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1.
Mol Cell Biochem ; 366(1-2): 41-8, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22438203

RESUMO

The study was focused to the influence of higher intake of cholesterol on properties of the renal Na,K-ATPase, a key system in maintaining the homeostasis of sodium in the organism. Feeding for 4 weeks with cholesterol-enriched food for rats afflicted with hereditary hypertriglyceridemia by itself enhanced the activity of Na,K-ATPase, probably as a consequence of higher number of active enzyme molecules as suggested by 32 % increase of V (max) value. This may be hypothesized as a reason for the increased retention of sodium. Three-week-lasting treatment of animals kept on high cholesterol diet with antioxidant SMe1EC2 in a dose of 10 mg kg(-1) day(-1) normalized the function of renal Na,K-ATPase to the level comparable in hypertriglyceridemic rats fed with the standard diet. Therefore, our results suggest that the antioxidant SMe1EC2 in the applied dose seems to be effective in the attenuation of cholesterol-induced retention of sodium. Treatment for 3 weeks with Fenofibrate in a dose of 100 mg kg(-1) day(-1) reversed the function of renal Na,K-ATPase only slightly.


Assuntos
Antioxidantes/farmacologia , Colesterol na Dieta/efeitos adversos , Homeostase/efeitos dos fármacos , Hiperlipoproteinemia Tipo IV/metabolismo , Indóis/farmacologia , Piridinas/farmacologia , Sódio/metabolismo , Animais , Antioxidantes/uso terapêutico , Peso Corporal , Colesterol/sangue , Taxa de Filtração Glomerular/efeitos dos fármacos , Hiperlipoproteinemia Tipo IV/tratamento farmacológico , Hiperlipoproteinemia Tipo IV/fisiopatologia , Indóis/uso terapêutico , Rim/efeitos dos fármacos , Rim/metabolismo , Rim/fisiopatologia , Cinética , Masculino , Tamanho do Órgão , Estresse Oxidativo , Proteínas/metabolismo , Piridinas/uso terapêutico , Ratos , ATPase Trocadora de Sódio-Potássio , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Triglicerídeos/sangue
2.
Atherosclerosis ; 219(1): 15-21, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21831376

RESUMO

Since its discovery, apolipoprotein A-V has been considered to be a potent factor affecting plasma triglycerides (TG) in humans and mice. Several single nucleotide polymorphisms in the APOA5 gene are associated with increased TG levels in humans, and some nonsense mutations affecting protein structure predispose for familial hypertriglyceridemia and late onset chylomicronemia. It is not clear, how apoA-V decreases plasma TG. There are three major hypotheses: apolipoprotein A-V could work through (1) an intracellular mechanism affecting VLDL production in the liver, (2) stimulation of proteoglycan-bound lipoprotein lipase at the endothelium of capillaries in peripheral organs, or (3) enhancing the clearance of TG-rich lipoproteins via lipoprotein receptors in the liver. There is good evidence for a role of apoA-V in extracellular TG metabolism and increasing support for an additional function of ApoA-V as a receptor ligand. The intracellular role of apoA-V for lipoprotein assembly and secretion is still speculative. This review discusses these possible mechanisms.


Assuntos
Apolipoproteínas A/fisiologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Triglicerídeos/metabolismo , Animais , Apolipoproteína A-V , Apolipoproteínas A/genética , Quilomícrons/sangue , Hepatócitos/fisiologia , Humanos , Lipase Lipoproteica/sangue , Fígado/metabolismo , Camundongos , Triglicerídeos/sangue
3.
J. physiol. biochem ; 66(3): 229-236, sept. 2010.
Artigo em Inglês | IBECS | ID: ibc-122828

