Assuntos
Analgésicos Opioides/efeitos adversos , Anemia/etiologia , Contaminação de Medicamentos , Hipocalcemia/etiologia , Intoxicação do Sistema Nervoso por Chumbo em Adultos/diagnóstico por imagem , Intoxicação do Sistema Nervoso por Chumbo em Adultos/etiologia , Transtornos Relacionados ao Uso de Opioides/complicações , Convulsões/etiologia , Tomografia Computadorizada por Raios X , Adulto , Analgésicos Opioides/análise , Anemia/sangue , Anemia/diagnóstico , Anemia/tratamento farmacológico , Biomarcadores/sangue , Cálcio/sangue , Quelantes/uso terapêutico , Hemoglobinas/metabolismo , Humanos , Hipocalcemia/sangue , Hipocalcemia/diagnóstico , Hipocalcemia/tratamento farmacológico , Intoxicação do Sistema Nervoso por Chumbo em Adultos/sangue , Intoxicação do Sistema Nervoso por Chumbo em Adultos/tratamento farmacológico , Masculino , Transtornos Relacionados ao Uso de Opioides/diagnóstico , Valor Preditivo dos Testes , Convulsões/diagnóstico , Convulsões/tratamento farmacológico , Resultado do TratamentoRESUMO
BACKGROUND AND OBJECTIVE: Lead poisoning is normally caused by repeated occupational inhalation of lead. However, lead may also be absorbed through the digestive route. Some alternative medical treatments, such as Ayurvedic medicine, can also contain lead and may result in poisoning. PATIENTS AND METHOD: We collected cases of lead poisoning related to Ayurvedic treatments attended at the Hospital Clinic of Barcelona. RESULTS: Two female patients, aged 45 and 57 years, respectively, who initiated Ayurvedic treatments which involved the ingestion of various medicaments, were included. The first patient presented with anemia and abdominal pain. The lead level was 74µg/dL and free erythrocyte protoporphyrin was 163µg/dL. She was treated with intravenous calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA) and later with oral dimercaptosuccinic acid (DMSA) with a good evolution. The second patient presented with abdominal pain and a Burton's line. The lead level was 52µg/dL and free erythrocyte protoporphyrin was 262µg/dL. She was treated with oral DMSA and evolved favorably. Lead concentrations in some of the tablets supplied to the patients reached 2,003 and 19,650µg/g of tablet. CONCLUSIONS: Lead poisoning may result from treatments based on Ayurvedic medicine and may reach epidemic proportions. Health control of alternative medicines is necessary.
Assuntos
Intoxicação do Sistema Nervoso por Chumbo em Adultos/etiologia , Ayurveda , Dor Abdominal/etiologia , Anemia Hipocrômica/etiologia , Bursite/complicações , Bursite/tratamento farmacológico , Terapia por Quelação , Ácido Edético/uso terapêutico , Feminino , Fibromialgia/complicações , Fibromialgia/tratamento farmacológico , Humanos , Intoxicação do Sistema Nervoso por Chumbo em Adultos/diagnóstico , Intoxicação do Sistema Nervoso por Chumbo em Adultos/tratamento farmacológico , Pessoa de Meia-Idade , Succímero/uso terapêutico , Talassemia beta/complicaçõesAssuntos
Intoxicação do Sistema Nervoso por Chumbo em Adultos/sangue , Chumbo/sangue , Exposição Ocupacional/prevenção & controle , Adulto , Humanos , Intoxicação do Sistema Nervoso por Chumbo em Adultos/tratamento farmacológico , Exposição Ocupacional/efeitos adversos , Estados Unidos , United States Occupational Safety and Health AdministrationRESUMO
Lead poisoning following intake of Ayurvedic medication is one of the recent areas of concern. We report a case of a 58-year-old type II diabetic man who was stable with diet control and 30 mg pioglitazone per day. He took Ayurvedic medication for generalized weakness and developed peripheral neuropathy following its intake. He was found to have high blood and urinary lead levels and was diagnosed to have subacute lead poisoning. He was treated with d-Penicillamine for 8 weeks, following which his lead levels became normal. The use of d-Penicillamine was proved highly effective in treating a case of lead poisoning.
Assuntos
Quelantes/uso terapêutico , Intoxicação do Sistema Nervoso por Chumbo em Adultos/tratamento farmacológico , Ayurveda , Penicilamina/uso terapêutico , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Doenças do Sistema Nervoso Periférico/tratamento farmacológico , Contaminação de Medicamentos , Humanos , Chumbo/sangue , Chumbo/urina , Intoxicação do Sistema Nervoso por Chumbo em Adultos/etiologia , Masculino , Pessoa de Meia-IdadeRESUMO
We present a case history of a 24 years old male who developed autonomic dysfunction, intestinal pseudo-obstruction and anemia due to lead poisoning. Concomitant recording of blood levels of lead and autonomic function showed a gradual decline in blood lead level (98.8 microg/dL at week 0, 56 microg/dL at week 6, and 40 microg/dL at week 52) and gradual improvement in autonomic functions. Decrease in blood lead levels with DMSA (Meso-2, 3-dimercaptosuccinic acid) therapy showed improvement in autonomic functions. At week 0, the patient had severe loss of autonomic tone and autonomic reactivity which improved at week 6. At the 52nd week, most of the autonomic parameters had normalized except for the persistence of mild loss of parasympathetic reactivity.
