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1.
Acta odontol. venez ; 52(3)2014. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-778007

RESUMO

El Osteoblastoma (OB) es un tumor benigno formador de tejido óseo de aparición muy rara en los maxilares. Su diagnóstico puede ser un gran reto para el patólogo bucal, ya que las características histopatológicas se asemejan a otros tumores más frecuentes en el macizo maxilofacial; por lo que es importante conocer a profundidad sus características clínicas, radiográficas e histopatológicas que nos conduzcan al diagnóstico asertivo de OB. Hasta los actuales momentos la última recopilación de casos de OB maxilares publicados en la literatura fue hecha por Morelos et al hasta el año 2011, quien obtuvo 88 casos. El objetivo de esta investigación fue realizar una revisión bibliográfica exhaustiva de casos documentados hasta la fecha en revisiones sistemáticas previas, obteniéndose 119 casos de OB maxilares. Adicionalmente, se aporta un caso más de OB de maxilar superior a la literatura académica...


Osteoblastoma is a rare bone-forming tumor that very rarely involves the jaws. The diagnosis should be very difficult to oral pathology expert because their histopathologic features are resembled with other bony tumors of the maxillofacial region. Therefore, is very important have depth knowledge about the clinical, radiographic and histopathologic features of OB, to make the correct diagnosis. Before this report, the last collection of maxillary OB cases was made by Morelos et al until the year 2011; they obtained 88 cases in their study. The main aim of this research was provide a systematic review of previously published cases; the result was 119 cases of maxillary OB. In addition, this paper added one more case of this rare lesion to the academic literature...


Assuntos
Humanos , Masculino , Adolescente , Adulto , Feminino , Criança , Adulto Jovem , Fibroma Ossificante/diagnóstico , Fibroma Ossificante/fisiopatologia , Osso e Ossos/anatomia & histologia , Osso e Ossos/patologia , Neoplasias do Seio Maxilar/fisiopatologia , Osteoblastoma/diagnóstico , Osteoblastoma/patologia , Neoplasias Ósseas , Neoplasias Bucais , Osteogênese , Patologia Bucal
2.
J Oral Sci ; 52(2): 329-32, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20587961

RESUMO

Juvenile ossifying fibroma (JOF) is an uncommon fibro-osseous lesion occurring in the facial bones. It has been recognised as a separate histopathological entity among the fibro-osseous group of lesions. Fibro-osseous lesions of the craniofacial bones are difficult to classify and treat however a common factor to all is the conversion of the bone to benign fibrous tissue with a varying degree of mineralised tissue. This case describes a 15 year old patient with a juvenile aggressive ossifying fibroma (JAOF) and an estimate of the rate of growth of such a rare lesion.


Assuntos
Fibroma Ossificante/patologia , Neoplasias Mandibulares/patologia , Adolescente , Biópsia , Fibroma Ossificante/fisiopatologia , Seguimentos , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Masculino , Neoplasias Mandibulares/fisiopatologia , Radiografia Panorâmica , Tomografia Computadorizada por Raios X/métodos , Recusa do Paciente ao Tratamento
4.
J Bone Miner Res ; 16(9): 1710-8, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11547842

RESUMO

We report an unusual generalized skeletal syndrome characterized by fibro-osseous lesions of the jawbones with a prominent psammomatoid body component, bone fragility, and bowing/sclerosis of tubular bones. The case fits with the emerging profile of a distinct syndrome with similarities to previously reported cases, some with an autosomal dominant inheritance and others sporadic. We suggest that the syndrome be named gnathodiaphyseal dysplasia. The patient had been diagnosed previously with polyostotic fibrous dysplasia (PFD) elsewhere, but further clinical evaluation, histopathological study, and mutation analysis excluded this diagnosis. In addition to providing a novel observation of an as yet poorly characterized syndrome, the case illustrates the need for stringent diagnostic criteria for FD. The jaw lesions showed fibro-osseous features with the histopathological characteristics of cemento-ossifying fibroma, psammomatoid variant. This case emphasizes that the boundaries between genuine GNAS1 mutation-positive FD and other fibro-osseous lesions occurring in the jawbones should be kept sharply defined, contrary to a prevailing tendency in the literature. A detailed pathological study revealed previously unreported features of cemento-ossifying fibroma, including the participation of myofibroblasts and the occurrence of psammomatoid bodies and aberrant mineralization, within the walls of blood vessels. Transplantation of stromal cells grown from the lesion into immunocompromised mice resulted in a close mimicry of the native lesion, including the sporadic formation of psammomatoid bodies, suggesting an intrinsic abnormality of bone-forming cells.


