Assuntos
Atitude do Pessoal de Saúde , Cultura , Leucemia Mieloide Aguda/psicologia , Leucemia Mieloide Aguda/terapia , Leucocitose/psicologia , Padrões de Prática Médica/estatística & dados numéricos , Padrões de Prática Médica/tendências , Gerenciamento Clínico , Humanos , Internet , Prognóstico , Inquéritos e Questionários , Estados UnidosRESUMO
The syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) now referred to in the IHS ICHD-II code 7.8, is only infrequently accompanied by a confusional state and severe agitation. We report the case of a 34-year-old man who suffered from three episodes of headache with transient focal neurological deficits that were consistent with HaNDL but that were accompanied by an intense, confusional agitated state that required admission, in the first episode, in a psychiatric unit.
Assuntos
Líquido Cefalorraquidiano , Confusão/complicações , Cefaleia/complicações , Leucocitose/complicações , Doenças do Sistema Nervoso/complicações , Doença Aguda , Adulto , Confusão/psicologia , Cefaleia/psicologia , Humanos , Leucocitose/psicologia , Masculino , Doenças do Sistema Nervoso/psicologiaRESUMO
Adult male rats were administered intrapleural (ipl) or intraperitoneal (i.p.) injection of lipopolysaccharide (LPS), 24 h after being submitted to forced swim test (FST). Four hours after LPS challenge, an increase in pleural and peritoneal leukocyte and neutrophil counts in animals not exposed to FST was noted. FST induced a marked increase in pleural, but not in peritoneal, neutrophil leukocytosis. The results suggest that lowered mood may increase inflammatory response to LPS.
Assuntos
Leucocitose/imunologia , Lipopolissacarídeos/administração & dosagem , Neutrófilos/imunologia , Neutrófilos/patologia , Animais , Líquido Ascítico/patologia , Depressão/imunologia , Depressão/psicologia , Inflamação/imunologia , Inflamação/psicologia , Injeções Intraperitoneais , Contagem de Leucócitos/métodos , Leucocitose/patologia , Leucocitose/psicologia , Masculino , Neutrófilos/efeitos dos fármacos , Pleura/patologia , Ratos , Ratos Wistar , Natação/fisiologia , Natação/psicologiaRESUMO
To date, there has been a small number of reports that severe depression is accompanied by disturbances in total white blood cell (i.e. leukocytosis) and leukocyte subset (i.e. neutrophilia, monocytosis, lymphopenia) counts. These results, however, have not yet been validated in a large-scale, well-controlled study. To this end, we have counted the number of leukocytes, monocytes, lymphocytes and granulocytes (neutrophils, eosinophils, basophils) in 22 healthy controls and in 109 depressed inpatients. We noted leukocytosis in major depressed patients compared with normal subjects, whilst minor depressives manifested intermediate findings. Leukocytosis was significantly more pronounced in major depressed males compared with major depressed females. Major depression related leukocytosis appears to be characterized by neutrophilia and monocytosis. There was a significant positive relationship between the overall severity of illness on one hand, and the degrees of leukocytosis, neutrophilia and monocytosis on the other. The total number of both phagocytic cell populations (i.e. monocytes and neutrophils) was significantly and positively related. Our results might point to the existence of an inflammatory process in major depressed subjects, particularly in males.
