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1.
J Egypt Natl Canc Inst ; 32(1): 26, 2020 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-32488371

RESUMO

BACKGROUND: Inflammatory myofibroblastic tumor (IMT) is a mesenchymal tumor mainly found in lung or retroperitoneum and rarely affects head and neck region. Extensive English literature search reveals that less than fifty cases of head and neck IMT have been reported so far, maxillary sinus being fewer. CASE PRESENTATION: We present a case of IMT involving maxillary sinus in a 48-year-old gentleman who attained complete clinico-radiologic response after treatment with radiotherapy (RT) and concurrent oral prednisolone. CONCLUSIONS: This is the first report where such magnificent response was attained in primary setting treated with RT and steroids as opposed to surgery which used to be considered as standard of care till now.


Assuntos
Granuloma de Células Plasmáticas/terapia , Seio Maxilar/patologia , Doenças dos Seios Paranasais/terapia , Prednisolona/uso terapêutico , Terapia Combinada , Granuloma de Células Plasmáticas/diagnóstico por imagem , Granuloma de Células Plasmáticas/radioterapia , Humanos , Masculino , Pessoa de Meia-Idade , Doenças dos Seios Paranasais/diagnóstico por imagem , Doenças dos Seios Paranasais/radioterapia
2.
Am J Otolaryngol ; 34(3): 252-4, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23369511

RESUMO

Inflammatory pseudotumor of the nasopharynx is a rare diagnosis that is often misinterpreted as carcinoma or lymphoma. It has been referred to as a tumefactive fibroinflammatory lesion, idiopathic pseudotumor, and fibrosing inflammatory pseudotumor. We present a rare case of a 40-year-old African American female from Kenya with inflammatory pseudotumor of the nasopharynx with perineural spread of disease along the trigeminal nerve to discuss the diagnosis and treatment of such an uncommon entity.


Assuntos
Granuloma de Células Plasmáticas/patologia , Doenças Nasofaríngeas/patologia , Nervo Trigêmeo/patologia , Adulto , Anti-Inflamatórios/administração & dosagem , Seio Cavernoso/patologia , Feminino , Forame Oval/patologia , Granuloma de Células Plasmáticas/tratamento farmacológico , Granuloma de Células Plasmáticas/radioterapia , Humanos , Imageamento por Ressonância Magnética , Doenças Nasofaríngeas/tratamento farmacológico , Doenças Nasofaríngeas/radioterapia , Prednisona/administração & dosagem , Dosagem Radioterapêutica
3.
Coll Antropol ; 36 Suppl 2: 143-6, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23397774

RESUMO

We present a case of inflammatory pseudotumor (IPT) presenting as a facial swelling after an accidental hit on a right side of a face. As swelling did not resolve, dental examination and teeth extraction were done by a dentist presuming the swelling was misdiagnosed with infection of dental origin. Swelling grew even bigger and patient was referred to Department of Maxillofacial Surgery. CT scan of the face and FNA of the lesion was ordered. A homogenous tumor mass in the right infraorbital region in front of anterior wall of the maxillary sinus was seen on CT The result of the FNA was reactive hyperplasia of the lymph node. Since the lesion was easily accessible surgical exploration and complete extirpation was done. Pathohistological analysis indicated a low grade B-cell Non Hodgkin lymphoma. PCR showed policlonality of B cells discarding the diagnosis of lymphoma. Pathohistological review showed diffuse intramuscular, perineural and perivascular infiltration with small lymphocytes without formation of germinative centers. Imunohistochemistry was positive for CD20 and CD3. Taking into account all features the diagnosis of IPT was established. Diagnosis of IPT is a diagnosis by exclusion, combining clinical, radiological and pathohistological characteristics. Lack of clear histologic criteria makes differential diagnosis extremely difficult. Our case is unique regarding localisation of head & neck IPT no case presenting on the face in infraorbital region has been described in the literature. Although IPT is very rare in general and especially on the face, one should be aware of it when considering differential diagnosis of facial swelling.


