Assuntos
Hemorragia da Coroide/virologia , Infecções Oculares Virais/diagnóstico por imagem , Imageamento por Ressonância Magnética , Nervo Óptico/diagnóstico por imagem , Hemorragia Retiniana/diagnóstico por imagem , Dengue Grave/diagnóstico por imagem , Doença Aguda , Hemorragia da Coroide/diagnóstico por imagem , Hemorragia da Coroide/cirurgia , Infecções Oculares Virais/cirurgia , Infecções Oculares Virais/virologia , Humanos , Masculino , Nervo Óptico/patologia , Hemorragia Retiniana/cirurgia , Hemorragia Retiniana/virologia , Dengue Grave/cirurgia , Dengue Grave/virologia , Vitrectomia , Hemorragia Vítrea/diagnóstico por imagem , Hemorragia Vítrea/cirurgia , Hemorragia Vítrea/virologia , Adulto JovemAssuntos
Dengue Grave/complicações , Hemorragia Vítrea/virologia , Adolescente , Feminino , Humanos , Acuidade VisualAssuntos
Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Herpes Zoster Oftálmico/diagnóstico , Herpesvirus Humano 3 , Síndrome de Necrose Retiniana Aguda/diagnóstico , Hemorragia Vítrea/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/etiologia , Doença Aguda , Adulto , DNA Viral/análise , Fundo de Olho , Herpes Zoster Oftálmico/etiologia , Herpesvirus Humano 3/genética , Humanos , Masculino , Síndrome de Necrose Retiniana Aguda/virologia , Vitrectomia , Corpo Vítreo/patologia , Corpo Vítreo/virologia , Hemorragia Vítrea/virologiaRESUMO
PURPOSE: To develop a sensitive and specific laboratory assay for the diagnosis of cytomegalovirus retinitis. METHOD: We used a polymerase chain reaction-based assay for detection of cytomegalovirus DNA in vitreous samples. We attempted to detect cytomegalovirus DNA in 19 vitreous samples from patients with the acquired immunodeficiency syndrome (AIDS) who had untreated cytomegalovirus retinitis and in 40 vitreous samples from patients with AIDS who had been treated with systemic ganciclovir or foscarnet, or both. We also attempted to detect cytomegalovirus DNA in vitreous samples from 54 immunocompetent patients, including 32 with retinal detachment or macular hole, 11 with vitreous inflammation, and 11 with vitreous hemorrhage. Additionally, we attempted to detect cytomegalovirus DNA in 15 vitreous samples from patients with AIDS who had vitreoretinal inflammation not caused by cytomegalovirus. RESULTS: Cytomegalovirus DNA was detected in 18 of 19 eyes with untreated cytomegalovirus retinitis. We detected cytomegalovirus DNA in 19 of 40 vitreous samples from patients with previously treated cytomegalovirus retinitis. Cytomegalovirus DNA was not detected in any of 69 patients who did not have a clinical diagnosis of cytomegalovirus retinitis. Thus, the assay had an estimated sensitivity of 95% in detecting untreated cytomegalovirus retinitis and a sensitivity of 48% in detecting cytomegalovirus retinitis that had been treated with systemic ganciclovir or foscarnet, or both. The assay did not give false-positive results in patients with vitreous hemorrhage or vitreous inflammation. Most important, the assay did not give false-positive results in AIDS patients with vitreous inflammation from causes other than cytomegalovirus retinitis. CONCLUSION: We have developed a sensitive and specific diagnostic assay that will assist in the diagnosis of cytomegalovirus retinitis.