29286527

RESUMO

OBJECTIVE: to determine the effectiveness of citrulline use for correcting endothelial dysfunction in children resi dents of radioactively contaminated areas. MATERIALS AND METHODS: A group of children residents of radioactively contaminated areas with the presence of clinical and paraclinical signs of endothelial dysfunction was selected to assess the effectiveness of correcting endothelial dysfunction by the usage of NO potential donator - citrulline according to the data of selective screen ing. There were determined the biochemical parameters of the content of NO stable metabolites, L arginine, lipid peroxidation, antioxidant enzymes in the blood serum; the indices of cellular and humoral immunity; the instrumen tal indices of vascular endothelium dependent reaction on occlusion test, the lung ventilation capacity, the bioelec tric activity of the myocardium, the autonomic regulation of the cardiovascular system.Examined children were received a course of citrulline malate. RESULTS AND CONCLUSIONS: An increased content of serum L arginine, nitrite, and amounts of NO metabolites was established in children with endothelial dysfunction who were received a course of citrulline malate. Bronchospasm elimination was noted in the significant part of examined patients after the drug use. Decreased recovery period and increased period of hypercompensation for thermographic circulation index in the test with post occlusion reac tive hyperemia were detected by an evaluation of indicators for vascular endothelium dependent vasodilatation using thermographic method indicating an increased endothelial vasomotor capacity. There was tendency to improve the processes of autonomic regulation of the heart rhythm and repolarization of the heart muscle. The antioxidant effect of used citrulline malate course was determined as: decreased content of serum LPO end products that react with thiobarbituric acid under elevated activity of antioxidant - catalase. An increase in the percentage of T lymphocyte, normalization of their subpopulation composition was noted in dynamics of citrulline malate application.


Assuntos
Espasmo Brônquico/prevenção & controle , Doenças Cardiovasculares/tratamento farmacológico , Acidente Nuclear de Chernobyl , Citrulina/análogos & derivados , Malatos/uso terapêutico , Doadores de Óxido Nítrico/uso terapêutico , Óxido Nítrico/uso terapêutico , Exposição à Radiação/efeitos adversos , Arginina/sangue , Espasmo Brônquico/etiologia , Espasmo Brônquico/imunologia , Espasmo Brônquico/fisiopatologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/imunologia , Doenças Cardiovasculares/fisiopatologia , Criança , Citrulina/química , Citrulina/metabolismo , Citrulina/uso terapêutico , Endotélio Vascular/efeitos dos fármacos , Endotélio Vascular/imunologia , Endotélio Vascular/patologia , Feminino , Humanos , Imunidade Celular/efeitos dos fármacos , Imunidade Humoral/efeitos dos fármacos , Peroxidação de Lipídeos , Malatos/química , Malatos/metabolismo , Masculino , Óxido Nítrico/metabolismo , Doadores de Óxido Nítrico/química , Doadores de Óxido Nítrico/metabolismo , Nitritos/sangue , Doses de Radiação , Poluentes Radioativos/efeitos adversos , População Rural , Sobreviventes , Linfócitos T/imunologia , Linfócitos T/patologia , Ucrânia , População Urbana
8.
Biomed Res Int ; 2013: 786462, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24228259

RESUMO

OBJECTIVES: To investigate the prevalence of tooth loss and different prosthetic rehabilitations among Iranian adults, as well as the potential determinants of tooth loss. METHODS: In a cross-sectional community-based study conducted among 8094 Iranian adults living in Isfahan province, a self-administered questionnaire was used to assess epidemiologic features of tooth loss. RESULTS: Thirty-two percent of subjects had all their teeth, 58.6% had lost less than 6, and 7.2% of participants had lost more than 6 teeth. One hundred and sixty-nine individuals (2.2%) were edentulous. Among participants, 2.3% had single jaw removable partial denture, 3.6% had complete removable denture in both jaws, and 4.6% had fixed prosthesis. Others reported no prosthetic rehabilitation (89.5%). In the age subgroup analysis (≤35 and >35 years old) tooth loss was more prevalent among men than women (OR = 2.8 and 1.9, resp., P < 0.01). Also, in both age groups, current and former smokers had higher levels of tooth loss than nonsmokers (P < 0.001 and P < 0.05, resp.). In addition, tooth loss was positively related to metabolic abnormality for age group >35 years (adjusted OR = 1.29, P < 0.01). CONCLUSIONS: Tooth loss is highly prevalent in Iranian adult population. Community programs promoting oral health for prevention of tooth loss should be considered taking into account its major determinants including lower educational level, male gender, smoking, and metabolic abnormality.


