[Radiation damage to the hemopoietic system of mice, carriers of the leukemia virus]. / Radiatsionnoe porazhenie sistemy gemopoéza u myshei--nositelei virusa leikoza.

The experiments with AKR mice, that are carriers of the T-cell leukemia virus showed their higher radiosensitivity as compared to (CBA x C57Bl)F1 mice in respect of survival and hemopoietic status. The regular patterns observed are presumed to result from lower ability of AKR mice to repair radiation damage and provide resistance to infections.

Effect of lysine on survival of AKR leukemic mice.

The effect of lysine/arginine antagonism on the survival of mice with virally - produced leukemia was investigated by feeding AKR mice diets low in arginine with varying amounts of lysine. Over a period of one year, a diet containing 5.6% lysine and no arginine resulted in a significantly lower mortality than one with lower levels of lysine, plus arginine.

Prevention of paralysis and suppression of lymphoma in wild mice by passive immunization to congenitally transmitted murine leukemia virus.

Lake Casitas wild mice were passively immunized as newborns with antiserum to congenitally transmitted murine leukemia virus. Immunization with immunoglobulin having a high neutralizing titer to ecotropic virus and a low titer to amphotropic virus correlated with the complete prevention of paralysis and a slight (25%), but statistically insignificant, reduction in the incidence of lymphoma. Occurrence of other tumor types and total mortality rate were not affected by immunization.

Congenital transmission of murine leukemia virus from wild mice prone to the development of lymphoma and paralysis.

Maternal congenital transmission of infectious murine leukemia virus, primarily via milk, was the major route of virus spread in Lake Casitas (LC) wild mice and in crosses of LC mice with uninfected wild and laboratory mice. An indirect extrachromosomal male transmission in utero of LC virus also readily occurred in matings of viremic LC males with C57L females but apparently not with other uninfected wild or NIH Swiss females. Both amphotropic and ecotropic classes of LC murine leukemia viruses were potentially transmissible by congenital and venereal epigenetic means and could induce the same two diseases, lymphoma and paralysis, that occurred naturally in LC wild mice. Lymphoma and paralysis both failed to occur in uninfected LC mice or their hybrid progeny that escaped congenital infection.

[Intrauterine transmission of induced hemoblastosis in monkeys, associated with type-C oncornavirus]. / Vnutriutrobnaia peredacha indutsirovannogo u obez'ian gemoblastoza, assotsiirovannogo s onkornavirusom C-tipa

The possibility of intrauterine transmission of hemoblastosis was investigated in a group of 118 M. arctoides females with induced viral hemoblastosis. In the course of observations pregnancy occurred in 9 cases. Four of seven babies, delivered at term have developed hemoblastosis. The main signs of the disease were revealed in babies from the first days of their life. Hemoblastosis was accompanied with the appearance of a specific surface antigen and the presence of the "C" type oncornavirus in blood and organs of the babies, and also in cells of one embryo. Viral hemoblastosis was successfully passaged from one of the babies to three juvenile monkeys of the same species.