Clinical and Histopathologic Correlates and Management Strategies for Inflammatory Myofibroblastic tumor of the lung. A case series and review of the literature.

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm that may arise in soft tissues of nearly every organ. Although IMTs are the most common lung tumors in pediatric populations, these tumors are extremely rare in adults, constituting less than 1% of adult lung tumors. IMTs are characterized by proliferating spindle cells with variable inflammatory component. The biological behavior of lung IMTs in adults is highly unpredictable, which confounds diagnosis and treatment. We retrospectively investigated patients with pulmonary lesions and the histopathologic diagnosis of inflammatory myofibroblastic tumor or its synonymous names (Plasma Cell Granuloma, xanthogranuloma, inflammatory pseudotumor, fibroxanthoma, and fibrous histiocytoma) at the MD Anderson Cancer Institute in the period between August 2000 and August 2016. We describe 7 adult cases of IMT of the lung that were diagnosed at MD Anderson Cancer Center. These cases highlight the tumor's variability in terms of clinical presentation, histopathology, and biologic behavior, and underscore the challenges in the management of these rare lung neoplasms.

Sindrome de Blesovsky. A propósito de un caso / Anatomical and clinical implications of the humeral torsion

Introducción: La atelectasia redonda de pulmón, conocida como síndrome de Blesovsky, constituye un pseudotumor pulmonar de ubicación periférica asociado a la exposición al asbesto y al engrosamiento pleural. Los hallazgos imagenológicos pueden establecer el diagnóstico,pero no puede descartarse algún proceso neoplásico maligno. La precisión en el diagnóstico puede dificultarse por causas como la progresión radiológica y empeoramiento clínico del paciente. Objetivo: Presentación de caso clínico y revisión bibliográfica. Caso clínico: Paciente de 76 años, masculino, que consulta por síndrome de impregnación, pérdida de peso y anemia de 2 meses de evolución. Estudios imagenológicos muestran imagen nodular de 20 mm en lóbulo inferior derecho. Exploración videotoracoscópica: engrosamiento pleural de aspecto benigno (fibrosis) sin palparse nódulo pulmonar. TAC control a los 3 meses: aumento de la imagen nodular (30 mm) Se decide reexploración y resección pulmonar. Pieza de patología: Atelectasia redonda. Discusión: La atelectasia redonda es una entidad benigna, que como tal tiende a ser estable y en algunos casos evoluciona a la resolución espontanea. Aunque la seguridad diagnóstica mediante la Tac es alta, no existe un patrón individual que permita diferenciarla de un proceso maligno. Precisa de un seguimiento clínico estrecho y de la realización de pruebas diagnósticas invasivas si persisten las dudas y/o se detecta un crecimiento de la lesión. Se acepta como conducta diagnóstica y/o terapéutica la resección pulmonar lobar o sublobar.

Introduction: Rounded atelectasis lung, known as Blesovsky syndrome, is a pulmonary pseudotumor of peripheral location associated with asbestos exposure and pleural thickening. Image findings may establish the diagnosis but a malignant neoplastic process can not be ruled out. The accuracy of the diagnosis canbe difficult for reasons such as radiological progression and clinical worsening of the patient.Objective: Clinical case presentation and literature review.Case Report: 76 years old male patient, who consults forimpregnation syndrome, weight loss and anemia 2 months ofevolution. Imaging studies show 20 mm nodular image in the rightlower lobe. Laparoscopic exploration: pleural thickening withbenign aspect (fibrosis) without palpable image. CT 3 monthslater: Increased nodular image (30 mm) It decides relaparoscopyand pulmonary resection. Piece lobectomy: rounded atelectasis.Discusion: Rounded atelectasis is a benign entity, and as suchtends to be stable and in some cases resolve spontaneously.Although security diagnosed by tomography is high, there is nosingle pattern that allows to differentiate from malignancy.Requires close clinical monitoring and invasive diagnostic tests ifdoubts persist and/or injury growth is detected. Lobar or sublobarlung resection is accepted as diagnostic and therapeutic conduct.

Granuloma pulmonar hialinizante / Pulmonary Hyalinizing Granuloma

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[Systemic disease with hepatic and pulmonary involvement]. / Systemerkrankung mit Leber- und Lungenbeteiligung.