Assuntos
Edema/diagnóstico , Face , Granuloma de Células Plasmáticas/diagnóstico , Diagnóstico Diferencial , Granuloma de Células Plasmáticas/patologia , Granuloma de Células Plasmáticas/radioterapia , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Tomografia Computadorizada por Raios X
4.
Artigo em Inglês | MEDLINE | ID: mdl-21701246

RESUMO

Radiation-induced sarcoma usually develops after an interval of more than 10 years from the completion of radiation therapy to the diagnosis of secondary sarcoma. However, the theory of radiation-induced transformation does not rule out postirradiation sarcomas with a short latency period. We experienced the case of a patient with postirradiation leiomyosarcoma of the tongue, which occurred 19 months after he had received chemoradiotherapy. Besides the short latency period, a pseudotumor stage developed between the time of radiation exposure and the development of leiomyosarcoma. In this article, we also describe an immunohistochemical approach to diagnose leiomyosarcoma and the efficacy of a gemcitabine and docetaxel regimen.


Assuntos
Granuloma de Células Plasmáticas/radioterapia , Neoplasias Induzidas por Radiação/etiologia , Sarcoma/etiologia , Neoplasias da Língua/etiologia , Biópsia , Diagnóstico Diferencial , Granuloma de Células Plasmáticas/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Induzidas por Radiação/diagnóstico , Sarcoma/diagnóstico , Fatores de Tempo , Doenças da Língua/patologia , Doenças da Língua/radioterapia , Neoplasias da Língua/diagnóstico
5.
Tumori ; 96(2): 322-6, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20572593

RESUMO

Mediastinal inflammatory pseudotumor is a rare disease with reactive pseudoneo-plastic features and a proven capacity for local invasion. The radiographic appearance of inflammatory pseudotumor is quite non-specific and the definitive diagnosis is based on the histological evaluation of tissue specimens. Resection of the lesion is the treatment of choice. However, nonsurgical treatments such as radiotherapy and steroids have been employed in the setting of incomplete surgical resection, tumor recurrence, and patients being unfit for surgery. The case described here is being reported because of the rare mediastinal location and atypical treatment approach including salvage irradiation and monitoring with FDG-PET/CT. Because of the irregular target volume inside the mediastinum as defined by FDG-PET/CT and the significant pulmonary comorbidity, it was deemed necessary to optimize dose delivery with intensity-modulated radiation therapy (IMRT). A possible gain by means of daily control of patient setup with image-guided radiation therapy was also hypothesized and we used tomotherapy to irradiate the lesion. The first FDG-PET/CT after treatment confirmed further reduction of the metabolic activity followed by stable disease in the mediastinum, with no new occurrence of disease 16, 24 and 30 months after tomotherapy.


Assuntos
Fluordesoxiglucose F18 , Granuloma de Células Plasmáticas/radioterapia , Neoplasias do Mediastino/radioterapia , Tomografia por Emissão de Pósitrons/métodos , Compostos Radiofarmacêuticos , Tomografia Computadorizada por Raios X/métodos , Adulto , Humanos , Neoplasias do Mediastino/diagnóstico por imagem
6.
Surg Neurol ; 72(6): 712-6; discussion 716, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19608242

RESUMO

BACKGROUND: Intracranial inflammatory pseudotumors are rare. This study describes an intracranial inflammatory pseudotumor at the left cerebellopontine angle. It is the second documented posterior fossa intracranial inflammatory pseudotumor, and it was treated by surgery and radiotherapy. CASE DESCRIPTION: A 49-year-old man presented with dizziness for 3 months and mild hoarseness for 1 month. Brain CT detected an intracranial tumor at the left cerebellopontine angle. Magnetic resonance imaging revealed a 3.6-cm heterogeneously enhancing mass. Suboccipital craniectomy with ventriculostomy was performed. The mass was well defined with a smooth surface, enclosed the low cranial nerves, and adhered to the dura matter. Pathologic examination revealed fibrous collagenous stroma with dense infiltrates of small lymphocytes and uninucleated histiocytes. Immunopositivity for T-200 and CD-68 was noted. Special staining for mycobacteria and fungus was negative. Serologic tests were positive for EBEA-Ab, EBNA-Ab, and EB-VCA-IgG. An inflammatory pseudotumor was diagnosed. Local recurrence was found 6 months later with a left oculomotor nerve palsy. Whole-brain irradiation with a total dose of 1200 cGy in 6 fractionations was done. Remission was found in follow-up neuroimages, and no recurrence was noted in 2 years' follow-up. CONCLUSION: Based on serologic findings and a literature review, the pathogenetic mechanism of this rare intracranial tumor is believed to be chronic reactive EBV infection. We propose that radiotherapy may be the best treatment option in the case of local recurrent intracranial inflammatory pseudotumors.