RESUMO

No disponible


Iron deposits are associated with lipid phenotype in familial hypertriglyceridemias, mainly familial combined hyperlipidemia (FCH) and familial hypertriglyceridemia (FHTG). In turn, diet plays an important role in hypertriglyceridemias although it is not known if dietary patterns are associated with iron concentration in these disorders. The objective was to determine the relationship between diet and iron deposits, measured through serum ferritin concentration, in patients with FCH and FHTG. The study was composed of 140 patients, 107 with FCH and 33 with FHTG. Subjects completed a validated 137-item food frequency questionnaire. Dividing subjects by ferritin tertiles adjusted by sex, there were no significant differences in dietary patterns except in dairy products consumption which was lower in the highest ferritin tertile. Subjects were also divided by triglycerides tertiles adjusted by sex. Those subjects in the highest tertile had lower HDL cholesterol and higher ferritin concentrations. Regarding to dietary parameters, there were significant differences in marine omega three fatty acids and vegetables presenting higher and lower consumption, respectively, those patients in the highest tertile of triglycerides. Moreover, there was not a significant correlation between dietary iron intake and any parameter, both biochemical and dietary, including ferritin concentrations. In conclusion, in patients with primary hypertriglyceridemia, triglycerides are associated with ferritin concentrations but dietary patterns are not related to iron deposits. Our results highly support the concept that the genetic mechanisms driven tohypertriglyceridemia also favor iron overload (AU)


Assuntos
Humanos , Sobrecarga de Ferro/fisiopatologia , Hiperlipidemia Familiar Combinada/fisiopatologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Comportamento Alimentar/fisiologia , Ferro da Dieta/análise
4.
Exp Biol Med (Maywood) ; 235(1): 40-6, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20404017

RESUMO

Hypertriglyceridemia (HTG) is one of the key features of dyslipidemia in type 2 diabetes, caused by the overproduction and/or decreased clearance of triglyceride (TG)-rich lipoproteins, and significantly promotes the development of cardiovascular diseases in diabetes. However, the effect of severe HTG on glucose metabolism has not previously been determined. Lipoprotein lipase (LPL) deficiency results in severe HTG in humans. By using LPL-deficient mice with severe HTG, we assessed the impact of severe HTG on insulin secretion and glucose tolerance in the present study. While young LPL-deficient mice (4 months of age) showed higher fasting blood glucose (7.42 +/- 0.84 versus 4.8 +/- 0.80 mmol/L, P < 0.01) and lower insulin concentrations (0.16 +/- 0.03 versus 0.48 +/- 0.14 ng/mL, P < 0.05), old mice (12 months of age) had higher insulin (1.70 +/- 0.35 versus 0.77 +/- 0.04 ng/mL, P < 0.05) but normal fasting blood glucose concentrations. Both young and old mice had elevated free fatty acid (FFA) concentrations and exhibited decreased early insulin response; however, only old mice showed impaired glucose tolerance, as compared with wild-type mice of a similar age. Morphological assessment showed enlarged islets in old LPL-deficient mice. These findings suggest that different tests for glucose homeostasis may be needed for patients with LPL deficiency and severe HTG, even though their glucose concentrations are normal at initial screening.


Assuntos
Intolerância à Glucose/fisiopatologia , Hipertrigliceridemia/fisiopatologia , Insulina/metabolismo , Animais , Glicemia/metabolismo , Modelos Animais de Doenças , Feminino , Intolerância à Glucose/sangue , Humanos , Hiperlipoproteinemia Tipo IV/genética , Hiperlipoproteinemia Tipo IV/fisiopatologia , Hipertrigliceridemia/sangue , Hipertrigliceridemia/patologia , Insulina/sangue , Secreção de Insulina , Lipase Lipoproteica/deficiência , Lipase Lipoproteica/genética , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Mutantes , Pâncreas/patologia
5.
Atherosclerosis ; 193(2): 321-7, 2007 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17055512

RESUMO

OBJECTIVE: Triglyceride-rich lipoproteins (TGRLs) are a cardiovascular risk factor and induce endothelial dysfunction. In the present study, we investigated the effects of post-prandial TGRLs from type IV hyperlipidemic subjects on endothelial activation addressing the effects of the lipoproteins on intracellular pathways and gene expression. METHODS: Thirty fasted hypertriglyceridemic patients were given an oral fat load (OFL) and blood samples were collected before the OFL (T0) and 2, 4, 6 and 8h thereafter. Endothelial function, determined as flow-mediated dilatation of the brachial artery, was assessed at the same time points. TGRLs were isolated at T0 and T4 (PP-TGRL) for in vitro studies. RESULTS: Compared with TGRLs, PP-TGRLs induced to a larger extent phosphorylation of p38 MAPK, CREB and IKB-alpha in human endothelial cells and increased the DNA binding activity of CREB, NFAT and NF-kappaB. Furthermore, PP-TRGLs upregulated the expression of several pro-inflammatory genes including vascular cell adhesion molecule-1 (VCAM-1), PECAM-1, ELAM-1, intercellular adhesion molecule-1 (ICAM-1), P-selectin, MCP-1, interleukin-6 (IL-6), TLR-4, CD40, ADAMTS1 and PAI-1. CONCLUSION: These effects may relate to the severe impairment of endothelial function seen during the post-prandial phase in hypertriglyceridemic patients.


