Assuntos
Broncografia , Reação a Corpo Estranho/induzido quimicamente , Granuloma de Corpo Estranho/induzido quimicamente , Iodopiridonas/efeitos adversos , Pneumopatias/induzido quimicamente , Pneumopatias/diagnóstico por imagem , Propiliodona/efeitos adversos , Granuloma de Corpo Estranho/patologia , Humanos , Pulmão/patologia , Pneumopatias/patologiaAssuntos
Anticorpos Antifúngicos/análise , Asma/induzido quimicamente , Cladosporium/imunologia , Meios de Contraste/efeitos adversos , Imunoglobulina E/análise , Iodopiridonas/efeitos adversos , Fungos Mitospóricos/imunologia , Propiliodona/efeitos adversos , Eosinofilia Pulmonar/induzido quimicamente , Broncografia , Humanos , Masculino , Pessoa de Meia-Idade , Alvéolos Pulmonares/diagnóstico por imagemRESUMO
Thyroid function was studied in 27 subjects who underwent bronchography with propyliodone (18-70 ml, containing 30% of organic iodine). Sustained elevations of serum non-hormonal iodine were observed, indicating that significant amounts of propyliodone were absorbed from the bronchial tree and also that elimination may take several weeks. During the period of anaesthesia, there was an increase in thyroxine-binding globulin and all thyroid hormones which was transient and probably reflected vascular response to the anaesthetic. T4-T3 conversion was inhibited with a nadir of T3 and a peak of rT3 occurring on the 2nd day after propyliodone exposure. FT4 increased gradually during the 2 weeks after bronchography, but remained within the normal range. 6 out of the 27 patients developed pathologic T4 levels, 3 elevated T3 levels, and 2 an abnormal response to thyrotropin-releasing hormone; these changes might have been confused with hyperthyroidism. None of the patients developed clinical thyrotoxicosis; however, in patients with autonomous thyroid tissue, the same precautions should be taken with propyliodone as with other iodine-containing agents which are known to induce hyperthyroidism in this situation.
Assuntos
Broncografia/efeitos adversos , Iodopiridonas/efeitos adversos , Propiliodona/efeitos adversos , Glândula Tireoide/fisiologia , Adulto , Proteínas Sanguíneas/metabolismo , Feminino , Humanos , Iodo/sangue , Masculino , Pessoa de Meia-Idade , Hormônio Liberador de Tireotropina , Tiroxina/sangue , Proteínas de Ligação a Tiroxina/metabolismo , Fatores de Tempo , Tri-Iodotironina/sangue , Tri-Iodotironina Reversa/sangueRESUMO
Severe reactions to oily propyliodone are rare. Side-effects are usually mild and self-limiting. Three cases are reported of early pulmonary reactions, the cause of which may be a chemical pneumonitis or possibly an allergic response to one of the components of the contrast medium. There was a good response to corticosteroid therapy in all three patients.
Assuntos
Iodopiridonas/efeitos adversos , Pneumopatias/induzido quimicamente , Óleos/efeitos adversos , Óleos de Plantas , Propiliodona/efeitos adversos , Adulto , Broncografia , Feminino , Humanos , Pneumopatias/diagnóstico por imagem , Masculino , Óleo de AmendoimRESUMO
Cerebral embolization of an aqueous solution of propyliodone (Dionosil) occurred during selective bronchographic studies following a fiberoptic bronchoscopic procedure with transbronchial biopsy in a patient undergoing investigation of a pulmonary lesion. The embolization resulted in a grand mal seizure and transient neurologic deficits. This potential complication has not been previously reported. We suggest that selective bronchographic studies be avoided when the transbronchial biopsy is associated with endobronchial bleeding.