Assuntos
Doenças Cerebelares/cirurgia , Ângulo Cerebelopontino/cirurgia , Granuloma de Células Plasmáticas/cirurgia , Doenças Cerebelares/diagnóstico , Doenças Cerebelares/patologia , Doenças Cerebelares/radioterapia , Ângulo Cerebelopontino/patologia , Terapia Combinada , Irradiação Craniana , Craniotomia , Fracionamento da Dose de Radiação , Seguimentos , Granuloma de Células Plasmáticas/diagnóstico , Granuloma de Células Plasmáticas/patologia , Granuloma de Células Plasmáticas/radioterapia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Recidiva , Tomografia Computadorizada por Raios X , Ventriculostomia
7.
Acta Otolaryngol ; 129(1): 108-12, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18607979

RESUMO

CONCLUSION: In this report we review the diagnosis, therapy, and outcome of laryngeal non-epithelial tumors and comment on the literature on these rare lesions. OBJECTIVES: Non-epithelial tumors of the larynx are rather rare and most cases have been reported as isolated or short series of cases from different centers all over the world. The aim of the present study was to review the 10-year experience with non-epithelial lesions in a 400-bed tertiary hospital covering a population of almost 250 000 people in Madrid, Spain. PATIENTS AND METHODS: We reviewed 2631 laryngeal samples corresponding to this time period. RESULTS: In all, 737 corresponded to carcinomas (726 squamous cell carcinomas). We had two cases of chondrosarcoma, one case of liposarcoma, one case of synovial sarcoma, and one neural benign tumor, suggestive of neurinoma. In this period we also had an inflammatory pseudotumor affecting the vocal cord, a case of primary laryngeal extramedullary plasmocytoma, and one case of high grade diffuse malignant lymphoma with exclusive involvement of the larynx. In our series most patients were women (five vs three patients) and ages ranged between 12 and 92 years.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Neoplasias Laríngeas/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/radioterapia , Criança , Condrossarcoma/patologia , Condrossarcoma/radioterapia , Condrossarcoma/cirurgia , Feminino , Granuloma de Células Plasmáticas/patologia , Granuloma de Células Plasmáticas/radioterapia , Granuloma de Células Plasmáticas/cirurgia , Humanos , Neoplasias Laríngeas/patologia , Neoplasias Laríngeas/radioterapia , Lipossarcoma/patologia , Lipossarcoma/radioterapia , Lipossarcoma/cirurgia , Linfoma não Hodgkin/patologia , Linfoma não Hodgkin/radioterapia , Linfoma não Hodgkin/cirurgia , Masculino , Pessoa de Meia-Idade , Neurilemoma/patologia , Neurilemoma/radioterapia , Neurilemoma/cirurgia , Plasmocitoma/patologia , Plasmocitoma/radioterapia , Plasmocitoma/cirurgia , Estudos Retrospectivos , Sarcoma Sinovial/patologia , Sarcoma Sinovial/radioterapia , Sarcoma Sinovial/cirurgia , Espanha , Prega Vocal/patologia , Prega Vocal/cirurgia , Adulto Jovem
8.
Otolaryngol Head Neck Surg ; 135(1): 144-8, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16815200

RESUMO

OBJECTIVE: To evaluate the response to steroid and radiation therapy in inflammatory pseudotumor (IPT) involving the skull base. STUDY DESIGN AND SETTING: Eight patients with IPT of the skull base were evaluated. Six patients were diabetic. All patients underwent initial high-dose steroid therapy. Seven of 8 patients underwent subsequent low-dose steroid maintenance. Additional low-dose radiation therapy was performed in 6 patients. We reviewed the medical records and radiologic findings of the patients to evaluate their responses to the steroid and radiation therapy. RESULTS: In all patients, the initial response to steroid therapy was fair. However, 7 patients showed symptom recurrence after cessation of steroid therapy. In 5 of 6 patients, low-dose radiation therapy resulted in recurrence. On follow-up MRI, none of the patients showed complete remission of the disease. CONCLUSION: This study shows aggressive clinical behavior of IPT involving the skull base and its poor response to steroid therapy and low-dose radiation therapy. For improving control, more aggressive initial efforts including high-dose radiation therapy with or without concurrent steroid therapy might play a role. EBM RATING: C-4.