Assuntos
Gorduras na Dieta/farmacologia , Células Endoteliais/efeitos dos fármacos , Hiperlipoproteinemia Tipo IV/fisiopatologia , Metabolismo dos Lipídeos/genética , Doenças Vasculares/genética , Doenças Vasculares/fisiopatologia , Adulto , Colesterol/metabolismo , Expressão Gênica , Humanos , Hiperlipoproteinemia Tipo IV/genética , Metabolismo dos Lipídeos/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , Período Pós-Prandial , Transdução de Sinais , Triglicerídeos/metabolismo
6.
Ann N Y Acad Sci ; 827: 494-509, 1997 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-9329780

RESUMO

The fatty acid (FA) compositions of liver and skeletal muscle structural lipids, overall phospholipids and phosphatidylcholine, and triglycerides (TG) were determined in the hereditary hypertriglyceridemic (HTG) rat, a nonobese animal model of the insulin resistance syndrome. Four groups of HTG rats and four groups of control animals were fed equal-energy diets for two weeks: basal (B), high-sucrose (HS), or fish oil-supplemented basal (BFO) or high-sucrose (HSFO) diets. In the liver of HTG rats, a decrease of n-6 long-chain polyunsaturated FA (PUFA), especially in 20:4n-6, in comparison with controls was found. Moreover, a concomitant accumulation of 18:2n-6 in structural lipids was observed. These differences were more pronounced in liver than in skeletal muscle. HS feeding raised the proportion of 18:1n-9 and decreased 18:2n-6 in lipid fractions. In both tissues and in both strains, the amounts of long-chain n-3 PUFA, as well as the level of total C20-22 PUFA, went up after fish oil feeding. However, the effects were somewhat less pronounced in the HTG rats. The increase in n-3 PUFA occurred mainly at the expense of reduced levels of 18:2n-6 in structural lipids and of 18:1n-9 in triglycerides. These changes were associated, in companion studies reported in this volume, with improved insulin action in HTG rats. In conclusion, the FA composition in lipid subclasses of HTG rats differs significantly from the controls mainly in liver structural lipids, suggesting the impairment of PUFA desaturation. Dietary change effected a similar modulation of FA profile across both strains, with fish oil increasing the levels of long-chain PUFA toward control values in the NTG rats. The HTG rat thus provides an interesting animal model for the study of impaired fatty acid metabolism.


Assuntos
Ácidos Graxos/metabolismo , Hiperlipoproteinemia Tipo IV/metabolismo , Resistência à Insulina , Metabolismo dos Lipídeos , Fígado/metabolismo , Músculo Esquelético/metabolismo , Animais , Peso Corporal , Dieta , Modelos Animais de Doenças , Ácidos Graxos/química , Hiperlipoproteinemia Tipo IV/fisiopatologia , Lipídeos/química , Masculino , Ratos
7.
Diabetes Res ; 26(4): 173-84, 1994.
Artigo em Inglês | MEDLINE | ID: mdl-7648791

RESUMO

The susceptibility of LDL to copper-catalyzed oxidation was evaluated in 24 patients with insulin-dependent and 16 patients with non-insulin-dependent diabetes mellitus, 14 abdominal and 14 gluteal-femoral obese women, 22 familial hypertriglyceridemic and 28 control subjects. Differences in the LDL susceptibilities were studied by measuring the changes of fluorescence intensity and expressed as lag-phase. The lag-phase was significantly shorter in patients with insulin-dependent, non-insulin-dependent diabetes mellitus, abdominal obesity and familial hypertriglyceridemic patients than in gluteal-femoral obese subjects and controls (p < 0.01). The shortest lag-phase was found in familial hypertriglyceridemic patients while intermediate values were found in insulin-dependent, non-insulin-dependent and abdominal obese patients who had only a slight increase in triglyceride values. Similarly the lowest value of the LDL cholesterol to protein ratio, as expression of LDL particle size, was found in familial hypertriglyceridemic patients (p < 0.01), while the patients with insulin-dependent, non-insulin-dependent diabetes mellitus and abdominal obesity had intermediate values. The ratio was found to be directly correlated with the length of the lag-phase (r = 0.87, p < 0.001). In spite of similar triglyceride and cholesterol to protein ratio values, however, the length of the lag-phase was significantly shorter in patients with insulin-dependent diabetes mellitus than in those with abdominal obesity. So it is concluded that the different susceptibility to oxidation found in the different groups of patients is only partially explained by plasma triglyceride values.


