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1.
Clin Lab ; 70(7)2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38965950

RESUMO

BACKGROUND: Mycobacterium abscessus is a new pathogen in recent years, which belongs to non-tuberculosis mycobacterium. Mycobacterium abscessus is widely involved in many nosocomial infections and secondary aggravation of genetic respiratory diseases. Mycobacterium abscessus is naturally resistant to most antibiotics and is difficult to treat. We report a case of mycobacterium abscessus infection with hemoptysis as the first manifestation. METHODS: Bronchoscopy, next-generation sequencing (NGS). RESULTS: Acid-fast staining of bronchoscopic lavage fluid showed that a small amount of acid-fast bacilli could be seen. NGS test showed the presence of Mycobacterium abscess, sequence number 137 (reference range ≥ 0), and symptomatic treatment against non-tuberculosis mycobacteria. CONCLUSIONS: For the follow-up infection of patients with hemoptysis, the treatment effect of antibiotics is not good, so the pathological tissue should be obtained by bronchoscopy or percutaneous lung biopsy in time, and the diagnosis should be confirmed by NGS if necessary.


Assuntos
Broncoscopia , Hemoptise , Infecções por Mycobacterium não Tuberculosas , Humanos , Hemoptise/diagnóstico , Hemoptise/etiologia , Hemoptise/microbiologia , Infecções por Mycobacterium não Tuberculosas/diagnóstico , Infecções por Mycobacterium não Tuberculosas/microbiologia , Infecções por Mycobacterium não Tuberculosas/complicações , Infecções por Mycobacterium não Tuberculosas/tratamento farmacológico , Masculino , Mycobacterium abscessus/isolamento & purificação , Mycobacterium abscessus/genética , Sequenciamento de Nucleotídeos em Larga Escala , Antibacterianos/uso terapêutico , Pessoa de Meia-Idade , Líquido da Lavagem Broncoalveolar/microbiologia , Feminino
2.
Cir Cir ; 90(5): 689-692, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36327475

RESUMO

Massive hemoptysis is a rare life-threatening complication of pulmonary actinomycosis that should be treated promptly due to the risk of asphyxiation and hemodynamic instability. We present the case of a 57-year-old female who was presented to our center with massive hemoptysis. Thoracic computed tomography scan revealed a cavitated lesion with perilesional ground-glass opacity. Right lower lobectomy was then performed using uniportal video-assisted thoracic surgery, excising a 13 × 12 × 8 cm cavitated lung fragment. The pathology service reported the presence of microscopical evidence of filamentous gram positive bacterial colonies, showing compatible features of pulmonary actinomycosis. The patient was discharged with oral penicillin with an uneventful post-operative course.


La hemoptisis masiva es una complicación poco frecuente de la actinomicosis pulmonar que pone en peligro la vida del paciente y que debe ser tratada con prontitud debido al riesgo de asfixia e inestabilidad hemodinámica. Presentamos una mujer de 57 años que acudió a nuestro centro con hemoptisis masiva. La tomografía reveló una cavitación con opacidad perilesional en vidrio deslustrado. Realizamos lobectomía mediante cirugía uniportal, extirpando un fragmento de lesión. Patología informó de la presencia de colonias bacterianas filamentosas grampositivas, mostrando características compatibles con actinomicosis pulmonar. El paciente fue dado de alta con penicilina oral, con un curso postoperatorio sin incidentes.


Assuntos
Actinomicose , Pneumopatias , Feminino , Humanos , Pessoa de Meia-Idade , Hemoptise/microbiologia , Hemoptise/terapia , Actinomicose/complicações , Actinomicose/cirurgia , Pneumopatias/diagnóstico por imagem , Pneumopatias/etiologia , Pneumopatias/cirurgia , Cirurgia Torácica Vídeoassistida , Tomografia Computadorizada por Raios X/efeitos adversos
3.
Ann Thorac Cardiovasc Surg ; 27(1): 10-17, 2021 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-33408306