Assuntos
Glucocorticoides/uso terapêutico , Granuloma de Células Plasmáticas/tratamento farmacológico , Granuloma de Células Plasmáticas/radioterapia , Prednisolona/uso terapêutico , Neoplasias da Base do Crânio/tratamento farmacológico , Neoplasias da Base do Crânio/radioterapia , Idoso , Relação Dose-Resposta a Droga , Feminino , Seguimentos , Glucocorticoides/administração & dosagem , Granuloma de Células Plasmáticas/diagnóstico , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Prednisolona/administração & dosagem , Estudos Retrospectivos , Neoplasias da Base do Crânio/diagnóstico , Resultado do Tratamento
9.
Ai Zheng ; 25(3): 348-51, 2006 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-16536992

RESUMO

BACKGROUND & OBJECTIVE: Lung carcinoma, pulmonary tuberculoma, and inflammatory pesudotumor are the most common solitary pulmonary nodules (SPN). Computed tomography (CT) is the major diagnostic examination of them. Most recent reports focused on their morphologic features on CT. The differential diagnoses are still difficult. This study was to explore their imaging features on helical incremental dynamic CT scan according to the differences of their hematal supply, and get more information for the diagnosis and differential diagnosis. METHODS: Incremental dynamic CT scan was performed on 115 cases of solitary pulmonary nodule. Of the 44 cases proved by postoperative pathology, 30 were lung carcinoma, 7 were pulmonary tuberculoma, and 7 were inflammatory pesudotumor. RESULTS: Of the 30 cases of lung carcinoma, 7 were mildly enhanced, 14 were moderately enhanced, 5 were highly enhanced, 2 were remarkably enhanced, and 7 were not enhanced; 9 had peak enhancement began at 18-28 s after injection, 17 began at 30-39 s, and 4 began at 40-44 s, with an average time of 32 s. Of the 7 cases of tuberculoma, 5 were not enhanced, and 2 were cricoid enhanced. All the 7 cases of inflammatory pesudotumor were remarkably enhanced, with the peak enhancement value of over 100 Hu in all cases; the peak enhancements began at 26 s, 28 s, 30 s, 32 s, 33 s, 110 s, and 122 s, respectively, after injection. CONCLUSION: Helical incremental dynamic CT is helpful in differential diagnoses of lung carcinoma, pulmonary tuberculoma, and inflammatory pesudotumor.


Assuntos
Granuloma de Células Plasmáticas/radioterapia , Neoplasias Pulmonares/diagnóstico por imagem , Tomografia Computadorizada Espiral/métodos , Tuberculoma/radioterapia , Tuberculose Pulmonar/diagnóstico por imagem , Adulto , Idoso , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Intensificação de Imagem Radiográfica
10.
J Neurosurg ; 104(1): 143-6, 2006 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16509158

RESUMO

Relapsing polychondritis (RP) is a rare systemic disease characterized by recurrent inflammation of the cartilaginous structures and connective tissue. Central nervous system lesions in association with RP have occasionally been reported, but intracranial mass lesions have not been described. The authors report the first such case, in which a 51-year-old man presented with parasagittal meningeal plasma cell granuloma with RP. The mass was subtotally resected and adjuvant radiotherapy was administered. The patient did not experience any recurrence of the lesion during an 8-year follow-up period. In this case, the exact diagnosis of RP was made based on symptoms of respiratory tract chondritis, which was successfully treated by the placement of tracheobronchial stents.


Assuntos
Granuloma de Células Plasmáticas/complicações , Granuloma de Células Plasmáticas/cirurgia , Neoplasias Meníngeas/complicações , Neoplasias Meníngeas/cirurgia , Policondrite Recidivante/etiologia , Granuloma de Células Plasmáticas/radioterapia , Humanos , Masculino , Neoplasias Meníngeas/radioterapia , Pessoa de Meia-Idade , Policondrite Recidivante/patologia , Stents
11.
Arch Pathol Lab Med ; 127(4): e220-3, 2003 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-12683907

RESUMO

We present an unusual case of intracranial plasma cell granuloma in a 70-year-old man with a 6-month history of progressive visual disturbance. The lesion extensively involved the cranial base, extended into the frontal region, and reached the floor of the third ventricle in the suprasellar area. Microscopic examination of multiple diagnostic transsphenoidal biopsies showed an inflammatory proliferation with a predominance of cells that were immunohistochemically determined to be polyclonal plasma cells. Ultrastructural analysis confirmed the presence of numerous mature plasma cells in a mixed inflammatory proliferation. In situ hybridization for Epstein-Barr viral RNA revealed no evidence of viral expression. The patient was treated with steroid therapy and radiotherapy, without any appreciable reduction of the lesion's size. He is alive with persistent severe visual disturbance 14 months after the diagnosis. We discuss the etiopathogenetic, diagnostic, and therapeutic issues related to this entity, and review the literature.


