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1.
J Cardiovasc Med (Hagerstown) ; 20(7): 419-426, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31593559

RESUMO

BACKGROUND AND AIM: Cardiovascular diseases (CVDs) are the most frequent causes of death in the world. Inflammation and oxidative damage contribute significantly to the development of atherosclerosis and CVDs. European Food Safety Authority scientific opinion has acknowledged that hydroxytyrosol (3,4-dihydroxyphenylethanol) and derivatives, contained in extra virgin olive oil (EVOO), typically used in Mediterranean diet may play a crucial role in the reduction of the inflammatory pathway and in the prevention of CVDs. The aim of the study was to determine the effect in healthy volunteers of 25 g of phenols-rich EVOO (p-EVOO). METHODS: The clinical study was a randomized, controlled trial to determine the acute effect in the postprandial time of 25 g of p-EVOO. We evaluated nutritional status using anthropometric parameters, body composition, serum metabolites, oxidative stress biomarkers and gene expression of eight genes related to oxidative stress and human inflammasome pathways, lasting 2 h after p-EVOO administration. Twenty-two participants resulted as eligible for the study. RESULTS: A significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index was highlighted (P < 0.05). Significant upregulation of catalase, superoxide dismutase 1 and upstream transcription factor 1 were observed (P < 0.05). CONCLUSION: The current study shows that intake of 25 g of p-EVOO has been able to be modulated, in the postprandial time, the antioxidant profile and the expression of inflammation and oxidative stress-related genes, as superoxide dismutase 1, upstream transcription factor 1 and catalase. We also observed a significant reduction of oxidized LDL, malondialdehyde, triglycerides and visceral adiposity index. We have demonstrated that a daily intake of phenols and antioxidants can reduce the inflammatory pathway and oxidative stress and therefore the risk of atherosclerosis and CVDs. More studies on a larger population are necessary before definitive conclusions can be drawn.Trial registration ClinicalTrials.gov NCT01890070.


Assuntos
Doenças Cardiovasculares/prevenção & controle , Lipoproteínas LDL/sangue , Nutrigenômica/métodos , Azeite de Oliva/metabolismo , Estresse Oxidativo/genética , Fenóis/sangue , Álcool Feniletílico/análogos & derivados , Adolescente , Adulto , Idoso , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/genética , Catalase/sangue , Catalase/genética , Dieta Saudável , Dieta Mediterrânea , Método Duplo-Cego , Feminino , Humanos , Mediadores da Inflamação/sangue , Masculino , Pessoa de Meia-Idade , Azeite de Oliva/administração & dosagem , Álcool Feniletílico/sangue , Período Pós-Prandial , Fatores de Proteção , Fatores de Risco , Cidade de Roma , Superóxido Dismutase-1/sangue , Superóxido Dismutase-1/genética , Fatores Estimuladores Upstream/sangue , Fatores Estimuladores Upstream/genética , Adulto Jovem
2.
J Lipid Res ; 48(1): 193-200, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17065663

RESUMO

Recently, the upstream stimulatory factor 1 gene (USF1) was proposed as a candidate gene for familial combined hyperlipidemia (FCH). In this study, we examined the previously identified risk haplotype of USF1 with respect to FCH and its related phenotypes in 36 Dutch FCH families. The diagnosis of FCH was based on both the traditional diagnostic criteria and a nomogram. The two polymorphisms, USF1s1 and USF1s2, were in complete linkage disequilibrium. No association was found for the individual single nucleotide polymorphisms (SNPs) with FCH defined by the nomogram (USF1s1, P = 0.53; USF1s2, P = 0.53), whereas suggestive associations were found when using the traditional diagnostic criteria for FCH (USF1s1, P = 0.08; USF1s2, P = 0.07). USF1 was associated with total cholesterol (USF1s1, P = 0.05; USF1s2, P = 0.04) and apolipoprotein B (USF1s1, P = 0.06; USF1s2, P = 0.04). Small dense LDL showed a suggestive association (USF1s1, P = 0.10; USF1s2, P = 0.09). The results from the haplotype analyses supported the results obtained for the individual SNPs. In conclusion, the previously identified risk haplotype of USF1 showed a suggestive association with FCH and contributed to the related lipid traits in our Dutch FCH families.


Assuntos
Hiperlipidemia Familiar Combinada/genética , Fatores Estimuladores Upstream/genética , Adulto , Apolipoproteínas B/sangue , Apolipoproteínas B/genética , Sequência de Bases , Primers do DNA , Feminino , Frequência do Gene , Humanos , Hiperlipidemia Familiar Combinada/sangue , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Países Baixos , Reação em Cadeia da Polimerase , Polimorfismo de Nucleotídeo Único , Estudos Retrospectivos , Fatores Estimuladores Upstream/sangue
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