Bidirectional associations between hyperopia, myopia, astigmatism, and strabismus, and attention-deficit/hyperactivity disorder in children: a national population-based cohort study.

OBJECTIVES: The present study analyzed the reciprocal relationships between four common pediatric ophthalmic diseases (i.e., hyperopia, myopia, astigmatism, and strabismus) and attention-deficit/hyperactivity disorder (ADHD) in children. METHODS: This study enrolled 86,028 children with ADHD and 1,798,673 children without ADHD in the Taiwan Maternal and Child Health Database who were born at any time from 2004 to 2017. Cox proportional hazards regression models were used to estimate the bidirectional relationships of the four ophthalmic diseases with ADHD in children after adjusting for age, sex, and gestational age at birth. Survival curves for time-to-event variables were estimated using the Kaplan-Meier method, and the log-rank test was used to compare the curves. RESULTS: The results indicated that ADHD significantly predicted the occurrence of hyperopia, myopia, astigmatism, and strabismus. Furthermore, hyperopia, myopia, astigmatism, and strabismus significantly predicted the occurrence of ADHD. The time between enrollment and ADHD diagnosis was shorter for patients with ophthalmic diseases than for the control group, and the time between enrollment and ophthalmic disease diagnosis was also shorter for ADHD patients than for the control group. Sex differences were found in the associations between ADHD and ophthalmic diseases. CONCLUSION: Clinicians should monitor children with ADHD for hyperopia, myopia, astigmatism, and strabismus to ensure appropriate treatment, and vice versa.

Avaliação e triagem da acuidade visual em escolares da primeira infância / Evaluation and screening of visual acuity in early childhood schoolchildren

Resumo Objetivo: Identificar a prevalência de alterações visuais em crianças de cinco anos em escolas públicas de Curitiba-PR. Métodos: As escolas foram selecionadas aleatoriamente dentro do município de Curitiba. As crianças com cinco anos completos em 2017 foram avaliadas com a tabela de Snellen, através de distância mínima correta para nitidez de imagem e teste de Hirschberg. Os pais responderam um questionário sobre uso de telas, sintomas oculares e histórico familiar da criança. Os resultados das avaliações foram analisados estatisticamente considerando nível de significância p≤0,05. Resultados: Em uma população de 459 crianças triadas, 219 (47,7%) pertenciam ao sexo feminino e 240 (52,3%) masculino, sendo que do total, 100 foram encaminhadas para avaliação oftalmológica especializada. A partir da triagem observou-se a prevalência de miopia de 10,7%, hipermetropia de 17,6% e estrabismo de 0,9%. Houve relação entre genitores com miopia e filhos míopes (p<0,05). Dentre as queixas oftalmológicas predominaram cefaleia (30,4%) e franzir de testa (10%). Conclusão: A prevalência de alterações visuais encontrada foi de 21,8%. A relação entre distúrbios visuais e o histórico familiar se mostrou estatisticamente significativa. Entretanto, apenas o tempo médio em frente à televisão apresentou influência, dentre os hábitos de vida, sobre as alterações da AV (p=0,028). Queixas oftalmológicas apesar de frequentes, não apresentaram correlação expressiva com a diminuição da acuidade visual.

Abstract Objective: To identify the incidence of visual impairment in 5-year-old children in public schools from Curitiba-PR. Methods: A selection of schools has been choosen randomly from Curitiba. The children, with completed 5 years at end of 2017 have been evaluated using Snellen table, trough minimum distance for image sharpness and Hirschberg test. Parents answered a questionnaire about the use of screens, ocular symptoms and family history of the child. Significance levels were defines as begin p≤0,05. Results: The results have shown that four hundred fifty-nine children were screened. Two hundred nineteen are female (47,7%) and two hundred fourty (52,3%), male. From all screened patients, one hundred were refered to specialized oftalmic evaluation. After trial completing, has been attained a prevalence value of 10,7% for myopia, 17,6% of hyperopia and 0,9% of strabismus. Strong correlation between parents and children has been undiscovered (p<0,05). From listed oftalmic complaints, headache (30,4%) and frown (10%) where most prevalent. Conclusion: It has been attained that the prevalence of visual acuity is 21,8%. The relation between visual acuity alteration and familiar history has been shown to be significant related. On the other side, the average time in front of television has been shown the only habit that has correlation with visual acuity reduction (p=0,028). Vision complaints, although very frequent, doesn't translate into increased probability of visual acuity alteration.