Assuntos
Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 2/sangue , Hiperlipoproteinemia Tipo IV/sangue , Lipoproteínas LDL/sangue , Obesidade/sangue , Adulto , Índice de Massa Corporal , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Diabetes Mellitus Tipo 1/fisiopatologia , Diabetes Mellitus Tipo 2/fisiopatologia , Feminino , Humanos , Hiperlipoproteinemia Tipo IV/fisiopatologia , Masculino , Obesidade/fisiopatologia , Oxirredução , Valores de Referência , Análise de Regressão , Triglicerídeos/sangue
8.
Life Sci ; 51(10): 733-40, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1513201

RESUMO

Hypertriglyceridemia was demonstrated in untreated hypertensive patients as well as in animals with genetic and experimental hypertension. The main purpose of the present study was to evaluate the possibility to use the hereditary hypertriglyceridemic (HTG) nonobese rats in hypertensive research. Direct measurement of blood pressure demonstrated significantly higher systolic, diastolic and mean arterial pressures in HTG rats in comparison with control Wistar rats. There was significant positive correlation between blood pressure and plasma triglyceride concentration (r = 0.585, n = 40, p less than 0.001). In addition, there were significantly increased plasma norepinephrine and epinephrine concentrations in HTG rats, suggesting that the stimulation of sympathetic nervous system could be one of the pathogenetic mechanisms involved in the increase of blood pressure of HTG rats.


Assuntos
Diabetes Mellitus/genética , Modelos Animais de Doenças , Hiperlipoproteinemia Tipo IV/genética , Hipertensão/genética , Animais , Glicemia/análise , Pressão Sanguínea , Peso Corporal , Epinefrina/sangue , Teste de Tolerância a Glucose , Hiperlipoproteinemia Tipo IV/sangue , Hiperlipoproteinemia Tipo IV/fisiopatologia , Insulina/sangue , Masculino , Modelos Genéticos , Norepinefrina/sangue , Ratos , Ratos Endogâmicos , Triglicerídeos/sangue
9.
Pediatr Nephrol ; 4(2): 122-8, 1990 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-2397177

RESUMO

A paediatric case of lipoprotein glomerulopathy, a new kidney disease characterized by glomerular lipoprotein thrombi, is reported. The patient had massive proteinuria from the age of 8 years, when the nephrotic syndrome was first detected. This was resistant to conventional treatment for more than 10 years. During the course of the disease, the hyperlipidaemia characteristic of hyper-pre-beta-lipoproteinaemia and elevation of apoprotein E persisted, and renal function gradually deteriorated. The renal histopathological findings from four biopsies were essentially the same, with storage of beta-lipoprotein in dilated, balloon-like glomerular capillary lumina. However, the number of glomeruli showing global sclerosis increased and tubulo-interstitial changes progressed in parallel with the gradual clinical deterioration. As in other cases reported in Japan some familial involvement has been noted.


Assuntos
Nefropatias/fisiopatologia , Lipoproteínas/metabolismo , Apolipoproteínas E/sangue , Criança , Humanos , Hiperlipoproteinemia Tipo IV/patologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Nefropatias/patologia , Glomérulos Renais/metabolismo , Glomérulos Renais/patologia , Masculino , Microscopia Eletrônica , Síndrome Nefrótica/patologia , Síndrome Nefrótica/fisiopatologia , Fatores de Tempo
10.
Minerva Med ; 79(5): 349-54, 1988 May.
Artigo em Italiano | MEDLINE | ID: mdl-3374826

