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1.
Vet Pathol ; 61(1): 46-57, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-37358305

RESUMO

Neural stem cell (NSC) lineage cells have not been fully identified in feline brains, and the NSC-like nature of feline glial tumors has not been determined. In this study, 6 normal cat brains (3 newborn and 3 older cats) and 13 feline glial tumors were analyzed using immunohistochemical NSC lineage markers. The feline glial tumors were subjected to immunohistochemical scoring followed by hierarchical cluster analysis. In newborn brains, glial acidic fibrillary protein (GFAP)/nestin/sex-determining region Y-box transcription factor 2 (SOX2)-immunopositive NSCs, SOX2-immunopositive intermediate progenitor cells, oligodendrocyte transcription factor 2 (OLIG2)/platelet-derived growth factor receptor-α (PDGFR-α)-immunopositive oligodendrocyte precursor cells (OPCs), OLIG2/GFAP-immunopositive immature astrocytes, and neuronal nuclear (NeuN)/ß-3 tubulin-immunopositive mature neuronal cells were observed. The apical membrane of NSCs was also immunopositive for Na+/H+ exchanger regulatory factor 1 (NHERF1). In mature brains, the NSC lineage cells were similar to those of the newborn brains. A total of 13 glial tumors consisted of 2 oligodendrogliomas, 4 astrocytomas, 3 subependymomas, and 4 ependymomas. Astrocytomas, subependymomas, and ependymomas were immunopositive for GFAP, nestin, and SOX2. Subependymomas and ependymomas showed dot-like or apical membrane immunolabeling for NHERF1, respectively. Astrocytomas were immunopositive for OLIG2. Oligodendrogliomas and subependymomas were immunopositive for OLIG2 and PDGFR-α. Feline glial tumors also showed variable immunolabeling for ß-3 tubulin, NeuN, and synaptophysin. Based on these results, feline astrocytomas, subependymomas, and ependymomas appear to have an NSC-like immunophenotype. In addition, astrocytomas, subependymomas, and ependymomas have the characteristics of glial, oligodendrocyte precursor, and ependymal cells, respectively. Feline oligodendrogliomas likely have an OPC-like immunophenotype. In addition, feline glial tumors may have multipotential stemness for differentiation into neuronal cells. These preliminary results should be validated by gene expression analyses in future studies with larger case numbers.


Assuntos
Astrocitoma , Doenças do Gato , Ependimoma , Glioma Subependimal , Glioma , Células-Tronco Neurais , Oligodendroglioma , Gatos , Animais , Oligodendroglioma/patologia , Oligodendroglioma/veterinária , Nestina , Glioma Subependimal/metabolismo , Glioma Subependimal/patologia , Glioma Subependimal/veterinária , Tubulina (Proteína)/metabolismo , Glioma/patologia , Glioma/veterinária , Encéfalo/patologia , Astrocitoma/patologia , Astrocitoma/veterinária , Ependimoma/veterinária , Células-Tronco Neurais/metabolismo , Células-Tronco Neurais/patologia , Proteína Glial Fibrilar Ácida/metabolismo
2.
Vet Pathol ; 50(2): 243-51, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22798290

RESUMO

Ependymal tumors are reported rarely in domestic animals. The aims of this study were to examine the clinical and pathologic features of ventricular and extraventricular ependymomas and subependymomas in 18 domestic cats examined between 1978 and 2011. Parameters examined included age, sex, breed, clinical signs, and macroscopic and histopathologic features. The mean age of affected cats was 9 years, 4 months; median age, 8.5 years. There were 8 female and 4 male cats, and 6 cats for which sex was not recorded. Breeds included 10 domestic shorthaired, 2 domestic longhaired, 1 Persian, and 1 Siamese. Clinical signs included altered mentation or behavior, seizures, circling, propulsive gait, generalized discomfort, and loss of condition. The tumors often formed intraventricular masses and usually arose from the lining of the lateral or third ventricles, followed by the fourth ventricle, mesencephalic aqueduct, and spinal cord central canal. Three tumors were extraventricular, forming masses within the cerebrum and adjacent subarachnoid space. Histologically, 15 tumors were classified as variants of ependymomas (classic, papillary, tanycytic, or clear cell) and 3 as subependymomas. Tumors were generally well demarcated; however, 6 ependymomas focally or extensively infiltrated the adjacent neural parenchyma. Characteristic perivascular pseudorosettes were observed in all ependymomas; true rosettes were less common. Some tumors had areas of necrosis, mineralization, cholesterol clefts, and/or hemorrhage. This cohort study of feline ependymal tumors includes subependymoma and primary extraventricular ependymoma, variants not previously described in the veterinary literature but well recognized in humans.


Assuntos
Doenças do Gato/classificação , Doenças do Gato/patologia , Neoplasias do Ventrículo Cerebral/veterinária , Ependimoma/veterinária , Glioma Subependimal/veterinária , Fatores Etários , Animais , Gatos , Neoplasias do Ventrículo Cerebral/classificação , Neoplasias do Ventrículo Cerebral/patologia , Ependimoma/classificação , Ependimoma/patologia , Feminino , Glioma Subependimal/classificação , Glioma Subependimal/patologia , Técnicas Histológicas/veterinária , Imuno-Histoquímica/veterinária , Masculino , Fatores Sexuais
3.
J Zoo Wildl Med ; 43(3): 629-31, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23082530

RESUMO

A 1-day-old male giraffe calf (Giraffa camelopardalis) was submitted for necropsy examination after sustaining postnatal head trauma from the cow. In addition to the expected findings of severe cerebral edema and epidural and subarachnoid hemorrhage, there also was present an incidental finding of a subependymal glioneuronal aqueductal hamartoma. Reports of this type of congenital lesion are rare in the human literature, and the lesion has not, to the authors' knowledge, previously been reported in this or any other veterinary species.


Assuntos
Antílopes , Neoplasias Encefálicas/patologia , Glioma Subependimal/veterinária , Hamartoma/veterinária , Animais , Animais Recém-Nascidos , Traumatismos Craniocerebrais/patologia , Traumatismos Craniocerebrais/veterinária , Evolução Fatal , Glioma Subependimal/classificação , Glioma Subependimal/patologia , Hamartoma/classificação , Hamartoma/patologia , Masculino , Mesencéfalo/patologia
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