RESUMO

OBJECTIVES: To evaluate plombage surgery for hemoptysis control in pulmonary aspergilloma in high-risk patients. METHODS: This study was carried out on 75 pulmonary aspergilloma patients presenting with hemoptysis that underwent a plombage surgery for approximately 7 years (November 2011-September 2018) at Pham Ngoc Thach Hospital. They revisited the hospital 6 months after plombage surgery and considered plombage removal. The group whose plombage was removed was compared with that whose plombage was retained 6 and 24 months after surgery. RESULTS: Hemoptysis reduced significantly after surgery. Hemoptysis ceased in 91.67% of the patients and diminished in 8.33% of the patients 6 months after surgery. Similarly, hemoptysis ceased in 87.32% of the patients and diminished in 12.68% of the patients 24 months after surgery. Body mass index (BMI) index, Karnofsky score, and forced expiratory volume in one second (FEV1) increased. Plombage surgery was performed with operative time of 129.5 ± 36.6 min, blood loss during operation of 250.7 ± 163.1 mL, and the number of table tennis balls of 4.22 ± 2.02. No deaths related to plombage surgery were recorded. Plombage was removed in 29 cases because of patients' requirements (89.8%), infection (6.8%), and pain (3.4%). There were no patient developing complications after the treatment and there were no statistically significant differences between the two groups. CONCLUSIONS: Plombage surgery is safe and effective for hemoptysis control in pulmonary aspergilloma. To minimize the risk of long-term complications, surgeons should remove the plombage 6 months after the initial operation.


Assuntos
Hemoptise/cirurgia , Técnicas Hemostáticas , Aspergilose Pulmonar/cirurgia , Procedimentos Cirúrgicos Torácicos , Adulto , Idoso , Remoção de Dispositivo , Feminino , Hemoptise/diagnóstico , Hemoptise/microbiologia , Técnicas Hemostáticas/efeitos adversos , Técnicas Hemostáticas/instrumentação , Humanos , Masculino , Pessoa de Meia-Idade , Aspergilose Pulmonar/diagnóstico , Aspergilose Pulmonar/microbiologia , Medição de Risco , Fatores de Risco , Procedimentos Cirúrgicos Torácicos/efeitos adversos , Procedimentos Cirúrgicos Torácicos/instrumentação , Fatores de Tempo , Resultado do Tratamento
5.
BMC Cardiovasc Disord ; 20(1): 494, 2020 11 23.
Artigo em Inglês | MEDLINE | ID: mdl-33228561

RESUMO

BACKGROUND: Infective endocarditis has a relevant clinical impact due to its high morbidity and mortality rates. Right-sided endocarditis has lower complication rates than left-sided endocarditis. Common complications are multiple septic pulmonary embolisms, haemoptysis, and acute renal failure. Risk factors associated with right-sided infective endocarditis are commonly related to intravenous drug abuse, central venous catheters, or infections due to implantable cardiac devices. However, patients with congenital ventricular septal defects might be at high risk of endocarditis and haemodynamic complications. CASE PRESENTATION: In the following, we present the case of a 23-year-old man without a previous intravenous drug history with tricuspid valve Staphylococcus aureus endocarditis complicated by acute renal failure and haemoptysis caused by multiple pulmonary emboli. In most cases, right-sided endocarditis is associated with several common risk factors, such as intravenous drug abuse, a central venous catheter, or infections due to implantable cardiac devices. In this case, we found a small perimembranous ventricular septal defect corresponding to a type 2 Gerbode defect. This finding raised the suspicion of a congenital ventricular septal defect complicated by a postendocarditis aneurysmal transformation. CONCLUSIONS: Management of the complications of right-sided infective endocarditis requires a multidisciplinary approach. Echocardiographic approaches should include screening for ventricular septal defects in patients without common risk factors for tricuspid valve endocarditis. Patients with undiagnosed congenital ventricular septal defects are at high risk of infective endocarditis. Therefore, endocarditis prophylaxis after dental procedures and/or soft-tissue infections is highly recommended. An acquired ventricular septal defect is a very rare complication of infective endocarditis. Surgical management of small ventricular septal defects without haemodynamic significance is still controversial.