RESUMO

Platelets play an essential role in the pathogenesis of atherosclerosis. Prostacyclin is a strong physiological inhibitor of platelets aggregation; prostacyclin indeed is involved in the regulation of platelet interactions with vessel walls and is considered to play a major role in the homeostatic balance. The impedance aggregometry allows the evaluation of platelet aggregation in whole blood. We valued platelet aggregation in whole blood induced by ADP (10 microM) in 40 healthy subjects and in 40 type II and type IV hyperlipemic subjects. Meanwhile by radioimmunoassay we dosed 6-keto PGF1 alpha, a stable product of prostacyclin, in 7 healthy subjects and in 33 hyperlipemic subjects. The statistical investigation put in evidence that at higher plasmatic levels of cholesterol, triglycerides and LDL correspond a greater platelet sensitivity to the aggregating agent, while the opposite happens to higher levels of HDL. The dosage of 6-keto PGF1 alpha put in evidence an increase of this substance in hyperlipemic as to healthy subjects, probably as an answer to augmented platelet aggregation.


Assuntos
Hiperlipoproteinemia Tipo II/fisiopatologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Agregação Plaquetária , Adulto , Colesterol/sangue , Feminino , Humanos , Hiperlipoproteinemia Tipo II/sangue , Hiperlipoproteinemia Tipo IV/sangue , Lipoproteínas LDL/sangue , Masculino , Pessoa de Meia-Idade , Triglicerídeos/sangue
11.
Minerva Med ; 78(23): 1739-43, 1987 Dec 15.
Artigo em Italiano | MEDLINE | ID: mdl-3696450

RESUMO

Platelets play an essential role in the pathogenesis of atherosclerosis; by impedance method we valued in whole blood platelet aggregation induced by collagen in 40 healthy subjects and in 40 type II and type IV hyperlipemic subjects. Meanwhile by radioimmunoassay we dosed thromboxane B2, a stable product of thromboxane A2, released by platelets during activation, in 7 healthy subjects and 25 hyperlipemic subjects. The statistical investigation put in evidence that at higher plasmatic levels of cholesterol, triglycerides and LDL correspond a greater platelet sensitivity to the aggregating agent, while the opposite happens to higher levels of HDL. The dosage of thromboxane B2 put in evidence a moderate increase in hyperlipemic as to healthy subjects, probably pointing to a state of platelet activity.


Assuntos
Hiperlipoproteinemia Tipo II/fisiopatologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Agregação Plaquetária , Tromboxano B2/sangue , Adulto , Feminino , Humanos , Hiperlipoproteinemia Tipo II/sangue , Hiperlipoproteinemia Tipo IV/sangue , Masculino , Pessoa de Meia-Idade , Radioimunoensaio
12.
Diabetologia ; 30(6): 380-5, 1987 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-3315795

RESUMO

The effects of 9 weeks of moderate intensity exercise training while on a weight-maintaining diet were studied in 19 untrained middle-aged, hypertriglyceridaemic, carbohydrate intolerant men. Initial mean maximum oxygen consumption was low (29.7 +/- 1.0 ml.min-1.kg-1; mean +/- SEM) and improved (34.2 +/- 1.4 ml.min-1.kg-1, p less than 0.01) with exercise training. Fasting glucose, insulin, lipid and lipoprotein concentrations did not change. While the abnormal glucose response to oral glucose did not change with training, insulin concentrations were significantly (p less than 0.05) lower at 90 and 120 min during the final oral glucose tolerance test. Insulin mediated glucose uptake did not change, indicating that the degree of exercise training failed to improve in vivo insulin sensitivity. Significant associations were found between the following parameters measured: fasting concentrations of triglycerides and insulin, very low density lipoprotein-triglycerides and glucose, and measures of in vivo insulin resistance and fasting insulin levels, suggesting that insulin resistance in these glucose intolerant subjects may play a role in their hypertriglyceridaemia. These data indicate that moderate increases in physical training alone are not sufficient to improve the carbohydrate, insulin and lipid metabolism of hypertriglyceridaemic, glucose intolerant men.


