RESUMO
Eosinophilic apoptotic (necrotic) keratinocytes in the lower epidermis and at the dermoepidermal junction are a feature of many interface dermatoses but are most reliably found in lichen planus. These structures are universally known as Civatte bodies. Nonetheless, they were first described by Raymond Sabouraud in 1912. Even after Achille Civatte discussed and beautifully illustrated them a decade later, it took until the late 1960s for the term Civatte body to win acceptance.
Assuntos
Apoptose , Epiderme/patologia , Queratinócitos/patologia , Líquen Plano/patologia , Epiderme/metabolismo , História do Século XX , História do Século XXI , Humanos , Queratinócitos/metabolismo , Líquen Plano/história , Líquen Plano/metabolismo , Necrose , Retratos como AssuntoRESUMO
El liquen plano (LP) es una dermatosis inflamatoria crónica que afecta a la piel, membranas mucosas, pelo y uñas; de etiología desconocida, en cuya patogenia existe un daño autoinmunitario mediado por linfocitos T frente a los queratinocitos basales que expresan autoantígenos alterados en su superficie. Se presenta con diferentes patrones clínicos, como LP oral, LP anular, LP lineal, LP atrófico, LP hipertrófico, LP ampollar, LP pigmentoso, LP actínico. Su presentación clásica se caracteriza por pápulas poligonales o placas, pruriginosas, de coloración violácea, superficie brillante, surcada por estrias blanquecinas, característicamente distribuidas en forma simétrica sobre todo en las superficies flexoras de la muñeca, tobillos y muslos. Evoluciona por brotes y su curso es autolimitado, se resuelve en un periodo de meses a años, pero puede persistir indefinidamente. Existen múltiples opciones de tratamiento que incluyen corticoides tópicos, intralesionales y sistémicos, retinoides, fototerapia, inmunomoduladores tópicos y en casos graves o resistentes al tratamiento, la ciclosporina, metotrexato y fotoféresis extracorpórea.
Lichen planus (LP) is a chronic inflammatory dermatosis that affectsthe skin, mucous membranes, hair and nails; of unknown aetiology, whose pathogenesis is autoimmune damage mediated by T cells against basal keratinocytes that express autoantigens altered on its surface. It comes with different clinical patterns, such as oralLP, LP annularis, LP linearis, LP, LP verrucosus, bullosa LP, LP pigmentosus, LP actinicus. Classical presentation is characterized bypolygonal papules or plaques, pruritic, violet colour, glossy surface, drained by whitish stretch marks, characteristically distributed in symmetrical form especially in surface flexors of the wrist, ankles and thighs. It evolves by outbreaks and its course is self-limited, resolving in a period of months to years, but may persist indefinitely. There are multiple treatment options including steroids topics, miscellaneous and systemic, retinoids, phototherapy, immunomodulators topical and in cases of severe or resistant to treatment, ciclosporin, methotrexate and photoferesis extracorporea.
Assuntos
Humanos , Masculino , Feminino , Ilustração Médica , Líquen Plano/diagnóstico , Líquen Plano/etiologia , Líquen Plano/história , Líquen Plano/patologia , Líquen Plano/terapia , Educação Médica ContinuadaRESUMO
In 1895, Louis-Fédéric Wickham described whitish streaks, now known as Wickham's striae, on the surface of lichen planus papules. This historical note reprises the original article by Wickham, discusses his life and work, and describes the clinical picture and histopathologic foundation of the striae. The clinical feature, the histopathology, and the pathogenesis of lichen planus are not discussed.
