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2.
Skinmed ; 15(1): 73-75, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28270316

RESUMO

A 45-year-old farmer presented with ulcers and plaques over his scrotum for the past 4 to 5 years. The condition started as a small lesion on the shaft of the penis, which improved with treatment; however, after 2 to 3 months, papulonodular lesions developed on the scrotum, which increased in size and subsequently broke down to form ulcers. He denied drug abuse but had a history of multiple unprotected sexual exposures. He was prescribed oral antibiotics, which improved the lesions, but he failed to take the antibiotics for more than a week. He also used powders, lotions, and salves (exact nature not known), which did not help and sometimes even burned the skin. After stopping the medicine, he developed new lesions that followed a similar course. Examination revealed nontender ulcers on the scrotum with raised, rolled-out margins and pale red, granulation tissue that bled on touch (Figure 1). In addition, there were nodules with a pinkish red granular surface and scaly erythematous plaques on the scrotum. Regional lymph nodes were not enlarged.


Assuntos
Antibacterianos/uso terapêutico , Doença de Bowen/patologia , Granuloma Inguinal/patologia , Neoplasias Cutâneas/patologia , Biópsia por Agulha , Doença de Bowen/complicações , Doença de Bowen/diagnóstico , Fármacos Dermatológicos/uso terapêutico , Fazendeiros , Seguimentos , Granuloma Inguinal/complicações , Granuloma Inguinal/diagnóstico , Granuloma Inguinal/tratamento farmacológico , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Recidiva , Medição de Risco , Neoplasias Cutâneas/diagnóstico , Resultado do Tratamento
3.
Int J STD AIDS ; 28(4): 411-414, 2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-27535727

RESUMO

Donovanosis is a rare, chronic and indolent sexually transmitted infection caused by Klebsiella granulomatis. The ulcers in donovanosis rarely undergo malignant transformation, which is usually seen in longstanding ulcers. We present a case of a 32-year-old male who presented with a two-month history of rapidly progressive, large, foul-smelling ulcers over the groin, distal penile shaft and scrotum. Crushed tissue smears from ulcers revealed basophilic intracellular and extracellular Donovan bodies. Fine needle aspiration cytology from inguinal lymph nodes and biopsy from the ulcers revealed well-differentiated squamous cell carcinoma. The current case aims to alert clinicians that donovanosis is a rare but possible cause of cutaneous malignancy. Nonetheless, the pathogenesis of malignant transformation in donovanosis needs further research.


Assuntos
Carcinoma de Células Escamosas/diagnóstico por imagem , Doxiciclina/administração & dosagem , Granuloma Inguinal/diagnóstico por imagem , Granuloma Inguinal/diagnóstico , Úlcera/diagnóstico por imagem , Adulto , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Biópsia , Carcinoma de Células Escamosas/tratamento farmacológico , Carcinoma de Células Escamosas/patologia , Granuloma Inguinal/tratamento farmacológico , Granuloma Inguinal/patologia , Humanos , Masculino , Pênis/patologia , Úlcera/tratamento farmacológico , Úlcera/patologia
4.
Dermatol Online J ; 22(4)2016 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-27617463

RESUMO

Granuloma inguinale, or Donovanosis, is a rare, sexually transmitted ulcerative disease primarily affecting the genital area. In this report, we present a case of a 50-year-old man that was diagnosed with granuloma inguinale after a 2-month history of a penile ulcer. Histological analysis demonstrated the presence of Donovan bodies within macrophages, confirming the diagnosis. He was subsequently treated with trimethoprim/sulfamethoxazole with improvement in the ulcer. This case serves as a reminder to clinicians that although granuloma inguinale is rarely encountered in the US, it should still be suspected in patients with non-healing penile ulcers.


Assuntos
Granuloma Inguinal/patologia , Doenças do Pênis/patologia , Úlcera/patologia , Antibacterianos/uso terapêutico , Granuloma Inguinal/diagnóstico , Granuloma Inguinal/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Doenças do Pênis/diagnóstico , Doenças do Pênis/tratamento farmacológico , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico , Úlcera/diagnóstico , Úlcera/tratamento farmacológico
5.
Rev. esp. patol ; 48(4): 212-216, oct.-dic. 2015. ilus
Artigo em Espanhol | IBECS | ID: ibc-143511