Assuntos
Antígenos de Plantas/imunologia , Espasmo Brônquico/imunologia , Bases de Dados Factuais , Glicoproteínas/imunologia , Imunoglobulina E/imunologia , Proteínas de Plantas/imunologia , Adolescente , Adulto , Anafilaxia/imunologia , Anafilaxia/prevenção & controle , Antígenos de Plantas/efeitos adversos , Espasmo Brônquico/patologia , Criança , Pré-Escolar , Doença Crônica , Feminino , Glicoproteínas/efeitos adversos , Humanos , Masculino , Proteínas de Plantas/efeitos adversos , Estudos Retrospectivos
9.
Biomed Res Int ; 2013: 746507, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24102058

RESUMO

Allergen component analysis is now available in many laboratories. The aim of this study was to examine the possible association between peanut allergen IgE components and severity of clinical reactions in patients with a history of peanut allergy. Data and sera collected from 192 patients within the Manchester Allergy Research Database and Serum Bank were used in this retrospective study. Sensitization to peanut specific IgE and Ara h 1, 2, 3, and 8 peanut IgE components, as measured by fluoroenzyme immunoassay, was not associated with anaphylaxis. In contrast, sensitization to the lipid-transfer protein Ara h 9 was significantly more prevalent in patients with peanut-associated bronchospasm (26% versus 9% of patients), even after adjusting for potential confounding effects of age, gender, and severity of concomitant chronic atopic diseases. Patients who were sensitized to Ara h 9 were more likely to have ingested rather than just have had skin contact with peanut and have a more rapid onset of symptoms. These results are consistent with observations that sensitization to heat and protease resistant lipid-transfer protein components of hazelnut, grains, and fruit is predictive of anaphylaxis.


Assuntos
Antígenos de Plantas/imunologia , Espasmo Brônquico/imunologia , Glicoproteínas/imunologia , Imunização , Proteínas de Plantas/imunologia , Alérgenos/imunologia , Anafilaxia/complicações , Anafilaxia/imunologia , Anafilaxia/patologia , Espasmo Brônquico/etiologia , Espasmo Brônquico/patologia , Criança , Pré-Escolar , Feminino , Humanos , Imunoglobulina E/imunologia , Masculino , Hipersensibilidade a Amendoim/complicações , Hipersensibilidade a Amendoim/imunologia , Hipersensibilidade a Amendoim/patologia
10.
Allergy ; 68(4): 462-71, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23414231

RESUMO

BACKGROUND: Nucleotides released to the extracellular space stimulate purinergic receptors, and their effects are modulated by ectonucleotidases. The role of ATP in the allergic bronchospasm has been scantly studied. METHODS: We used several techniques (plethysmography, organ baths, confocal microscopy, RT-PCR, ATP measurement) to explore the role of nucleotides and ectonucleotidases in the allergic bronchospasm in guinea pigs. RESULTS: While allergenic challenge with a low-dose ovalbumin (OVA) only produced a small bronchospasm (~2-fold the basal lung resistance), previous inhibition of ectonucleotidases by ARL-67156 greatly intensified this response (~11-fold the basal lung resistance, with 44% mortality). Bronchoalveolar lavage fluid obtained during this bronchospasm contained increased ATP concentration. This potentiation was abolished by antagonism of purinergic receptors (suramin+RB2) or TXA2 receptor (SQ29548), or by intratracheal apyrase. In tracheal rings and lung parenchyma strips, OVA caused a concentration-dependent contraction. Suramin+RB2 or levamisole produced a significant rightward displacement of this response, and ARL-67156 did not modify it. Platelets stimulated with OVA released ATP. Confocal images of nonsensitized tracheas showed slight fluorescence for P2Y6 receptors in epithelium and none for P2Y4 . Sensitized animals showed strong fluorescence to both receptors and to alkaline phosphatase in the airway epithelium. This correlated with a large increment in mRNA for P2Y4 and P2Y6 receptors in sensitized animals. CONCLUSIONS: Nucleotides greatly potentiate the allergic bronchospasm when ectonucleotidases activity is diminished, and this effect is probably favored by the upregulation of P2Y4 and P2Y6 receptors in airway epithelium during sensitization. These results prompt for further research on these mechanisms in human asthma.


