1.
Rev. méd. Chile
; 122(7): 737-45, jul. 1994. ilus
Artigo
em Espanhol
| LILACS
| ID: lil-136916
RESUMO
In order to clarify the blunting effect of peptides released by pepsin from blood plasma on ANP diuretic action, 2 prokinins designated PU-16 were tested. Both of them were able to inhibit in nanomolar doses the diuretic-saluretic action of 0.5 ug i.v. bolus of ANP given to anesthetized rats either by intravenous route or introduced in the duodenal lumen. PU-16 in doses of 0.5 ug and 1 ug were able to reduce in 72 and 96.5 per cent respectively the natriuresis induced bu 0.5 ug intravenous bolus of ANP. The data support the hypothesis that prokinins liberated in the digestive tract, could be physiological factors involved in hydrosaline homeostasis, moderating the ANP mediated increase of water, Na and K excretion during digestion
Assuntos
Animais , Ratos , Digestão/fisiologia , Sistema Digestório , Diurese/efeitos dos fármacos , Natriurese/fisiologia , Fator Natriurético Atrial/antagonistas & inibidores , Peptídeos/urina , Fator Natriurético Atrial/farmacocinética
2.
Medicina (B Aires)
; 47(2): 191-200, 1987.
Artigo
em Espanhol
| MEDLINE
| ID: mdl-2961971