Assuntos
Injúria Renal Aguda/etiologia , Circulação Coronária , Endocardite Bacteriana/microbiologia , Comunicação Interventricular/fisiopatologia , Hemodinâmica , Hemoptise/etiologia , Infecções Estafilocócicas/microbiologia , Injúria Renal Aguda/microbiologia , Injúria Renal Aguda/fisiopatologia , Antibacterianos/uso terapêutico , Tratamento Conservador , Endocardite Bacteriana/complicações , Endocardite Bacteriana/diagnóstico , Endocardite Bacteriana/tratamento farmacológico , Comunicação Interventricular/complicações , Comunicação Interventricular/diagnóstico por imagem , Hemoptise/microbiologia , Hemoptise/fisiopatologia , Humanos , Masculino , Fatores de Risco , Infecções Estafilocócicas/complicações , Infecções Estafilocócicas/diagnóstico , Infecções Estafilocócicas/tratamento farmacológico , Resultado do Tratamento , Adulto Jovem
6.
Intern Med ; 59(2): 193-198, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31941869

RESUMO

Objective Hemorrhagic pneumonia due to Stenotrophomonas maltophilia (SM) in severely immunocompromised patients has a very poor prognosis. However, the risk factors for hemorrhagic pneumonia are not clear. Methods This study assessed the predictive factors of hemorrhagic pneumonia caused by SM. The medical records of patients admitted to Osaka City University Hospital with SM bacteremia between January 2008 and December 2017 were retrospectively reviewed. Patients All patients who had positive blood cultures for SM were included in this study. They were categorized into two groups: the SM bacteremia with hemorrhagic pneumonia group and the SM bacteremia without hemorrhagic pneumonia group. The clinical background characteristics and treatments were compared between these groups. Results The 35 patients with SM bacteremia included 4 with hemorrhagic pneumonia and 31 without hemorrhagic pneumonia. Hematologic malignancy (p=0.03) and thrombocytopenia (p=0.04) as well as the prior use of quinolone within 30 days (p=0.04) were more frequent in the SM bacteremia patients with hemorrhagic pneumonia than in those without hemorrhagic pneumonia. The mortality of the SM bacteremia patients with hemorrhagic pneumonia was higher than that of those without hemorrhagic pneumonia group (p=0.02). Conclusion Patients with SM bacteremia who have hematologic malignancy, thrombocytopenia, and a history of using quinolone within the past 30 days should be treated with deliberation.


Assuntos
Infecções por Bactérias Gram-Negativas/complicações , Hemorragia/microbiologia , Pneumonia Bacteriana/complicações , Stenotrophomonas maltophilia/imunologia , Adulto , Feminino , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Neoplasias Hematológicas/complicações , Hemoptise/microbiologia , Humanos , Hospedeiro Imunocomprometido , Masculino , Pessoa de Meia-Idade , Pneumonia Bacteriana/tratamento farmacológico , Prognóstico , Quinolonas/uso terapêutico , Estudos Retrospectivos , Fatores de Risco , Trombocitopenia/complicações , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
8.
BMJ Case Rep ; 12(5)2019 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-31151976

RESUMO

A 35-year-old male patient reached the emergency department after an episode of massive haemoptysis a few hours ago. Fever and dyspnea were mentioned to be present the last 5 days. His medical history included only malaria, successfully treated 2 years ago. Clinical examination revealed high fever, jaundice, cyanosis, tachypnea and bilateral rales on pulmonary auscultation. Laboratory investigation showed high erythrocyte sedimentation rate and C reactive protein, leucocytosis, anaemia, mild thrombocytopaenia, renal impairment, hyperbilirubinaemia and abnormal liver function tests; arterial blood gas analysis showed respiratory alkalosis with severe hypoxia. Thoracic X-ray revealed bilateral pulmonary infiltrates, whereas abdominal and heart ultrasound detected hepatomegaly and small pericardial infusion, respectively. The diagnosis of leptospirosis along with acute respiratory distress syndrome was confirmed by positive IgM Leptospira antibodies. Empirical treatment with triple antibiotic therapy and corticosteroids was applied. The patient was discharged after 1 week, without any symptoms and with almost normal laboratory tests.


