Prognostic factors among single primary gliosarcoma cases: A study using Surveillance, Epidemiology, and End Results data from 1973-2013.

BACKGROUND: Prognostic factors for single primary gliosarcoma (PGS) remain unknown. OBJECTIVE: The purpose of our study was to examine patient, tumor, and treatment characteristics as potential predictors of survival using Surveillance, Epidemiology, and End Results (SEER) program data (1973-2013). METHODS: The patients of single PGS were selected based on the exclusion criteria from SEER. Kaplan-Meier survival analysis, log-rank test and Cox proportional hazards models were used to analyze all the data. RESULTS: Single PGS has an apparent popularity for the temporal lobe (35.2%, hazard ratio [HR] = 0.440, 95%CI = 0.251-0.770) and frontal lobe (20.9%, HR = 0.408, 95%CI = 0.231-0.720) which could achieve a better survival rate than cerebrum (P = .034). The mean age at diagnosis was 60.07 ± 14.161. The overall 6-month, 1-year, 2-year, and 5-year survival was 55.40%, 29.58%, 10.01%, and 2.73%. Age at diagnosis was proved to be a significant predictor of overall survival (OS) (P < .001). There is no significant difference in race, marital status, or grade. Patients' tumor size which is located in 41-60 mm (P = .047, HR = 1.468, 95%CI = 1.004-2.147) and >60 mm (P= .003, HR = 1.899, 95%CI = 1.244-2.901) showed a higher risk of death. Surgery played a critical role in OS (P < .001). Radiation after surgery was another predictor of OS of PGS (P < .001). Among all the radiation methods, combination of beam with implants or isotopes (P = .000, HR = 0.491, 95%CI = 0.412-0.585) or radiation NOS (P = .027, HR = 0.362, 95%CI = 0.148-0.889) were more beneficial to patients. CONCLUSION: This study indicated that single PGS has a poor prognosis. Prognosis of single PGS would become poorer along with patients' age and tumor size (>40 mm). Surgery intervention and radiation therapy were beneficial factors.

Gliosarcoma intraventricular: reporte de un caso y revisión de la literatura / Intraventricular glicosarcoma: A case report and revision of literature

El gliosarcoma es una variante del glioblastoma multiforme. Es un tumor que se distingue por presentar un patrón bifásico con un componente glial de alto grado y otro mesenquimatoso. La teoría monoclonal es la más aceptada en la actualidad, planteándose que ambos componentes se originan de una sola célula precursora. Sus manifestaciones clínico-epidemiológicas y pronóstico son similares al del glioblastoma multiforme. El gliosarcoma intraventricular es una entidad rara que ha sido reportada en 5 casos en la bibliografía consultada. Nosotros presentamos el caso de una paciente de 29 años de edad con el diagnóstico histológico de esta patología. Nosotros discutimos el caso y revisamos la literatura(AU)

Glicosarcoma is a variation of multiform glioblastoma. It is a tumor characterized by a biphasic pattern with a glial component of high level and a mesenchimatous one. The monoclonal theory is mostly accepted nowadays, showing that both components are created from the main cell. The clinic- epidemiologic and prognosis manifestations are similar to the multiform glioblastoma. The intraventricular gliosarcoma is a weird entity that has been reported in five cases in the consulted bibliography. It was presented a 29 –year- old female patient with the histologic diagnosis of this pathology. We discussed the case and checked the literature(EU)