RESUMO
On the 3rd day after the last administration of phenobarbital (50 mg/kg orally, 4 days), benzonal (35 mg/kg orally, 4 days), zixorine (200 mg/kg orally, 4 days) and 3-methylcholanthrene (20 mg/kg subcutaneously, 2 days) the rats exhibited a decrease of iodamide secretion in the kidneys. The administration of zixorine to the dog (200 mg orally, 6 days) led to a significant decrease of iodamide transport in the first two weeks after discontinuation of the drug administration.
Assuntos
Iodamida/farmacocinética , Rim/efeitos dos fármacos , Microssomos/efeitos dos fármacos , Animais , Transporte Biológico/efeitos dos fármacos , Depressão Química , Indução Enzimática/efeitos dos fármacos , Feminino , Rim/enzimologia , Masculino , Microssomos/enzimologia , Ratos , Fatores de TempoRESUMO
In chronic experiments on dogs it was shown that verografin and iodamide are excreted from the body not only by filtration but by tubular excretion as well. The maximal transport of verografin and iodamide is significantly lower than that of cardiotrast. In experiments on rats similar results were obtained. Concurrent administration of verografin and iodamide with cardiotrast decreases their excretion in the urine in rats that is probably due to competition for the common transport system in the epithelium of renal tubules.