Assuntos
Neoplasias Encefálicas/diagnóstico , Lobo Frontal/patologia , Granuloma de Células Plasmáticas/diagnóstico , Neoplasias da Base do Crânio/diagnóstico , Idoso , Neoplasias Encefálicas/tratamento farmacológico , Neoplasias Encefálicas/radioterapia , Lobo Frontal/efeitos dos fármacos , Granuloma de Células Plasmáticas/complicações , Granuloma de Células Plasmáticas/tratamento farmacológico , Granuloma de Células Plasmáticas/radioterapia , Humanos , Masculino , Neoplasias da Base do Crânio/tratamento farmacológico , Neoplasias da Base do Crânio/radioterapia , Falha de Tratamento , Transtornos da Visão/tratamento farmacológico , Transtornos da Visão/etiologia , Transtornos da Visão/radioterapia
12.
Thorac Cardiovasc Surg ; 49(2): 124-6, 2001 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11339451

RESUMO

Inflammatory pseudotumor is a rare clinical entity. We report here the case of a 14-year-old boy who underwent lung resection en bloc with the lower esophagus, the mediastinal pleura and the diaphragm for an inflammatory pseudotumor of the left lower lobe. Postoperative radiotherapy was administered. The patient is well at 9-year follow-up. Inflammatory pseudotumor may present a particularly aggressive behavior. Multimodality approach, including extensive surgical resection, may be necessary in dealing with this disease.


Assuntos
Granuloma de Células Plasmáticas/radioterapia , Granuloma de Células Plasmáticas/cirurgia , Pneumopatias/radioterapia , Pneumopatias/cirurgia , Doenças do Mediastino/radioterapia , Doenças do Mediastino/cirurgia , Adolescente , Terapia Combinada , Esofagectomia , Seguimentos , Granuloma de Células Plasmáticas/diagnóstico , Humanos , Pneumopatias/diagnóstico , Masculino , Doenças do Mediastino/diagnóstico , Pneumonectomia , Índice de Gravidade de Doença , Tomografia Computadorizada por Raios X , Resultado do Tratamento
13.
Virchows Arch ; 433(4): 391-4, 1998 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-9808443

RESUMO

A 59-year-old woman who had received cobalt-60 (60Co) interstitial radiation therapy (total 44 Gy) in the right bucco-gingival region for inflammatory pseudotumour was found to have metachronous double malignant neoplasms. Initial osteosarcoma of the right mandibular angle and subsequent squamous cell carcinoma of the right buccal mucosa were identified 28 and 33 years after the radiation, respectively. Since both tumours were located very close to the focus of previous radiation, the therapy was considered to be responsible for their genesis. The patient had systemic metastases of the osteosarcoma.


Assuntos
Carcinoma de Células Escamosas/etiologia , Radioisótopos de Cobalto/efeitos adversos , Neoplasias Mandibulares/etiologia , Mucosa Bucal/efeitos da radiação , Neoplasias Bucais/etiologia , Neoplasias Induzidas por Radiação/etiologia , Segunda Neoplasia Primária/etiologia , Osteossarcoma/etiologia , Adulto , Carcinoma de Células Escamosas/diagnóstico por imagem , Carcinoma de Células Escamosas/patologia , Radioisótopos de Cobalto/uso terapêutico , Feminino , Granuloma de Células Plasmáticas/complicações , Granuloma de Células Plasmáticas/patologia , Granuloma de Células Plasmáticas/radioterapia , Humanos , Neoplasias Mandibulares/diagnóstico por imagem , Neoplasias Mandibulares/patologia , Doenças da Boca/complicações , Doenças da Boca/patologia , Doenças da Boca/radioterapia , Mucosa Bucal/diagnóstico por imagem , Neoplasias Bucais/diagnóstico por imagem , Neoplasias Bucais/patologia , Neoplasias Induzidas por Radiação/diagnóstico por imagem , Neoplasias Induzidas por Radiação/patologia , Segunda Neoplasia Primária/diagnóstico por imagem , Segunda Neoplasia Primária/patologia , Osteossarcoma/diagnóstico por imagem , Osteossarcoma/patologia , Tomografia Computadorizada por Raios X
14.
Ophthalmology ; 103(10): 1619-27, 1996 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8874435