Assuntos
Hemoptise/microbiologia , Síndrome do Desconforto Respiratório/microbiologia , Doença de Weil/diagnóstico , Doença Aguda , Adulto , Doenças dos Trabalhadores Agrícolas/diagnóstico , Doenças dos Trabalhadores Agrícolas/microbiologia , Antibacterianos/uso terapêutico , Diagnóstico Diferencial , Quimioterapia Combinada , Humanos , Masculino , Doença de Weil/tratamento farmacológico
9.
BMC Infect Dis ; 19(1): 436, 2019 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-31101082

RESUMO

BACKGROUND: Information on non-tuberculosis mycobacterial (NTM) diseases remains limited in Singapore and other Southeast Asian countries. This study aimed to delineate epidemiological and clinical features of pulmonary NTM disease. METHODS: A retrospective review was performed on all NTM isolates identified in Singapore General Hospital from 2012 to 2016 using the 2007 ATS/IDSA diagnostic criteria. RESULTS: A total of 2026 NTM isolates from 852 patients were identified. M. abscessus-chelonae group (1010, 49.9%) was the most commonly isolated and implicated in pulmonary NTM disease. Pulmonary cases (352, 76%) had the highest prevalence among patients diagnosed with NTM diseases (465/852, 54.6%) with no gender difference. Male patients were older (68.5 years, P = 0.014) with a higher incidence of chronic obstructive pulmonary disease (COPD) (23.6%, P < 0.001) and recurrent cough with phlegm production (51.6%, P = 0.035). In contrast, more female patients had bronchiectasis (50%, P < 0.001) and haemoptysis (37.6%, P = 0.042). Age and COPD were associated with multiple NTM species isolation per patient. CONCLUSIONS: M. abscessus-chelonae group was the commonest NTM species isolated in Singapore. Pulmonary NTM infection has the highest frequency with male and female patients associated with a higher incidence of COPD and bronchiectasis respectively. Age and COPD were associated with multiple NTM species isolation per patient.


Assuntos
Pneumopatias/microbiologia , Infecções por Mycobacterium não Tuberculosas/epidemiologia , Infecções por Mycobacterium não Tuberculosas/etiologia , Micobactérias não Tuberculosas/isolamento & purificação , Idoso , Bronquiectasia/epidemiologia , Bronquiectasia/microbiologia , Comorbidade , Feminino , Hemoptise/epidemiologia , Hemoptise/microbiologia , Hospitais Gerais , Humanos , Incidência , Pneumopatias/epidemiologia , Masculino , Pessoa de Meia-Idade , Infecções por Mycobacterium não Tuberculosas/microbiologia , Micobactérias não Tuberculosas/patogenicidade , Prevalência , Doença Pulmonar Obstrutiva Crônica/epidemiologia , Doença Pulmonar Obstrutiva Crônica/microbiologia , Estudos Retrospectivos , Fatores Sexuais , Singapura/epidemiologia
10.
Emerg Radiol ; 26(5): 501-506, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31129737

RESUMO

PURPOSE: To evaluate the clinical outcomes of bronchial artery embolization (BAE) using a gelatin sponge for hemoptysis from pulmonary aspergilloma and compare them with treatment outcomes for hemoptysis from other diseases. METHODS: Fifty-two patients underwent BAE using a gelatin sponge. The etiology of hemoptysis was pulmonary aspergilloma in 8 (PA group) and other diseases in 44 (control group). The technical success rate, clinical success rate, hemoptysis-free rate, and complication rate were compared between the PA group and control group. Technical success was defined as the complete cessation of the targeted feeding artery as confirmed by digital subtraction angiography, and clinical success as the cessation of hemoptysis within 24 h of BAE. Recurrent hemoptysis was defined as a single or multiple episodes of hemoptysis causing > 30 ml of bleeding per day. RESULTS: Technical and clinical success rates were 100% in both groups. Hemoptysis-free rates were 85% at 6 months and 72% at 12-60 months in the control group, and 38% at 6-12 months and 25% thereafter in the PA group (P = 0.0009). No complications were observed following BAE in any case in the two groups. CONCLUSION: BAE using a gelatin sponge may not be effective for hemoptysis from pulmonary aspergilloma.


