RESUMO
The proposed pathogenesis of Sydenham's chorea (SC) is an autoantibody-mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement-inactivated serum from SC patients was associated with a significant increase in Ca2+ levels evoked by KCl stimulus (mean +/- SEM, 341.0 +/- 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 +/- 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca2+ levels determined by SC patients sera correlated directly with the enzyme-linked immunosorbent assay optical density values for anti-basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction.
Assuntos
Cálcio/metabolismo , Coreia/sangue , Proteínas do Sistema Complemento/farmacologia , Líquido Intracelular/metabolismo , Células PC12/efeitos dos fármacos , Soro/metabolismo , Adolescente , Animais , Anticorpos/farmacologia , Gânglios da Base/imunologia , Criança , Coreia/imunologia , Ensaio de Imunoadsorção Enzimática/métodos , Feminino , Humanos , Microscopia Confocal/métodos , Cloreto de Potássio/farmacologia , RatosAssuntos
Criança , Humanos , Doenças Autoimunes do Sistema Nervoso/imunologia , Transtorno Obsessivo-Compulsivo/imunologia , Infecções Estreptocócicas/imunologia , Doenças Autoimunes do Sistema Nervoso/microbiologia , Gânglios da Base/imunologia , Western Blotting , Transtorno Obsessivo-Compulsivo/microbiologia , Infecções Estreptocócicas/complicações , Streptococcus pyogenes , Transtornos de Tique/tratamento farmacológico , Transtornos de Tique/microbiologiaRESUMO
Use of oral contraceptives is a recognised but infrequent cause of chorea. This type of chorea has usually been considered a reactivation of Sydenham's chorea by an unknown mechanism. A patient developed a chorea triggered by the use of oral contraceptives with no definite evidence of previous Sydenham's chorea or recent streptoccocal infections. However, the patient had positive anti-basal ganglia antibodies, which supports an immunological basis for the pathophysiology of this chorea.