Assuntos
Espasmo Brônquico/enzimologia , Espasmo Brônquico/imunologia , Hipersensibilidade/enzimologia , Hipersensibilidade/imunologia , Nucleotidases/metabolismo , Nucleotídeos/metabolismo , Trifosfato de Adenosina/análogos & derivados , Trifosfato de Adenosina/metabolismo , Trifosfato de Adenosina/farmacologia , Fosfatase Alcalina/metabolismo , Animais , Plaquetas/efeitos dos fármacos , Plaquetas/metabolismo , Espasmo Brônquico/induzido quimicamente , Espasmo Brônquico/genética , Líquido da Lavagem Broncoalveolar/imunologia , Relação Dose-Resposta a Droga , Espaço Extracelular/metabolismo , Cobaias , Hidrólise/efeitos dos fármacos , Hipersensibilidade/genética , Nucleotidases/antagonistas & inibidores , Ovalbumina/efeitos adversos , Ovalbumina/imunologia , Receptores Purinérgicos P2/genética , Receptores Purinérgicos P2/metabolismo
11.
Ann Allergy Asthma Immunol ; 109(5): 303-8, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23062383

RESUMO

BACKGROUND: Despite the universality and clinical significance of exercise-induced bronchospasm (EIB), the mechanisms responsible for it are incompletely understood. OBJECTIVE: To investigate the role of exhaled RANTES (regulated on activation, normal T-cell expressed and secreted) and interleukin (IL) 4 in EIB in children with asthma. METHODS: Fifty-six children with asthma were evaluated with exercise challenge and exhaled RANTES and IL-4 levels. Exhaled breath condensate was collected before and 30 minutes after exercise challenge. RANTES and IL-4 concentrations were determined using a specific immunoassay kit. RESULTS: A significant increase was found in RANTES levels after exercise challenge in the asthmatic children (P<.001). A statistically significant increase in RANTES levels was noted after exercise challenge in both the asthmatic children with EIB (n=25, P=.007) and in the non-EIB asthmatic group (n=31, P=.005). Our study revealed that exhaled RANTES level correlates significantly well with percentage of forced expiratory volume in 1 second (FEV1), exacerbation frequency, serum IgE, and body mass index. No statistically significant increase was found in IL-4 levels after exercise challenge. The maximal postexercise decrease in FEV1 strongly correlated with total eosinophil count (P<.001, r = -0.61) and baseline ratio of FEV1 to forced vital capacity (FVC) (P=.002, r=0.40). Results from multivariate regression analysis adjusted for age, sex, and atopy as covariates showed that eosinophil count and FEV1/FVC ratio were significantly associated with EIB. CONCLUSION: We found that exercise challenge, leading to hyperosmolar stimulus, may increase exhaled RANTES levels in children with asthma. In addition, exhaled RANTES levels correlate well with serum IgE, severity of asthma, FEV1/FVC ratio, and body mass index. RANTES and IL-4 may not be independent predictors for EIB. Furthermore, eosinophil count and FEV1/FVC ratio may predict the presence and severity of EIB in asthmatic children.


Assuntos
Asma Induzida por Exercício/imunologia , Asma Induzida por Exercício/metabolismo , Quimiocina CCL5/sangue , Teste de Esforço , Expiração , Interleucina-4/sangue , Adolescente , Asma Induzida por Exercício/fisiopatologia , Espasmo Brônquico/imunologia , Espasmo Brônquico/metabolismo , Espasmo Brônquico/fisiopatologia , Criança , Feminino , Humanos , Masculino , Estudos Prospectivos
12.
Vet J ; 192(1): 49-56, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22136877