Assuntos
Artérias Brônquicas , Embolização Terapêutica/métodos , Esponja de Gelatina Absorvível/uso terapêutico , Hemoptise/microbiologia , Hemoptise/terapia , Aspergilose Pulmonar/complicações , Adulto , Idoso , Idoso de 80 Anos ou mais , Angiografia Digital , Feminino , Hemoptise/diagnóstico por imagem , Humanos , Pneumopatias/complicações , Masculino , Pessoa de Meia-Idade , Aspergilose Pulmonar/diagnóstico por imagem , Estudos Retrospectivos
11.
Medicine (Baltimore) ; 97(39): e12612, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30278580

RESUMO

RATIONALE: Aspergillus and Cryptococcus exposure can cause serious secondary infections in human lungs, especially in immunocompromised patients or in conjunction with a chronic disease caused by low disease resistance. Primary invasive fungal infections are clinically rare; therefore, coexistence of 2 fungi at an infection site is uncommon. This paper reports a case of healthy male who was diagnosed with both Cryptococcus neoformans and Aspergillus infections. PATIENT CONCERNS: A healthy 33-year-old male office worker was admitted to the Second Hospital of Jilin University for hemoptysis. A chest computed tomography (CT) scan showed a cavity, which was formed by the thick dorsal wall of the lower left lobe with an irregular inner wall and burr changes around the lesion. INTERVENTION: After 1.0 week of antibiotic and antituberculosis treatment, the hemoptysis symptoms remained. A resection of the left lower lobe was performed. DIAGNOSES: The postoperative pathological reports indicated the presence of both Aspergillus and Cryptococcus. The 2 fungal lesions were separate but within the same location. OUTCOMES: After treatment, the patient no longer had hemoptysis. LESSONS: The current study indicated that fungi can infect not only immunocompromised patients but also healthy people, and that there can be 2 separate fungal infections at the same infection site.


Assuntos
Aspergilose/diagnóstico , Coinfecção , Criptococose/diagnóstico , Cryptococcus neoformans , Pneumopatias Fúngicas/diagnóstico , Adulto , Aspergilose/imunologia , Criptococose/imunologia , Hemoptise/microbiologia , Humanos , Imunocompetência , Pneumopatias Fúngicas/imunologia , Masculino
13.
Rev Mal Respir ; 35(3): 295-304, 2018 Mar.
Artigo em Francês | MEDLINE | ID: mdl-29627293

RESUMO

INTRODUCTION: The pseudotumorous form of tuberculosis is a rare entity. Whatever its location, it can simulate neoplasia by its radiological and/or endoscopic appearances. We highlight the diagnostic difficulties associated with this type of presentation. METHODS: We performed a retrospective study of inpatient records from 2003 to 2016 in the pneumology department of La Rabta Hospital to identify cases of thoracic tuberculous pseudo-tumor. RESULTS: Seventeen patients were identified. The median age was 41 years and their symptomatology was dominated by cough and general debility. All had abnormal radiology with 10 cases of suspect lesions. Fibre-optic bronchoscopy revealed endobronchial abnormalities in 11 cases. The median overall diagnostic delay was 97 days. The diagnosis was confirmed bacteriologically in five cases, histologically in 14 cases and based on clinical presumption in one case. The progression was favourable: 13 patients have been declared cured and four patients are still undergoing treatment. CONCLUSION: Making a positive diagnosis of thoracic tuberculous pseudotumour can be difficult, as bacteriological samples are often negative. This can lead to a significant delay in diagnosis and treatment.