RESUMO

El tumor fibrohistiocítico plexiforme (TFHP) es una rara neoplasia mesenquimal de malignidad intermedia, con alta tasa de recidiva local y potencial metastásico ganglionar o pulmonar. Suele afectar tejidos blandos superficiales de extremidades superiores de niños y adultos jóvenes, con predilección femenina. Presentamos el caso de un niño de 10 años con tumoración de crecimiento progresivo, dependiente del plano cutáneo en rodilla derecha con adenopatías inguinales ipsilaterales. Se le realiza resección amplia de la lesión con linfadenectomía inguinocrural. El estudio histopatológico reveló una neoplasia de patrón plexiforme con componente bifásico (células mononucleares tipo histiocitos asociado a células gigantes tipo osteoclasto, CD68 positivas y células fusiformes, actina de músculo liso positivas); favoreciendo el diagnóstico de esta entidad con metástasis ganglionar (AU)


Plexiform fibrohistiocytic tumour (TFHP) is a rare mesenchymal neoplasm of intermediate malignancy but with a high rate of local recurrence and potential for lymph node or pulmonary metastases. It usually affects superficial soft tissues of the upper extremities of children and young adults and is more frequent in females. We report a case of a 10 year old boy with progressive tumour growth, under the skin in the right knee with ipsilateral inguinal lymphadenopathy. He underwent wide resection of the lesion with inguinal lymphadenectomy. Histopathology revealed a plexiform pattern with a biphasic component (mononuclear histiocytic cells associated with CD68 positive osteoclast-like giant cells and smooth muscle actin-positive spindle cells); favoring the diagnosis of TFHP with lymph node metastasis (AU)


Assuntos
Criança , Humanos , Masculino , Neurofibroma Plexiforme/cirurgia , Neurofibroma Plexiforme , Condrossarcoma Mesenquimal/complicações , Joelho/patologia , Joelho , Articulação do Joelho/patologia , Diagnóstico Diferencial , Neoplasias de Tecidos Moles/complicações , Neoplasias de Tecidos Moles/patologia , Granuloma Inguinal/complicações , Granuloma Inguinal/patologia , Canal Inguinal/patologia , Tumores Fibrosos Solitários/complicações , Tumores Fibrosos Solitários/patologia , Imageamento por Ressonância Magnética , Espectroscopia de Ressonância Magnética/métodos , Imuno-Histoquímica/métodos
6.
Int J STD AIDS ; 25(12): 894-7, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24554002

RESUMO

Donovanosis causes granulomatous ulceration of genitalia and neighbouring sites with little tendency to heal spontaneously. It is uncommonly seen nowadays in sexually transmitted infection clinics of north India. The present case is reported for its scarcity and to make clinicians aware of this disease which may rarely accompany carcinoma.


Assuntos
Carcinoma de Células Escamosas/complicações , Granuloma Inguinal/complicações , Antibacterianos/uso terapêutico , Biópsia , Carcinoma de Células Escamosas/patologia , Granuloma Inguinal/microbiologia , Granuloma Inguinal/patologia , Granuloma Inguinal/terapia , Humanos , Klebsiella/isolamento & purificação , Infecções por Klebsiella/diagnóstico , Infecções por Klebsiella/tratamento farmacológico , Pessoa de Meia-Idade , Úlcera Cutânea/etiologia , Resultado do Tratamento
7.
Am J Dermatopathol ; 34(8): 818-21, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23169417

RESUMO

Two infants, 6 months and 4 months of age, presented with bilateral or unilateral external auditory canal polyps and otorrhea, respectively. Additional findings on examination included otitis media and mastoiditis. Tympanic membrane perforation was noted in one patient and a postauricular abscess in the other. Incisional biopsies of the polyps and abscess were reported as nonspecific mixed inflammation and abscess wall, respectively. There was a limited response to an empirical 5-day course of trimethoprim sulfamethoxazole. The children were referred to the academic hospital, and excision of the polyps and biopsies of the middle ear, mastoid, and postauricular abscess was undertaken. All the biopsies demonstrated donovanosis. Reappraisal of the initial incisional biopsies also confirmed donovanosis. Trimethoprim sulfamethoxazole was administered to both patients for 3 weeks, with resolution of the lesions. Subsequent investigations confirmed genital tract donovanosis, human immunodeficiency virus seropositivity, acquired immunodeficiency syndrome, and pulmonary tuberculosis in both mothers. Heightened awareness of the occurrence of donovanosis at unusual sites and improved recognition of the histomorphological features of the disease, especially in small and superficial biopsies, are pivotal not only for its correct diagnosis in extragenital cutaneous and extracutaneous locations but also for timely and adequate therapy and an improved infant and maternal outcome.


