Assuntos
Isobutiratos , Odorantes , Perfumes , Animais , Humanos , Qualidade de Produtos para o Consumidor , Bases de Dados de Compostos Químicos , Determinação de Ponto Final , Isobutiratos/toxicidade , Isobutiratos/química , Nível de Efeito Adverso não Observado , Perfumes/toxicidade , Perfumes/química , Medição de Risco , Testes de ToxicidadeAssuntos
Perfumes , Humanos , Perfumes/toxicidade , Perfumes/química , Animais , Medição de Risco , Odorantes , Isobutiratos/toxicidade , Isobutiratos/química , Testes de Toxicidade , Determinação de Ponto Final , Qualidade de Produtos para o Consumidor , Nível de Efeito Adverso não Observado , Bases de Dados de Compostos QuímicosRESUMO
The existing information supports the use of this material as described in this safety assessment. Octyl isobutyrate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog hexyl isobutyrate (CAS # 2349-07-7) show that octyl isobutyrate is not expected to be genotoxic. Data on analog propyl (2S)-2-(1,1-dimethylpropoxy)-propanoate (CAS # 319002-92-1) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose and reproductive toxicity endpoints. Data from analog hexyl 2-methylbutyrate (CAS # 10032-15-2) provided octyl isobutyrate a No Expected Sensitization Induction Level (NESIL) of 7000 µg/cm2 for the skin sensitization endpoint. Octyl isobutyrate is not expected to be phototoxic/photoallergenic based on ultraviolet/visible (UV/Vis) spectra. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material; exposure to is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; octyl isobutyrate was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
Assuntos
Isobutiratos/toxicidade , Odorantes , Humanos , Testes de Mutagenicidade , Testes de ToxicidadeAssuntos
Isobutiratos , Perfumes , Testes de Toxicidade , Animais , Feminino , Humanos , Masculino , Ratos , Células Cultivadas , Bases de Dados de Compostos Químicos , Isobutiratos/química , Isobutiratos/toxicidade , Testes para Micronúcleos , Monoterpenos/química , Monoterpenos/toxicidade , Perfumes/química , Perfumes/toxicidade , Ratos Sprague-Dawley , Reprodução/efeitos dos fármacos , Absorção Cutânea/efeitos dos fármacosAssuntos
Isobutiratos/toxicidade , Perfumes/toxicidade , Compostos Alílicos/química , Compostos Alílicos/toxicidade , Qualidade de Produtos para o Consumidor , Humanos , Isobutiratos/química , Perfumes/química , Sistema de Registros , Medição de Risco , Testes de Toxicidade , Compostos Orgânicos Voláteis/química , Compostos Orgânicos Voláteis/toxicidadeAssuntos
Isobutiratos/toxicidade , Perfumes/toxicidade , Animais , Qualidade de Produtos para o Consumidor , Bases de Dados de Compostos Químicos , Humanos , Isobutiratos/química , Perfumes/química , Ratos , Sistema de Registros , Medição de Risco , Testes de Toxicidade , Compostos Orgânicos Voláteis/química , Compostos Orgânicos Voláteis/toxicidadeAssuntos
Isobutiratos/toxicidade , Perfumes/toxicidade , Terpenos/toxicidade , Animais , Ecotoxicologia , Determinação de Ponto Final , Escherichia coli/efeitos dos fármacos , Humanos , Isobutiratos/química , Odorantes , Perfumes/química , Medição de Risco , Salmonella typhimurium/efeitos dos fármacos , Terpenos/químicaAssuntos
Indenos/toxicidade , Isobutiratos/toxicidade , Perfumes/toxicidade , Animais , Ecotoxicologia , Determinação de Ponto Final , Escherichia coli/efeitos dos fármacos , Humanos , Indenos/química , Isobutiratos/química , Odorantes , Perfumes/química , Medição de Risco , Salmonella typhimurium/efeitos dos fármacosAssuntos
Compostos de Benzil/toxicidade , Isobutiratos/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Animais , Compostos de Benzil/química , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Isobutiratos/química , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
A toxicologic and dermatologic review of benzyl isobutyrate when used as a fragrance ingredient is presented. Benzyl isobutyrate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for benzyl isobutyrate were evaluated, then summarized, and includes: physical properties, acute toxicity, skin irritation, or skin sensitization data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.