Assuntos
Granuloma de Células Plasmáticas/diagnóstico , Tuberculose Pulmonar/diagnóstico , Adulto , Broncoscopia , Diagnóstico Diferencial , Feminino , Granuloma de Células Plasmáticas/microbiologia , Hemoptise/diagnóstico , Hemoptise/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia Torácica , Estudos Retrospectivos , Tuberculose Pulmonar/complicações , Tunísia , Adulto Jovem
14.
Acad Radiol ; 25(8): 1018-1024, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29371122

RESUMO

RATIONALE AND OBJECTIVES: This prospective study aimed to evaluate the diagnostic performance of dual-input computed tomography perfusion technique (DI-CTP) in identifying the bronchial-pulmonary artery fistula in patients tuberculosis with massive hemoptysis. MATERIAL AND METHODS: Twenty patients with tuberculosis with massive hemoptysis were enrolled from January 2015 to December 2015. The association between DI-CTP parameters and the diagnostic outcomes of digital subtraction angiography was assessed. Diagnostic efficacy of DI-CTP was evaluated by receiver operating curve (ROC) analyses using the diagnostic outcomes of digital subtraction angiography, which is the gold standard for identifying bronchial-pulmonary artery fistula. RESULTS: Compared to lung segments with normal blood flow (n = 304), those with bronchial-pulmonary artery fistula (n = 164) had a reduced pulmonary flow value, perfusion index (PI) value, and an elevated bronchial artery (BF) value in the DI-CTP scan, which was further confirmed by multivariate logistic regression. ROC analysis showed that PI and bronchial artery has an excellent diagnostic performance (both area under the ROC curve > 0.9, P < .001) and high sensitivity and specificity (from 0.79 to 0.95 at the optimal cutoff). PI has the best diagnostic performance, with an overall diagnostic accuracy of 0.91. CONCLUSIONS: DI-CTP scan possesses the diagnostic value for detecting bronchial-pulmonary artery fistula in patients with tuberculosis with massive hemoptysis, providing an alternative diagnostic method.


Assuntos
Fístula Brônquica/diagnóstico por imagem , Hemoptise/microbiologia , Pulmão/irrigação sanguínea , Artéria Pulmonar/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Tuberculose Pulmonar/complicações , Fístula Vascular/diagnóstico por imagem , Adolescente , Adulto , Idoso , Angiografia Digital , Artérias Brônquicas/diagnóstico por imagem , Fístula Brônquica/microbiologia , Feminino , Humanos , Pulmão/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Curva ROC , Sensibilidade e Especificidade , Fístula Vascular/microbiologia
15.
Lung ; 196(1): 33-42, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29026982

RESUMO

PURPOSE: Severe hemoptysis (SH) associated with non-tuberculosis bacterial lower respiratory tract infection (LRTI) is poorly described, and the efficacy of the usual decision-making process is unknown. This study aimed at describing the clinical, radiological patterns, mechanism, and microbiological spectrum of SH related to bacterial LRTI, and assessing whether the severity of hemoptysis and the results of usual therapeutic strategy are influenced by the presence of parenchymal necrosis. METHODS: A single-center analysis of patients with SH related to bacterial LRTI from a prospective registry of consecutive patients with SH admitted to the intensive care unit of a tertiary referral center between November 1996 and May 2013. RESULTS: Of 1504 patients with SH during the study period, 65 (4.3%) had SH related to bacterial LRTI, including non-necrotizing infections (n = 31), necrotizing pneumonia (n = 23), pulmonary abscess (n = 10), and excavated nodule (n = 1). The presence of parenchymal necrosis (n = 34, 52%) was associated with a more abundant bleeding (volume: 200 ml [70-300] vs. 80 ml [30-170]; p = 0.01) and a more frequent need for endovascular procedure (26/34; 76% vs. 9/31; 29%; p < 0.001). Additionally, in case of parenchymal necrosis, the pulmonary artery vasculature was involved in 16 patients (47%), and the failure rate of endovascular treatment was up to 25% despite multiple procedures. CONCLUSIONS: Bacterial LRTI is a rare cause of SH. The presence of parenchymal necrosis is more likely associated with bleeding severity, pulmonary vasculature involvement, and endovascular treatment failure.


