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J Pediatr ; 173: 169-74, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26898807

RESUMO

OBJECTIVE: To determine whether renal transplantation survival is similar in children receiving pediatric en bloc kidneys compared with those receiving standard deceased donor kidneys. STUDY DESIGN: We compared time to allograft failure and estimated glomerular filtration rate (eGFR) in pediatric recipients of en bloc and standard criteria deceased donor renal transplants using Organ Procurement and Transplantation Network data for 2000-2013. Cox regression analysis was used to compare time to allograft failure, and the Student t test was used to compare eGFR. RESULTS: A total of 6882 recipients met the study inclusion criteria; 1.8% received an en bloc transplant. The adjusted hazard for allograft failure was similar for recipients of en bloc kidneys compared with standard criteria kidneys (hazard ratio, 1.15; 95% CI, 0.83-1.59; P = .41). The median wait time for transplantation was significantly shorter for recipients of en bloc kidneys (157 days vs 208 days; P = .03). Moreover, eGFR was superior for recipients of en bloc kidneys up to 5 years post-transplantation. CONCLUSION: Transplantation of en bloc pediatric kidneys should be considered a viable option for pediatric recipients and may afford unique benefits by reducing wait times and promoting preservation of graft function.


Assuntos
Sobrevivência de Enxerto , Transplante de Rim/métodos , Coleta de Tecidos e Órgãos/métodos , Adolescente , Soro Antilinfocitário/uso terapêutico , Criança , Estudos de Coortes , Isquemia Fria/estatística & dados numéricos , Feminino , Taxa de Filtração Glomerular , Humanos , Imunossupressores/uso terapêutico , Masculino , Estudos Retrospectivos , Tempo para o Tratamento , Estados Unidos
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