We discuss the history of a 39 year old woman with multiple patchy consolidations on high - resolution computed tomography in combination with a delayed diagnosis of primary biliary cirrhosis. Further we review the differential diagnostic considerations and step by step diagnostic and therapeutic options. Based on the presentation with symptoms of a mitigated pneumonia at the beginning of the disease, the differential diagnosis of cryptogenic organising pneumonia (CO) is discussed. The diagnosis of COP is often delayed. The theoretic background of primary biliary cirrhosis and the association with pulmonary disease are broadly discussed.

Concomitant inflammatory pseudotumor of the temporal bone and lung: a case report.

Inflammatory pseudotumors are histologically benign but locally destructive lesions that are usually found in the lung, although some cases of temporal bone involvement have been reported. To the best of our knowledge, no case of simultaneous involvement of the temporal bone and the lung has been previously reported in the literature. We describe such a case in a 39-year-old man. The temporal bone lesion was removed in its entirety, and the lung lesion was treated with steroid therapy. At the 2-month follow-up, the size of the lung mass on chest x-ray was significantly reduced, and at 1 year, the patient was asymptomatic.

Endobronchial pseudo-tumour caused by herpes simplex.

Herpes simplex virus (HSV) causes tracheobronchitis and pneumonitis; however, to date, there has only been one report of an endobronchial mass caused by HSV type II. This case study describes a 68-yr-old female with severe kyphoscoliosis who was intubated for acute on chronic hypercapnic respiratory failure and developed blood-tinged endotracheal secretions. Fibreoptic bronchoscopy demonstrated an endobronchial mass in the right middle lobe. Cultures grew HSV type I and biopsy specimens demonstrated cytopathological changes consistent with HSV infection. This is the first reported case of HSV type I presenting as an endobronchial tumour.

Pulmonary inflammatory pseudotumor--a report of 28 cases.

BACKGROUND: Pulmonary inflammatory pseudotumor is an uncommon benign lesion of the lung. In Korea, most literature of the pulmonary inflammatory pseudotumor was case reports. METHODS: We collected 28 cases of pulmonary inflammatory pseudotumor in Korea. This collective series included 4 cases from our hospital and 24 cases were reviewed from the literature since 1977. The analysis involved the age, sex, chief complaint, hematologic examination, size and location of the lesion, cavity formation, presence of calcification and treatment method. RESULTS: Male was more prevalent (81.5%) than female and mean age was 37.9 years old (6-63 yrs). Chief complaints were cough (44.4%), chest pain (29.6%), fever (22.2%), hemoptysis (15%), sputum (15%) and dyspnea (11.1%). There were asymptomatic cases in 11.1%. Hematologic examination revealed normal finding (53.3%) and anemia (20%). The mean size of the lesion was 4.76 cm (1.5-14 cm) and the locations were parenchymal (85.7%), endobronchial (10.7%) and endotracheal (3.6%). Except the endotracheal case, the lesions were in the right (46.4%), the left (42.8%) and bilateral (7.1%). Calcifications (18.5%) and cavitations (11.1%) were present. Diagnostic methods were open thoracotomy (82.1%), bronchoscopy (3.6%), needle aspiration biopsy (7.1%) and core needle gun biopsy (7.1%). Treatments were surgery (85.2%), steroid therapy (7.4%), rigid bronchoscopic removal (3.7%) and observation (3.7%). Postoperative recurrence occurred in only 1 case (4.3%). CONCLUSION: Pulmonary inflammatory pseudotumor was more prevalent in the male, and patients presented with the respiratory symptoms were common. It was necessary to do surgery in most cases for diagnosis and/or treatment.

[Diagnostic and therapeutic approach to plasma cell granuloma of the lung. Apropos of a case of favourable course under antibiotics]. / Approche diagnostique et thérapeutique du granulome plasmocytaire du poumon. A propos d'un cas d'évolution favorable sous antibiotiques.

Plasma cell granulomas are more often solitary benign tumoral lesions, which need early surgery both for diagnostic and therapeutic reasons. The authors report a case of multiple plasma cell granuloma, diagnosed on biopsies obtained by thoracoscopy, and with a good response to a long-term antibiotic treatment. A review of the literature shows that this behaviour may represent an interesting alternative to systematical surgery in some cases.