Assuntos
Infecções Bacterianas/complicações , Hemoptise/microbiologia , Abscesso Pulmonar/complicações , Pulmão/patologia , Pneumonia/complicações , Artéria Pulmonar/patologia , Doenças Vasculares/complicações , Adulto , Idoso , Broncoscopia , Angiografia por Tomografia Computadorizada , Procedimentos Endovasculares , Feminino , Hemoptise/terapia , Humanos , Abscesso Pulmonar/diagnóstico por imagem , Abscesso Pulmonar/microbiologia , Masculino , Pessoa de Meia-Idade , Necrose/complicações , Necrose/diagnóstico por imagem , Necrose/microbiologia , Pneumonia/diagnóstico por imagem , Pneumonia/microbiologia , Radiografia Torácica , Estudos Retrospectivos , Índice de Gravidade de Doença , Resultado do Tratamento , Doenças Vasculares/microbiologia , Doenças Vasculares/cirurgia
17.
Indian J Tuberc ; 64(3): 228-231, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28709495

RESUMO

Coexistence of pulmonary cryptococcosis with other infections has commonly been described in immuno-suppressed individuals. In immuno-competent hosts, such coexistence is rare and mostly described in disseminated disease or uncommonly involving different sites. The simultaneous coinfection of cryptococcosis and tuberculosis of lung in an immuno-competent host is extremely rare with only one previously reported case in the literature. This is the second such case and the first to be reported in India. We describe a case of a 36-year-old immuno-competent male who presented with haemoptysis and cough. Computed tomography showed a sub-pleural lung nodule. Diagnostic thoracoscopic wedge resection of the right lung nodule revealed granulomatous inflammation with cryptococcus on histopathology. Coexistent tuberculosis was diagnosed by microbiological culture study on lung tissue. The patient responded clinically to fluconazole and anti-tubercular therapy. This case shows that although rare, coexistent infections can occur in immuno-competent persons and highlights the importance of careful evaluation and tissue microbiological culture examination.


Assuntos
Criptococose/complicações , Criptococose/diagnóstico , Tuberculose Pulmonar/complicações , Tuberculose Pulmonar/diagnóstico , Adulto , Coinfecção/diagnóstico , Tosse/microbiologia , Criptococose/patologia , Hemoptise/microbiologia , Humanos , Imunocompetência , Masculino , Radiografia , Toracoscopia , Tuberculose Pulmonar/patologia
18.
Pediatr Pulmonol ; 52(8): E46-E48, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-28440965

RESUMO

Pulmonary sequestration (PS) happens when an area of the lung receives its arterial blood supply from systemic circulation, resulting in a non-functional lesion (Intralobar or extralobar). Hydatid cyst results from infection of the tapeworm Echinococcus. We report a case of hydatid cyst existed concurrently with intralobar PS. A 12-year-old girl presented with recurrent hemoptysis of 2 years duration. Serology for Echinococcus granulosus was positive. CT chest suggested intralobar PS in the right middle lobe, which was surgically removed. In conclusion, recurrent localized pulmonary infections should raise the suspicion of intralobar PS which may rarely coexist with hydatid cyst.


Assuntos
Sequestro Broncopulmonar , Equinococose Pulmonar , Hemoptise , Animais , Sequestro Broncopulmonar/sangue , Sequestro Broncopulmonar/diagnóstico por imagem , Sequestro Broncopulmonar/microbiologia , Sequestro Broncopulmonar/cirurgia , Criança , Equinococose Pulmonar/sangue , Equinococose Pulmonar/diagnóstico por imagem , Equinococose Pulmonar/microbiologia , Equinococose Pulmonar/cirurgia , Echinococcus granulosus/isolamento & purificação , Feminino , Hemoptise/sangue , Hemoptise/diagnóstico por imagem , Hemoptise/microbiologia , Hemoptise/cirurgia , Humanos , Pulmão/diagnóstico por imagem , Pulmão/patologia , Tomografia Computadorizada por Raios X
19.
Pneumologie ; 71(5): 293-296, 2017 May.
Artigo em Alemão | MEDLINE | ID: mdl-28346957