Assuntos
Meato Acústico Externo/patologia , Otopatias/patologia , Granuloma Inguinal/patologia , Transmissão Vertical de Doenças Infecciosas , Pólipos/patologia , Anti-Infecciosos/uso terapêutico , Otopatias/tratamento farmacológico , Otopatias/etiologia , Feminino , Granuloma Inguinal/tratamento farmacológico , Granuloma Inguinal/etiologia , Humanos , Lactente , Masculino , Pólipos/tratamento farmacológico , Pólipos/etiologia
8.
Int J STD AIDS ; 23(11): 835-6, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23155109

RESUMO

Genital elephantiasis is a disease that is characterized by massive enlargement of the genitalia. Early aetiological diagnosis is of paramount importance so that development of genital elephantiasis can be prevented; otherwise it is not completely reversible with medical therapy and often requires surgical intervention. Chronic mental distress and disability can result as it interferes with daily/routine activities of the affected individual. Over time, the infectious causes of genital elephantiasis have evolved, from syphilis in the pre-penicillin era to donovanosis, lymphogranuloma venereum and recently filariasis, tuberculosis, leishmaniasis, HIV and chromoblastomycosis. With a declining prevalence globally, donovanosis is at risk of being forgotten as a cause of genital swelling; however, it is known to persist for years without treatment and can lead to complications such as lymphoedema and genital mutilation. We herein present a case of genital elephantiasis that was eventually diagnosed as being due to donovanosis.


Assuntos
Elefantíase/patologia , Genitália Masculina/patologia , Granuloma Inguinal/complicações , Granuloma Inguinal/patologia , Adulto , Histocitoquímica , Humanos , Masculino , Microscopia
9.
Intern Med ; 51(17): 2479-81, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22975572

RESUMO

A 46-year-old man complained of ulcerovegetative lesions in the anogenital region, which he had noted one month prior to presentation. The patient had a history of travel to African countries. Therefore, the ulcerovegetative lesions of the patient were suspected to be granuloma inguinale (GI). Calymmatobacterium granulomatis was not observed in the direct examination of scrapings collected from the base of the ulcerovegetative lesion. Instead, a histological examination revealed cutaneous metastasis of mucinous adenocarcinoma of the rectum. Therefore, a diagnosis of GI was eliminated. As the patient did not report his history of rectal cancer and had travelled to African countries, we had primarily focused on the diagnosis of GI.


Assuntos
Adenocarcinoma/diagnóstico , Adenocarcinoma/secundário , Granuloma Inguinal/diagnóstico , Neoplasias Retais/diagnóstico , Neoplasias Retais/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/secundário , África , Calymmatobacterium , Quimioterapia Adjuvante , Colostomia , Diagnóstico Diferencial , Granuloma Inguinal/microbiologia , Granuloma Inguinal/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Retais/cirurgia , Pele/microbiologia , Pele/patologia , Recusa do Paciente ao Tratamento
10.
Rev. esp. patol ; 45(2): 122-124, abr.-jun. 2012. ilus
Artigo em Espanhol | IBECS | ID: ibc-99814

RESUMO

Presentamos en nuestro trabajo un hibernoma localizado en la región inguinal, diagnosticado en un varón de 64 años. Elementos clave para el diagnóstico fueron la identificación del tejido graso pardo y la ausencia de lipoblastos, lo que nos permitió descartar la posibilidad de un liposarcoma. Los estudios inmunohistoquímicos y citogenéticos apoyaron nuestra sospecha diagnostica(AU)


A case of hibernoma located in the inguinal region in a 64 year old male is presented. The identification of brown adipose tissue and the absence of lipoblasts were the most important diagnostic features, essential in the differential diagnosis with liposarcoma. Immunohistochemistry and cytogenetics confirmed the diagnosis of a hibernoma(AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Lipoma/diagnóstico , Lipoma/patologia , Neoplasias Lipomatosas/diagnóstico , Neoplasias Lipomatosas/patologia , Granuloma Inguinal/diagnóstico , Granuloma Inguinal/patologia , Tecido Adiposo/anatomia & histologia , Tecido Adiposo/patologia , Tecido Adiposo/ultraestrutura , Neoplasias Lipomatosas
11.
An Bras Dermatol ; 86(3): 585-6, 2011.
Artigo em Inglês, Português | MEDLINE | ID: mdl-21738983

RESUMO

The authors present images of two of the most common clinical forms of granuloma inguinale (donovanosis) in males and females. Donovanosis is considered a sexually transmitted disease that is endemic in tropical and subtropical regions of the world. Two microscopic images are also shown, one of a direct smear (the presence of Donovan bodies within large mononuclear cells identified using Giemsa stain) and the other of typical histological findings (rod-shaped Donovan bodies within a mononuclear histiocyte).