RESUMO

The objective of this study was to determine if inhaled salmeterol, a long-acting ß(2)-adrenergic agonist, and oral doxycycline, a tetracycline antibiotic displaying matrix metalloproteinase (MMP) inhibitory activity, reduce airway inflammation and obstruction in cats with experimentally-induced asthma. Eight Ascaris suum (AS)-sensitised cats were enrolled in a prospective study in which they underwent four AS-challenges at 1 month intervals. The challenged animals were given no treatment or were treated on 4 consecutive days with either: (1) oral prednisolone (1mg/kg twice daily), (2) inhaled salmeterol (50 µg twice daily), or (3) oral doxycycline (5mg/kg twice daily), according to a randomised cross-over design. Inhibition of allergen-induced early (EAR) and late (LAR) asthmatic reactions were assessed by barometric whole-body plethysmography. Cytology and measurement of MMP-2 and -9 activities were carried out on bronchoalveolar lavage fluid (BALF). Although none of the treatments prevented the EAR, prednisolone treatment inhibited the LAR. Relative to untreated cats, the eosinophil percentage and MMP-2 activity in BALF were significantly reduced following prednisolone treatment (P<0.05). Short-term therapy with either salmeterol or doxycycline had no effect on the EAR or LAR or on airway inflammation. Given the chronic nature of this disease in cats, long-term therapy may be required to produce more favourable functional and clinical outcomes.


Assuntos
Agonistas de Receptores Adrenérgicos beta 2/administração & dosagem , Albuterol/análogos & derivados , Anti-Inflamatórios/administração & dosagem , Asma/veterinária , Espasmo Brônquico/veterinária , Doenças do Gato/tratamento farmacológico , Doxiciclina/administração & dosagem , Prednisolona/administração & dosagem , Administração por Inalação , Administração Oral , Albuterol/administração & dosagem , Animais , Antígenos de Helmintos/efeitos adversos , Ascaris suum/imunologia , Asma/tratamento farmacológico , Asma/imunologia , Espasmo Brônquico/tratamento farmacológico , Espasmo Brônquico/imunologia , Broncodilatadores/administração & dosagem , Carbacol/farmacologia , Doenças do Gato/imunologia , Gatos , Agonistas Colinérgicos/farmacologia , Estudos Cross-Over , Feminino , Masculino , Estudos Prospectivos , Xinafoato de Salmeterol , Fatores de Tempo
13.
Immunol Allergy Clin North Am ; 31(4): 663-75, v, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21978850

RESUMO

Much has been learned from epidemiologic studies conducted in the past 4 decades that can be directly applied to the management of workers affected with occupational asthma. Studies have provided information about host factors, environmental exposure, and occupational agents posing the highest risks for development of severe irreversible airway obstruction and asthma disability. Investigators have developed methods for screening workers at risk and novel interventions that may prevent new cases among exposed worker populations. Less is known about the natural history and chronic morbidity associated with work-aggravated asthma and irritant-induced asthma syndromes; more studies are needed in at-risk worker populations.


Assuntos
Asma Ocupacional/epidemiologia , Espasmo Brônquico/epidemiologia , Exposição Ocupacional/prevenção & controle , Alérgenos/efeitos adversos , Animais , Asma Ocupacional/diagnóstico , Asma Ocupacional/etiologia , Asma Ocupacional/imunologia , Asma Ocupacional/prevenção & controle , Espasmo Brônquico/diagnóstico , Espasmo Brônquico/etiologia , Espasmo Brônquico/imunologia , Espasmo Brônquico/prevenção & controle , Detergentes/efeitos adversos , Estudos Epidemiológicos , Farinha/efeitos adversos , Humanos , Imunoglobulina E/imunologia , Irritantes/efeitos adversos , Isocianatos/efeitos adversos , Látex/efeitos adversos , Morbidade , Vigilância da População , Pyroglyphidae/imunologia , Alimentos Marinhos/efeitos adversos , Estados Unidos/epidemiologia
14.
J Anesth ; 24(1): 143-5, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20052499

RESUMO

We report on a patient who presented with recurrent severe shock during general anesthesia. The patient was a man scheduled for lung surgery whose first attack was a coronary spasm, which was followed by a second shock with severe bronchospasm and hypotension 4 weeks later. An elevated serum tryptase concentration was observed, and subsequent skin testing revealed negative reactions to some drugs administered in this case. This case serves to alert anesthetists to the possibility of some different forms of allergy and highlights the importance of rigorous investigation of all the reagents and phenomena.