Associação entre hiperopia e outros erros refrativos e visuais em crianças / Associations between hyperopia and others refractive and visual errors in children

RESUMO Objetivo: Investigar a associação da hipermetropia com ambliopia, estrabismo, anisometropia e astigmatismo. Métodos: A hiperopia foi classificada em Grupo 1: maior ou igual a +5.00D; Grupo 2: maior que +3.25D e menor que +5.00D, com diferença de equivalente esférico maior ou igual a 0.50D; Grupo 3: maior que +3.25D e menor que +5.00D, com diferença de equivalente esférico menor que 0.50D e Grupo 4: com equivalente esférico maior e igual a +2.00D. O Grupo controle pertencente ao equivalente esférico menor que +2.00D. Resultados: A presença de hipermetropia maior e igual a SE+2.00D foi significativamente associada à maior proporção de crianças com ambliopia (27,2 vs. 14,8%, OR = 2,150, p<0,001) e estrabismo (70,8 vs. 39,3%, OR = 3,758, p<0,0001. A presença de hipermetropia também foi significativamente associada à maior proporção de anisometropia nos grupos com hipermetropia maior e igual a SE+2.00 (29,1 vs. 9,9%, OR = 3,708, p<0,0001) e astigmatismo (24 vs. 9,9%, OR = 2,859 p<0,0001). Conclusão: A presença e magnitude da hipermetropia entre crianças foram associadas à maior proporção de erros refrativos e visuais, como estrabismo, ambliopia, astigmatismo e anisometropia.

RESUMO Objective: Evaluate ocular trauma cases related to falling in elderly patients e compare the prevalence and severity of the cases. Methods: A series of cases was made with 52 patients aging 60 or more within the period of 36 months presenting ocular trauma related to falling, whereas the prevalence between the gender, the need for hospitalization or surgery and subsequent visual deficit were evaluated, as well as the severity of the cases. Results: Thirty-three (63.5%) of 52 patients were from the female gender, over which 30.3% had need for surgery and 18.2% developed visual deficit and 19 (36.5%) were from the male gender where 42.1% needed surgery and 26.3% developed visual deficit. Conclusions: The study has shown a higher prevalence of cases in the female gender, although the severity was higher in the male gender.

Moderate hyperopia prevalence and associated factors among elementary school students.

Hyperopia is the most common refractive condition in childhood. There are few studies on moderate hyperopia and associated factors. This study aims to investigate the prevalence of moderate hyperopia and associated factors among school children. A cross-sectional study comprising 1,032 students attending 1st to 8th grades at two public schools was conducted in a Southern Brazilian urban area in 2012. Cycloplegia was used to examine both eyes and refractive error was measured through auto-refraction. A socioeconomic and cultural questionnaire was administered. Multivariable analysis was performed through Poisson regression. Moderate hyperopia prevalence was 13.4% (95% CI, 11.2-15.4) and 85% of these did not wear glasses. Age was inversely associated with moderate hyperopia, while female gender RP = 1.39 (95%CI, 1.02 - 1.90) and white skin RP = 1.66 (95%CI, 1.04 - 2.66) were risk factors for this outcome. This study makes progress in estimating mild and moderate hyperopia prevalence both by age range and specific age. It emphasizes how the lack of this condition being corrected in southern Brazil is a serious problem. It highlights the importance of detailing and characterizing the amount of time spent on close-range, long-range and outdoor activities.