Assuntos
Calymmatobacterium , Granuloma Inguinal/patologia , Corantes Azur , Feminino , Humanos , Masculino , Coloração e Rotulagem
12.
An. bras. dermatol ; 86(3): 585-586, maio-jun. 2011. ilus
Artigo em Português | LILACS | ID: lil-592159

RESUMO

Os autores apresentam imagens de duas formas clínicas mais frequentes da Donovanose, em ambos sexos. A donovanose é considerada uma doença sexualmente transmissível, endêmica nas regiões tropicais e semitropicais do globo. Apresentam também imagens de duas lâminas: uma da pesquisa direta (corpúsculos de Donovan, dentro de grandes células mononucleadas coradas de vermelho pelo Giemsa) e outra de achados histológicos típicos (formato de alfinete dentro do histiócito).


The authors present images of two of the most common clinical forms of granuloma inguinale (donovanosis) in males and females. Donovanosis is considered a sexually transmitted disease that is endemic in tropical and subtropical regions of the world. Two microscopic images are also shown, one of a direct smear (the presence of Donovan bodies within large mononuclear cells identified using Giemsa stain) and the other of typical histological findings (rod-shaped Donovan bodies within a mononuclear histiocyte).


Assuntos
Feminino , Humanos , Masculino , Calymmatobacterium , Granuloma Inguinal/patologia , Corantes Azur , Coloração e Rotulagem
13.
Int J STD AIDS ; 21(9): 609-10, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21097731

RESUMO

Donovanosis is a rare sexually transmitted infection now mainly seen in sporadic cases in Papua New Guinea, South Africa, India, Brazil and Australia. The causative organism is Calymmatobacterium granulomatis though a proposal has been put forward that the organism be reclassified as Klebsiella granulomatis comb. nov. The incubation period is approximately 50 days with genital papules developing into ulcers that increase in size. Four types of lesions are described - ulcerogranulomatous, hypertrophic, necrotic and sclerotic. The diagnosis is usually confirmed by microscopic identification of characteristic Donovan bodies on stained tissue smears. More recently, polymerase chain reaction (PCR) methods have been developed. The recommended treatment is azithromycin 1 g weekly until complete healing is achieved.


Assuntos
Calymmatobacterium/isolamento & purificação , Granuloma Inguinal/diagnóstico , Granuloma Inguinal/tratamento farmacológico , Antibacterianos/administração & dosagem , Azitromicina/administração & dosagem , Europa (Continente) , Granuloma Inguinal/patologia , Histocitoquímica , Microscopia , Reação em Cadeia da Polimerase
14.
Dermatol Online J ; 14(9): 8, 2008 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-19061590
19.
West Indian Med J ; 51(3): 194-6, 2002 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12501553

RESUMO

Donovanosis is a sexually transmitted infection which presents with genital ulceration and inguinal lymphadenopathy. Rarely, it presents with extra-genital manifestations. We present a case of disseminated donovanosis with cervical ulceration, massive pelvic lymphadenopathy, osteomyelitis of the wrists and septic arthritis of the knees and right elbow. A 23-year-old gravida two presented with wasting, oedema, ascites, bilateral iliac lymphadenopathy, anaemia and a large ulcer of the cervix uteri. Two months later in the outpatient clinic, she was much improved but still had post-coital bleeding and a hyperaemic cervix, suggestive of persistent infection. The course of antibiotics was therefore repeated. Histopathological examination of a specimen from colposcopic biopsy of the cervix uteri revealed granuloma inguinale. She improved after several courses of antibiotics, blood transfusion, surgical débridement and aspiration of affected joints.


Assuntos
Ossos do Carpo/diagnóstico por imagem , Granuloma Inguinal/diagnóstico , Osteomielite/diagnóstico , Adulto , Feminino , Granuloma Inguinal/complicações , Granuloma Inguinal/patologia , Humanos , Osteomielite/diagnóstico por imagem , Osteomielite/etiologia , Radiografia
20.
Int J STD AIDS ; 13(12): 855-6, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12537743

RESUMO

A 23-year-old male presented with oral ulcers. Tissue smear showed Donovan bodies. The patient was treated with oral tetracycline.


Assuntos
Granuloma Inguinal/patologia , Doenças da Boca/microbiologia , Doenças da Boca/patologia , Adulto , Antibacterianos/uso terapêutico , Eunuquismo , Granuloma Inguinal/tratamento farmacológico , Humanos , Masculino , Doenças da Boca/tratamento farmacológico , Tetraciclina/uso terapêutico
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