Assuntos
Anafilaxia/etiologia , Anestesia Geral/efeitos adversos , Complicações Intraoperatórias , Idoso , Espasmo Brônquico/imunologia , Vasoespasmo Coronário/imunologia , Hipersensibilidade a Drogas/etiologia , Humanos , Hipotensão/imunologia , Pulmão/cirurgia , Masculino , Prevenção Secundária , Choque/etiologia , Testes Cutâneos
15.
Clin Exp Allergy ; 39(9): 1324-9, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19638039

RESUMO

Rackemann described the 'intrinsic asthma' population over 50 years ago as a unique subgroup that was characterized by onset of progressive loss of lung function beginning later in life, possibly after a respiratory infection. It has also been associated with a female predominance, aspirin-sensitive bronchospasm, and nasal polyposis. While the aetiology is not understood, we propose that persistent respiratory infections play a central role in the development of intrinsic asthma.


Assuntos
Asma/etiologia , Infecções Respiratórias/complicações , Anti-Inflamatórios não Esteroides/efeitos adversos , Anti-Inflamatórios não Esteroides/uso terapêutico , Aspirina/efeitos adversos , Aspirina/uso terapêutico , Asma/imunologia , Asma/fisiopatologia , Espasmo Brônquico/etiologia , Espasmo Brônquico/imunologia , Espasmo Brônquico/fisiopatologia , Feminino , Humanos , Pulmão/imunologia , Pulmão/fisiopatologia , Masculino , Pólipos Nasais/complicações , Pólipos Nasais/imunologia , Pólipos Nasais/fisiopatologia , Infecções Respiratórias/imunologia , Infecções Respiratórias/fisiopatologia , Fatores Sexuais
17.
Allergol Int ; 55(4): 369-72, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17130678

RESUMO

Respiratory viral infections profoundly influence the disease activity of wheezing illnesses and asthma in early childhood. Viral bronchiolitis shares many features with asthma and a subset of children develop recurrent wheezing after their initial illness. Recently mechanisms for virus-induced exacerbations of childhood asthma are beginning to be focused on and defined. Viruses cause systemic immune activation and also produce local inflammation. These factors are likely to affect airway pathogenesis leading to airway narrowing, an increase in mucus production, and eventually bronchospasm, and airway obstruction. These new insights related to the pathogenesis and disease activity are likely to provide new targets for the therapy and prevention of early asthma in childhood.


Assuntos
Asma/etiologia , Infecções Respiratórias/complicações , Viroses/complicações , Adolescente , Obstrução das Vias Respiratórias/etiologia , Obstrução das Vias Respiratórias/imunologia , Obstrução das Vias Respiratórias/fisiopatologia , Asma/genética , Asma/imunologia , Asma/fisiopatologia , Espasmo Brônquico/etiologia , Espasmo Brônquico/imunologia , Espasmo Brônquico/fisiopatologia , Criança , Pré-Escolar , Predisposição Genética para Doença , Humanos , Lactente , Inflamação , Pulmão/fisiopatologia , Fenótipo , Recidiva , Sons Respiratórios , Infecções Respiratórias/genética , Infecções Respiratórias/imunologia , Infecções Respiratórias/fisiopatologia , Fatores de Risco , Viroses/genética , Viroses/imunologia , Viroses/fisiopatologia
19.
Pol Merkur Lekarski ; 19(112): 506-10, 2005 Oct.
Artigo em Polonês | MEDLINE | ID: mdl-16379312

