RESUMO
Ethchlorvynol remains a drug that frequently surfaces in clinical emergency practice despite safer and more effective pharmaceutical agents on the market. Effects such as poisoning, dependence, ocular damage, and overdose continue to receive attention in the literature. Awareness of complications and treatment in ethchlorvynol exposure requires attention to a drug remaining clinically available without an appropriate clinical indication.
Assuntos
Overdose de Drogas/terapia , Emergências , Etclorvinol/efeitos adversos , Fenômenos Químicos , Química , Overdose de Drogas/diagnóstico , Overdose de Drogas/epidemiologia , Etclorvinol/farmacocinética , Etclorvinol/farmacologia , Hemoperfusão , Humanos , Intubação Gastrointestinal , Sucção , Estados Unidos/epidemiologiaRESUMO
Ethchlorvynol (Placidyl) is a nonbarbiturate sedative hypnotic. Two fatal cases of ethchlorvynol overdose are reported. Toxicological analyses of body fluids and tissues were performed by gas chromatography using a flame-ionization detector. The quantitative method was sensitive and reproducible. Body distribution of ethchlorvynol in blood and other tissues is presented. Biological samples analyzed included blood, urine, bile, liver, kidney, eye fluid, and gastric contents. Results presented add to the pharmacokinetic data needed to study the disposition of drugs in different tissues. Findings in present two cases are compared with published toxicological data.