Moderate hyperopia prevalence and associated factors among elementary school students / Prevalência de hipermetropia e fatores associados em escolares do ensino fundamental

Hyperopia is the most common refractive condition in childhood. There are few studies on moderate hyperopia and associated factors. This study aims to investigate the prevalence of moderate hyperopia and associated factors among school children. A cross-sectional study comprising 1,032 students attending 1st to 8th grades at two public schools was conducted in a Southern Brazilian urban area in 2012. Cycloplegia was used to examine both eyes and refractive error was measured through auto-refraction. A socioeconomic and cultural questionnaire was administered. Multivariable analysis was performed through Poisson regression. Moderate hyperopia prevalence was 13.4% (95% CI, 11.2-15.4) and 85% of these did not wear glasses. Age was inversely associated with moderate hyperopia, while female gender RP = 1.39 (95%CI, 1.02 - 1.90) and white skin RP = 1.66 (95%CI, 1.04 - 2.66) were risk factors for this outcome. This study makes progress in estimating mild and moderate hyperopia prevalence both by age range and specific age. It emphasizes how the lack of this condition being corrected in southern Brazil is a serious problem. It highlights the importance of detailing and characterizing the amount of time spent on close-range, long-range and outdoor activities.

A hipermetropia é o estado refrativo mais comum na infância. Este estudo objetiva investigar a prevalência de hipermetropia moderada e fatores associados entre escolares, tendo em vista haver poucos estudos sobre o assunto. Métodos: Estudo transversal com 1.032 crianças do 1º ao 8º anos de duas escolas públicas da zona urbana de uma cidade do sul do Brasil, no período de abril a dezembro de 2012. Ambos os olhos foram cicloplegiados e o erro refrativo foi medido através de autorrefração. Foi aplicado questionário socioeconômico e cultural. A análise multivariada foi realizada utilizando a regressão de Poisson. Resultados: A prevalência de hipermetropia moderada foi de 13,4% IC95% (11,2% - 15,4%) e 85% deles não usam óculos. Idade ficou inversamente associada com hipermetropia moderada enquanto sexo feminino OR=1,39 IC95% (1,02 - 1,90) e cor de pele branca OR=1,66 IC95% (1,04 - 2,66) foram fatores de risco para o desfecho. Conclusão: Este estudo avança na estimativa de prevalência de hipermetropia leve e moderada por faixa etária e por idade específica, enfatizando o grave problema da falta de correção no sul do Brasil. O estudo destaca a importância de detalhar e caracterizar a quantidade de tempo gasto em atividades de longe e de perto e ao ar livre.

Hyperopia: a meta-analysis of prevalence and a review of associated factors among school-aged children.

BACKGROUND: Studies show great variability in the prevalence of hyperopia among children. This study aimed to synthesize the existing knowledge about hyperopia prevalence and its associated factors in school children and to explore the reasons for this variability. METHODS: This systematic review followed PRISMA guidelines. Searching several international databases, the review included population- or school-based studies assessing hyperopia through cycloplegic autorefraction or cycloplegic retinoscopy. Meta-analysis of hyperopia prevalence was performed following MOOSE guidelines and using the random effects model. RESULTS: The review included 40 cross-sectional studies. The prevalence of hyperopia ranged from 8.4% at age six, 2-3% from 9 to 14 years and approximately 1% at 15 years. With regard to associated factors, age has an inverse association with hyperopia. The frequency of hyperopia is higher among White children and those who live in rural areas. There is no consensus about the association between hyperopia and gender, family income and parental schooling. CONCLUSION: Future studies should use standardized methods to classify hyperopia and sufficient sample size when evaluating age-specific prevalence. Furthermore, it is necessary to deepen the understanding about the interactions among hyperopic refractive error and accommodative and binocular functions as a way of identifying groups of hyperopic children at risk of developing visual, academic and even cognitive function sequelae.