Assuntos
Síndrome de Camurati-Engelmann/patologia , Cementoma/patologia , Fibroma Ossificante/patologia , Displasia Fibrosa Poliostótica/patologia , Neoplasias Maxilomandibulares/patologia , Arcada Osseodentária/patologia , Animais , Síndrome de Camurati-Engelmann/diagnóstico por imagem , Síndrome de Camurati-Engelmann/genética , Síndrome de Camurati-Engelmann/fisiopatologia , Cementoma/diagnóstico por imagem , Cementoma/genética , Cementoma/fisiopatologia , Pré-Escolar , Análise Mutacional de DNA , Fibroma Ossificante/diagnóstico por imagem , Fibroma Ossificante/genética , Fibroma Ossificante/fisiopatologia , Displasia Fibrosa Poliostótica/diagnóstico por imagem , Displasia Fibrosa Poliostótica/genética , Displasia Fibrosa Poliostótica/fisiopatologia , Subunidades alfa Gs de Proteínas de Ligação ao GTP/genética , Humanos , Arcada Osseodentária/fisiopatologia , Neoplasias Maxilomandibulares/diagnóstico por imagem , Neoplasias Maxilomandibulares/genética , Neoplasias Maxilomandibulares/fisiopatologia , Masculino , Camundongos , Radiografia , Síndrome
5.
Pediatr Dent ; 23(3): 245-8, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11447957

RESUMO

PURPOSE: Reported clinicopathologic studies on the peripheral ossifying fibroma (POF), a reactive gingival lesion, have not addressed the pediatric population in specific detail. This study, the first devoted to children, investigated the clinical features of a large number of POFs and compared the findings to cases reported in the English language literature. METHODS: Detailed clinical and historical information of 134 surgically removed POFs in patients aged 1-19 formed the basis of this study. Clinical manifestations, histogenesis, treatment rationale with pediatric considerations, and biologic behavior were emphasized. RESULTS: The POF was found more frequently in females (60%). It had a predilection for the maxillary gingiva (60%) and for the incisor/cuspid region. The average patient age was 14 years. Only 2 (1%) POFs were found to be unequivocally associated with primary teeth. The clinician seldom included the POF in the differential diagnosis. The recurrence rate after surgical excision was 8%. CONCLUSIONS: This study revealed that a POF arising from the periodontal ligament of a primary tooth is most likely a rare event. However, the pediatric patient with a POF has special management considerations compared to the adult. Because of the POF behavior pattern, a proper treatment protocol is warranted with close postoperative follow-up.


Assuntos
Fibroma Ossificante/fisiopatologia , Neoplasias Gengivais/fisiopatologia , Adolescente , Adulto , Fatores Etários , Criança , Pré-Escolar , Dente Canino/patologia , Diagnóstico Diferencial , Feminino , Fibroma Ossificante/patologia , Fibroma Ossificante/cirurgia , Seguimentos , Neoplasias Gengivais/patologia , Neoplasias Gengivais/cirurgia , Humanos , Incisivo/patologia , Lactente , Louisiana , Masculino , Neoplasias Mandibulares/fisiopatologia , Neoplasias Maxilares/fisiopatologia , Recidiva Local de Neoplasia/patologia , Fatores Sexuais , Dente Decíduo/patologia
7.
Ophthalmic Plast Reconstr Surg ; 12(3): 174-7, 1996 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-8869972

RESUMO

Juvenile ossifying fibroma is an osseous tumor encased in a sclerotic shell. We report findings of juvenile ossifying fibroma in the orbit of a six-year-old boy. The bony aspects of this tumor may be suspected on physical examination. Magnetic resonance imaging was not helpful in the diagnosis of this fibroma. In fact, the technology was misleading because it did not define clearly the bony aspects of the tumor. In this case, the less costly computerized tomography revealed the bony encasement of the tumor and best defined the borders. With the trend in health care of cost containment, it may be that computerized tomography is the appropriate primary imaging study for some suspected orbital tumors based on thorough clinical examination.


Assuntos
Fibroma Ossificante/diagnóstico , Neoplasias Orbitárias/diagnóstico , Criança , Diagnóstico Diferencial , Fibroma Ossificante/fisiopatologia , Fibroma Ossificante/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Neoplasias Orbitárias/fisiopatologia , Neoplasias Orbitárias/cirurgia , Tomografia Computadorizada por Raios X , Acuidade Visual
8.
RPG rev. pos-grad ; 3(2): 161-7, abr.-jun. 1996. ilus, tab, graf
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-197592

RESUMO

Avaliaçäo da proliferaçäo celular através da análise quantitativa e morfométrica das regiöes organizadoras nucleolares (NORs) foi realizada em 10 casos de fibromas ossificantes periféricos e em 10 casos de fibromas ossificantes, com a finalidade de coletar informaçöes sobre essas duas entidades. Para a identificaçäo das NORs, realizamos a técnica da prata coloidal, conhecida como técnica do AgNOR. Com a análise dos parâmetros das NORs, verificamos, para ambas as lesöes que apresentam comportamento benigno; entretanto, essa própria análise demonstrou uma atividade proliferativa maior do fibroma ossificante em relaçäo ao fibroma ossificante periférico


Assuntos
Humanos , Feminino , Adolescente , Adulto , Fibroma Ossificante/fisiopatologia , Neoplasias Gengivais/diagnóstico , Neoplasias Maxilares/diagnóstico , Fibromatose Gengival/fisiopatologia , Lesões dos Tecidos Moles , Região Organizadora do Nucléolo
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