Assuntos
Encefalite por Herpes Simples/diagnóstico por imagem , Herpes Simples/diagnóstico por imagem , Neuroimagem/métodos , Criança , Encefalite por Herpes Simples/história , Feminino , História do Século XX , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Neuroimagem/história , Pediatria/história , Publicações Periódicas como Assunto/história , Tomografia Computadorizada por Raios X/métodosRESUMO
Diagnosis of fetal infection has depended on identification of pathogens by means of microbiological cultures, immunologic techniques, and special molecular biology techniques that can identify organisms known or suspected of being associated with adverse outcomes of pregnancy. Rubella, cytomegalovirus (CMV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV), for example, are capable of gaining access to the amniotic cavity and producing fetal infection, even when amniotic membranes are intact. Intrauterine invasion by viruses can be associated with maternal symptoms of infection or can be completely silent. In many instances extensive fetal compromise with irreversible structural damage or fetal death will have occurred by the time infection is confirmed by culture or other histopathological methods. The evidence of fetal infection may be as subtle as nascent intrauterine growth restriction (IUGR), mildly inappropriate calcification of fetal organs, placenta, cord, and membranes, and failure to adequately develop fetal fat reserves. The evidence of infection may be as dramatic as obvious fetal malformation, severe central nervous system structural damage, or fetal death. Sonography is capable of detecting most of the grave alterations and some of the subtle effects that are typical of fetal infection.
Assuntos
Doenças Fetais/diagnóstico por imagem , Doenças Fetais/virologia , Ultrassonografia Doppler em Cores , Ultrassonografia Pré-Natal , Viroses/diagnóstico por imagem , Infecções por Citomegalovirus/diagnóstico por imagem , Feminino , Herpes Simples/diagnóstico por imagem , Herpes Zoster/diagnóstico por imagem , Humanos , Gravidez , Rubéola (Sarampo Alemão)/diagnóstico por imagem , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Viroses/virologiaRESUMO
We report two cases of herpes simplex pneumonia in children. One patient had Down syndrome, and the other was immunosuppressed by cancer therapy. Both had interstitial pneumonitis with nonspecific physical, radiographic, and laboratory findings, and both died. The diagnosis of herpes simplex pneumonia was made by isolation of herpes simplex virus from autopsy lung cultures as well as by demonstration of antigen in the tissue with an immunoperoxidase procedure. Inasmuch as herpes simplex pneumonia is a potentially treatable infection, early virologic studies are recommended in immunocompromised children with progressive pneumonitis of undetermined cause.