RESUMO

This paper reports on the case of a 19 year old asylum seeker from Eritrea who presented with hemoptysis, a positive tuberculosis screening (Enzyme Linked Immuno Spot Assay - EliSpot) and mushy faeces submitted with a suspected diagnosis of tuberculosis. Laboratory testing revealed thrombopenia, leukopenia and eosinophilia, while the chest X-ray was inconspicuous. Acid-proof rod bacteria were neither evident in bronchoscopy samples nor in expectorated sputum samples. However, sonographic findings showed a profound splenomegaly, and laboratory testing revealed a Schistosoma mansoni infection. This case demonstrates that in asylum seekers with suspected tuberculosis endemic diseases of the home country need to be considered as alternative diagnoses.


Assuntos
Erros de Diagnóstico/prevenção & controle , Hemoptise/diagnóstico , Hemoptise/microbiologia , Refugiados , Esquistossomose mansoni/diagnóstico por imagem , Esquistossomose mansoni/microbiologia , Tuberculose/diagnóstico , Animais , Diagnóstico Diferencial , Reações Falso-Positivas , Hemoptise/etiologia , Humanos , Masculino , Programas de Rastreamento/métodos , Schistosoma mansoni , Esquistossomose mansoni/complicações , Tuberculose/complicações , Tuberculose/microbiologia , Adulto Jovem
20.
BMJ Open ; 7(2): e014805, 2017 02 17.
Artigo em Inglês | MEDLINE | ID: mdl-28213604

RESUMO

OBJECTIVES: Evidence on the safety and long-term efficacy of super selective bronchial artery embolisation (ssBAE) using platinum coils in patients with haemoptysis is insufficient. The objective of the present study was to evaluate the safety and the 3-year postprocedure haemoptysis-free survival rate of de novo elective ssBAE using platinum coils rather than particles for the treatment of haemoptysis. DESIGN: A single-centre retrospective observational study. SETTING: Hemoptysis and Pulmonary Circulation Center in Japan. PARTICIPANTS: A total of 489 consecutive patients with massive and non-massive haemoptysis who underwent de novo elective ssBAE without malignancy or haemodialysis. INTERVENTIONS: ssBAE using platinum coils. All patients underwent CT angiography before the procedure for identifying haemoptysis-related arteries (HRAs) and for procedural planning. PRIMARY AND SECONDARY OUTCOME MEASURES: The composite of the 3-year recurrence of haemoptysis and mortality from the day of the last ssBAE session. Each component of the primary end point and procedural success defined as successful embolisation of all target HRAs were also evaluated. RESULTS: The median patient age was 69 years, and 46.4% were men. The total number of target vessels was 4 (quartile 2-7), and the procedural success rate was 93.4%. There were 8 (1.6%) major complications: 1 aortic dissection, 2 symptomatic cerebellar infarctions and 5 mediastinal haematoma cases. The haemoptysis-free survival rates were estimated by the Kaplan-Meier analysis at 86.9% (95% CI 83.7% to 90.2%) at 1 year, 79.4% (74.8% to 84.3%) at 2 years and 57.6% (45.1% to 73.4%) at 3 years. Although not statistically significant by the adjusted analysis of variance with multiple imputation of missing variables, cryptogenic haemoptysis tended to show the most favourable outcome and non-tuberculous mycobacterium showed the worst outcome (adjusted p=0.250). CONCLUSIONS: We demonstrated the safety and long-term efficacy of elective ssBAE using platinum coils and established that it can be a valuable therapeutic option for treating patients with haemoptysis.


Assuntos
Artérias Brônquicas , Embolização Terapêutica , Hemoptise/terapia , Idoso , Artérias Brônquicas/diagnóstico por imagem , Angiografia por Tomografia Computadorizada , Intervalo Livre de Doença , Embolização Terapêutica/efeitos adversos , Embolização Terapêutica/instrumentação , Feminino , Seguimentos , Hemoptise/diagnóstico por imagem , Hemoptise/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Platina , Recidiva , Estudos Retrospectivos , Fatores de Tempo
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