RESUMO

PURPOSE: Lacrimal gland pseudotumors belong to the group of orbital pseudotumor. Systemic corticosteroids are advocated as the primary treatment of choice in orbital pseudotumor, but recurrent and refractory cases are commonly described. In this retrospective study, the authors evaluate alteerative treatment options such as surgical excision or debulking of lacrimal gland pseudotumors. METHODS: The records of 26 patients referred to the Orbital Center of Amsterdam between 1976 and 1994 with a diagnosis of lacrimal gland pseudotumor were reviewed with special reference to computed tomography scans, histopathologic specimens (in 23 patients), treatment regimens, and final clinical outcome. RESULTS: Histopathologic review showed 15 nonsclerosing (classic) and 8 sclerosing lacrimal gland pseudotumors. Initial treatment consisted of corticosteroids alone (9/26), surgery alone (7/26), a combination of surgery and irradiation (5/26), a combination of surgery and corticosteroids (4/26), or indomethacin alone (1/26). Surgery comprised tumor excision or tumor debulking. Of the patients treated with corticosteroids alone, 55% (5/9) responded initially but only 22% (2/9) obtained a cure. However, all patients treated with surgery combined with corticosteroids/irradiation (9/9), with surgery alone (7/7), or with indomethacin alone (1/1) responded well without recurrences. The main complication of therapy was dry eye syndrome, the incidence being highest in patients who received surgery of the palpebral lobe or irradiation. The mean follow-up was 4.9 years. CONCLUSION: Surgical excision or debulking is a safe and effective treatment option in lacrimal gland pseudotumors, even in the histopathologic sclerosing variant.


Assuntos
Granuloma de Células Plasmáticas/cirurgia , Doenças do Aparelho Lacrimal/cirurgia , Adulto , Idoso , Anti-Inflamatórios não Esteroides/uso terapêutico , Quimioterapia Adjuvante , Terapia Combinada , Feminino , Glucocorticoides/uso terapêutico , Granuloma de Células Plasmáticas/tratamento farmacológico , Granuloma de Células Plasmáticas/patologia , Granuloma de Células Plasmáticas/radioterapia , Humanos , Indometacina/uso terapêutico , Doenças do Aparelho Lacrimal/tratamento farmacológico , Doenças do Aparelho Lacrimal/patologia , Doenças do Aparelho Lacrimal/radioterapia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Radioterapia Adjuvante , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Resultado do Tratamento
15.
Am J Otol ; 17(1): 123-6, 1996 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-8694115

RESUMO

Plasma cell granulomas are uncommon, benign tumors comprised primarily of mature plasma cells and are a distinct entity, separate from plasmacytomas. They are rarely found in the head and neck, and have never been reported in the temporal bone. This case represents the first report of a plasma cell granuloma originating in the temporal bone. Treatment options include surgical removal and radiation therapy.


Assuntos
Granuloma de Células Plasmáticas/patologia , Neoplasias Cranianas/patologia , Osso Temporal/patologia , Audiometria , Terapia Combinada , Eletronistagmografia , Granuloma de Células Plasmáticas/radioterapia , Granuloma de Células Plasmáticas/cirurgia , Perda Auditiva/diagnóstico , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias Cranianas/radioterapia , Neoplasias Cranianas/cirurgia , Osso Temporal/cirurgia , Tomografia Computadorizada por Raios X
16.
J Laryngol Otol ; 109(9): 895-8, 1995 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-7494132

RESUMO

The occurrence of plasma cell granuloma of the larynx appears to be unusual. Review of the literature revealed only two previously reported cases. We present an additional case of plasma cell granuloma of the larynx. The diagnosis was made by histological and immunohistochemical examinations. The tumour was successfully treated by radiation therapy.


Assuntos
Granuloma de Células Plasmáticas/patologia , Doenças da Laringe/patologia , Granuloma de Células Plasmáticas/radioterapia , Humanos , Doenças da Laringe/radioterapia , Laringe/patologia , Masculino , Pessoa de Meia-Idade
17.
Comput Med Imaging Graph ; 16(1): 31-7, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1555180

RESUMO

A 50-year-old farmer with plasma cell granuloma had PET scans showing marked accumulation of C-11 Met. The PET had superiority in imaging the existence and extent of the lesion and monitored therapeutic response as compared with CT and MR imaging. PET yields information on hemocirculatory and metabolic aspects of this rare disease.