Descripción de la función de sensibilidad al contraste en pacientes miopes e hipermétropes / Contrast sensitivity function in myopic and hyperopic patients

Objetivo: describir la Función de Sensibilidad al Contraste (FSC) en pacientes con miopía, astigmatismo miópico, hipermetropía y astigmatismo hipermetrópico. Diseño del estudio: serie de casos, descriptivo. Métodos: se incluyeron sujetos con miopía, astigmatismo miópico, hipermetropía y astigmatismo hipermetrópico, candidatos para cirugía refractiva y evaluados en la Unidad de Cirugía Refractiva de la Clínica de Oftalmología de Cali, con agudeza visual mejor corregida (AVMC) >=20/20, menores de 50 años de edad y sin antecedente de cirugía refractiva. La función sensibilidad al contraste se midió con el sistema OPTEC® 6500 (Stereo Optical Co, Inc., Chicago, USA) en frecuencias espaciales de 1.5, 3.0, 6.0, 12 y 18 ciclos/grado en condiciones fotópicas (85 cd/m2) y mesópicas (3 cd/m2). Se aplicaron las prueba no paramétrica de Wilcoxon y de Mann-Whitney para comparar diferencias entre la FSC entre los grupos de miopía/astigmatismo miópico e hipermetropía/astigmatismo hipermetrópico en las diferentes frecuencias espaciales. Resultados: se incluyeron 188 ojos de 95 sujetos con miopía y astigmatismo miópico (promedio de edad = 30,6 ± 7,6 años, 51% hombres) y 121 ojos de 64 sujetos con hipermetropía y astigmatismo hipermetrópico (promedio de edad = 43 ± 6,1 años, 62 % mujeres). La sensibilidad al contraste en los pacientes de ambos grupos fue mayor significativamente en condiciones fotópicas que en condiciones mesópicas, excepto en la frecuencia espacial de 3 ciclos/grado del grupo de miopía/astigmatismo miópico. Se encontró diferencia estadísticamente significativa del valor de la FSC entre los grupos de miopía/astigmatismo miópico e hipermetropía/astigmatismo hipermetrópico en condiciones fotópicas en casi todas las frecuencias espaciales, excepto en 3 ciclos/grado y en condiciones mesópicas en las frecuencias espaciales de 1.5, 3 y 6 ciclos/grado. Conclusiones: los valores de FSC son mayores en el grupo de pacientes con miopía y astigmatismo miópico que en los del grupo de hipermetropía y astigmatismo hipermetrópico. Estos valores podrían usarse como referencia en estos grupos de pacientes en nuestra población.

Purpose: to describe the contrast sensitivity function (CSF) in patients with myopia, hyperopia and astigmatism. Study design: descriptive case series study. Methods: subjects with myopia/myopic astigmatism and with hyperopia/hyperopic astigmatism looking for refractive surgery, and evaluated at the Unit of Refractive Surgery in the Clínica de Oftalmología de Cali were included. Their Best Spectacle Corrected Visual Acuity (BSCVA) was >=20/20, age less than 50 years and no previous refractive surgery. The CSF was measured using the OPTEC® 6500 (Stereo Optical Co, Inc, Chicago, USA) system for spatial frequencies 1.5, 3.0, 6.0, 12 and 18 cycles/degree in photopic (85 cd/m2) and mesopic (3 cd/m2) conditions. Statistical analysis was done using the Wilcoxon and Mann-Whitney tests for non-parametric samples, comparing the myopia/myopic astigmatism and the hyperopia /hyperopic astigmatism groups. Results: 188 eyes of 95 subjects with myopia/myopic astigmatism (age = 30,6 ± 7.6 years, 51% men) and 121 eyes of 64 subjects with hyperopia/hyperopic astigmatism (age = 43± 6.1 years, 62% women) were analyzed. The CSF was higher in both groups in photopic conditions except in 3 cycles per degree in myopia/myopic astigmatism group. Significant differences in the CSF were found between the two groups in photopic conditions excluding the 3 cycles per degree. In mesopic conditions diff erences were found for the spatial frequencies 1.5, 3 and 6 cycles per degree. Conclusions: The patients of the myopia/myopic astigmatism group had a contrast sensitivity function higher than those of hyperopia/hyperopic astigmatism group. These values could be used as reference for these patients in our population.

[Evaluation of predictability and refractive changes in pediatric pseudophakia]. / Evaluación de la predictibilidad y cambio refractivo en pseudofaquia pediátrica.

