RESUMO
GH, PRL, LH, FSH and TSH were measured in serum and in cerebrospinal fluid (CSF) in 16 patients with chromophobe adenomas, in 8 with acromegaly and in 18 subjects with neurological diseases without endocrine troubles. Elevated mean GH and PRL levels in serum and in CSF were found in patients with chromophobe adenomas and with acromegaly. No constant correlation was observed between serum and CSF values. The highest hormonal levels in CSF were usually observed in adenomas with suprasellar extension, but this finding was inconstant. The determination of hormonal levels in CSF does not seem to supply any reliable information about the characteristics of pituitary tumors.
Assuntos
Adenoma Cromófobo/líquido cefalorraquidiano , Hormônio do Crescimento/metabolismo , Hormônios Hipofisários/líquido cefalorraquidiano , Neoplasias Hipofisárias/metabolismo , Prolactina/metabolismo , Acromegalia/líquido cefalorraquidiano , Adulto , Gonadotropinas Hipofisárias/líquido cefalorraquidiano , Hormônio do Crescimento/líquido cefalorraquidiano , Humanos , Pessoa de Meia-Idade , Prolactina/líquido cefalorraquidiano , Tireotropina/líquido cefalorraquidianoRESUMO
Plasma and cerebrospinal fluid (CSF) specimens were measured simultaneously for human chorionic gonadotropin (HCG) in two patients with HCG-secreting choriocarcinoma. In the patients with hypothalamic tumors, the CSF HCG levels were higher than the plasma HCG concentrations. In the patient with gestational choriocarcinoma with no known cerebral metastases, the plasma HCG level greatly exceeded the CSF HCG concentration. The finding of a CSF HCG concentration that approaches or exceeds the plasma value would be a useful screening procedure in localizing a pathologic source of HCG secretion in patients with a suspected hypothalamic tumor. An unexpected finding in the patient who also had a hypothalamic embryonal cell carcinoma and hypocortisolism was an extremely high concentration of a biologically inactive adrenocorticotropic like substance in the CSF.