Assuntos
Glicemia/metabolismo , Erros Inatos do Metabolismo dos Carboidratos/fisiopatologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Insulina , Lipídeos/sangue , Lipoproteínas/sangue , Educação Física e Treinamento , Metabolismo Basal , Pressão Sanguínea , Peso Corporal , Dieta , Teste de Tolerância a Glucose , Frequência Cardíaca , Humanos , Resistência à Insulina , Masculino , Pessoa de Meia-Idade , Esforço Físico
13.
Artigo em Inglês | MEDLINE | ID: mdl-3474772

RESUMO

Alloxan-diabetic cholesterol-fed rabbits exhibiting severe hypertriglyceridemia are protected against atherosclerosis. In such rabbits most of the plasma cholesterol is found in lipoproteins with a diameter of 75 nm or larger. In the present report it is hypothesized, that due to their large sizes, the lipoproteins of the severely hypertriglyceridemic diabetic rabbits are not able to penetrate the endothelial layer of the arteries. Therefore, the macrophages and smooth muscle cells of the intima will only come in contact with relatively small amounts of cholesterol-carrying lipoproteins. Consequently, cellular accumulation of cholesterol, which is a necessary step in the formation of an atherosclerotic lesion, will be retarded. There are certain parallels between hypertriglyceridemic cholesterol-fed alloxan-diabetic rabbits and humans with familial lipoprotein lipase deficiency, familial apolipoprotein C-II deficiency and insulin-dependent diabetes mellitus in the ketoacidotic state. Based on reports about patients with these metabolic disorders, we suggest that cholesterol in very large lipoproteins also in humans is less atherogenic than cholesterol in smaller lipoproteins.


Assuntos
Apolipoproteínas C/deficiência , Arteriosclerose/prevenção & controle , Diabetes Mellitus Experimental/fisiopatologia , Dieta Aterogênica , Hiperlipoproteinemia Tipo IV/fisiopatologia , Lipase Lipoproteica/deficiência , Lipoproteínas/sangue , Animais , Apolipoproteína C-II , Colesterol/sangue , Colesterol na Dieta , Feminino , Humanos , Hiperlipoproteinemia Tipo IV/sangue , Masculino , Coelhos , Valores de Referência , Triglicerídeos/sangue
15.
Laryngoscope ; 96(2): 186-9, 1986 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-3945147

RESUMO

Twenty-five hyperlipidemic, neurologically and audiologically asymptomatic patients were compared to 20 normolipemic control subjects regarding different interpeak latency differences (IPLD) of auditory brain stem evoked potentials (ABEP). ABEP were recorded in response to click stimuli presented at a rate of 10/sec and 55/sec. The net effect of increasing stimulus rate (ISR) on IPLD of ABEP was significantly greater in the hyperlipidemic patients for IPLD (V-I) and IPLD (III-I). ISR of ABEP indicates a trend of subclinical impairments of brain stem function in hyperlipidemic patients, probably due to ischemia accelerated by their condition.


Assuntos
Tronco Encefálico/fisiologia , Potenciais Evocados Auditivos , Hiperlipidemias/fisiopatologia , Estimulação Acústica/métodos , Adulto , Audiometria de Tons Puros , Feminino , Humanos , Hiperlipoproteinemia Tipo II/fisiopatologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Tempo de Reação/fisiologia
16.
Atherosclerosis ; 56(1): 111-8, 1985 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-2992534

RESUMO

Eight patients with type IV and V hyperlipoproteinemia were put on a mackerel and herring diet of an isocaloric regimen for 2 weeks, in a cross-over design. At the end of the dietary periods a predominant increase of eicosapentaenoic acid (EPA - C20:5, n-3) in cholesterol esters and of docosahexaenoic acid (DHA - C22:6, n-3) in serum triglycerides, being more pronounced after mackerel as compared to herring diet, could be confirmed. After mackerel diet serum triglycerides and total cholesterol were significantly lower, returning to basal levels 3 months later. High density lipoprotein (HDL) cholesterol appeared slightly increased after mackerel diet and decreased to initial values thereafter. After herring diet, which contained half as much EPA as compared to mackerel diet, the differences were minor. The decline of free fatty acids (FFA) and insulin at the end of the mackerel period reached the level of significance 60 min and 120 min, respectively, after glucose load. A significantly lower systolic blood pressure in recumbent and upright position after the mackerel period could be found, whereas diastolic pressure and blood pressure after herring diet remained unchanged.


