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1.
J Med Toxicol ; 20(2): 218-221, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38231419

RESUMO

INTRODUCTION: Guanfacine, an alpha-2 adrenergic agonist, is used to treat attention deficit hyperactivity disorder (ADHD). Although cardiovascular effects including hypotension and bradycardia are common adverse effects of guanfacine, the effect of guanfacine on QT intervals remains unclear. The association between the serum concentration of guanfacine and its toxicity has also not been fully investigated. CASE REPORT: This is a case of a 21-year-old woman with ADHD who developed repeated presyncope 1 day before admission. She was taking 3 mg of extended-release guanfacine and 50 mg of sertraline. On admission, she had bradycardia and hypotension. An electrocardiogram (ECG) showed a QT interval of 0.68 s and a QTcF interval of 0.648 s. The QT intervals were manually measured and corrected by the Fridericia formula (QTcF = QT/RR1/3). Although she denied taking an overdose of guanfacine and other drugs, we suspected guanfacine toxicity. The serum guanfacine concentration was 13.0 ng/mL on admission and decreased to 3.2 ng/mL on day 1 and 0.4 ng/mL on day 2. Changes in QTcF intervals and her vital signs correlated with serum guanfacine concentrations. CONCLUSION: Supratherapeutic serum guanfacine concentrations may induce QT prolongation.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Hipotensão , Feminino , Humanos , Adulto Jovem , Agonistas de Receptores Adrenérgicos alfa 2/toxicidade , Transtorno do Deficit de Atenção com Hiperatividade/induzido quimicamente , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Bradicardia/induzido quimicamente , Guanfacina/toxicidade , Hipotensão/induzido quimicamente
2.
J Toxicol Sci ; 48(12): 641-644, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38044125

RESUMO

Guanfacine hydrochloride extended-release (GXR) is used to treat attention deficit hyperactivity disorder. It is a selective α2A-adrenorecepor agonist that was reported to cause QT prolongation and hypotension in the event of overdosing. We report the case of a 17-year-old man who took 226 tablets of GXR 3 mg for attempted suicide. He was found complaining of dyspnea, and emergency medical services were called. When the patient was transferred to our hospital, his Glasgow coma scale was 12 (E4V3M5). He was agitated and hypoxemic. He was intubated for invasive mechanical ventilation under sedation. His chest X-ray and computed tomography scan showed pulmonary edema. Transthoracic echocardiography showed markedly reduced cardiac function. His serum guanfacine concentration peaked on day 3 after admission. His pulmonary edema improved quickly after a decrease in serum guanfacine concentration, but cardiac decompensation persisted for about 1 month. This case reveals that the decline in cardiac function after guanfacine intoxication is prolonged even after its serum concentration has decreased.


Assuntos
Guanfacina , Edema Pulmonar , Adolescente , Humanos , Masculino , Agonistas de Receptores Adrenérgicos alfa 2/efeitos adversos , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Preparações de Ação Retardada/efeitos adversos , Guanfacina/sangue , Guanfacina/toxicidade , Edema Pulmonar/induzido quimicamente
4.
Eksp Klin Farmakol ; 60(3): 12-5, 1997.
Artigo em Russo | MEDLINE | ID: mdl-9324388

RESUMO

Guanfacine in analgesic doses of 2.0 and 4.0 mg/kg inhibits the background activity of the spinal cord posterior horn neurons and their responses to nociceptive stimulation of the receptive field in conscious rats. Naloxone (0.1 mg/kg) does not change, whereas prazosin and yohimbine (both on doses of 0.1 mg/kg) remove and partly relieve the depressant effect of guanfacine.


Assuntos
Agonistas alfa-Adrenérgicos/toxicidade , Antagonistas Adrenérgicos alfa/farmacologia , Analgésicos/toxicidade , Guanfacina/toxicidade , Neurônios Motores/efeitos dos fármacos , Medula Espinal/efeitos dos fármacos , Simpatolíticos/toxicidade , Administração Oral , Agonistas alfa-Adrenérgicos/administração & dosagem , Antagonistas Adrenérgicos alfa/administração & dosagem , Antagonistas Adrenérgicos alfa/uso terapêutico , Analgésicos/administração & dosagem , Animais , Depressão/induzido quimicamente , Depressão/tratamento farmacológico , Guanfacina/administração & dosagem , Masculino , Neurônios Motores/citologia , Naloxona/administração & dosagem , Naloxona/farmacologia , Naloxona/uso terapêutico , Antagonistas de Entorpecentes/administração & dosagem , Antagonistas de Entorpecentes/farmacologia , Antagonistas de Entorpecentes/uso terapêutico , Prazosina/administração & dosagem , Prazosina/farmacologia , Prazosina/uso terapêutico , Ratos , Medula Espinal/citologia , Simpatolíticos/administração & dosagem , Ioimbina/administração & dosagem , Ioimbina/farmacologia , Ioimbina/uso terapêutico
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