OBJECTIVE: Evaluate the predictability of the postoperative refraction and refractive changes in pediatric pseudophakia. METHODS: Prospective, longitudinal follow-up on patients under the age of 15 years operated on for a cataract with intraocular lens, with 5 continuous years of follow-up. The patients were divided into 4 groups according to age at the time of the surgery: group from 0 to 2 years old, from 3 to 5 years old, from 6 to 8 years old, and 9 years and over. Error prediction and refractive change were studied. Statistical analysis was performed using the Student t and ANOVA test. RESULTS: A total of 60 eyes were included (44 patients). No significant differences were found between the unilateral and bilateral group. The prediction error in the 0 to 2 years group was 1.5±1.8 D, significantly higher than in the other groups (ANOVA P=.01). Refractive change in 5 years of the group of 0 to 2 years was -4.7±3.4 D (ANOVA P=.0002), while in the other groups it was significantly lower, with no differences between them. CONCLUSIONS: The 0 to 2 years group was less hyperopic than expected, 100% within the accepted of 2 standard deviations, but with a high variability. The refractive change observed in this group coincides with previous reports that the largest growth and increase in axial length occurs during the first 2 years. The calculation and use of an IOL in children has a better immediate refractive prediction, and at long term in those older than 2 years of age.

Age of first distance spectacle prescription for manifest hyperopia.

PURPOSE: This study explores the natural history of hyperopic refractive error in relation to the recalled age of first distance prescription. METHODS: A population of adult office workers, coming for a general health check-up without refractive selection, completed a questionnaire about age of first distance prescription and were refracted by an ophthalmologist with non-cycloplegic subjective procedures. Hyperopia was defined as a spherical equivalent of +0.75 diopters or more. This study included 145 hyperopes aged 50-65 years at interview. RESULTS: The hyperopic subjects were first prescribed spectacles for distance vision in a broad spectrum of ages, from early childhood to adulthood. The subjects with older ages of first prescription tended to develop lower amounts of refractive error but this relation was not significant (Spearman's rho -0.126, p = 0.131). CONCLUSIONS: The age of first spectacle prescription in hyperopes is not strongly related to the final refractive error developed in adulthood.

[Refractive state in patients with phacoemulsification of cataract in uncommon situations]. / Estado refractivo en pacientes sometidos a facoemulsificación de catarata con situaciones especiales.

BACKGROUND: We undertook this study to determine the refractive state in patients who underwent non-complicated phacoemulsification under unusual situations. METHODS: This was a clinical, open, transversal, prospective and comparative study. Patients had the following conditions: congenital cataracts, hyperopia, myopia, and emetropia with previous corneal transplantation or vitreous cavity filled with silicone oil. RESULTS: Thirty-six eyes were included in our study vs. control group (52 emetropic eyes). There was no statistical significance in spherical equivalent 6 weeks postoperatively, with 59% of patients within +1.00 D, 73% +2.00 D and 28% > +2.00 D. CONCLUSIONS: Refractive state was favorable with an average of 0.96 D +/- 6.27.

Estado refractivo en pacientes sometidos a facoemulsificación de catarata con situaciones especiales / Refractive state in patients with phacoemulsification of cataract in uncommon situations

BACKGROUND: We undertook this study to determine the refractive state in patients who underwent non-complicated phacoemulsification under unusual situations. METHODS: This was a clinical, open, transversal, prospective and comparative study. Patients had the following conditions: congenital cataracts, hyperopia, myopia, and emetropia with previous corneal transplantation or vitreous cavity filled with silicone oil. RESULTS: Thirty-six eyes were included in our study vs. control group (52 emetropic eyes). There was no statistical significance in spherical equivalent 6 weeks postoperatively, with 59% of patients within +1.00 D, 73% +2.00 D and 28% > +2.00 D. CONCLUSIONS: Refractive state was favorable with an average of 0.96 D +/- 6.27.

[Prevalence of refractive errors in students in Northeastern Brazil]. / Prevalência dos erros refrativos em estudantes do Nordeste Brasileiro.

