RESUMO
An 11-week-old, female Alaskan husky dog housed outdoors in the Yukon, Canada, was diagnosed with infectious canine hepatitis. The predisposing factors in this puppy for such a rare disease included inappropriate vaccination program, potential contact with endemic wildlife, and immunosuppression due to prednisone treatment.
Hépatite canine infectieuse associée au traitement par la prednisone. Une chienne Husky d'Alaska âgée de 11 semaines logée en plein air au Yukon, au Canada, a été diagnostiquée avec l'hépatite canine infectieuse. Les facteurs prédisposants chez ce chiot pour une telle maladie rare incluaient un programme de vaccination inadéquat, le contact potentiel avec des animaux sauvages indigènes et l'immunosuppression en raison du traitement avec de la prednisone.(Traduit par Isabelle Vallières).
Assuntos
Hepatite Infecciosa Canina/diagnóstico , Animais , Animais Selvagens , Cães , Feminino , Hepatite Infecciosa Canina/etiologia , Hospedeiro Imunocomprometido , Prednisona/efeitos adversos , Prednisona/uso terapêutico , Vacinação/efeitos adversos , Vacinação/veterináriaRESUMO
A 4-month-old, male, healthy dog developed CNS-symptoms 10 days after the second vaccination with live, attenuated distemper and canine hepatitis virus. The animal was euthanized after 2 weeks of illness. Light and electron microscopic examination of the CNS showed a partly necrotizing encephalomyelitis with numberous intranuclear and intracytoplasmic inclusion bodies, and the presence of probable pseudomyxovirus nucleocapsids and of crystalloid and tubuloreticular aggregates. Although there was conformity of inclusion bodies and probable viral structures as revealed by electron microscopy, the latter showed a much wider distribution. In addition, viral structures of a different type were found in polymorphonuclear leukocytes and vascular endothelial cells. Several morphological criteria led to the supposition that they are Picornaviruses, or possibly Arenaviruses. It is thought that their role in the disease process was at best an indirect one.
Assuntos
Cinomose/prevenção & controle , Encefalomielite/veterinária , Hepatite Infecciosa Canina/etiologia , Vacinação/efeitos adversos , Animais , Encéfalo/patologia , Cães , Encefalomielite/patologia , Hepatite Infecciosa Canina/patologia , Hepatite Infecciosa Canina/prevenção & controle , Masculino , Microscopia Eletrônica , Ponte/ultraestrutura , Medula Espinal/patologiaRESUMO
Two cases of acute, fatal, hepatitis occurred in young, striped skunks (Mephitis mephitis) trapped in southern Ontario. Histologically, lesions in the liver were similar to infectious canine hepatitis. A virus was isolated which produced large intranuclear inclusions in dog kidney cell cultures. These inclusions were Feulgen-positive and fluoresced green with acridine orange stain. The skunk hepatitis isolate was identified as the virus of infectious canine hepatitis by virus neutralization tests.