Assuntos
Encefalopatias/diagnóstico , Granuloma de Células Plasmáticas/diagnóstico , Tomografia Computadorizada de Emissão , Encefalopatias/diagnóstico por imagem , Encefalopatias/radioterapia , Granuloma de Células Plasmáticas/diagnóstico por imagem , Granuloma de Células Plasmáticas/radioterapia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Dosagem Radioterapêutica , Tomografia Computadorizada por Raios X
18.
Cancer ; 67(4): 929-32, 1991 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-1789819

RESUMO

Plasma cell granuloma is a rare, benign tumor most commonly found in the lungs in patients younger than 30 years. Although presentation has been reported at a number of other anatomic sites, this report is the first of plasma cell granuloma of the nasal cavity. The tumor was initially resected, but progression was seen at 1-month follow-up. Because further surgery to completely eradicate the tumor would have been extensive and disfiguring, 40-Gy external beam radiation was given in 20 fractions using a three-field wedge technique. Most recent clinical follow-up at 27 months showed local control. Surgery remains the treatment of choice for plasma cell granuloma when the disease can be completely resected. However, irradiation can also be effective in patients with recurrent or inoperable local disease.


Assuntos
Radioisótopos de Cobalto/uso terapêutico , Granuloma de Células Plasmáticas/radioterapia , Recidiva Local de Neoplasia/radioterapia , Doenças Nasais/radioterapia , Adolescente , Terapia Combinada , Seguimentos , Granuloma de Células Plasmáticas/cirurgia , Humanos , Masculino , Doenças Nasais/cirurgia , Dosagem Radioterapêutica
19.
Acta Neurochir (Wien) ; 99(3-4): 152-6, 1989.
Artigo em Inglês | MEDLINE | ID: mdl-2672705

RESUMO

Two patients suffering from diabetes insipidus, with additional symptoms of impaired vision and signs of panhypopituitarism and increased intracranial pressure, showed a normal sella tursica in the X-ray examination of the skull but large, dense space-occupying lesions in the hypothalamus on CT scans of the brain. NMR performed in one patient disclosed suprasellar growth of a hypothalamic lesion. Proliferation of lymphoplasmocytes and mature plasma cells was seen by light microscopic and electromicroscopical examination of biopsy samples in both cases; histiocytes and multinucleated giant cells were absent; tuberculosis, syphilis and sarcoidosis were ruled out by appropriate tests. Plasma cells exhibited polyclonal immunoglobulin expression as revealed by immunocytochemistry using the PAP method. Taken together these features are typical of plasma cell granuloma. Transitory remission after radiotherapy was obtained in one patient.


Assuntos
Granuloma de Células Plasmáticas/patologia , Granuloma/patologia , Doenças Hipotalâmicas/patologia , Adulto , Terapia Combinada , Feminino , Seguimentos , Granuloma de Células Plasmáticas/radioterapia , Granuloma de Células Plasmáticas/cirurgia , Humanos , Doenças Hipotalâmicas/radioterapia , Doenças Hipotalâmicas/cirurgia , Hipotálamo/patologia , Técnicas Imunoenzimáticas , Imunoglobulinas/análise , Microscopia Eletrônica , Pessoa de Meia-Idade , Atrofia Óptica/patologia , Plasmócitos/patologia , Complicações Pós-Operatórias/patologia , Recidiva
20.
J Neurosurg ; 69(5): 785-8, 1988 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-3183738

RESUMO

The authors report the fourth case of primary intracranial plasma-cell granuloma. The patient was a 16-year-old girl who presented with loss of vision as the major clinical feature. The tumor resembled a meningioma both preoperatively and grossly at surgery. Because the tumor did not respond to steroid treatment following subtotal surgical excision, radiation therapy was administered to the affected area. Major considerations in the differential diagnosis of this neoplasm are discussed.


Assuntos
Encefalopatias/patologia , Granuloma de Células Plasmáticas/patologia , Granuloma/patologia , Adolescente , Encefalopatias/radioterapia , Encefalopatias/cirurgia , Terapia Combinada , Diagnóstico Diferencial , Feminino , Granuloma de Células Plasmáticas/radioterapia , Granuloma de Células Plasmáticas/cirurgia , Humanos , Período Pós-Operatório , Tomografia Computadorizada por Raios X , Transtornos da Visão/etiologia , Transtornos da Visão/fisiopatologia
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