PURPOSE: To determine the prevalence of refractive errors in the public and private school system in the city of Natal, Northeastern Brazil. METHODS: Refractometry was performed on both eyes of 1,024 randomly selected students, enrolled in the 2001 school year and the data were evaluated by the SPSS Data Editor 10.0. Ametropia was divided into: 1- from 0.1 to 0.99 diopter (D); 2- 1.0 to 2.99 D; 3- 3.00 to 5.99 D and 4- 6D or greater. Astigmatism was regrouped in: I- with-the-rule (axis from 0 to 30 and 150 to 180 degrees), II- against-the-rule (axis between 60 and 120 degrees) and III- oblique (axis between > 30 and < 60 and >120 and <150 degrees). The age groups were categorized as follows, in: 1- 5 to 10 years, 2- 11 to 15 years, 3- 16 to 20 years, 4- over 21 years. RESULTS: Among refractive errors, hyperopia was the most common with 71%, followed by astigmatism (34%) and myopia (13.3%). Of the students with myopia and hyperopia, 48.5% and 34.1% had astigmatism, respectively. With respect to diopters, 58.1% of myopic students were in group 1, and 39% distributed between groups 2 and 3. Hyperopia were mostly found in group 1 (61.7%) as well as astigmatism (70.6%). The association of the astigmatism axes of both eyes showed 92.5% with axis with-the-rule in both eyes, while the percentage for those with axis against-the-rule was 82.1% and even lower for the oblique axis (50%). CONCLUSION: The results found differed from those of most international studies, mainly from the Orient, which pointed to myopia as the most common refractive error, and corroborates the national ones, with the majority being hyperopia.

Prevalence of refractive errors in students in Northeastern Brazil

OBJETIVO: Determinar a prevalência das ametropias em estudantes das redes pública e privada de Natal-RN. MÉTODOS: Foi realizada refratometria de 2.048 olhos de estudantes matriculados no ano letivo de 2001 e os dados avaliados com planilha do SPSS Data Editor 11. As ametropias foram divididas em: 1- de 0,1 até 0,99D (dioptria); 2- 1,0 até 2,99D; 3- 3,00 até 5,99D e 4- 6D ou maior. O astigmatismo foi reagrupado em I- a favor da regra (eixo entre 0 a 30 e 150 a 180 graus), II- contra a regra (eixo entre 60 e 120 graus) e III- oblíquo (eixo entre >30 e <60 e >120 e <150 graus). A faixa etária foi categorizada em 1- 5 a 10 anos, 2- 11 a 15 anos, 3- 16 a 20 anos, 4- 21anos ou mais. RESULTADOS: Dos erros refrativos, a hipermetropia foi o mais comum com 71%, em seguida astigmatismo, 34% e miopia, 13,3%. 48,5% dos míopes e 34,1% dos hipermétropes tinham astigmatismo. De acordo com as dioptrias, 58,1% dos míopes estão no grupo 1, 39% distribuídos entre os grupos 2 e 3. Os hipermétropes enquadram-se em sua maioria no grupo 1 (61,7%) e o astigmatismo no mesmo grupo com 70,6%. A associação dos eixos do astigmatismo dos dois olhos mostrou 95,2% com eixo a favor da regra nos dois olhos, diminuindo a porcentagem para os do eixo contra a regra (82,1%) e menor ainda para os do eixo oblíquo, apenas 50%. CONCLUSAO: Os resultados encontrados mostraram discordância com a maioria dos trabalhos internacionais, principalmente os orientais, que apontam a miopia como o erro refrativo mais comum e corrobora os nacionais, com a grande parte sendo hipermétropes.

Refractive error in a Puerto Rican rural population.

The distribution of refractive error in migrant workers and their families living in Patillas, Puerto Rico was studied. A total of 1,109 patients with an age range of 5-81 years and above was screened using the modified clinical technique. The refractive distribution of the total screened indicated that 10.2 percent had myopia, 17.7 percent had hyperopia and the rest had a combination of other refractive error (astigmatism, anisometropia and emmetropia). Myopia was most frequent in the age group 11-20 years (16.7 percent) and 21-30 years (16.8 percent) and decreased in the younger and older age groups. Frequency of hyperopia increased from age 31-70 years and then decreased thereafter. Hyperopic astigmatism was more common than myopic astigmatism across all age groups.