RESUMO

UNLABELLED: In the epidemiological study there was suggested that respiratory tract infections--were a strong risk factors for the beginning and development of bronchial asthma. The aim of the study was the evaluation of intracellular cytokine IL-4 and IFN-gamma on peripheral blood T subsets in children with atopic asthma (AA) and recurrent respiratory tract infection with bronchospasm (RRTI). METHOD: Peripheral blood T cells were stained with fluorescence-labelled antibodies specific for intracellular cytokines IFN-gamma and IL-4 and cell surface markers CD3, CD4 and CD8, and were subjected to flow-cytometric analysis. RESULTS: Comparing peripheral blood lymphocytes of atopic asthma patients with those of recurrent infections we found significantly more cells positive for IL-4 in asthma patients than in recurrent infection patients, both in the CD3+ subsets (p<0.03) and CD4+ subset (p<0.01). We have also found that percentage of CD4+ was significantly lower (p<0.007) and percentage of CD8+ cells was significantly higher (p<0.05) in RRTI group comparing to atopic asthma patients. In AA group there was a significant increase intracellular expression of IL-4 among the CD3+ (p<0.03) and CD4+ (p<0.01) subsets and no significant differences among CD8+ subset. In AA group there was a significant decrease ratio of IFN-gamma/IL-4 among all of the evaluated subsets. CONCLUSION: Basing oneself on these results we conclude that markers of atopy are: increased intracellular expression of IL-4 among CD4+ cells and decreased IFN-gamma.


Assuntos
Asma/imunologia , Hiper-Reatividade Brônquica/imunologia , Espasmo Brônquico/imunologia , Interferon gama/sangue , Interleucina-4/sangue , Complexo CD3/sangue , Antígenos CD4/sangue , Antígenos CD8/sangue , Criança , Pré-Escolar , Feminino , Citometria de Fluxo/métodos , Humanos , Masculino , Estatísticas não Paramétricas
20.
Am J Vet Res ; 66(7): 1121-7, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16111148

RESUMO

OBJECTIVE: To compare the effects of an orally administered corticosteroid (prednisone), an inhaled corticosteroid (flunisolide), a leukotriene-receptor antagonist (zafirlukast), an antiserotonergic drug (cyproheptadine), and a control substance on the asthmatic phenotype in cats with experimentally induced asthma. ANIMALS: 6 cats with asthma experimentally induced by the use of Bermuda grass allergen (BGA). PROCEDURES: A randomized, crossover design was used to assess changes in the percentage of eosinophils in bronchoalveolar lavage fluid (BALF); airway hyperresponsiveness; blood lymphocyte phenotype determined by use of flow cytometry; and serum and BALF content of BGA-specific IgE, IgG, and IgA determined by use of ELISAs. RESULTS: Mean +/- SE eosinophil percentages in BALF when cats were administered prednisone (5.0 +/- 2.3%) and flunisolide (2.5 +/- 1.7%) were significantly lower than for the control treatment (33.7 +/- 11.1%). We did not detect significant differences in airway hyperresponsiveness or lymphocyte surface markers among treatments. Content of BGA-specific IgE in serum was significantly lower when cats were treated with prednisone (25.5 +/- 5.4%), compared with values for the control treatment (63.6 +/- 12.9%); no other significant differences were observed in content of BGA-specific immunoglobulins among treatments. CONCLUSIONS AND CLINICAL RELEVANCE: Orally administered and inhaled corticosteroids decreased eosinophilic inflammation in airways of cats with experimentally induced asthma. Only oral administration of prednisone decreased the content of BGA-specific IgE in serum; no other significant local or systemic immunologic effects were detected among treatments. Inhaled corticosteroids can be considered as an alternate method for decreasing airway inflammation in cats with asthma.


Assuntos
Antiasmáticos/uso terapêutico , Asma/veterinária , Espasmo Brônquico/veterinária , Doenças do Gato/tratamento farmacológico , Resistência das Vias Respiratórias/efeitos dos fármacos , Animais , Asma/tratamento farmacológico , Asma/imunologia , Espasmo Brônquico/tratamento farmacológico , Espasmo Brônquico/imunologia , Líquido da Lavagem Broncoalveolar/citologia , Doenças do Gato/imunologia , Gatos , Estudos Cross-Over , Ciproeptadina/uso terapêutico , Feminino , Fluocinolona Acetonida/análogos & derivados , Fluocinolona Acetonida/uso terapêutico , Imunoglobulina A/sangue , Imunoglobulina G/sangue , Indóis , Inflamação/tratamento farmacológico , Inflamação/veterinária , Masculino , Fenilcarbamatos , Prednisona/uso terapêutico , Terapia Respiratória/veterinária , Sulfonamidas , Compostos de Tosil/uso terapêutico
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...