Assuntos
Compostos de Benzil/toxicidade , Isobutiratos/toxicidade , Perfumes , Animais , Compostos de Benzil/farmacocinética , Feminino , Humanos , Isobutiratos/farmacocinética , Masculino , Coelhos , Ratos , Pele/efeitos dos fármacos , Testes de ToxicidadeRESUMO
A toxicologic and dermatologic review of phenethyl isobutyrate when used as a fragrance ingredient is presented. Phenethyl isobutyrate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate, and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for phenethyl isobutyrate were evaluated, then summarized, and includes: physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, and genotoxicity data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.
Assuntos
Isobutiratos/toxicidade , Perfumes , Animais , Feminino , Humanos , Isobutiratos/farmacocinética , Masculino , Coelhos , Ratos , Ratos Wistar , Pele , Testes de ToxicidadeRESUMO
A toxicologic and dermatologic review of (4-methoxyphenyl)methyl isobutyrate when used as a fragrance ingredient is presented. (4-Methoxyphenyl)methyl isobutyrate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to (4-methoxyphenyl)methyl isobutyrate and is not intended as a stand-alone document. Available data were evaluated, then summarized, and includes physical properties data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.
Assuntos
Isobutiratos/toxicidade , Perfumes , Animais , Humanos , Isobutiratos/farmacocinética , Pele/efeitos dos fármacos , Testes de ToxicidadeRESUMO
A toxicologic and dermatologic review of 1,1-dimethyl-2-phenylethyl isobutyrate when used as a fragrance ingredient is presented. 1,1-Dimethyl-2-phenylethyl isobutyrate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1,1-dimethyl-2-phenylethyl isobutyrate were evaluated, then summarized, and includes physical properties data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al., 2012 for an overall assessment of the safe use of this material and all AAASAE in fragrances.
Assuntos
Isobutiratos/toxicidade , Perfumes , Animais , Humanos , Isobutiratos/farmacocinética , Pele/efeitos dos fármacos , Testes de ToxicidadeRESUMO
A toxicologic and dermatologic review of α-methylbenzyl isobutyrate when used as a fragrance ingredient is presented. α-Methylbenzyl isobutyrate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for α-methylbenzyl isobutyrate were evaluated, then summarized, and includes physical properties data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.
Assuntos
Isobutiratos/toxicidade , Perfumes , Animais , Humanos , Testes de ToxicidadeRESUMO
A toxicologic and dermatologic review of 2-phenoxyethyl isobutyrate when used as a fragrance ingredient is presented. 2-Phenoxyethyl isobutyrate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-phenoxyethyl isobutyrate were evaluated, then summarized, and includes: physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, toxicokinetics, repeated dose, and genotoxicity data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.
Assuntos
Isobutiratos/toxicidade , Perfumes , Animais , Feminino , Humanos , Isobutiratos/farmacocinética , Masculino , Coelhos , Ratos , Pele/efeitos dos fármacos , Testes de ToxicidadeRESUMO
A toxicologic and dermatologic review of 3-phenylpropyl isobutyrate when used as a fragrance ingredient is presented. 3-Phenylpropyl isobutyrate is a member of the fragrance structural group cinnamyl phenylpropyl compounds. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. They are simple aromatic compounds with saturated propyl or unsaturated propenyl side chains containing a primary oxygenated functional group which has little toxic potential. 3-Phenyl-1-propyl derivatives participate in the same beta oxidation pathways as do their parent cinnamic acid derivatives. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 3-phenylpropyl isobutyrate was evaluated then summarized and includes physical properties, acute toxicity, skin irritation and skin sensitization. A safety assessment of all cinnamyl phenyl propyl compounds will be published simultaneously with this document. Please refer to Belsito et al. (2011) for an overall assessment of the safe use of this material and all cinnamyl phenylpropyl materials in fragrances. Belsito, D., Bickers, D., Bruze, M., Dagli, M.L., Fryer, A., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of cinnamyl phenylpropyl compounds when used as fragrance ingredients.