Assuntos
Pressão Sanguínea , Peixes , Hiperlipoproteinemia Tipo IV/dietoterapia , Hiperlipoproteinemia Tipo V/dietoterapia , Lipídeos/sangue , Lipoproteínas/sangue , Adulto , Animais , Colesterol/sangue , Ácidos Docosa-Hexaenoicos , Ácido Eicosapentaenoico , Ácidos Graxos Insaturados/metabolismo , Feminino , Teste de Tolerância a Glucose , Humanos , Hiperlipoproteinemia Tipo IV/sangue , Hiperlipoproteinemia Tipo IV/fisiopatologia , Hiperlipoproteinemia Tipo V/sangue , Hiperlipoproteinemia Tipo V/fisiopatologia , Masculino , Pessoa de Meia-Idade , Triglicerídeos/sangue
18.
Haemostasis ; 15(6): 371-6, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-4076844

RESUMO

Platelet adhesion was studied in whole blood using a simple stagnation flow method in patients at high risk for the development of atherosclerosis. Fourteen patients with hypercholesterolemia, 26 with hypertriglyceridemia and 25 normolipidemic hypertensive subjects were compared with 75 normal (normotensive and normolipidemic) subjects. Increased platelet adhesion was found in hypercholesterolemic (but not hypertriglyceridemic) patients only when native blood with no anticoagulants was used. In hypertensive patients, platelet adhesion was significantly elevated, but remarkably reduced by beta-blocker drugs. Propranolol and atenolol significantly reduced platelet adhesion, but this effect was found to take a longer time than that required for significant blood pressure reduction.


Assuntos
Hiperlipidemias/fisiopatologia , Hipertensão/fisiopatologia , Adesividade Plaquetária/efeitos dos fármacos , Adulto , Arteriosclerose/fisiopatologia , Atenolol/farmacologia , Atenolol/uso terapêutico , Humanos , Hipercolesterolemia/fisiopatologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Hipertensão/tratamento farmacológico , Pessoa de Meia-Idade , Propranolol/farmacologia , Propranolol/uso terapêutico , Fatores de Tempo
19.
Scand J Gastroenterol ; 18(7): 897-902, 1983 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-6676922

RESUMO

Lipid composition, cholesterol saturation, and cholesterol crystal formation of gallbladder bile were studied in seven type-IV hyperlipoproteinemic subjects who did not have gallstones. Thereafter, biliary cholesterol solubilization was overloaded, first by clofibrate and then by caloric restriction treatment. Initially increased cholesterol saturation was still increased by both clofibrate and caloric restriction treatment, but none of the subjects developed cholesterol crystals in bile, indicating that they had a mechanism to maintain cholesterol in solution in the bile despite remarkable supersaturation. This suggests that the patients who are at risk of developing gallstones can be better selected by cholesterol crystal analysis of bile samples than by analysis of lipid composition of bile.


Assuntos
Ácidos e Sais Biliares/análise , Colesterol/fisiologia , Clofibrato/uso terapêutico , Ingestão de Energia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Idoso , Clofibrato/análise , Cristalização , Feminino , Humanos , Hiperlipoproteinemia Tipo IV/terapia , Lipídeos/análise , Masculino , Pessoa de Meia-Idade , Solubilidade
20.
Pathol Biol (Paris) ; 31(4): 248-58, 1983 Apr.
Artigo em Francês | MEDLINE | ID: mdl-6346238

RESUMO

Primary hyperlipoproteinemias are of great interest as for the physician, as for the searcher, because of their atherogenic properties; on the other hand, a new type of hyperlipoprotenemia, namely hyperalphalipoproteinemia, seems to be a protective factor against clinical complications of atherosclerosis. The clinical, biological and pathophysiologic aspects of these diseases are studied both from author's experience and from the literature data.


Assuntos
Hiperlipoproteinemias/fisiopatologia , Lipoproteínas/fisiologia , Humanos , Hiperlipidemia Familiar Combinada/fisiopatologia , Hiperlipoproteinemia Tipo I/fisiopatologia , Hiperlipoproteinemia Tipo II/fisiopatologia , Hiperlipoproteinemia Tipo III/fisiopatologia , Hiperlipoproteinemia Tipo IV/fisiopatologia , Hiperlipoproteinemia Tipo V/fisiopatologia , Hiperlipoproteinemias/diagnóstico , Hiperlipoproteinemias/terapia , Lipoproteínas HDL/sangue
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